DE60120197D1 - Verfahren zur herstellung von 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen - Google Patents
Verfahren zur herstellung von 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazolenInfo
- Publication number
- DE60120197D1 DE60120197D1 DE60120197T DE60120197T DE60120197D1 DE 60120197 D1 DE60120197 D1 DE 60120197D1 DE 60120197 T DE60120197 T DE 60120197T DE 60120197 T DE60120197 T DE 60120197T DE 60120197 D1 DE60120197 D1 DE 60120197D1
- Authority
- DE
- Germany
- Prior art keywords
- amino
- group
- tetrahydrobenzothiazolene
- alkyl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002262A ES2187249B1 (es) | 2000-09-18 | 2000-09-18 | Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles. |
ES200002262 | 2000-09-18 | ||
PCT/NL2001/000680 WO2002022590A1 (en) | 2000-09-18 | 2001-09-14 | Process for preparation of 2-amino-6-(alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60120197D1 true DE60120197D1 (de) | 2006-07-06 |
DE60120197T2 DE60120197T2 (de) | 2007-03-15 |
Family
ID=8494959
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60120197T Expired - Fee Related DE60120197T2 (de) | 2000-09-18 | 2001-09-14 | Verfahren zur herstellung von 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen |
Country Status (10)
Country | Link |
---|---|
US (3) | US6770761B2 (de) |
EP (2) | EP1318986B1 (de) |
AT (2) | ATE327985T1 (de) |
AU (2) | AU2002211055A1 (de) |
DE (1) | DE60120197T2 (de) |
DK (2) | DK1318986T3 (de) |
ES (3) | ES2187249B1 (de) |
PT (2) | PT1318986E (de) |
SI (1) | SI1318986T1 (de) |
WO (2) | WO2002022590A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2241118A (en) * | 1990-02-15 | 1991-08-21 | Ibm | Electrical apparatus with forced air cooling |
US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
EP2305253A1 (de) * | 2001-12-11 | 2011-04-06 | University Of Virginia Patent Foundation | Verwendung von Pramipexol zur Behandlung amyotropher Lateralsklerose |
US8679533B2 (en) * | 2002-07-25 | 2014-03-25 | Pharmacia Corporation | Pramipexole once-daily dosage form |
US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
GB0221513D0 (en) * | 2002-09-17 | 2002-10-23 | Generics Uk Ltd | Novel compounds and processes |
GB2394951A (en) * | 2002-11-04 | 2004-05-12 | Cipla Ltd | One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole |
US7365086B2 (en) * | 2003-07-25 | 2008-04-29 | Synthon Ip Inc. | Pramipexole acid addition salts |
CA2560128A1 (en) | 2004-03-19 | 2005-10-06 | Dipharma S.P.A. | Intermediates for the preparation of pramipexole |
EP1773793A2 (de) * | 2004-07-03 | 2007-04-18 | Merck Generics (UK) Limited | Verfahren zur herstellung von pramipexol durch chirale chromatographie |
KR20070050081A (ko) | 2004-08-13 | 2007-05-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 프라미펙솔 또는 약제학적으로 허용되는 이의 염을포함하는 연장 방출형 펠렛 제형, 이의 제조방법 및 이의용도 |
KR101052436B1 (ko) * | 2004-08-13 | 2011-07-29 | 베링거 인겔하임 인터내셔날 게엠베하 | 프라미펙솔 또는 약제학적으로 허용되는 이의 염을함유하는 연장 방출형 정제 제형, 이의 제조방법 및 이의용도 |
US20060069263A1 (en) * | 2004-09-30 | 2006-03-30 | Irina Gribun | Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole |
