AU2002246499B2 - Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors - Google Patents

Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors Download PDF

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Publication number
AU2002246499B2
AU2002246499B2 AU2002246499A AU2002246499A AU2002246499B2 AU 2002246499 B2 AU2002246499 B2 AU 2002246499B2 AU 2002246499 A AU2002246499 A AU 2002246499A AU 2002246499 A AU2002246499 A AU 2002246499A AU 2002246499 B2 AU2002246499 B2 AU 2002246499B2
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AU
Australia
Prior art keywords
alkyl
substituted
fluoroalkyl
ora
halogen
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Ceased
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AU2002246499A
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AU2002246499A1 (en
Inventor
Neville J. Anthony
Jennifer J. Bennett
Robert P. Gomez
Steven D. Young
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Merck and Co Inc
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Merck and Co Inc
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Publication of AU2002246499A1 publication Critical patent/AU2002246499A1/en
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Publication of AU2002246499B2 publication Critical patent/AU2002246499B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compression Or Coding Systems Of Tv Signals (AREA)
  • Pyrrole Compounds (AREA)
  • Decoration By Transfer Pictures (AREA)
  • Indole Compounds (AREA)
AU2002246499A 2000-10-12 2001-10-09 Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors Ceased AU2002246499B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23967900P 2000-10-12 2000-10-12
US60/239,679 2000-10-12
PCT/US2001/042565 WO2002055079A2 (en) 2000-10-12 2001-10-09 Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors

Publications (2)

Publication Number Publication Date
AU2002246499A1 AU2002246499A1 (en) 2003-02-06
AU2002246499B2 true AU2002246499B2 (en) 2005-12-22

Family

ID=22903252

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002246499A Ceased AU2002246499B2 (en) 2000-10-12 2001-10-09 Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors

Country Status (9)

Country Link
US (1) US6841558B2 (https=)
EP (1) EP1326610B1 (https=)
JP (1) JP2004517860A (https=)
AT (1) ATE345129T1 (https=)
AU (1) AU2002246499B2 (https=)
CA (1) CA2425625A1 (https=)
DE (1) DE60124577T2 (https=)
ES (1) ES2274913T3 (https=)
WO (1) WO2002055079A2 (https=)

