PT1318987E - Processo de resolucao do 2-amino-6-propilamino-4,5,6,7-tetra-hidrobenzotiazole e compostos para esse fim - Google Patents

Processo de resolucao do 2-amino-6-propilamino-4,5,6,7-tetra-hidrobenzotiazole e compostos para esse fim

Info

Publication number
PT1318987E
PT1318987E PT01981155T PT01981155T PT1318987E PT 1318987 E PT1318987 E PT 1318987E PT 01981155 T PT01981155 T PT 01981155T PT 01981155 T PT01981155 T PT 01981155T PT 1318987 E PT1318987 E PT 1318987E
Authority
PT
Portugal
Prior art keywords
compounds
tetrahydrobenzotiazole
propylamino
resolution
amino
Prior art date
Application number
PT01981155T
Other languages
English (en)
Inventor
Pospisilik Karel
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of PT1318987E publication Critical patent/PT1318987E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
PT01981155T 2000-09-18 2001-09-18 Processo de resolucao do 2-amino-6-propilamino-4,5,6,7-tetra-hidrobenzotiazole e compostos para esse fim PT1318987E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002262A ES2187249B1 (es) 2000-09-18 2000-09-18 Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.

Publications (1)

Publication Number Publication Date
PT1318987E true PT1318987E (pt) 2005-10-31

Family

ID=8494959

Family Applications (2)

Application Number Title Priority Date Filing Date
PT01979066T PT1318986E (pt) 2000-09-18 2001-09-14 Processo para preparacao de 2-amino -6-(alquil) amino-4,5,6,7 tetra-hidrobenzotiazoles
PT01981155T PT1318987E (pt) 2000-09-18 2001-09-18 Processo de resolucao do 2-amino-6-propilamino-4,5,6,7-tetra-hidrobenzotiazole e compostos para esse fim

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT01979066T PT1318986E (pt) 2000-09-18 2001-09-14 Processo para preparacao de 2-amino -6-(alquil) amino-4,5,6,7 tetra-hidrobenzotiazoles

Country Status (10)

Country Link
US (3) US6770761B2 (pt)
EP (2) EP1318986B1 (pt)
AT (2) ATE327985T1 (pt)
AU (2) AU2002211055A1 (pt)
DE (1) DE60120197T2 (pt)
DK (2) DK1318986T3 (pt)
ES (3) ES2187249B1 (pt)
PT (2) PT1318986E (pt)
SI (1) SI1318986T1 (pt)
WO (2) WO2002022590A1 (pt)

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US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
PA8578501A1 (es) 2002-07-25 2005-02-04 Pharmacia Corp Forma de dosificacion una vez al dia de pramipexol
GB0221513D0 (en) 2002-09-17 2002-10-23 Generics Uk Ltd Novel compounds and processes
GB2394951A (en) * 2002-11-04 2004-05-12 Cipla Ltd One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
US7365086B2 (en) * 2003-07-25 2008-04-29 Synthon Ip Inc. Pramipexole acid addition salts
JP2007529446A (ja) 2004-03-19 2007-10-25 ディファルマ・ソシエタ・ペル・アチオニ プラミペキソールの製造のための中間体
US20080096939A1 (en) * 2004-07-03 2008-04-24 Andreas Keil Process For Preparation Of Pramipexole By Chiral Chromatography
CA2576386A1 (en) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
PT1781260E (pt) * 2004-08-13 2010-12-20 Boehringer Ingelheim Int Formulação em comprimido de libertação prolongada contendo pramipexole ou um seu sal farmaceuticamente aceitável, um método para a preparação do mesmo e sua utilização
US20060069263A1 (en) * 2004-09-30 2006-03-30 Irina Gribun Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole
ES2310146B1 (es) * 2004-12-30 2009-11-11 Chemagis Ltd. Nuevo procedimiento para preparar pramipexol y su mezcla isomerica optica mediante reduccion con triacetoxiborohidruro de sodio.
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WO2006117614A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride
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JP2009504748A (ja) * 2005-08-15 2009-02-05 ユニバーシティ オブ バージニア パテント ファウンデーション Ｒ（＋）プラミペキソールを用いた神経回復
EP1926486A4 (en) * 2005-09-21 2009-06-10 Chemagis Ltd NOVEL (S) -2,6-DIAMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLE MONOTARTRATE POLYMORPHS AND METHODS OF MAKING AND USING THE SAME
WO2007054970A2 (en) * 2005-10-25 2007-05-18 Alembic Limited Novel polymorphic forms of (s)-(-)-2-amino-6-(n- propylamino) 4,5,6,7- tetrahydrobenzothiazole
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) * 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
US20090098202A1 (en) * 2006-02-10 2009-04-16 Boehringer Ingelheim International Gmbh Extended Release Formulation
JP2009526021A (ja) * 2006-02-10 2009-07-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 放出を加減した製剤
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
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ATE405554T1 (de) * 2006-06-26 2008-09-15 Helm Ag Verfahren zur herstellung von pramipexole
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US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
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WO2010022140A1 (en) * 2008-08-19 2010-02-25 Knopp Neurosciences, Inc. Compositions and methods of using (r)-pramipexole
WO2010148409A1 (en) * 2009-06-19 2010-12-23 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
ITMI20101998A1 (it) * 2010-10-27 2012-04-28 Dipharma Francis Srl Procedimento per la racemizzazione di acidi carbossilici
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
CN104072442B (zh) * 2013-03-28 2016-09-28 成都弘达药业有限公司 一种化合物及其制备方法
EP3838271A1 (en) 2013-07-12 2021-06-23 Knopp Biosciences LLC Treating elevated levels of eosinophils and/or basophils
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
CA2921378A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
HUE055850T2 (hu) 2013-08-13 2022-01-28 Knopp Biosciences Llc Készítmények és módszerek a krónikus urticaria (csalánkiütés) kezelésére
CN108084115B (zh) * 2017-12-28 2020-03-17 上海博志研新药物技术有限公司 盐酸普拉克索及其中间体的制备方法
CN110669024A (zh) * 2019-10-30 2020-01-10 福建福瑞明德药业有限公司 一种(s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑*l-酒石酸盐的碱析方法
CN116178304A (zh) * 2023-03-10 2023-05-30 中国药科大学 一种盐酸普拉克索的合成方法

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Also Published As

Publication number Publication date
ES2242778T3 (es) 2005-11-16
DE60120197T2 (de) 2007-03-15
ES2187249A1 (es) 2003-05-16
ATE327985T1 (de) 2006-06-15
AU2002212815A1 (en) 2002-03-26
WO2002022591A1 (en) 2002-03-21
US6727367B2 (en) 2004-04-27
US20040068119A1 (en) 2004-04-08
EP1318987B1 (en) 2005-08-10
EP1318986B1 (en) 2006-05-31
DK1318987T3 (da) 2005-12-12
US20040029936A1 (en) 2004-02-12
US6770761B2 (en) 2004-08-03
DE60120197D1 (de) 2006-07-06
DK1318986T3 (da) 2006-10-02
ES2260296T3 (es) 2006-11-01
ES2187249B1 (es) 2004-09-16
WO2002022590A1 (en) 2002-03-21
SI1318986T1 (sl) 2006-10-31
ATE301646T1 (de) 2005-08-15
AU2002211055A1 (en) 2002-03-26
EP1318986A1 (en) 2003-06-18
EP1318987A1 (en) 2003-06-18
US20020103240A1 (en) 2002-08-01
PT1318986E (pt) 2006-10-31

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