US20060148866A1 (en) * | 2004-12-30 | 2006-07-06 | Chemagis Ltd. | Novel process for preparing pramipexole and its optical isomeric mixture by reduction with sodium triacetoxyborohydride |
CN1834092B (zh) * | 2005-03-15 | 2010-04-28 | 姜能桥 | 盐酸普拉克索的制备方法 |
US20090062549A1 (en) * | 2005-05-03 | 2009-03-05 | Seema Kanwar | Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride |
ES2264378B1 (es) * | 2005-05-09 | 2007-11-01 | Ragactives, S.L. | Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios. |
DE602006009670D1 (de) * | 2005-08-15 | 2009-11-19 | Univ Virginia | Neurorestauration mit r(+) pramipexol |
WO2007040474A1 (en) * | 2005-09-21 | 2007-04-12 | Chemagis Ltd. | Novel polymorphs of (s)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole monotartrate and methods of producing and using the same |
WO2007054970A2 (en) * | 2005-10-25 | 2007-05-18 | Alembic Limited | Novel polymorphic forms of (s)-(-)-2-amino-6-(n- propylamino) 4,5,6,7- tetrahydrobenzothiazole |
PL378587A1 (pl) * | 2005-12-29 | 2007-07-09 | Instytut Farmaceutyczny | Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli |
ITMI20060044A1 (it) * | 2006-01-13 | 2007-07-14 | Dipharma Spa | Sintesi di intermedi pr la preparazione di pramipexolo |
WO2007090881A2 (en) * | 2006-02-10 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Modified release formulation |
WO2007090883A1 (en) * | 2006-02-10 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Extended release formulation |
US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
WO2007121188A2 (en) * | 2006-04-10 | 2007-10-25 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
PL2026803T3 (pl) | 2006-05-16 | 2012-05-31 | Knopp Neurosciences Inc | Kompozycje R(+) i S(-) pramipeksolu i sposoby ich zastosowania |
DE602006002385D1 (de) * | 2006-06-26 | 2008-10-02 | Helm Ag | Verfahren zur Herstellung von Pramipexole |
WO2008001204A2 (en) * | 2006-06-29 | 2008-01-03 | Antares Pharma Ipl Ag | Transdermal compositions of pramipexole having enhanced permeation properties |
US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
RU2454409C2 (ru) * | 2007-03-14 | 2012-06-27 | Нопп Ньюросайенсиз, Инк. | Синтез хирально очищенных замещенных бензотиазолдиаминов |
EP2225199A2 (de) * | 2007-12-18 | 2010-09-08 | Watson Pharma Private Limited | Verbessertes herstellungsverfahren für (s)-pregabalin |
KR20110071064A (ko) | 2008-08-19 | 2011-06-28 | 크놉 뉴로사이언시스 인코포레이티드 | (r)-프라미펙솔을 사용하는 조성물 및 방법 |
US20110009460A1 (en) * | 2009-06-19 | 2011-01-13 | Valentin Gribkoff | Compositions and methods for treating amyotrophic lateral sclerosis |
ITMI20101998A1 (it) * | 2010-10-27 | 2012-04-28 | Dipharma Francis Srl | Procedimento per la racemizzazione di acidi carbossilici |
US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
CN104072442B (zh) * | 2013-03-28 | 2016-09-28 | 成都弘达药业有限公司 | 一种化合物及其制备方法 |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
SI3019167T1 (sl) | 2013-07-12 | 2021-04-30 | Knopp Biosciences Llc | Zdravljenje povišanih ravni eozinofilcev in / ali bazofilcev |
US9763918B2 (en) | 2013-08-13 | 2017-09-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
WO2015023786A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
