DK1318987T3 - Fremgangsmåde til resolution af 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazol og forbindelser til brug hertil - Google Patents

Fremgangsmåde til resolution af 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazol og forbindelser til brug hertil

Info

Publication number
DK1318987T3
DK1318987T3 DK01981155T DK01981155T DK1318987T3 DK 1318987 T3 DK1318987 T3 DK 1318987T3 DK 01981155 T DK01981155 T DK 01981155T DK 01981155 T DK01981155 T DK 01981155T DK 1318987 T3 DK1318987 T3 DK 1318987T3
Authority
DK
Denmark
Prior art keywords
compounds
tetrahydrobenzothiazole
propylamino
resolution
amino
Prior art date
Application number
DK01981155T
Other languages
English (en)
Inventor
Karel Pospisilik
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Application granted granted Critical
Publication of DK1318987T3 publication Critical patent/DK1318987T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Steroid Compounds (AREA)
DK01981155T 2000-09-18 2001-09-18 Fremgangsmåde til resolution af 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazol og forbindelser til brug hertil DK1318987T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200002262A ES2187249B1 (es) 2000-09-18 2000-09-18 Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.
PCT/NL2001/000691 WO2002022591A1 (en) 2000-09-18 2001-09-18 Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole and compounds therefor

Publications (1)

Publication Number Publication Date
DK1318987T3 true DK1318987T3 (da) 2005-12-12

Family

ID=8494959

Family Applications (2)

Application Number Title Priority Date Filing Date
DK01979066T DK1318986T3 (da) 2000-09-18 2001-09-14 Fremgangsmåde til fremstilling af 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoler
DK01981155T DK1318987T3 (da) 2000-09-18 2001-09-18 Fremgangsmåde til resolution af 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazol og forbindelser til brug hertil

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK01979066T DK1318986T3 (da) 2000-09-18 2001-09-14 Fremgangsmåde til fremstilling af 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoler

Country Status (10)

Country Link
US (3) US6770761B2 (da)
EP (2) EP1318986B1 (da)
AT (2) ATE327985T1 (da)
AU (2) AU2002211055A1 (da)
DE (1) DE60120197T2 (da)
DK (2) DK1318986T3 (da)
ES (3) ES2187249B1 (da)
PT (2) PT1318986E (da)
SI (1) SI1318986T1 (da)
WO (2) WO2002022590A1 (da)

