DE60116758T2 - Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform - Google Patents

Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform Download PDF

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Publication number
DE60116758T2
DE60116758T2 DE60116758T DE60116758T DE60116758T2 DE 60116758 T2 DE60116758 T2 DE 60116758T2 DE 60116758 T DE60116758 T DE 60116758T DE 60116758 T DE60116758 T DE 60116758T DE 60116758 T2 DE60116758 T2 DE 60116758T2
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Prior art keywords
region
toxic
liquid
dosage form
potent
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE60116758T
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German (de)
English (en)
Other versions
DE60116758D1 (de
Inventor
C. Francis Somerville PAYUMO
Chen-Chao West Windsor WANG
K. Jill Edison SHERWOOD
J. Michael Winchester CIMA
M. Christopher Princeton Junction GAYLO
C. Donald Rednor MONKHOUSE
Jaedeok West Orange YOO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
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Massachusetts Institute of Technology
Therics Inc
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Publication of DE60116758D1 publication Critical patent/DE60116758D1/de
Publication of DE60116758T2 publication Critical patent/DE60116758T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893Tablet coating processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00Processes of additive manufacturing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00Materials specially adapted for additive manufacturing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00Products made by additive manufacturing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60116758T 2000-05-18 2001-05-18 Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform Expired - Lifetime DE60116758T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20589600P 2000-05-18 2000-05-18
US205896P 2000-05-18
PCT/US2001/040763 WO2001087272A2 (en) 2000-05-18 2001-05-18 Encapsulating a toxic core within a non-toxic region in an oral dosage form

Publications (2)

Publication Number Publication Date
DE60116758D1 DE60116758D1 (de) 2006-04-06
DE60116758T2 true DE60116758T2 (de) 2006-11-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE60116758T Expired - Lifetime DE60116758T2 (de) 2000-05-18 2001-05-18 Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform

Country Status (9)

Country Link
US (2) US7276252B2 (enExample)
EP (1) EP1286663B1 (enExample)
JP (2) JP5178982B2 (enExample)
AT (1) ATE315930T1 (enExample)
AU (1) AU2001263506A1 (enExample)
CA (1) CA2408956C (enExample)
DE (1) DE60116758T2 (enExample)
ES (1) ES2257412T3 (enExample)
WO (1) WO2001087272A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155871B2 (en) 2010-11-19 2015-10-13 C. Miethke Gmbh & Co Kg Electrically operable, in one possible embodiment programmable hydrocephalus valve

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Publication number Priority date Publication date Assignee Title
US9155871B2 (en) 2010-11-19 2015-10-13 C. Miethke Gmbh & Co Kg Electrically operable, in one possible embodiment programmable hydrocephalus valve

Also Published As

Publication number Publication date
US20020015728A1 (en) 2002-02-07
EP1286663A2 (en) 2003-03-05
JP5178982B2 (ja) 2013-04-10
ES2257412T3 (es) 2006-08-01
US7875290B2 (en) 2011-01-25
JP2003533470A (ja) 2003-11-11
CA2408956A1 (en) 2001-11-22
CA2408956C (en) 2011-07-12
US7276252B2 (en) 2007-10-02
EP1286663B1 (en) 2006-01-18
DE60116758D1 (de) 2006-04-06
WO2001087272A3 (en) 2002-04-18
WO2001087272A2 (en) 2001-11-22
AU2001263506A1 (en) 2001-11-26
US20060110443A1 (en) 2006-05-25
JP2012082224A (ja) 2012-04-26
ATE315930T1 (de) 2006-02-15

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