CN108084115B (zh) * | 2017-12-28 | 2020-03-17 | 上海博志研新药物技术有限公司 | 盐酸普拉克索及其中间体的制备方法 |
CN110669024A (zh) * | 2019-10-30 | 2020-01-10 | 福建福瑞明德药业有限公司 | 一种(s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑*l-酒石酸盐的碱析方法 |
CN116178304A (zh) * | 2023-03-10 | 2023-05-30 | 中国药科大学 | 一种盐酸普拉克索的合成方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE45735T1 (de) * | 1984-12-22 | 1989-09-15 | Thomae Gmbh Dr K | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel. |
EP0207696A1 (de) * | 1985-06-24 | 1987-01-07 | Eli Lilly And Company | Dialkylaminotetrahydrobenzothiazole und -oxazole |
DE3620813A1 (de) * | 1986-06-21 | 1987-12-23 | Boehringer Ingelheim Kg | Neue tetrahydro-benzothiazole, ihre herstellung und verwendung |
-
2000
- 2000-09-18 ES ES200002262A patent/ES2187249B1/es not_active Expired - Fee Related
-
2001
- 2001-09-14 AT AT01979066T patent/ATE327985T1/de not_active IP Right Cessation
- 2001-09-14 DE DE60120197T patent/DE60120197T2/de not_active Expired - Fee Related
- 2001-09-14 AU AU2002211055A patent/AU2002211055A1/en not_active Abandoned
- 2001-09-14 WO PCT/NL2001/000680 patent/WO2002022590A1/en active IP Right Grant
- 2001-09-14 SI SI200130558T patent/SI1318986T1/sl unknown
- 2001-09-14 ES ES01979066T patent/ES2260296T3/es not_active Expired - Lifetime
- 2001-09-14 US US10/380,758 patent/US6770761B2/en not_active Expired - Fee Related
- 2001-09-14 PT PT01979066T patent/PT1318986E/pt unknown
- 2001-09-14 DK DK01979066T patent/DK1318986T3/da active
- 2001-09-14 EP EP01979066A patent/EP1318986B1/de not_active Expired - Lifetime
- 2001-09-18 US US09/953,870 patent/US6727367B2/en not_active Expired - Fee Related
- 2001-09-18 ES ES01981155T patent/ES2242778T3/es not_active Expired - Lifetime
- 2001-09-18 EP EP01981155A patent/EP1318987B1/de not_active Expired - Lifetime
- 2001-09-18 AT AT01981155T patent/ATE301646T1/de not_active IP Right Cessation
- 2001-09-18 WO PCT/NL2001/000691 patent/WO2002022591A1/en active IP Right Grant
- 2001-09-18 DK DK01981155T patent/DK1318987T3/da active
- 2001-09-18 AU AU2002212815A patent/AU2002212815A1/en not_active Abandoned
- 2001-09-18 PT PT01981155T patent/PT1318987E/pt unknown
-
2003
- 2003-10-06 US US10/678,081 patent/US20040068119A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2187249B1 (es) | 2004-09-16 |
ES2260296T3 (es) | 2006-11-01 |
ATE327985T1 (de) | 2006-06-15 |
US20040068119A1 (en) | 2004-04-08 |
PT1318987E (pt) | 2005-10-31 |
EP1318986A1 (de) | 2003-06-18 |
DK1318986T3 (da) | 2006-10-02 |
AU2002211055A1 (en) | 2002-03-26 |
US20020103240A1 (en) | 2002-08-01 |
ATE301646T1 (de) | 2005-08-15 |
EP1318987B1 (de) | 2005-08-10 |
DK1318987T3 (da) | 2005-12-12 |
WO2002022591A1 (en) | 2002-03-21 |
ES2187249A1 (es) | 2003-05-16 |
DE60120197T2 (de) | 2007-03-15 |
SI1318986T1 (sl) | 2006-10-31 |
ES2242778T3 (es) | 2005-11-16 |
US6727367B2 (en) | 2004-04-27 |
WO2002022590A1 (en) | 2002-03-21 |
AU2002212815A1 (en) | 2002-03-26 |
PT1318986E (pt) | 2006-10-31 |
US20040029936A1 (en) | 2004-02-12 |
EP1318986B1 (de) | 2006-05-31 |
EP1318987A1 (de) | 2003-06-18 |
US6770761B2 (en) | 2004-08-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |