DE69518409D1 - Verfahren zur kondensation von peptidsegmenten - Google Patents
Verfahren zur kondensation von peptidsegmentenInfo
- Publication number
- DE69518409D1 DE69518409D1 DE69518409T DE69518409T DE69518409D1 DE 69518409 D1 DE69518409 D1 DE 69518409D1 DE 69518409 T DE69518409 T DE 69518409T DE 69518409 T DE69518409 T DE 69518409T DE 69518409 D1 DE69518409 D1 DE 69518409D1
- Authority
- DE
- Germany
- Prior art keywords
- peptide segments
- organic solvent
- condensing peptide
- ubiquitous
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/023—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution using racemisation inhibiting agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/222,767 US5502165A (en) | 1994-04-04 | 1994-04-04 | Process for peptide segment condensation |
PCT/US1995/003952 WO1995027727A2 (en) | 1994-04-04 | 1995-03-31 | Process for peptide segment condensation |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69518409D1 true DE69518409D1 (de) | 2000-09-21 |
DE69518409T2 DE69518409T2 (de) | 2001-02-15 |
Family
ID=22833593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69518409T Expired - Fee Related DE69518409T2 (de) | 1994-04-04 | 1995-03-31 | Verfahren zur kondensation von peptidsegmenten |
Country Status (8)
Country | Link |
---|---|
US (2) | US5502165A (de) |
EP (1) | EP0755374B1 (de) |
JP (1) | JPH09511743A (de) |
AT (1) | ATE195507T1 (de) |
AU (1) | AU690255B2 (de) |
CA (1) | CA2186605A1 (de) |
DE (1) | DE69518409T2 (de) |
WO (1) | WO1995027727A2 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5502165A (en) * | 1994-04-04 | 1996-03-26 | Merck & Co., Inc. | Process for peptide segment condensation |
US7049059B2 (en) * | 2000-12-01 | 2006-05-23 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression |
ES2670854T3 (es) * | 2012-10-10 | 2018-06-01 | Piramal Enterprises Limited | Un proceso mejorado para la preparación de perindoprilo intermedio |
MX365465B (es) | 2013-03-21 | 2019-06-04 | Sanofi Aventis Deutschland | Sintesis de productos peptidicos que contienen imida ciclica. |
SG11201506804VA (en) | 2013-03-21 | 2015-09-29 | Sanofi Aventis Deutschland | Synthesis of hydantoin containing peptide products |
EP4201951B1 (de) * | 2021-12-21 | 2023-11-22 | Bachem Holding AG | Verfahren zur peptidsynthese |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU466760B2 (en) * | 1972-03-14 | 1975-11-06 | Takeda Chemical Industries Ltd. | Process for producing peptide |
DD160415A1 (de) * | 1981-05-04 | 1983-07-27 | Rudolf Doelling | Verfahren zur herstellung von peptiden |
DE3542442A1 (de) * | 1985-11-30 | 1987-06-04 | Hoechst Ag | Verfahren zur herstellung von peptiden unter der verwendung von perchloraten |
JP2585530B2 (ja) * | 1986-04-23 | 1997-02-26 | 株式会社日立製作所 | 半導体集積回路装置 |
JPH0634745B2 (ja) * | 1986-05-07 | 1994-05-11 | 味の素株式会社 | N−保護ペプチドの酵素的合成法 |
DE4016596A1 (de) * | 1990-05-23 | 1991-11-28 | Hoechst Ag | Ein neues kupplungsreagenz fuer die peptidsynthese |
EP0614894A1 (de) * | 1993-03-12 | 1994-09-14 | Merck & Co. Inc. | Verfahren zur Herstellung von substituierten Amidederivaten von Piperazinylcamphorsulfonyl Oxytocin Antagonisten |
AU7836594A (en) * | 1994-03-14 | 1995-10-03 | Merck & Co., Inc. | Pyridyl ethylation of lactam derivatives |
WO1995025101A1 (en) * | 1994-03-14 | 1995-09-21 | Merck & Co., Inc. | Pyridil ethylation of lactams |
US5502165A (en) * | 1994-04-04 | 1996-03-26 | Merck & Co., Inc. | Process for peptide segment condensation |
-
1994
- 1994-04-04 US US08/222,767 patent/US5502165A/en not_active Expired - Fee Related
-
1995
- 1995-03-31 AU AU22337/95A patent/AU690255B2/en not_active Ceased
- 1995-03-31 US US08/721,989 patent/US5773575A/en not_active Expired - Fee Related
- 1995-03-31 AT AT95915464T patent/ATE195507T1/de not_active IP Right Cessation
- 1995-03-31 EP EP95915464A patent/EP0755374B1/de not_active Expired - Lifetime
- 1995-03-31 CA CA002186605A patent/CA2186605A1/en not_active Abandoned
- 1995-03-31 WO PCT/US1995/003952 patent/WO1995027727A2/en active IP Right Grant
- 1995-03-31 JP JP7526374A patent/JPH09511743A/ja not_active Withdrawn
- 1995-03-31 DE DE69518409T patent/DE69518409T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1995027727A2 (en) | 1995-10-19 |
DE69518409T2 (de) | 2001-02-15 |
AU2233795A (en) | 1995-10-30 |
EP0755374B1 (de) | 2000-08-16 |
US5502165A (en) | 1996-03-26 |
US5773575A (en) | 1998-06-30 |
AU690255B2 (en) | 1998-04-23 |
EP0755374A4 (de) | 1998-09-16 |
CA2186605A1 (en) | 1995-10-19 |
JPH09511743A (ja) | 1997-11-25 |
EP0755374A1 (de) | 1997-01-29 |
WO1995027727A3 (en) | 1996-10-03 |
ATE195507T1 (de) | 2000-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |