SI1318986T1 - Postopek za pripravo 2-amino-6-(alkil)amino-4,5,6,7 -tetrahidrobenzotiazolov - Google Patents
Postopek za pripravo 2-amino-6-(alkil)amino-4,5,6,7 -tetrahidrobenzotiazolovInfo
- Publication number
- SI1318986T1 SI1318986T1 SI200130558T SI200130558T SI1318986T1 SI 1318986 T1 SI1318986 T1 SI 1318986T1 SI 200130558 T SI200130558 T SI 200130558T SI 200130558 T SI200130558 T SI 200130558T SI 1318986 T1 SI1318986 T1 SI 1318986T1
- Authority
- SI
- Slovenia
- Prior art keywords
- amino
- group
- tetrahydrobenzothiazoles
- alkyl
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Steroid Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002262A ES2187249B1 (es) | 2000-09-18 | 2000-09-18 | Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles. |
PCT/NL2001/000680 WO2002022590A1 (en) | 2000-09-18 | 2001-09-14 | Process for preparation of 2-amino-6-(alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1318986T1 true SI1318986T1 (sl) | 2006-10-31 |
Family
ID=8494959
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200130558T SI1318986T1 (sl) | 2000-09-18 | 2001-09-14 | Postopek za pripravo 2-amino-6-(alkil)amino-4,5,6,7 -tetrahidrobenzotiazolov |
Country Status (10)
Country | Link |
---|---|
US (3) | US6770761B2 (sl) |
EP (2) | EP1318986B1 (sl) |
AT (2) | ATE327985T1 (sl) |
AU (2) | AU2002211055A1 (sl) |
DE (1) | DE60120197T2 (sl) |
DK (2) | DK1318986T3 (sl) |
ES (3) | ES2187249B1 (sl) |
PT (2) | PT1318986E (sl) |
SI (1) | SI1318986T1 (sl) |
WO (2) | WO2002022590A1 (sl) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2241118A (en) * | 1990-02-15 | 1991-08-21 | Ibm | Electrical apparatus with forced air cooling |
US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
CA2468747C (en) * | 2001-12-11 | 2011-05-31 | University Of Virginia Patent Foundation | Use of pramipexole to treat amyotrophic lateral sclerosis |
US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
US8679533B2 (en) | 2002-07-25 | 2014-03-25 | Pharmacia Corporation | Pramipexole once-daily dosage form |
GB0221513D0 (en) | 2002-09-17 | 2002-10-23 | Generics Uk Ltd | Novel compounds and processes |
GB2394951A (en) * | 2002-11-04 | 2004-05-12 | Cipla Ltd | One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole |
US7365086B2 (en) * | 2003-07-25 | 2008-04-29 | Synthon Ip Inc. | Pramipexole acid addition salts |
US7741490B2 (en) | 2004-03-19 | 2010-06-22 | Dipharma S.P.A. | Intermediates for the preparation of pramipexole |
EP1773793A2 (en) * | 2004-07-03 | 2007-04-18 | Merck Generics (UK) Limited | Process for the preparation of pramipexole by chiral chromatography |
CA2576386A1 (en) * | 2004-08-13 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
ATE486588T1 (de) * | 2004-08-13 | 2010-11-15 | Boehringer Ingelheim Int | Tablettenformulierung mit verlängerter freisetzung mit pramipexol oder einem pharmazeutisch zulässigen salz davon, herstellungsverfahren und verwendung dafür |
US20060069263A1 (en) * | 2004-09-30 | 2006-03-30 | Irina Gribun | Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole |
US20060148866A1 (en) * | 2004-12-30 | 2006-07-06 | Chemagis Ltd. | Novel process for preparing pramipexole and its optical isomeric mixture by reduction with sodium triacetoxyborohydride |
