ATE346079T1 - Neues reagens zur markierung von nukleinsäuren - Google Patents
Neues reagens zur markierung von nukleinsäurenInfo
- Publication number
- ATE346079T1 ATE346079T1 AT01121139T AT01121139T ATE346079T1 AT E346079 T1 ATE346079 T1 AT E346079T1 AT 01121139 T AT01121139 T AT 01121139T AT 01121139 T AT01121139 T AT 01121139T AT E346079 T1 ATE346079 T1 AT E346079T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acids
- new reagent
- label
- marking nucleic
- amide bond
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 238000002372 labelling Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000001668 nucleic acid synthesis Methods 0.000 abstract 1
- 150000008300 phosphoramidites Chemical class 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
- Y10T428/2996—Glass particles or spheres
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polyamides (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10044373A DE10044373A1 (de) | 2000-09-08 | 2000-09-08 | Neues Reagenz zur Markierung von Nukleinsäuren |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE346079T1 true ATE346079T1 (de) | 2006-12-15 |
Family
ID=7655459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01121139T ATE346079T1 (de) | 2000-09-08 | 2001-09-04 | Neues reagens zur markierung von nukleinsäuren |
Country Status (7)
Country | Link |
---|---|
US (1) | US6875850B2 (de) |
EP (1) | EP1186613B8 (de) |
JP (1) | JP3684182B2 (de) |
AT (1) | ATE346079T1 (de) |
CA (1) | CA2356552C (de) |
DE (2) | DE10044373A1 (de) |
ES (1) | ES2276733T3 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7205106B1 (en) | 2001-07-20 | 2007-04-17 | Roche Molecular Systems, Inc. | Association of polymorphisms in IL4-related genes with autoimmune disease |
US7122189B2 (en) | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
US7087229B2 (en) * | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
EP1431297A1 (de) * | 2002-12-20 | 2004-06-23 | Boehringer Mannheim Gmbh | Mannitol- und Glucitolderivate |
ATE319699T1 (de) * | 2002-12-20 | 2006-03-15 | Hoffmann La Roche | Mannitol- und glucitolderivate |
US7560231B2 (en) | 2002-12-20 | 2009-07-14 | Roche Molecular Systems, Inc. | Mannitol and glucitol derivatives |
EP2370450A1 (de) | 2008-11-27 | 2011-10-05 | Roche Diagnostics GmbH | Gezielte synthese von oligophosphoramidatstereoisomeren |
AU2010296018B2 (en) | 2009-09-16 | 2016-05-05 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
US8394948B2 (en) * | 2009-09-30 | 2013-03-12 | Glen Research Corporation | Reagents utilizing a serinol scaffold for labeling synthetic oligonucleotides |
AR080793A1 (es) | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | Anticuerpos biespecificos |
ES2605493T3 (es) | 2010-12-23 | 2017-03-14 | F. Hoffmann-La Roche Ag | Detección de un polipéptido modificado post-traduccionalmente mediante un agente ligante bivalente |
EP2655413B1 (de) | 2010-12-23 | 2019-01-16 | F.Hoffmann-La Roche Ag | Polypeptid-polynukleotid-komplex und verwendung bei der gezielten effektorrest-bereitstellung |
JP6162044B2 (ja) | 2010-12-23 | 2017-07-12 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 結合剤 |
US9428809B2 (en) * | 2011-08-12 | 2016-08-30 | National Institute Of Advanced Industrial Science And Technology | Solid-phase carrier for aminated oligonucleotide |
BR112014019579A2 (pt) | 2012-02-10 | 2019-10-15 | Genentech, Inc | Anticorpo de cadeia única, polinucleotídeo, vetor, célula hospedeira, método de produção de um anticorpo de cadeia única, heteromultímero e método de produção do heteromultímero |
WO2014001324A1 (en) | 2012-06-27 | 2014-01-03 | Hoffmann-La Roche Ag | Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof |
EP2867254B1 (de) | 2012-06-27 | 2017-10-25 | F. Hoffmann-La Roche AG | Verfahren zum herstellen von antikörper-fc-region-konjugaten mit mindestens einer bindungsstelle, die spezifisch an ein target bindet, und verwendungen davon |
WO2016087416A1 (en) | 2014-12-03 | 2016-06-09 | F. Hoffmann-La Roche Ag | Multispecific antibodies |
WO2017124016A2 (en) * | 2016-01-15 | 2017-07-20 | Isi Life Sciences, Inc. | Compositions and methods for internalizing pro-labeled molecules into targeted cells and transforming them in situ into labeled molecules |
WO2018026538A1 (en) * | 2016-08-02 | 2018-02-08 | ISI Life Sciences Inc. | Novel scaffolds for intracellular compound delivery for the detection of cancer cells |
EP3493855A4 (de) | 2016-08-02 | 2020-04-01 | ISI Life Sciences, Inc. | Zusammensetzungen und verfahren zur detektion von krebszellen in einer gewebeprobe |
US10753942B2 (en) | 2017-05-15 | 2020-08-25 | Indicator Systems International, Inc. | Methods to detect remnant cancer cells |
US11384376B2 (en) | 2018-05-31 | 2022-07-12 | Roche Molecular Systems, Inc. | Reagents and methods for post-synthetic modification of nucleic acids |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5451463A (en) * | 1989-08-28 | 1995-09-19 | Clontech Laboratories, Inc. | Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides |
US5141837A (en) * | 1990-02-23 | 1992-08-25 | Eastman Kodak Company | Method for preparing coating compositions containing photoconductive perylene pigments |
US5290925A (en) | 1990-12-20 | 1994-03-01 | Abbott Laboratories | Methods, kits, and reactive supports for 3' labeling of oligonucleotides |
US5624711A (en) * | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
US5736626A (en) | 1996-01-29 | 1998-04-07 | The Perkin-Elmer Corporation | Solid support reagents for the direct synthesis of 3'-labeled polynucleotides |
ES2304573T3 (es) | 1996-06-04 | 2008-10-16 | University Of Utah Research Foundation | Recipiente para llevar a cabo y controlar procesos biologicos. |
-
2000
- 2000-09-08 DE DE10044373A patent/DE10044373A1/de not_active Withdrawn
-
2001
- 2001-08-30 US US09/943,411 patent/US6875850B2/en not_active Expired - Lifetime
- 2001-09-04 AT AT01121139T patent/ATE346079T1/de active
- 2001-09-04 EP EP01121139A patent/EP1186613B8/de not_active Expired - Lifetime
- 2001-09-04 ES ES01121139T patent/ES2276733T3/es not_active Expired - Lifetime
- 2001-09-04 DE DE60124637T patent/DE60124637T2/de not_active Expired - Lifetime
- 2001-09-04 CA CA002356552A patent/CA2356552C/en not_active Expired - Lifetime
- 2001-09-07 JP JP2001272569A patent/JP3684182B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1186613A1 (de) | 2002-03-13 |
EP1186613B1 (de) | 2006-11-22 |
JP2003012951A (ja) | 2003-01-15 |
DE10044373A1 (de) | 2002-03-21 |
DE60124637T2 (de) | 2007-09-13 |
US20020110691A1 (en) | 2002-08-15 |
CA2356552A1 (en) | 2002-03-08 |
CA2356552C (en) | 2009-07-28 |
US6875850B2 (en) | 2005-04-05 |
EP1186613B8 (de) | 2007-02-07 |
JP3684182B2 (ja) | 2005-08-17 |
DE60124637D1 (de) | 2007-01-04 |
ES2276733T3 (es) | 2007-07-01 |
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Legal Events
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UEP | Publication of translation of european patent specification |
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