DE60118206T2 - Antikonvulsive derivate zur behandlung und vorbeugung der entwicklung von typ ii diabetes und syndrom x - Google Patents
Antikonvulsive derivate zur behandlung und vorbeugung der entwicklung von typ ii diabetes und syndrom x Download PDFInfo
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- DE60118206T2 DE60118206T2 DE60118206T DE60118206T DE60118206T2 DE 60118206 T2 DE60118206 T2 DE 60118206T2 DE 60118206 T DE60118206 T DE 60118206T DE 60118206 T DE60118206 T DE 60118206T DE 60118206 T2 DE60118206 T2 DE 60118206T2
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- 230000001991 pathophysiological effect Effects 0.000 description 1
- 230000008289 pathophysiological mechanism Effects 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
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- 230000037081 physical activity Effects 0.000 description 1
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- 229920000573 polyethylene Polymers 0.000 description 1
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 208000022530 polyphagia Diseases 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000005195 poor health Effects 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 208000037821 progressive disease Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 231100000272 reduced body weight Toxicity 0.000 description 1
- 238000011808 rodent model Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 201000002852 simple partial epilepsy Diseases 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- QAHVHSLSRLSVGS-UHFFFAOYSA-N sulfamoyl chloride Chemical compound NS(Cl)(=O)=O QAHVHSLSRLSVGS-UHFFFAOYSA-N 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001975 sympathomimetic effect Effects 0.000 description 1
- 235000013759 synthetic iron oxide Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- 239000004408 titanium dioxide Substances 0.000 description 1
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- 210000002700 urine Anatomy 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21714100P | 2000-07-07 | 2000-07-07 | |
| US217141P | 2000-07-07 | ||
| US27002201P | 2001-02-20 | 2001-02-20 | |
| US270022P | 2001-02-20 | ||
| PCT/US2001/021404 WO2002003984A2 (en) | 2000-07-07 | 2001-07-06 | Anticonvulsant derivatives useful for treating and preventing the development of type ii diabetes mellitus and syndrome x |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60118206D1 DE60118206D1 (de) | 2006-05-11 |
| DE60118206T2 true DE60118206T2 (de) | 2006-12-14 |
Family
ID=26911655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60118206T Expired - Lifetime DE60118206T2 (de) | 2000-07-07 | 2001-07-06 | Antikonvulsive derivate zur behandlung und vorbeugung der entwicklung von typ ii diabetes und syndrom x |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6852701B2 (enExample) |
| EP (1) | EP1309324B1 (enExample) |
| JP (1) | JP4920163B2 (enExample) |
| CN (1) | CN101404993A (enExample) |
| AR (1) | AR032465A1 (enExample) |
| AT (1) | ATE320805T1 (enExample) |
| AU (1) | AU2001280486A1 (enExample) |
| BR (1) | BR0112519A (enExample) |
| CA (1) | CA2415093A1 (enExample) |
| DE (1) | DE60118206T2 (enExample) |
| DK (1) | DK1309324T3 (enExample) |
| ES (1) | ES2260261T3 (enExample) |
| HU (1) | HUP0302307A3 (enExample) |
| IL (1) | IL153713A0 (enExample) |
| MX (1) | MXPA03000136A (enExample) |
| MY (1) | MY126897A (enExample) |
| NO (1) | NO20030064L (enExample) |
| NZ (1) | NZ523531A (enExample) |
| PL (1) | PL365680A1 (enExample) |
| PT (1) | PT1309324E (enExample) |
| RU (1) | RU2268720C2 (enExample) |
| WO (1) | WO2002003984A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080255093A1 (en) * | 1999-06-14 | 2008-10-16 | Tam Peter Y | Compositions and methods for treating obesity and related disorders |
| US7674776B2 (en) * | 1999-06-14 | 2010-03-09 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
| US20080103179A1 (en) * | 2006-10-27 | 2008-05-01 | Tam Peter Y | Combination Therapy |
