DE60124577T2 - Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer - Google Patents

Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer Download PDF

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Publication number
DE60124577T2
DE60124577T2 DE60124577T DE60124577T DE60124577T2 DE 60124577 T2 DE60124577 T2 DE 60124577T2 DE 60124577 T DE60124577 T DE 60124577T DE 60124577 T DE60124577 T DE 60124577T DE 60124577 T2 DE60124577 T2 DE 60124577T2
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Germany
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alkyl
substituted
fluoroalkyl
halogen
independently selected
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Expired - Fee Related
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DE60124577T
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German (de)
English (en)
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DE60124577D1 (en
Inventor
Neville J. Rahway ANTHONY
Robert P. Rahway GOMEZ
Jennifer J. Rahway BENNETT
Steven D. Rahway YOUNG
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Merck and Co Inc
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Merck and Co Inc
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Publication of DE60124577T2 publication Critical patent/DE60124577T2/de
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Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Decoration By Transfer Pictures (AREA)
  • Compression Or Coding Systems Of Tv Signals (AREA)
  • Pyrrole Compounds (AREA)
DE60124577T 2000-10-12 2001-10-09 Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer Expired - Fee Related DE60124577T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23967900P 2000-10-12 2000-10-12
US239679P 2000-10-12
PCT/US2001/042565 WO2002055079A2 (en) 2000-10-12 2001-10-09 Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors

Publications (2)

Publication Number Publication Date
DE60124577D1 DE60124577D1 (en) 2006-12-28
DE60124577T2 true DE60124577T2 (de) 2007-09-27

Family

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DE60124577T Expired - Fee Related DE60124577T2 (de) 2000-10-12 2001-10-09 Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer

Country Status (9)

Country Link
US (1) US6841558B2 (https=)
EP (1) EP1326610B1 (https=)
JP (1) JP2004517860A (https=)
AT (1) ATE345129T1 (https=)
AU (1) AU2002246499B2 (https=)
CA (1) CA2425625A1 (https=)
DE (1) DE60124577T2 (https=)
ES (1) ES2274913T3 (https=)
WO (1) WO2002055079A2 (https=)

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CA2498111A1 (en) 2002-09-11 2004-03-25 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
US20040157804A1 (en) 2002-10-16 2004-08-12 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
EP2161258A3 (en) 2002-11-20 2010-04-07 Japan Tabacco Inc. 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
EP1578748B1 (en) 2002-12-27 2010-09-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors
KR20060006047A (ko) * 2003-04-28 2006-01-18 티보텍 파마슈티칼즈 리미티드 Ｈｉｖ 인테그레이즈 저해제
US7812016B2 (en) 2003-05-13 2010-10-12 Smithkline Beecham Corporation Naphthyridine integrase inhibitors
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
US20070185007A1 (en) 2003-09-19 2007-08-09 Haolun Jin Aza-quinolinol phosphonate integrase inhibitor compounds
CA2542047A1 (en) 2003-10-20 2005-05-12 Merck & Co., Inc. Hydroxy pyridopyrrolopyrazine dione compounds useful as hiv integrase inhibitors
WO2005075475A1 (ja) * 2004-02-04 2005-08-18 Shionogi & Co., Ltd. Ｈｉｖインテグラーゼ阻害活性を有するナフチリジン誘導体
CA2555176A1 (en) 2004-02-11 2005-08-25 Smithkline Beecham Corporation Hiv integrase inhibitors
JP2007528396A (ja) * 2004-03-09 2007-10-11 メルク　エンド　カムパニー　インコーポレーテッド Ｈｉｖインテグラーゼ阻害薬
EP1725556A1 (en) 2004-03-09 2006-11-29 Merck & Co., Inc. Hiv integrase inhibitors
WO2005087766A1 (en) 2004-03-09 2005-09-22 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv integrase inhibitors
JP2007528394A (ja) 2004-03-09 2007-10-11 メルク　エンド　カムパニー　インコーポレーテッド Ｈｉｖインテグラーゼ阻害薬
ES2529038T3 (es) * 2004-05-07 2015-02-16 Merck Sharp & Dohme Corp. Inhibidores de la integrasa de VIH
MY134672A (en) 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
WO2005113509A1 (en) 2004-05-20 2005-12-01 Japan Tobacco Inc. Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
EP3287130A1 (en) 2004-05-21 2018-02-28 Japan Tobacco Inc. Combinations comprising a 4-isoquinolone derivative and protease inhibitors
US7476666B2 (en) 2004-06-09 2009-01-13 Merck & Co., Inc. HIV integrase inhibitors
CN101146811B (zh) * 2005-03-31 2012-01-11 P.安杰莱蒂分子生物学研究所 Hiv整合酶抑制剂
CA2607151C (en) * 2005-05-10 2012-06-19 Merck & Co., Inc. Hiv integrase inhibitors
CA2622639C (en) * 2005-10-04 2012-01-03 Istituto Di Recerche Di Biologia Molecolare P. Angeletti S.P.A. Hiv integrase inhibitors
JP2009513640A (ja) * 2005-10-27 2009-04-02 メルク エンド カムパニー インコーポレーテッド Ｈｉｖインテグラーゼインヒビター
EP1790342A1 (de) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
RS54047B1 (sr) 2006-03-06 2015-10-30 Japan Tobacco Inc. Postupak za dobijanje jedinjenja 4-oksohinolina
NZ572367A (en) 2006-05-16 2011-09-30 Gilead Sciences Inc Fused cyclic compounds as integrase inhibitors
US20100056516A1 (en) * 2006-07-17 2010-03-04 Williams Peter D 1-hydroxy naphthyridine compounds as anti-hiv agents
KR20090077813A (ko) 2006-09-29 2009-07-15 아이데닉스 파마슈티칼스, 인코포레이티드 Ｈｉｖ 억제제로서의 거울상이성질체적으로 순수한 포스포인돌
WO2008048538A1 (en) * 2006-10-18 2008-04-24 Merck & Co., Inc. Hiv integrase inhibitors
US8513420B2 (en) * 2007-03-19 2013-08-20 Monika Mazik Amino-naphthyridine derivatives
EP1972627A1 (en) * 2007-03-19 2008-09-24 Technische Universität Carolo-Wilhelmina zu Braunschweig Amino-napthyridine derivatives
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DE102009038123A1 (de) * 2009-08-17 2011-02-24 Aicuris Gmbh & Co. Kg Substituierte (Thiazolyl-carbonyl)imidazolidinone und ihre Verwendung
WO2011045330A1 (en) 2009-10-13 2011-04-21 Tibotec Pharmaceuticals Macrocyclic integrase inhibitors
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
RU2567385C2 (ru) 2010-04-02 2015-11-10 ЯНССЕН Ар ЭНД Ди АЙРЛЭНД Макроциклические ингибиторы интегразы
US9029391B2 (en) 2011-01-24 2015-05-12 Viiv Healthcare Uk Limited Isoquinoline compounds and methods for treating HIV
JP2016524607A (ja) 2013-05-16 2016-08-18 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ Ｈｉｖ−１インテグラーゼの薬物耐性株を阻害するための化合物

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Also Published As

Publication number Publication date
ES2274913T3 (es) 2007-06-01
CA2425625A1 (en) 2002-07-18
US20040044207A1 (en) 2004-03-04
JP2004517860A (ja) 2004-06-17
ATE345129T1 (de) 2006-12-15
EP1326610A4 (en) 2004-06-09
WO2002055079A2 (en) 2002-07-18
AU2002246499B2 (en) 2005-12-22
EP1326610B1 (en) 2006-11-15
WO2002055079A3 (en) 2002-09-06
EP1326610A2 (en) 2003-07-16
US6841558B2 (en) 2005-01-11
DE60124577D1 (en) 2006-12-28

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: ANTHONY, NEVILLE, J., RAHWAY, NJ 07065-0907, US

Inventor name: GOMEZ, ROBERT, P., RAHWAY, NJ 07065-0907, US

Inventor name: BENNETT, JENNIFER, J., RAHWAY, NJ 07065-0907, US

Inventor name: YOUNG, STEVEN, D., RAHWAY, NJ 07065-0907, US

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK & CO., INC., RAHWAY, N.J., US

8339 Ceased/non-payment of the annual fee