CN1834092B (zh) * | 2005-03-15 | 2010-04-28 | 姜能桥 | 盐酸普拉克索的制备方法 |
WO2006117614A1 (en) * | 2005-05-03 | 2006-11-09 | Ranbaxy Laboratories Limited | Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride |
ES2264378B1 (es) * | 2005-05-09 | 2007-11-01 | Ragactives, S.L. | Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios. |
CA2619217A1 (en) * | 2005-08-15 | 2007-02-22 | University Of Virginia Patent Foundation | Neurorestoration with r(+) pramipexole |
EP1926486A4 (en) * | 2005-09-21 | 2009-06-10 | Chemagis Ltd | NOVEL (S) -2,6-DIAMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLE MONOTARTRATE POLYMORPHS AND METHODS OF MAKING AND USING THE SAME |
WO2007054970A2 (en) * | 2005-10-25 | 2007-05-18 | Alembic Limited | Novel polymorphic forms of (s)-(-)-2-amino-6-(n- propylamino) 4,5,6,7- tetrahydrobenzothiazole |
PL378587A1 (pl) * | 2005-12-29 | 2007-07-09 | Instytut Farmaceutyczny | Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli |
ITMI20060044A1 (it) * | 2006-01-13 | 2007-07-14 | Dipharma Spa | Sintesi di intermedi pr la preparazione di pramipexolo |
US20090041844A1 (en) * | 2006-02-10 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Modified Release Formulation |
US20090098202A1 (en) * | 2006-02-10 | 2009-04-16 | Boehringer Ingelheim International Gmbh | Extended Release Formulation |
US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
WO2007121188A2 (en) * | 2006-04-10 | 2007-10-25 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
AU2007253899A1 (en) * | 2006-05-16 | 2007-11-29 | Knopp Neurosciences, Inc. | Compositions of R(+) and S(-) pramipexole and methods of using the same |
EP1878731B1 (en) * | 2006-06-26 | 2008-08-20 | Helm AG | Process for producing pramipexole |
WO2008001204A2 (en) * | 2006-06-29 | 2008-01-03 | Antares Pharma Ipl Ag | Transdermal compositions of pramipexole having enhanced permeation properties |
US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
RU2454409C2 (ru) * | 2007-03-14 | 2012-06-27 | Нопп Ньюросайенсиз, Инк. | Синтез хирально очищенных замещенных бензотиазолдиаминов |
WO2009087674A2 (en) * | 2007-12-18 | 2009-07-16 | Watson Pharma Private Limited | Improved process for the preparation of (s)-pregabalin |
CA2734491A1 (en) * | 2008-08-19 | 2010-02-25 | Knopp Neurosciences, Inc. | Compositions and methods of using (r)-pramipexole |
AU2010262970A1 (en) * | 2009-06-19 | 2012-01-12 | Knopp Neurosciences, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
ITMI20101998A1 (it) * | 2010-10-27 | 2012-04-28 | Dipharma Francis Srl | Procedimento per la racemizzazione di acidi carbossilici |
WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
CN104072442B (zh) * | 2013-03-28 | 2016-09-28 | 成都弘达药业有限公司 | 一种化合物及其制备方法 |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
CN105764507B (zh) | 2013-07-12 | 2019-07-19 | 诺普生物科学有限责任公司 | 治疗升高的嗜酸性粒细胞和/或嗜碱性粒细胞的水平 |
AU2014306683B2 (en) | 2013-08-13 | 2017-10-12 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders |
ES2871556T3 (es) | 2013-08-13 | 2021-10-29 | Knopp Biosciences Llc | Composiciones y métodos para el tratamiento de la urticaria crónica |
CN108084115B (zh) * | 2017-12-28 | 2020-03-17 | 上海博志研新药物技术有限公司 | 盐酸普拉克索及其中间体的制备方法 |
CN110669024A (zh) * | 2019-10-30 | 2020-01-10 | 福建福瑞明德药业有限公司 | 一种(s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑*l-酒石酸盐的碱析方法 |
CN116178304A (zh) * | 2023-03-10 | 2023-05-30 | 中国药科大学 | 一种盐酸普拉克索的合成方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3572485D1 (en) * | 1984-12-22 | 1989-09-28 | Thomae Gmbh Dr K | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs |
EP0207696A1 (en) * | 1985-06-24 | 1987-01-07 | Eli Lilly And Company | Dialkylaminotetrahydrobenzothiazoles and oxazoles |
DE3620813A1 (de) * | 1986-06-21 | 1987-12-23 | Boehringer Ingelheim Kg | Neue tetrahydro-benzothiazole, ihre herstellung und verwendung |
-
2000
- 2000-09-18 ES ES200002262A patent/ES2187249B1/es not_active Expired - Fee Related
-
2001
- 2001-09-14 DK DK01979066T patent/DK1318986T3/da active
- 2001-09-14 US US10/380,758 patent/US6770761B2/en not_active Expired - Fee Related
- 2001-09-14 AT AT01979066T patent/ATE327985T1/de not_active IP Right Cessation
- 2001-09-14 EP EP01979066A patent/EP1318986B1/en not_active Expired - Lifetime
- 2001-09-14 ES ES01979066T patent/ES2260296T3/es not_active Expired - Lifetime
- 2001-09-14 SI SI200130558T patent/SI1318986T1/sl unknown
- 2001-09-14 AU AU2002211055A patent/AU2002211055A1/en not_active Abandoned
- 2001-09-14 WO PCT/NL2001/000680 patent/WO2002022590A1/en active IP Right Grant
- 2001-09-14 DE DE60120197T patent/DE60120197T2/de not_active Expired - Fee Related
- 2001-09-14 PT PT01979066T patent/PT1318986E/pt unknown
- 2001-09-18 AU AU2002212815A patent/AU2002212815A1/en not_active Abandoned
- 2001-09-18 US US09/953,870 patent/US6727367B2/en not_active Expired - Fee Related
- 2001-09-18 DK DK01981155T patent/DK1318987T3/da active
- 2001-09-18 PT PT01981155T patent/PT1318987E/pt unknown
- 2001-09-18 EP EP01981155A patent/EP1318987B1/en not_active Expired - Lifetime
- 2001-09-18 AT AT01981155T patent/ATE301646T1/de not_active IP Right Cessation
- 2001-09-18 ES ES01981155T patent/ES2242778T3/es not_active Expired - Lifetime
- 2001-09-18 WO PCT/NL2001/000691 patent/WO2002022591A1/en active IP Right Grant
-
2003
- 2003-10-06 US US10/678,081 patent/US20040068119A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1318986B1 (en) | 2006-05-31 |
ATE301646T1 (de) | 2005-08-15 |
PT1318987E (pt) | 2005-10-31 |
US20040068119A1 (en) | 2004-04-08 |
EP1318986A1 (en) | 2003-06-18 |
ES2187249A1 (es) | 2003-05-16 |
US6727367B2 (en) | 2004-04-27 |
AU2002211055A1 (en) | 2002-03-26 |
ES2187249B1 (es) | 2004-09-16 |
ES2260296T3 (es) | 2006-11-01 |
WO2002022590A1 (en) | 2002-03-21 |
WO2002022591A1 (en) | 2002-03-21 |
ATE327985T1 (de) | 2006-06-15 |
DK1318987T3 (da) | 2005-12-12 |
PT1318986E (pt) | 2006-10-31 |
US6770761B2 (en) | 2004-08-03 |
DE60120197T2 (de) | 2007-03-15 |
AU2002212815A1 (en) | 2002-03-26 |
ES2242778T3 (es) | 2005-11-16 |
DK1318986T3 (da) | 2006-10-02 |
EP1318987A1 (en) | 2003-06-18 |
EP1318987B1 (en) | 2005-08-10 |
US20040029936A1 (en) | 2004-02-12 |
US20020103240A1 (en) | 2002-08-01 |
DE60120197D1 (de) | 2006-07-06 |
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