| US7208477B2 (en) | 2002-12-02 | 2007-04-24 | University Of Florida Research Foundation, Inc. | Treatments for benign tumors, cancers, neoplasias, and/or other inflammatory disorders or diseases |
| MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| TW200612905A (en) * | 2004-06-16 | 2006-05-01 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| PE20060500A1 (es) * | 2004-08-24 | 2006-07-13 | Janssen Pharmaceutica Nv | Derivados de heteroaril sulfamida benzo-fusionada como anticonvulsivantes |
| BRPI0610864A2 (pt) * | 2005-05-20 | 2010-08-03 | Janssen Pharmaceutica Nv | processo para preparação de derivados de sulfamida |
| US8497298B2 (en) * | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
| US8691867B2 (en) | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
| US20070155823A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents |
| US20070155827A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression |
| AR058389A1 (es) * | 2005-12-19 | 2008-01-30 | Janssen Pharmaceutica Nv | Uso de derivados heterociclicos benzo-fusionados de sulfamida para el tratamiento de la obesidad |
| US8937096B2 (en) * | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
| US8716231B2 (en) * | 2005-12-19 | 2014-05-06 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
| US20070191453A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of benzo-heteroaryl sulfamide derivatives for the treatment of substance abuse and addiction |
| US20070191459A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels |
| US20070191474A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine |
| US20070191449A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression |
| US20070191461A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine |
| JP2009537635A (ja) | 2006-05-19 | 2009-10-29 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 癲癇の処置のための共同−療法 |
| US9744137B2 (en) | 2006-08-31 | 2017-08-29 | Supernus Pharmaceuticals, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| EP2394643B1 (en) | 2006-11-17 | 2015-09-02 | Supernus Pharmaceuticals, Inc. | Sustained-release formulations of topiramate |
| CN102114002B (zh) * | 2006-12-04 | 2016-05-11 | 苏佩努斯制药公司 | 托吡酯的增强的立即释放制剂 |
| AU2008209320B2 (en) * | 2007-01-25 | 2013-05-30 | NAIA Metabolic, Inc. | Insulin sensitisers and methods of treatment |
| US20090076128A1 (en) * | 2007-09-15 | 2009-03-19 | Protia Llc | Deuterium-enriched topiramate |
| US20090247616A1 (en) * | 2008-03-26 | 2009-10-01 | Smith-Swintosky Virginia L | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety |
| US20090247617A1 (en) * | 2008-03-26 | 2009-10-01 | Abdel-Magid Ahmed F | Process for the preparation of benzo-fused heteroaryl sulfamates |
| US8580298B2 (en) | 2008-06-09 | 2013-11-12 | Vivus, Inc. | Low dose topiramate/phentermine composition and methods of use thereof |
| US20090304789A1 (en) | 2008-06-09 | 2009-12-10 | Thomas Najarian | Novel topiramate compositions and an escalating dosing strategy for treating obesity and related disorders |
| PE20110060A1 (es) | 2008-06-23 | 2011-01-31 | Janssen Pharmaceutica Nv | Forma cristalina de (2s)-(-)-n-(6-cloro-2,3-dihidro-benzo[1,4]dioxin-2-ilmetil)-sulfamida |
| US8815939B2 (en) * | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
| JP6055076B2 (ja) | 2012-03-23 | 2016-12-27 | インスティテュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー．エル．エー．チャイナ | シネフリン及びトピラマートを含む組み合わせ製品 |
| CN102579367B (zh) | 2012-03-23 | 2014-03-12 | 中国人民解放军军事医学科学院毒物药物研究所 | 托吡酯缓释药物组合物、其制备方法及用途 |
| CN103316026B (zh) | 2012-03-23 | 2016-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 含芬特明和托吡酯的联合产品及其制备方法 |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| US10278948B1 (en) | 2015-09-03 | 2019-05-07 | Tian Xia | Method for transnasal delivery of anticonvulsant and therapeutic treatments |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4513006A (en) * | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| IL103172A (en) * | 1991-09-19 | 1997-01-10 | Mcneilab Inc | Preparation of chlorosulfate and sulfamate derivatives of 2, 3:4, 5-bis-o-(1-methylethylidene)-beta-d-fructopyranose and (1-methylcyclohexyl) methanol |
