DE69903627T2 - Tetrahydroisochinolinderivate als modulatoren von dopamin d3 rezeptoren - Google Patents

Tetrahydroisochinolinderivate als modulatoren von dopamin d3 rezeptoren

Info

Publication number
DE69903627T2
DE69903627T2 DE69903627T DE69903627T DE69903627T2 DE 69903627 T2 DE69903627 T2 DE 69903627T2 DE 69903627 T DE69903627 T DE 69903627T DE 69903627 T DE69903627 T DE 69903627T DE 69903627 T2 DE69903627 T2 DE 69903627T2
Authority
DE
Germany
Prior art keywords
tetrahydroisochinoline
dopamine
modulators
receptors
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69903627T
Other languages
English (en)
Other versions
DE69903627D1 (de
Inventor
Clive Leslie Branch
Christopher N Johnson
Geoffrey Stemp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of DE69903627D1 publication Critical patent/DE69903627D1/de
Publication of DE69903627T2 publication Critical patent/DE69903627T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69903627T 1998-06-10 1999-06-01 Tetrahydroisochinolinderivate als modulatoren von dopamin d3 rezeptoren Expired - Fee Related DE69903627T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9812522.2A GB9812522D0 (en) 1998-06-10 1998-06-10 Compounds
PCT/EP1999/003840 WO1999064412A1 (en) 1998-06-10 1999-06-01 Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors

Publications (2)

Publication Number Publication Date
DE69903627D1 DE69903627D1 (de) 2002-11-28
DE69903627T2 true DE69903627T2 (de) 2003-06-26

Family

ID=10833528

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69903627T Expired - Fee Related DE69903627T2 (de) 1998-06-10 1999-06-01 Tetrahydroisochinolinderivate als modulatoren von dopamin d3 rezeptoren

Country Status (7)

Country Link
EP (1) EP1086095B1 (de)
JP (1) JP2002517493A (de)
CA (1) CA2334814A1 (de)
DE (1) DE69903627T2 (de)
ES (1) ES2186365T3 (de)
GB (1) GB9812522D0 (de)
WO (1) WO1999064412A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
US10870660B2 (en) 2016-07-28 2020-12-22 Shionogi & Co., Ltd. Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
BR112020014875A2 (pt) * 2018-01-26 2020-12-08 Shionogi & Co., Ltd. Composto cíclico condensado tendo antagonismo de receptor de dopamina d3

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199802284T2 (xx) * 1996-05-11 2000-05-22 Smithkline Beecham P.L.C. Dopamin D3 resept�rlerinin mod�lat�rleri olarak tetrahidroizokuinolin t�revleri.
PL336628A1 (en) * 1997-05-03 2000-07-03 Smithkline Beecham Plc Derivatives of tetrahydroisoquinoline as modulators of d3 dopamine receptors
GB9709303D0 (en) * 1997-05-09 1997-06-25 Smithkline Beecham Plc Compounds

Also Published As

Publication number Publication date
EP1086095B1 (de) 2002-10-23
WO1999064412A1 (en) 1999-12-16
CA2334814A1 (en) 1999-12-16
DE69903627D1 (de) 2002-11-28
GB9812522D0 (en) 1998-08-05
ES2186365T3 (es) 2003-05-01
EP1086095A1 (de) 2001-03-28
JP2002517493A (ja) 2002-06-18

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee