ATE348819T1 - Ein verfahren zur synthese von ritonavir - Google Patents

Ein verfahren zur synthese von ritonavir

Info

Publication number
ATE348819T1
ATE348819T1 AT00964626T AT00964626T ATE348819T1 AT E348819 T1 ATE348819 T1 AT E348819T1 AT 00964626 T AT00964626 T AT 00964626T AT 00964626 T AT00964626 T AT 00964626T AT E348819 T1 ATE348819 T1 AT E348819T1
Authority
AT
Austria
Prior art keywords
ritonavir
stages
process described
synthesis
btc
Prior art date
Application number
AT00964626T
Other languages
English (en)
Inventor
Pietro Bellani
Marco Frigerio
Patrizia Castoldi
Original Assignee
Archimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Archimica Srl filed Critical Archimica Srl
Application granted granted Critical
Publication of ATE348819T1 publication Critical patent/ATE348819T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Silicon Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00964626T 1999-09-21 2000-09-18 Ein verfahren zur synthese von ritonavir ATE348819T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001950A IT1313624B1 (it) 1999-09-21 1999-09-21 Procedimento per la sintesi del ritonavir

Publications (1)

Publication Number Publication Date
ATE348819T1 true ATE348819T1 (de) 2007-01-15

Family

ID=11383628

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00964626T ATE348819T1 (de) 1999-09-21 2000-09-18 Ein verfahren zur synthese von ritonavir

Country Status (11)

Country Link
US (1) US6407252B1 (de)
EP (1) EP1133485B1 (de)
JP (1) JP2003509504A (de)
KR (1) KR100708581B1 (de)
AT (1) ATE348819T1 (de)
AU (1) AU7554600A (de)
DE (1) DE60032453T2 (de)
ES (1) ES2278631T3 (de)
HU (1) HUP0104259A3 (de)
IT (1) IT1313624B1 (de)
WO (1) WO2001021603A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006090270A1 (en) * 2005-02-28 2006-08-31 Ranbaxy Laboratories Limited Acid addition salt of 2-isopropyl-4-(((n-methyl)amino)methyl)thiazole and its?use in the preparation of ritonavir
US8501792B2 (en) 2008-02-19 2013-08-06 David A. Potter Treating cancer with desthiazolyl ritonavir
US8598216B1 (en) * 2010-12-17 2013-12-03 Abbvie Inc. Ritonavir bis-hydrochloride
CN108218808A (zh) * 2018-04-04 2018-06-29 盐城迪赛诺制药有限公司 一种利托那韦的制备方法
EP3842323B1 (de) 2019-11-11 2024-06-26 Andrus Research Inc. Entfaltbare verkleidung für ein transportfahrzeug

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5539122A (en) 1989-05-23 1996-07-23 Abbott Laboratories Retroviral protease inhibiting compounds
US5354866A (en) 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
KR100333016B1 (ko) 1992-12-29 2002-11-22 아보트 러보러터리즈 레트로바이러스성프로테아제억제화합물,이의제조방법및이를함유하는약제학적조성물
US5559158A (en) * 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
US5491253A (en) 1993-10-22 1996-02-13 Abbott Laboratories Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
EP0748801B1 (de) * 1994-03-02 2001-12-19 Daicel Chemical Industries, Ltd. 2-isoxazolin-derivate, verfahren zu deren herstellung sowie verfahren zur herstellung von verwandten verbindungen
ATE187160T1 (de) * 1994-07-29 1999-12-15 Abbott Lab Verfahren zur herstellung eines substituierten 2,5-diamino-3-hydroxy hexanes
US5567823A (en) * 1995-06-06 1996-10-22 Abbott Laboratories Process for the preparation of an HIV protease inhibiting compound
US6022989A (en) 1996-06-28 2000-02-08 Abbott Laboratories Process for the preparation of an activated amino acid
US5932766A (en) 1997-05-30 1999-08-03 Abbott Laboratories Process for the preparation of substituted keto-enamines
US5959118A (en) 1997-08-29 1999-09-28 Abbott Laboratories Process for the preparation of 5-hydroxymethylthiazoles

Also Published As

Publication number Publication date
ITMI991950A0 (it) 1999-09-21
US6407252B1 (en) 2002-06-18
JP2003509504A (ja) 2003-03-11
WO2001021603A1 (en) 2001-03-29
KR20010086449A (ko) 2001-09-12
EP1133485A1 (de) 2001-09-19
AU7554600A (en) 2001-04-24
IT1313624B1 (it) 2002-09-09
DE60032453D1 (de) 2007-02-01
ES2278631T3 (es) 2007-08-16
EP1133485B1 (de) 2006-12-20
ITMI991950A1 (it) 2001-03-21
KR100708581B1 (ko) 2007-04-18
HUP0104259A2 (en) 2002-08-28
HUP0104259A3 (en) 2002-12-28
DE60032453T2 (de) 2007-10-04

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