| US5242942A (en) * | 1992-04-28 | 1993-09-07 | Mcneilab, Inc. | Anticonvulsant fructopyranose cyclic sulfites and sulfates |
| US5384327A (en) | 1992-12-22 | 1995-01-24 | Mcneilab, Inc. | Anticonvulsant sorbopyranose sulfamates |
| SK284305B6 (sk) * | 1996-06-28 | 2005-01-03 | Ortho-Mcneil Pharmaceutical, Inc. | Liečivo na liečbu obezity |
| UA65607C2 (uk) * | 1998-03-04 | 2004-04-15 | Орто-Макнейл Фармацевтикал, Інк. | Фармацевтична композиція (варіанти) та спосіб її приготування |
| ES2238999T3 (es) | 1999-02-24 | 2005-09-16 | University Of Cincinnati | Uso de derivados de sulfamato para tratar trastornos en el control de los impulsos. |
| US6191163B1 (en) * | 1999-04-08 | 2001-02-20 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful in lowering lipids |
| JP2003530300A (ja) | 1999-04-08 | 2003-10-14 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 体重低下を維持することに有用な抗痙攣薬誘導体 |
| NZ514811A (en) | 1999-04-08 | 2005-01-28 | Ortho Mcneil Pharm Inc | Anticonvulsant derivatives useful in reducing blood glucose levels |
| WO2000076493A1 (en) * | 1999-06-14 | 2000-12-21 | Thomas Najarian | Combination therapy for effecting weight loss and treating obesity |
-
2001
- 2001-07-06 DK DK01958878T patent/DK1309324T3/da active
- 2001-07-06 EP EP01958878A patent/EP1309324B1/en not_active Expired - Lifetime
- 2001-07-06 CA CA002415093A patent/CA2415093A1/en not_active Abandoned
- 2001-07-06 US US09/900,567 patent/US6852701B2/en not_active Expired - Lifetime
- 2001-07-06 NZ NZ523531A patent/NZ523531A/en unknown
- 2001-07-06 ES ES01958878T patent/ES2260261T3/es not_active Expired - Lifetime
- 2001-07-06 RU RU2003100076/14A patent/RU2268720C2/ru not_active IP Right Cessation
- 2001-07-06 MX MXPA03000136A patent/MXPA03000136A/es active IP Right Grant
- 2001-07-06 CN CNA018151590A patent/CN101404993A/zh active Pending
- 2001-07-06 PL PL01365680A patent/PL365680A1/xx not_active Application Discontinuation
- 2001-07-06 MY MYPI20013235 patent/MY126897A/en unknown
- 2001-07-06 AU AU2001280486A patent/AU2001280486A1/en not_active Abandoned
- 2001-07-06 PT PT01958878T patent/PT1309324E/pt unknown
- 2001-07-06 IL IL15371301A patent/IL153713A0/xx unknown
- 2001-07-06 AT AT01958878T patent/ATE320805T1/de active
- 2001-07-06 DE DE60118206T patent/DE60118206T2/de not_active Expired - Lifetime
- 2001-07-06 BR BR0112519-2A patent/BR0112519A/pt not_active IP Right Cessation
- 2001-07-06 HU HU0302307A patent/HUP0302307A3/hu unknown
- 2001-07-06 JP JP2002508438A patent/JP4920163B2/ja not_active Expired - Lifetime
- 2001-07-06 WO PCT/US2001/021404 patent/WO2002003984A2/en not_active Ceased
- 2001-07-10 AR ARP010103263A patent/AR032465A1/es not_active Application Discontinuation
-
2003
- 2003-01-06 NO NO20030064A patent/NO20030064L/no not_active Application Discontinuation
-
2004
- 2004-05-11 US US10/843,134 patent/US7109174B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PT1309324E (pt) | 2006-06-30 |
| DE60118206D1 (de) | 2006-05-11 |
| WO2002003984A2 (en) | 2002-01-17 |
| US20040209824A1 (en) | 2004-10-21 |
| DK1309324T3 (da) | 2006-06-12 |
| HUP0302307A3 (en) | 2007-05-29 |
| JP4920163B2 (ja) | 2012-04-18 |
| HUP0302307A2 (hu) | 2003-10-28 |
| EP1309324B1 (en) | 2006-03-22 |
| NO20030064L (no) | 2003-03-06 |
| US7109174B2 (en) | 2006-09-19 |
| MY126897A (en) | 2006-10-31 |
| PL365680A1 (en) | 2005-01-10 |
| WO2002003984A3 (en) | 2003-03-06 |
| EP1309324A2 (en) | 2003-05-14 |
| IL153713A0 (en) | 2003-07-06 |
| US6852701B2 (en) | 2005-02-08 |
| MXPA03000136A (es) | 2004-09-13 |
| CN101404993A (zh) | 2009-04-08 |
| AR032465A1 (es) | 2003-11-12 |
| AU2001280486A1 (en) | 2002-01-21 |
| NZ523531A (en) | 2005-07-29 |
| JP2004510700A (ja) | 2004-04-08 |
| ATE320805T1 (de) | 2006-04-15 |
| ES2260261T3 (es) | 2006-11-01 |
| RU2268720C2 (ru) | 2006-01-27 |
| CA2415093A1 (en) | 2002-01-17 |
| NO20030064D0 (no) | 2003-01-06 |
| US20020037861A1 (en) | 2002-03-28 |
| BR0112519A (pt) | 2004-03-30 |
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