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US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
PE20040134A1 (es) 2002-07-25 2004-03-06 Pharmacia Corp Forma de dosificacion de una vez al dia de pramipexol
GB0221513D0 (en) * 2002-09-17 2002-10-23 Generics Uk Ltd Novel compounds and processes
GB2394951A (en) * 2002-11-04 2004-05-12 Cipla Ltd One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
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US20080096939A1 (en) * 2004-07-03 2008-04-24 Andreas Keil Process For Preparation Of Pramipexole By Chiral Chromatography
UA93608C2 (ru) * 2004-08-13 2011-02-25 Берингер Ингельхайм Интернациональ Гмбх композициЯ таблетки пролонгированного высвобождения, которая содержит прамипексол или его фармацевтически приемлемую соль, СПОСОБ EE ИЗГОТОВЛЕНИЯ И EE ПРИМЕНЕНИЕ
WO2006015943A2 (en) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
US20060069263A1 (en) * 2004-09-30 2006-03-30 Irina Gribun Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole
US20060148866A1 (en) * 2004-12-30 2006-07-06 Chemagis Ltd. Novel process for preparing pramipexole and its optical isomeric mixture by reduction with sodium triacetoxyborohydride
CN1834092B (zh) * 2005-03-15 2010-04-28 姜能桥 盐酸普拉克索的制备方法
WO2006117614A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride
ES2264378B1 (es) * 2005-05-09 2007-11-01 Ragactives, S.L. Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios.
DE602006009670D1 (de) * 2005-08-15 2009-11-19 Univ Virginia Neurorestauration mit r(+) pramipexol
WO2007040474A1 (en) * 2005-09-21 2007-04-12 Chemagis Ltd. Novel polymorphs of (s)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole monotartrate and methods of producing and using the same
WO2007054970A2 (en) * 2005-10-25 2007-05-18 Alembic Limited Novel polymorphic forms of (s)-(-)-2-amino-6-(n- propylamino) 4,5,6,7- tetrahydrobenzothiazole
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) * 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
US20090041844A1 (en) * 2006-02-10 2009-02-12 Boehringer Ingelheim International Gmbh Modified Release Formulation
US20090098202A1 (en) * 2006-02-10 2009-04-16 Boehringer Ingelheim International Gmbh Extended Release Formulation
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
CA2652251A1 (en) 2006-05-16 2007-11-29 Knopp Neurosciences, Inc. Compositions of r(+) and s(-) pramipexole and methods for using the same
ATE405554T1 (de) * 2006-06-26 2008-09-15 Helm Ag Verfahren zur herstellung von pramipexole
WO2008001204A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal compositions of pramipexole having enhanced permeation properties
US8524695B2 (en) * 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
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US20100312010A1 (en) * 2007-12-18 2010-12-09 Watson Pharma Private Limited Process for the Preparation of (S)-Pregabalin
US20110190356A1 (en) * 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
CN102802418A (zh) * 2009-06-19 2012-11-28 诺普神经科学股份有限公司 用于治疗肌萎缩性侧索硬化的组合物和方法
ITMI20101998A1 (it) * 2010-10-27 2012-04-28 Dipharma Francis Srl Procedimento per la racemizzazione di acidi carbossilici
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
CN104072442B (zh) * 2013-03-28 2016-09-28 成都弘达药业有限公司 一种化合物及其制备方法
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
DK3019167T3 (da) 2013-07-12 2021-03-15 Knopp Biosciences Llc Behandling af forhøjede niveauer af eosinophiler og/eller basophiler
ES2813674T3 (es) 2013-08-13 2021-03-24 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b
WO2015023790A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
CN108084115B (zh) * 2017-12-28 2020-03-17 上海博志研新药物技术有限公司 盐酸普拉克索及其中间体的制备方法
CN110669024A (zh) * 2019-10-30 2020-01-10 福建福瑞明德药业有限公司 一种(s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑*l-酒石酸盐的碱析方法
CN116178304B (zh) * 2023-03-10 2024-10-25 中国药科大学 一种盐酸普拉克索的合成方法

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DE3620813A1 (de) * 1986-06-21 1987-12-23 Boehringer Ingelheim Kg Neue tetrahydro-benzothiazole, ihre herstellung und verwendung

Also Published As

Publication number Publication date
US20020103240A1 (en) 2002-08-01
ATE301646T1 (de) 2005-08-15
AU2002212815A1 (en) 2002-03-26
US6727367B2 (en) 2004-04-27
ATE327985T1 (de) 2006-06-15
EP1318986B1 (en) 2006-05-31
US6770761B2 (en) 2004-08-03
DE60120197D1 (de) 2006-07-06
PT1318987E (pt) 2005-10-31
PT1318986E (pt) 2006-10-31
ES2242778T3 (es) 2005-11-16
US20040029936A1 (en) 2004-02-12
US20040068119A1 (en) 2004-04-08
EP1318986A1 (en) 2003-06-18
EP1318987A1 (en) 2003-06-18
DE60120197T2 (de) 2007-03-15
WO2002022590A1 (en) 2002-03-21
SI1318986T1 (sl) 2006-10-31
EP1318987B1 (en) 2005-08-10
DK1318986T3 (da) 2006-10-02
ES2260296T3 (es) 2006-11-01
WO2002022591A1 (en) 2002-03-21
AU2002211055A1 (en) 2002-03-26
ES2187249A1 (es) 2003-05-16
ES2187249B1 (es) 2004-09-16

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