DE60116758T2 - Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform - Google Patents
Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform Download PDFInfo
- Publication number
- DE60116758T2 DE60116758T2 DE60116758T DE60116758T DE60116758T2 DE 60116758 T2 DE60116758 T2 DE 60116758T2 DE 60116758 T DE60116758 T DE 60116758T DE 60116758 T DE60116758 T DE 60116758T DE 60116758 T2 DE60116758 T2 DE 60116758T2
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- toxic
- liquid
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- potent
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20589600P | 2000-05-18 | 2000-05-18 | |
| US205896P | 2000-05-18 | ||
| PCT/US2001/040763 WO2001087272A2 (en) | 2000-05-18 | 2001-05-18 | Encapsulating a toxic core within a non-toxic region in an oral dosage form |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60116758D1 DE60116758D1 (de) | 2006-04-06 |
| DE60116758T2 true DE60116758T2 (de) | 2006-11-02 |
Family
ID=22764098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60116758T Expired - Lifetime DE60116758T2 (de) | 2000-05-18 | 2001-05-18 | Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7276252B2 (enExample) |
| EP (1) | EP1286663B1 (enExample) |
| JP (2) | JP5178982B2 (enExample) |
| AT (1) | ATE315930T1 (enExample) |
| AU (1) | AU2001263506A1 (enExample) |
| CA (1) | CA2408956C (enExample) |
| DE (1) | DE60116758T2 (enExample) |
| ES (1) | ES2257412T3 (enExample) |
| WO (1) | WO2001087272A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9155871B2 (en) | 2010-11-19 | 2015-10-13 | C. Miethke Gmbh & Co Kg | Electrically operable, in one possible embodiment programmable hydrocephalus valve |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030118645A1 (en) * | 1998-04-29 | 2003-06-26 | Pather S. Indiran | Pharmaceutical compositions for rectal and vaginal administration |
| US6565882B2 (en) * | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| US6541014B2 (en) * | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) * | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| US6518330B2 (en) * | 2001-02-13 | 2003-02-11 | Board Of Trustees Of University Of Illinois | Multifunctional autonomically healing composite material |
| US7300668B2 (en) | 2001-10-29 | 2007-11-27 | Massachusetts Institute Of Technology | System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing |
| US20030099708A1 (en) * | 2001-10-29 | 2003-05-29 | Therics, Inc | Printing or dispensing a suspension such as three-dimensional printing of dosage forms |
| JP4845340B2 (ja) * | 2001-10-29 | 2011-12-28 | マサチューセッツ インスティテュート オブ テクノロジー | 三次元プリント投薬形態のような物品の一軸圧縮のためのシステムおよび方法 |
| DE60323482D1 (de) * | 2002-05-06 | 2008-10-23 | Massachusetts Inst Technology | Diffusionskontrollierte arzneiform sowie herstellungsmethode mittels dreidimensionalem drucken |
| EP1648415A4 (en) * | 2003-07-21 | 2011-11-16 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION |
| WO2005009368A2 (en) | 2003-07-21 | 2005-02-03 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| JP2006528185A (ja) * | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
| CA2535177A1 (en) * | 2003-08-11 | 2005-02-24 | Advancis Pharmaceutical Corporation | Robust pellet |
| CA2535398C (en) | 2003-08-12 | 2013-11-12 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
| WO2005023184A2 (en) * | 2003-08-29 | 2005-03-17 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
| AU2004273830B2 (en) * | 2003-09-15 | 2011-03-24 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| US20050087902A1 (en) * | 2003-10-28 | 2005-04-28 | Isaac Farr | Alginate-based materials, methods of application thereof, and systems for using the alginate-based materials |
| EP1701705A4 (en) * | 2003-12-24 | 2007-08-08 | Advancis Pharmaceutical Corp | IMPROVED ABSORPTION OF DOSAGE FORMS WITH MODIFIED RELEASE |
| US7566747B2 (en) * | 2004-05-07 | 2009-07-28 | The Board Of Trustees Of The University Of Illinois | Wax particles for protection of activators, and multifunctional autonomically healing composite materials |
| TWI547431B (zh) * | 2004-06-09 | 2016-09-01 | 史密斯克萊美占公司 | 生產藥物之裝置及方法 |
| US20060002594A1 (en) * | 2004-06-09 | 2006-01-05 | Clarke Allan J | Method for producing a pharmaceutical product |
| JPWO2006004069A1 (ja) * | 2004-07-01 | 2008-04-24 | 日本碍子株式会社 | 微小カプセルおよびその製造方法 |
| EP1771158A4 (en) * | 2004-07-02 | 2008-03-12 | Advancis Pharmaceutical Corp | TABLET FOR PULSE DISTRIBUTION |
| WO2006058247A2 (en) * | 2004-11-26 | 2006-06-01 | Aprecia Pharmaceuticals Co. | Dosage forms and methods of use thereof |
| US7829000B2 (en) * | 2005-02-25 | 2010-11-09 | Hewlett-Packard Development Company, L.P. | Core-shell solid freeform fabrication |
| US7612152B2 (en) * | 2005-05-06 | 2009-11-03 | The Board Of Trustees Of The University Of Illinois | Self-healing polymers |
| US7914776B2 (en) * | 2005-10-07 | 2011-03-29 | Adolor Corporation | Solid dispersions of opioid antagonists |
| US8778924B2 (en) * | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| EP1973972A2 (en) * | 2006-01-05 | 2008-10-01 | The Board Of Trustees Of The University Of Illinois | Self-healing coating system |
| GB0608402D0 (en) * | 2006-04-28 | 2006-06-07 | Diurnal Ltd | Thyroid treatment |
| US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
| US7569625B2 (en) * | 2006-06-02 | 2009-08-04 | The Board Of Trustees Of The University Of Illinois | Self-healing elastomer system |
| EP3299033A1 (en) | 2006-07-25 | 2018-03-28 | Lipoxen Technologies Limited | N-terminal polysialylation |
| US20080107725A1 (en) * | 2006-10-13 | 2008-05-08 | Albano Antonio A | Pharmaceutical Solid Dosage Forms Comprising Amorphous Compounds Micro-Embedded in Ionic Water-Insoluble Polymers |
| US20080299391A1 (en) * | 2007-05-31 | 2008-12-04 | White Scott R | Capsules, methods for making capsules, and self-healing composites including the same |
| WO2009007969A2 (en) * | 2007-07-09 | 2009-01-15 | Colint Ltd. | Portable hydration apparatus |
| US20090181254A1 (en) * | 2008-01-15 | 2009-07-16 | The Board Of Trustees Of The University Of Illinois | Multi-capsule system and its use for encapsulating active agents |
| JP2011074015A (ja) * | 2009-09-30 | 2011-04-14 | Tomita Pharmaceutical Co Ltd | 固形製剤及びその製造方法 |
| BR112013030093B1 (pt) * | 2011-05-25 | 2019-12-10 | Taiho Pharmaceutical Co Ltd | comprimido revestido seco de desintegração oral contendo tegafur, gimeracilo e oteracilo potássico |
| US9381154B2 (en) * | 2011-06-09 | 2016-07-05 | Xerox Corporation | Direct inkjet fabrication of drug delivery devices |
| US8414654B1 (en) * | 2011-11-23 | 2013-04-09 | Amendia, Inc. | Bone implants and method of manufacture |
| CN102551927A (zh) * | 2011-11-29 | 2012-07-11 | 上海大学 | 嵌入式分级释药三维支架及其制备方法 |
| US8888480B2 (en) | 2012-09-05 | 2014-11-18 | Aprecia Pharmaceuticals Company | Three-dimensional printing system and equipment assembly |
| KR101697105B1 (ko) | 2012-09-05 | 2017-01-17 | 아프레시아 파마슈티칼스 컴퍼니 | 3차원 인쇄 시스템 및 장비 어셈블리 |
| US20140099351A1 (en) * | 2012-10-04 | 2014-04-10 | Axxia Pharmaceuticals, Llc | Process for making controlled release medical implant products |
| HK1216513A1 (zh) | 2013-03-15 | 2016-11-18 | 阿普雷奇亚制药有限责任公司 | 包含左乙拉西坦的快速分散劑型 |
| US9339489B2 (en) | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
| ES2761407T3 (es) | 2013-03-15 | 2020-05-19 | Aprecia Pharmaceuticals LLC | Forma de dosificación rápidamente dispersable de topiramato |
| EP2968354B1 (en) * | 2013-03-15 | 2019-11-13 | Aprecia Pharmaceuticals LLC | Rapidly dispersible dosage form of oxcarbazepine |
| JP6233996B2 (ja) | 2013-08-16 | 2017-11-22 | ザ エクスワン カンパニー | 3次元印刷される金属鋳造用鋳型及び同鋳型の製造方法 |
| US20160243621A1 (en) | 2013-10-17 | 2016-08-25 | The Exone Company | Three-Dimensional Printed Hot Isostatic Pressing Containers and Processes for Making Same |
| US11001048B2 (en) | 2013-12-23 | 2021-05-11 | The Exone Company | Method of three-dimensional printing using a multi-component build powder |
| ES2745763T3 (es) | 2013-12-23 | 2020-03-03 | The Exone Co | Métodos y sistemas para la impresión en tres dimensiones utilizando múltiples fluidos aglutinantes |
| WO2015130963A2 (en) | 2014-02-27 | 2015-09-03 | Xenetic Biosciences, Inc. | Compositions and methods for administering insulin or insulin-like protein to the brain |
| US20170120329A1 (en) | 2014-05-29 | 2017-05-04 | The Exone Company | Process for Making Nickel-Based Superalloy Articles by Three-Dimensional Printing |
| WO2016011098A2 (en) | 2014-07-17 | 2016-01-21 | The Exone Company | Methods and apparatuses for curing three-dimensional printed articles |
| US9854828B2 (en) | 2014-09-29 | 2018-01-02 | William Langeland | Method, system and apparatus for creating 3D-printed edible objects |
| EP3227109B1 (en) | 2014-12-03 | 2020-08-19 | The Exone Company | Process for making densified carbon articles by three dimensional printing |
| EP3302442B1 (en) | 2015-06-03 | 2024-10-16 | Triastek, Inc. | Dosage forms and use thereof |
| CN116423825A (zh) | 2015-08-21 | 2023-07-14 | 阿普雷奇亚制药有限责任公司 | 三维打印系统和设备组件 |
| CN118975972A (zh) | 2015-10-23 | 2024-11-19 | 林德拉治疗公司 | 用于治疗剂缓释的胃驻留系统及其使用方法 |
| BR112018011636B1 (pt) | 2015-12-08 | 2024-03-12 | Lyndra Therapeutics, Inc | Sistema de residência gástrico para liberação sustentada de um agente terapêutico |
| JP6878417B2 (ja) * | 2016-02-17 | 2021-05-26 | トリアステック インコーポレイテッド | 剤形およびそれらの使用 |
| EP3981392A1 (en) | 2016-05-05 | 2022-04-13 | Triastek, Inc. | Controlled release dosage form |
| CN119925721A (zh) | 2016-05-27 | 2025-05-06 | 林德拉治疗公司 | 用于胃驻留系统的材料结构 |
| US10765658B2 (en) | 2016-06-22 | 2020-09-08 | Mastix LLC | Oral compositions delivering therapeutically effective amounts of cannabinoids |
| GB201612853D0 (en) | 2016-07-25 | 2016-09-07 | Univ Central Lancashire | Solid dosage form production |
| CN110022861B (zh) | 2016-09-30 | 2024-06-28 | 林德拉治疗公司 | 用于金刚烷类药物缓释的胃驻留系统 |
| GB201620066D0 (en) | 2016-11-28 | 2017-01-11 | Ucl Business Plc | Solid Pharmaceutical dosage formulations and processes |
| US12102721B2 (en) | 2017-01-26 | 2024-10-01 | Triastek, Inc. | Dosage forms of controlled release at specific gastrointestinal sites |
| US11602502B2 (en) | 2017-02-24 | 2023-03-14 | Hewlett-Packard Development Company, L.P. | Three-dimensional (3D) printing a pharmaceutical tablet |
| GR1009361B (el) * | 2017-05-11 | 2018-09-17 | Κωνσταντινος Ηλια Θεοδοσοπουλος | Συστημα παραγωγης μεσω τρισδιαστατης εκτυπωσης, δισκιων, κοκκιων και καψουλων |
| US10435576B2 (en) | 2017-05-26 | 2019-10-08 | Infinite Material Solutions, Llc | Water soluble polymer compositions |
| AU2018279853B2 (en) | 2017-06-09 | 2024-07-04 | Lyndra Therapeutics, Inc. | Gastric residence systems with release rate-modulating films |
| CN116270513A (zh) | 2018-01-09 | 2023-06-23 | 南京三迭纪医药科技有限公司 | 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型 |
| US10350822B1 (en) | 2018-01-09 | 2019-07-16 | Triastek Inc. | Dosage forms with desired release profiles and methods of designing and making thereof |
| DE102018107585B3 (de) * | 2018-03-29 | 2019-03-28 | Universität Rostock | Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen |
| IT201800004265A1 (it) | 2018-04-06 | 2019-10-06 | Apparato e metodo per la produzione automatizzata di forme di dosaggio personalizzabili. | |
| US11278501B2 (en) | 2018-10-15 | 2022-03-22 | Aprecia Pharmaceuticals LLC | Method and system for forming a dosage form within a packaging |
| CN113557001B (zh) * | 2019-01-07 | 2023-10-20 | 卢克斯坎创新私人有限责任公司 | 用于将粉末状、液体状、糊状、包封的或颗粒状活性成分组合物压片的装置 |
| US11724486B2 (en) | 2019-07-09 | 2023-08-15 | Kyndryl, Inc. | Printing customized medication based on current user data and medical records of the user |
| GB201913972D0 (en) | 2019-09-27 | 2019-11-13 | Univ Ulster | Pharmaceutical Delivery Device and method of manufacture |
| US12371581B2 (en) | 2020-03-25 | 2025-07-29 | Infinite Material Solutions, Llc | High performance water soluble polymer compositions |
| MX2022016117A (es) | 2020-06-26 | 2023-04-05 | Aprecia Pharmaceuticals LLC | Tabletas rapidamente orodispersables que tienen una cavidad interior. |
| US20230390193A1 (en) | 2020-10-30 | 2023-12-07 | Triastek, Inc. | Gastroretentive pharmaceutical dosage form |
| US12251208B2 (en) | 2020-11-30 | 2025-03-18 | International Business Machines Corporation | Time controlled medication |
| GB2608846A (en) * | 2021-07-14 | 2023-01-18 | Quay Pharmaceuticals Ltd | Method and apparatus for additive manufacturing |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2801203A (en) * | 1951-03-22 | 1957-07-30 | Byk Gulden Lomberg Chem Fab | X-ray method of digestive enzyme diagnosis using protected core of contrast agent |
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| US5082669A (en) * | 1989-07-20 | 1992-01-21 | Dainippon Pharmaceutical Co., Ltd. | Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked |
| US5215989A (en) * | 1989-12-08 | 1993-06-01 | Merck & Co., Inc. | Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents |
| US5314696A (en) * | 1991-06-27 | 1994-05-24 | Paulos Manley A | Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor |
| WO1994009762A1 (en) * | 1992-11-05 | 1994-05-11 | Merck & Co., Inc. | Drug delivery device |
| US6280771B1 (en) * | 1997-02-20 | 2001-08-28 | Therics, Inc. | Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof |
| ZA949929B (en) * | 1993-12-23 | 1995-08-23 | Akzo Nobel Nv | Sugar-coated pharmaceutical dosage unit. |
| JPH07223970A (ja) | 1994-02-10 | 1995-08-22 | Tanabe Seiyaku Co Ltd | 消化管内適所放出製剤 |
| JP3867171B2 (ja) * | 1994-04-22 | 2007-01-10 | アステラス製薬株式会社 | 結腸特異的薬物放出システム |
| US5597829A (en) * | 1994-05-09 | 1997-01-28 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of camptothecin and methods for uses thereof |
| US5783212A (en) * | 1996-02-02 | 1998-07-21 | Temple University--of the Commonwealth System of Higher Education | Controlled release drug delivery system |
| WO1998036739A1 (en) * | 1997-02-20 | 1998-08-27 | Therics, Inc. | Dosage forms exhibiting multiphasic release kinetics and methods of manufacture thereof |
| US6046177A (en) * | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
| US6294199B1 (en) * | 1999-04-13 | 2001-09-25 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising administering amoxycillin |
-
2001
- 2001-05-18 ES ES01937808T patent/ES2257412T3/es not_active Expired - Lifetime
- 2001-05-18 DE DE60116758T patent/DE60116758T2/de not_active Expired - Lifetime
- 2001-05-18 AU AU2001263506A patent/AU2001263506A1/en not_active Abandoned
- 2001-05-18 CA CA2408956A patent/CA2408956C/en not_active Expired - Fee Related
- 2001-05-18 EP EP01937808A patent/EP1286663B1/en not_active Expired - Lifetime
- 2001-05-18 WO PCT/US2001/040763 patent/WO2001087272A2/en not_active Ceased
- 2001-05-18 JP JP2001583741A patent/JP5178982B2/ja not_active Expired - Fee Related
- 2001-05-18 US US09/861,480 patent/US7276252B2/en not_active Expired - Lifetime
- 2001-05-18 AT AT01937808T patent/ATE315930T1/de not_active IP Right Cessation
-
2005
- 2005-10-07 US US11/246,910 patent/US7875290B2/en not_active Expired - Fee Related
-
2012
- 2012-01-25 JP JP2012012834A patent/JP2012082224A/ja not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9155871B2 (en) | 2010-11-19 | 2015-10-13 | C. Miethke Gmbh & Co Kg | Electrically operable, in one possible embodiment programmable hydrocephalus valve |
Also Published As
| Publication number | Publication date |
|---|---|
| US20020015728A1 (en) | 2002-02-07 |
| EP1286663A2 (en) | 2003-03-05 |
| JP5178982B2 (ja) | 2013-04-10 |
| ES2257412T3 (es) | 2006-08-01 |
| US7875290B2 (en) | 2011-01-25 |
| JP2003533470A (ja) | 2003-11-11 |
| CA2408956A1 (en) | 2001-11-22 |
| CA2408956C (en) | 2011-07-12 |
| US7276252B2 (en) | 2007-10-02 |
| EP1286663B1 (en) | 2006-01-18 |
| DE60116758D1 (de) | 2006-04-06 |
| WO2001087272A3 (en) | 2002-04-18 |
| WO2001087272A2 (en) | 2001-11-22 |
| AU2001263506A1 (en) | 2001-11-26 |
| US20060110443A1 (en) | 2006-05-25 |
| JP2012082224A (ja) | 2012-04-26 |
| ATE315930T1 (de) | 2006-02-15 |
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Owner name: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRID, US |