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IL161337A0 (en) 2001-10-26 2004-09-27 Angeletti P Ist Richerche Bio N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase
ATE355064T1 (de) * 2001-10-26 2006-03-15 Angeletti P Ist Richerche Bio Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
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ATE404537T1 (de) 2002-08-13 2008-08-15 Shionogi & Co Heterocyclische verbindungen mit hiv-integrase- hemmender wirkung
ATE404563T1 (de) * 2002-09-11 2008-08-15 Merck & Co Inc 8-hydroxy-1- oxotetrahydropyrrolopyrazinverbindungen, die sich als inhibitoren von hiv-integrase eignen
CA2498111A1 (en) * 2002-09-11 2004-03-25 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
WO2004035577A2 (en) 2002-10-16 2004-04-29 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
SK2662004A3 (sk) 2002-11-20 2005-06-02 Japan Tobacco, Inc. Zlúčenina s obsahom 4-oxochinolínu a jej použitie ako inhibítora integráz
NZ540729A (en) 2002-12-27 2008-03-28 Angeletti P Ist Richerche Bio Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds useful as HIV integrase inhibitors
AU2004234087A1 (en) * 2003-04-28 2004-11-11 Tibotec Pharmaceuticals Ltd. HIV integrase inhibitors
EP1622615A4 (en) 2003-05-13 2009-02-18 Smithkline Beecham Corp INHIBITORS OF THE INTEGRASE OF NAPHTHYRIDINE
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
CA2537325A1 (en) * 2003-09-19 2005-03-31 Gilead Sciences, Inc. Aza-quinolinol phosphonate integrase inhibitor compounds
AU2004285449A1 (en) 2003-10-20 2005-05-12 Merck & Co., Inc. Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors
JP4789144B2 (ja) * 2004-02-04 2011-10-12 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有するナフチリジン誘導体
CN1976915A (zh) 2004-02-11 2007-06-06 史密丝克莱恩比彻姆公司 Hiv整合酶抑制剂
US7820680B2 (en) * 2004-03-09 2010-10-26 Merck & Co., Inc. HIV integrase inhibitors
US20070161639A1 (en) 2004-03-09 2007-07-12 Philip Jones Hiv integrase inhibitors
CN101014574A (zh) * 2004-03-09 2007-08-08 默克公司 Hiv整合酶抑制剂
JP4625838B2 (ja) * 2004-03-09 2011-02-02 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラーゼ阻害薬
US7538112B2 (en) * 2004-05-07 2009-05-26 Merck & Co., Inc. HIV integrase inhibitors
US7531554B2 (en) 2004-05-20 2009-05-12 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as HIV integrase inhibitor
MY134672A (en) 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
EP1758581A1 (en) 2004-05-21 2007-03-07 Japan Tobacco, Inc. Combinations comprising a 4-isoquinolone derivative and anti-hiv agents
US7476666B2 (en) 2004-06-09 2009-01-13 Merck & Co., Inc. HIV integrase inhibitors
CA2600832C (en) * 2005-03-31 2011-12-13 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Hiv integrase inhibitors
WO2006121831A2 (en) * 2005-05-10 2006-11-16 Merck & Co., Inc. Hiv integrase inhibitors
US7939537B2 (en) * 2005-10-04 2011-05-10 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. HIV integrase inhibitors
AU2006306355A1 (en) * 2005-10-27 2007-05-03 Merck & Co., Inc. HIV integrase inhibitors
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
EP1790342A1 (de) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
ES2531190T3 (es) 2006-03-06 2015-03-11 Japan Tobacco Inc Método para producir un compuesto de 4-oxoquinolina
AU2007254190A1 (en) 2006-05-16 2007-11-29 Gilead Sciences, Inc. Integrase inhibitors
US20100056516A1 (en) * 2006-07-17 2010-03-04 Williams Peter D 1-hydroxy naphthyridine compounds as anti-hiv agents
JP2010504978A (ja) 2006-09-29 2010-02-18 アイデニクス ファーマシューティカルズ，インコーポレーテッド Ｈｉｖ阻害剤としての鏡像異性的に純粋なホスホインドール
WO2008048538A1 (en) * 2006-10-18 2008-04-24 Merck & Co., Inc. Hiv integrase inhibitors
EP1972627A1 (en) * 2007-03-19 2008-09-24 Technische Universität Carolo-Wilhelmina zu Braunschweig Amino-napthyridine derivatives
US8513420B2 (en) * 2007-03-19 2013-08-20 Monika Mazik Amino-naphthyridine derivatives
ES2572631T3 (es) 2008-01-25 2016-06-01 Chimerix, Inc. Métodos de tratamiento de infecciones virales
DE102009038123A1 (de) 2009-08-17 2011-02-24 Aicuris Gmbh & Co. Kg Substituierte (Thiazolyl-carbonyl)imidazolidinone und ihre Verwendung
ES2446720T3 (es) 2009-10-13 2014-03-10 Elanco Animal Health Ireland Limited Inhibidores de la integrasa macrocíclica
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
WO2011121105A1 (en) 2010-04-02 2011-10-06 Tibotec Pharmaceuticals Macrocyclic integrase inhibitors
WO2012102985A1 (en) * 2011-01-24 2012-08-02 Glaxosmithkline Llc Isoquinoline compounds and methods for treating hiv
CN105611927A (zh) 2013-05-16 2016-05-25 美国政府(由卫生和人类服务部的部长所代表) 用于抑制耐药性hiv-1整合酶耐药株的化合物

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Publication number Priority date Publication date Assignee Title
US3945995A (en) * 1973-04-05 1976-03-23 Sumitomo Chemical Company, Limited D-α-(4-hydroxypyridine-3-carbonamido)-p-hydroxyphenylacetamidopenicillanic acid
US4416884A (en) * 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
WO1998011073A1 (en) * 1996-09-10 1998-03-19 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents
WO1999016747A1 (en) * 1997-09-30 1999-04-08 Daiichi Pharmaceutical Co., Ltd. Sulfonyl derivatives

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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US3945995A (en) * 1973-04-05 1976-03-23 Sumitomo Chemical Company, Limited D-α-(4-hydroxypyridine-3-carbonamido)-p-hydroxyphenylacetamidopenicillanic acid
US4416884A (en) * 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
WO1998011073A1 (en) * 1996-09-10 1998-03-19 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents
WO1999016747A1 (en) * 1997-09-30 1999-04-08 Daiichi Pharmaceutical Co., Ltd. Sulfonyl derivatives

Also Published As

Publication number Publication date
WO2002055079A2 (en) 2002-07-18
DE60124577T2 (de) 2007-09-27
CA2425625A1 (en) 2002-07-18
DE60124577D1 (en) 2006-12-28
ATE345129T1 (de) 2006-12-15
EP1326610B1 (en) 2006-11-15
US6841558B2 (en) 2005-01-11
WO2002055079A3 (en) 2002-09-06
ES2274913T3 (es) 2007-06-01
US20040044207A1 (en) 2004-03-04
JP2004517860A (ja) 2004-06-17
EP1326610A2 (en) 2003-07-16
EP1326610A4 (en) 2004-06-09

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired