DE60108420T2 - Morpholinderivate als antagonisten an orexinrezeptoren - Google Patents
Morpholinderivate als antagonisten an orexinrezeptoren Download PDFInfo
- Publication number
- DE60108420T2 DE60108420T2 DE60108420T DE60108420T DE60108420T2 DE 60108420 T2 DE60108420 T2 DE 60108420T2 DE 60108420 T DE60108420 T DE 60108420T DE 60108420 T DE60108420 T DE 60108420T DE 60108420 T2 DE60108420 T2 DE 60108420T2
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- alkyl
- radical
- optionally substituted
- phenyl
- alkoxy
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| GB0114291A GB0114291D0 (en) | 2001-06-12 | 2001-06-12 | Compounds |
| GB0114291 | 2001-06-12 | ||
| PCT/EP2001/013687 WO2002044172A1 (en) | 2000-11-28 | 2001-11-22 | Morpholine derivatives as antagonists of orexin receptors |
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| DE60108420D1 DE60108420D1 (en) | 2005-02-17 |
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| DE (1) | DE60108420T2 (enExample) |
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| MXPA03010129A (es) * | 2001-05-05 | 2004-03-10 | Smithkline Beecham Plc | N-aroilaminas-ciclicas. |
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| GB0130335D0 (en) * | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| CN1556705B (zh) | 2002-07-09 | 2010-04-28 | 埃科特莱茵药品有限公司 | 7,8,9,10-四氢-6H-氮杂卓并、6,7,8,9-四氢-吡啶并和2,3-二氢-2H-吡咯并[2,1-b]-喹唑啉酮衍生物 |
| WO2004026866A1 (en) * | 2002-09-18 | 2004-04-01 | Glaxo Group Limited | N-aroyl cyclic amines as orexin receptor antagonists |
| RU2334735C2 (ru) | 2002-10-11 | 2008-09-27 | Актелион Фармасьютиклз Лтд. | Производные сульфониламиноуксусной кислоты и их применение в качестве антагонистов рецепторов орексина |
| GB0225944D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
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| US20060178307A1 (en) * | 2005-01-26 | 2006-08-10 | The Regents Of The University Of California | Modulation of NMDA receptor currents via orexin receptor and/or CRF receptor |
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| CL2008000836A1 (es) | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
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| US8030495B2 (en) | 2007-05-23 | 2011-10-04 | Coleman Paul J | Cyclopropyl pyrrolidine orexin receptor antagonists |
| UA99620C2 (en) | 2007-05-23 | 2012-09-10 | Мерк Шарп Энд Доме Корп. | Pyridyl piperidine orexin receptor antagonists |
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| NZ583487A (en) * | 2007-07-27 | 2011-09-30 | Actelion Pharmaceuticals Ltd | 2-aza-bicyclo[3.3.0]octane derivatives |
| EP2207778A2 (en) * | 2007-09-24 | 2010-07-21 | Actelion Pharmaceuticals Ltd. | Pyrrolidines and piperidines as orexin receptor antagonists |
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| CN102015645B (zh) * | 2008-04-30 | 2012-11-14 | 埃科特莱茵药品有限公司 | 哌啶和吡咯烷化合物 |
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| CN102083827A (zh) * | 2008-07-07 | 2011-06-01 | 埃科特莱茵药品有限公司 | 作为食欲素受体拮抗剂的噻唑烷化合物 |
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| EA201171293A1 (ru) | 2009-04-24 | 2012-05-30 | Глэксо Груп Лимитед | 3-азабицикло[4.1.0]гептаны, применяемые в качестве антагонистов орексина |
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| JP2013502447A (ja) | 2009-08-24 | 2013-01-24 | グラクソ グループ リミテッド | 睡眠障害の治療のためのオレキシン受容体アンタゴニストとしての５−メチル−ピペリジン誘導体 |
| US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
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| KR102272746B1 (ko) | 2013-06-05 | 2021-07-08 | 보슈 헬스 아일랜드 리미티드 | 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법 |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
| UA119549C2 (uk) | 2013-12-03 | 2019-07-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ТА ЇЇ ЗАСТОСУВАННЯ ЯК АНТАГОНІСТА ОРЕКСИНОВОГО РЕЦЕПТОРА |
| MX366642B (es) | 2013-12-04 | 2019-07-17 | Idorsia Pharmaceuticals Ltd | Uso de derivados de bencimidazol-prolina. |
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| DK3414241T3 (da) | 2016-02-12 | 2022-08-01 | Astrazeneca Ab | Halogensubstituerede piperidiner som orexinreceptormodulatorer |
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| WO2018106518A1 (en) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
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| WO2023218023A1 (en) | 2022-05-13 | 2023-11-16 | Idorsia Pharmaceuticals Ltd | Thiazoloaryl-methyl substituted cyclic hydrazine-n-carboxamide derivatives |
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| GB202311281D0 (en) * | 2023-07-21 | 2023-09-06 | Bial Portela & Ca Sa | Orexin receptor antagonists |
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| DE3621775A1 (de) * | 1986-03-13 | 1988-01-07 | Thomae Gmbh Dr K | Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
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| WO2000047577A1 (en) * | 1999-02-12 | 2000-08-17 | Smithkline Beecham Plc | Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists |
| FR2791346B3 (fr) * | 1999-03-25 | 2001-04-27 | Sanofi Sa | Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant |
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| IL155093A0 (en) * | 2000-09-29 | 2003-10-31 | Glaxo Group Ltd | Morpholin-acetamide derivatives for the treatment on inflammatory diseases |
| GB0130335D0 (en) * | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
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2001
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- 2001-11-22 ES ES01994716T patent/ES2234929T3/es not_active Expired - Lifetime
- 2001-11-22 DE DE60108420T patent/DE60108420T2/de not_active Expired - Lifetime
- 2001-11-22 US US10/432,421 patent/US6943160B2/en not_active Expired - Fee Related
- 2001-11-22 AU AU2002224885A patent/AU2002224885A1/en not_active Abandoned
- 2001-11-22 AT AT01994716T patent/ATE286897T1/de not_active IP Right Cessation
- 2001-11-22 JP JP2002546542A patent/JP4246490B2/ja not_active Expired - Fee Related
- 2001-11-22 EP EP01994716A patent/EP1353918B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002044172A1 (en) | 2002-06-06 |
| EP1353918B1 (en) | 2005-01-12 |
| JP4246490B2 (ja) | 2009-04-02 |
| US6943160B2 (en) | 2005-09-13 |
| DE60108420D1 (en) | 2005-02-17 |
| AU2002224885A1 (en) | 2002-06-11 |
| JP2004521087A (ja) | 2004-07-15 |
| ES2234929T3 (es) | 2005-07-01 |
| ATE286897T1 (de) | 2005-01-15 |
| US20040058921A1 (en) | 2004-03-25 |
| EP1353918A1 (en) | 2003-10-22 |
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| 8364 | No opposition during term of opposition |