HUP0003455A2 - Benzoxazin- és benzotiazinszármazékok és gyógyszerekben történő alkalmazásuk - Google Patents
Benzoxazin- és benzotiazinszármazékok és gyógyszerekben történő alkalmazásukInfo
- Publication number
- HUP0003455A2 HUP0003455A2 HU0003455A HUP0003455A HUP0003455A2 HU P0003455 A2 HUP0003455 A2 HU P0003455A2 HU 0003455 A HU0003455 A HU 0003455A HU P0003455 A HUP0003455 A HU P0003455A HU P0003455 A2 HUP0003455 A2 HU P0003455A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- hydrogen
- optionally substituted
- hydrogen atom
- Prior art date
Links
- UJVBZCCNLAAMOV-UHFFFAOYSA-N 2h-1,2-benzothiazine Chemical class C1=CC=C2C=CNSC2=C1 UJVBZCCNLAAMOV-UHFFFAOYSA-N 0.000 title 1
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical compound C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- -1 amino- Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
Abstract
A találmány (I) általános képletű vegyületekre, a vegyületekettartalmazó gyógyászati készítményekre és a vegyületek ilyenkészítmények előállítására történő alkalmazására vonatkozik, aképletben X jelentése O, SOm vagy Se, R1 jelentése -NO2, -CF3, -OCF3,helyettesített amino-, -SO2NR7R8, -CONR7R8, -CO-R14 általános képletűcsoport, ciano- vagy adott esetben helyettesített arilcsoport, 5- vagy6-tagú heteroarilcsoport, helyettesített alkil-, alkenil- vagyalkinilcsoport, vagy cikloalkilcsoport, R2 jelentése hidrogénatom vagyR1 és R2 együtt két szomszédos szénatommal adott esetbenhelyettesített gyűrűt alkot, amely monociklusos vagy biciklusos,telített vagy telítetlen és benzolgyűrűvel kondenzált lehet, R3jelentése hidrogénatom, halogénatom, -S-R9 vagy -O-R9 általánosképletű csoport és R1-gyel azonos vagy attól eltérő, R4 jelentésehidrogénatom vagy acilcsoport, R5 jelentése hidrogénatom, R6 jelentéseadott esetben helyettesített cikloalkil-, aril-, alkil-, alkenil- vagyalkinilcsoport, R7 és R8 jelentése hidrogénatom, alkil-, adott esetbenhelyettesített fenil-, benzil- vagy cikloalkilcsoport, R9 jelentésehidrogénatom vagy alkilcsoport, m értéke 0, 1 vagy 2, és R14 jelentésehidrogénatom, fenilcsoport, adott esetben helyettesített alkil- vagyalkenilcsoport. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19740386 | 1997-09-08 | ||
| DE19826232 | 1998-06-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0003455A2 true HUP0003455A2 (hu) | 2002-11-28 |
| HUP0003455A3 HUP0003455A3 (en) | 2002-12-28 |
Family
ID=26039966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0003455A HUP0003455A3 (en) | 1997-09-08 | 1998-09-08 | Benzoxazine and benzothiazine derivatives and their use in pharmaceuticals |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6365736B1 (hu) |
| EP (1) | EP1015437B1 (hu) |
| JP (1) | JP2001515892A (hu) |
| KR (1) | KR20010023746A (hu) |
| CN (1) | CN1136203C (hu) |
| AT (1) | ATE255567T1 (hu) |
| AU (1) | AU741297B2 (hu) |
| BR (1) | BR9812160A (hu) |
| CA (1) | CA2303440A1 (hu) |
| DE (1) | DE59810359D1 (hu) |
| DK (1) | DK1015437T3 (hu) |
| ES (1) | ES2212361T3 (hu) |
| HU (1) | HUP0003455A3 (hu) |
| IL (1) | IL134930A (hu) |
| IS (1) | IS5390A (hu) |
| NO (1) | NO317416B1 (hu) |
| NZ (1) | NZ503230A (hu) |
| PL (1) | PL339073A1 (hu) |
| PT (1) | PT1015437E (hu) |
| SK (1) | SK3102000A3 (hu) |
| TR (1) | TR200000637T2 (hu) |
| TW (1) | TW457236B (hu) |
| WO (1) | WO1999012915A1 (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19844291A1 (de) * | 1998-09-18 | 2000-03-23 | Schering Ag | Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
| WO2000024746A1 (de) * | 1998-10-27 | 2000-05-04 | Schering Aktiengesellschaft | Thienooxazine als nos-hemmer |
| DE19941115A1 (de) * | 1999-08-25 | 2001-03-01 | Schering Ag | Neue Benzoxazin- und Bezothiazin-Derivate und deren Verwendung in Arzneimitteln |
| DE10020667A1 (de) * | 2000-04-19 | 2001-11-22 | Schering Ag | Neue Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
| AU2001262200A1 (en) * | 2000-04-25 | 2001-11-07 | Schering Aktiengesellschaft | Benzoxazine derivatives and benzothiazine derivatives having nos-inhibitory and antioxidant properties |
| ITTO20040125A1 (it) * | 2004-03-01 | 2004-06-01 | Rotta Research Lab | Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica |
| AR056893A1 (es) * | 2005-12-28 | 2007-10-31 | Takeda Pharmaceutical | Compuestos heterociclicos fusionados y no fusionados, antagonistas de receptores mineralocorticoides |
| KR101044880B1 (ko) * | 2008-06-12 | 2011-06-28 | 일양약품주식회사 | 항궤양제 화합물의 합성에 유용한 중간체의 제조방법 |
| KR101293384B1 (ko) * | 2010-10-13 | 2013-08-05 | 주식회사 대웅제약 | 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도 |
| CN106279139B (zh) * | 2016-08-08 | 2018-12-28 | 湘潭大学 | 可用作sglt2抑制剂的化合物及其制备方法和用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629322A (en) * | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
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1998
- 1998-09-08 AT AT98952562T patent/ATE255567T1/de not_active IP Right Cessation
- 1998-09-08 CN CNB988109255A patent/CN1136203C/zh not_active Expired - Fee Related
- 1998-09-08 US US09/581,119 patent/US6365736B1/en not_active Expired - Fee Related
- 1998-09-08 IL IL13493098A patent/IL134930A/en not_active IP Right Cessation
- 1998-09-08 SK SK310-2000A patent/SK3102000A3/sk unknown
- 1998-09-08 KR KR1020007002401A patent/KR20010023746A/ko active IP Right Grant
- 1998-09-08 CA CA002303440A patent/CA2303440A1/en not_active Abandoned
- 1998-09-08 PT PT98952562T patent/PT1015437E/pt unknown
- 1998-09-08 EP EP98952562A patent/EP1015437B1/de not_active Expired - Lifetime
- 1998-09-08 WO PCT/DE1998/002690 patent/WO1999012915A1/de not_active Application Discontinuation
- 1998-09-08 JP JP2000510723A patent/JP2001515892A/ja active Pending
- 1998-09-08 HU HU0003455A patent/HUP0003455A3/hu unknown
- 1998-09-08 TR TR2000/00637T patent/TR200000637T2/xx unknown
- 1998-09-08 DK DK98952562T patent/DK1015437T3/da active
- 1998-09-08 BR BR9812160-0A patent/BR9812160A/pt not_active Application Discontinuation
- 1998-09-08 NZ NZ503230A patent/NZ503230A/en unknown
- 1998-09-08 ES ES98952562T patent/ES2212361T3/es not_active Expired - Lifetime
- 1998-09-08 TW TW087114926A patent/TW457236B/zh not_active IP Right Cessation
- 1998-09-08 AU AU10220/99A patent/AU741297B2/en not_active Ceased
- 1998-09-08 DE DE59810359T patent/DE59810359D1/de not_active Expired - Fee Related
- 1998-09-08 PL PL98339073A patent/PL339073A1/xx not_active Application Discontinuation
-
2000
- 2000-02-29 IS IS5390A patent/IS5390A/is unknown
- 2000-03-07 NO NO20001149A patent/NO317416B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE59810359D1 (de) | 2004-01-15 |
| JP2001515892A (ja) | 2001-09-25 |
| KR20010023746A (ko) | 2001-03-26 |
| IS5390A (is) | 2000-02-29 |
| EP1015437A1 (de) | 2000-07-05 |
| EP1015437B1 (de) | 2003-12-03 |
| CA2303440A1 (en) | 1999-03-18 |
| US6365736B1 (en) | 2002-04-02 |
| WO1999012915A1 (de) | 1999-03-18 |
| ATE255567T1 (de) | 2003-12-15 |
| TW457236B (en) | 2001-10-01 |
| TR200000637T2 (tr) | 2000-07-21 |
| SK3102000A3 (en) | 2000-10-09 |
| DK1015437T3 (da) | 2004-03-15 |
| PL339073A1 (en) | 2000-12-04 |
| CN1136203C (zh) | 2004-01-28 |
| AU1022099A (en) | 1999-03-29 |
| IL134930A0 (en) | 2001-07-24 |
| NO20001149L (no) | 2000-05-05 |
| ES2212361T3 (es) | 2004-07-16 |
| IL134930A (en) | 2004-06-20 |
| NO317416B1 (no) | 2004-10-25 |
| NZ503230A (en) | 2002-03-28 |
| PT1015437E (pt) | 2004-04-30 |
| HUP0003455A3 (en) | 2002-12-28 |
| AU741297B2 (en) | 2001-11-29 |
| BR9812160A (pt) | 2000-07-18 |
| CN1278802A (zh) | 2001-01-03 |
| NO20001149D0 (no) | 2000-03-07 |
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