DE60043868D1 - Abgeschwächte Mikroorganismen für die Behandlung von Infektionen - Google Patents

Abgeschwächte Mikroorganismen für die Behandlung von Infektionen

Info

Publication number
DE60043868D1
DE60043868D1 DE60043868T DE60043868T DE60043868D1 DE 60043868 D1 DE60043868 D1 DE 60043868D1 DE 60043868 T DE60043868 T DE 60043868T DE 60043868 T DE60043868 T DE 60043868T DE 60043868 D1 DE60043868 D1 DE 60043868D1
Authority
DE
Germany
Prior art keywords
infections
treatment
attenuated microorganisms
attenuated
microorganisms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60043868T
Other languages
English (en)
Inventor
Gordon Dougan
Joseph David Santangelo
David William Holden
Jacqueline Elizabeth Shea
Zoe Hindle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emergent Product Development UK Ltd
Original Assignee
Microscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microscience Ltd filed Critical Microscience Ltd
Application granted granted Critical
Publication of DE60043868D1 publication Critical patent/DE60043868D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255—Salmonella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42—Salmonella
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60043868T 1999-05-10 2000-05-09 Abgeschwächte Mikroorganismen für die Behandlung von Infektionen Expired - Lifetime DE60043868D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9910812.8A GB9910812D0 (en) 1999-05-10 1999-05-10 Vaccine composition

Publications (1)

Publication Number Publication Date
DE60043868D1 true DE60043868D1 (de) 2010-04-01

Family

ID=10853168

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60031974T Expired - Lifetime DE60031974T2 (de) 1999-05-10 2000-05-09 Abgeschwächte Mikroorganismen zur Behandlung von Infektionen
DE60043868T Expired - Lifetime DE60043868D1 (de) 1999-05-10 2000-05-09 Abgeschwächte Mikroorganismen für die Behandlung von Infektionen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60031974T Expired - Lifetime DE60031974T2 (de) 1999-05-10 2000-05-09 Abgeschwächte Mikroorganismen zur Behandlung von Infektionen

Country Status (28)

Country Link
US (3) US6756042B1 (de)
EP (2) EP1702927B1 (de)
JP (1) JP4583607B2 (de)
KR (2) KR100811319B1 (de)
CN (1) CN1177863C (de)
AP (1) AP1470A (de)
AT (2) ATE346090T1 (de)
AU (1) AU763898B2 (de)
BR (1) BRPI0010418B8 (de)
CA (1) CA2372553C (de)
CY (1) CY1107656T1 (de)
CZ (1) CZ301926B6 (de)
DE (2) DE60031974T2 (de)
DK (1) DK1183269T3 (de)
EA (1) EA004921B1 (de)
ES (1) ES2277591T3 (de)
GB (1) GB9910812D0 (de)
HU (1) HUP0201117A3 (de)
IL (3) IL146255A0 (de)
MA (1) MA25411A1 (de)
MX (1) MXPA01011477A (de)
NO (1) NO329520B1 (de)
NZ (1) NZ539260A (de)
OA (1) OA11940A (de)
PT (1) PT1183269E (de)
TR (1) TR200702949T2 (de)
WO (1) WO2000068261A2 (de)
ZA (1) ZA200108912B (de)

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WO1996017951A2 (en) * 1994-12-09 1996-06-13 Rpms Technology Limited Identification of genes responsible for in vivo survival of microorganisms
DK1108034T3 (da) * 1998-09-04 2008-11-10 Emergent Product Dev Uk Ltd Svækkede salmonella SPI2-mutanter som antigenbærere
GB9910812D0 (en) * 1999-05-10 1999-07-07 Microscience Ltd Vaccine composition
GB0105924D0 (en) * 2001-03-09 2001-04-25 Microscience Ltd Promoter
US7449178B2 (en) * 2002-04-05 2008-11-11 Merial Limited Attenuated gram negative bacteria
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
WO2008153772A2 (en) * 2007-05-25 2008-12-18 Emergent Product Development Gaithersburg Inc. Chlamydia vaccine comprising htra polypeptides
EP2326344A4 (de) * 2008-06-16 2013-08-07 Prokarium Ltd Impfstoffe mit salmonellen-vektor gegen chlamydien und anwendungsverfahren
CA2733425A1 (en) 2008-08-06 2010-02-11 Emergent Product Development Uk Limited Vaccines against clostridium difficile and methods of use
US20120064114A1 (en) * 2008-10-21 2012-03-15 Emergent Product Development United Kingdom Use of e. coli surface antigen 3 sequences for the export of heterologous antigens
US8481052B2 (en) 2011-05-17 2013-07-09 Cj Cheiljedang Corporation Avirulent Salmonella gallinarum variants and pharmaceutical composition using the same
EP3613430A2 (de) 2013-10-11 2020-02-26 Servizo Galego De Saúde (Sergas) Abgeschwächte lebendimpfstoffe
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
EP3922255A1 (de) 2020-06-10 2021-12-15 Prokarium Limited Krebstherapie
EP4124342A1 (de) 2021-07-28 2023-02-01 Prokarium Limited Krebstherapie mit lebenden attenuierten bakterien
CA3238816A1 (en) 2021-12-09 2023-06-15 Prokarium Limited Combination cancer therapy
WO2024061748A1 (en) 2022-09-21 2024-03-28 Prokarium Limited Salmonella strain with chromosomally integrated landing pad
GB202215134D0 (en) 2022-10-13 2022-11-30 Prokarium Ltd Composition

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US4704362A (en) * 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
NO794196L (no) * 1978-12-22 1980-06-24 Biogen Nv Fremgangsmaate ved fremstilling av et rekombinert dna molekyl
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US5210035A (en) * 1980-05-19 1993-05-11 Board Of Trustees Of Leland Stanford Jr. University Non-reventing live vaccines
US4550081A (en) * 1980-05-19 1985-10-29 The Board Of Trustees Of The Leland Stanford Jr. University Non-reverting salmonella
US4837151A (en) * 1980-05-19 1989-06-06 The Board Of Trustees Of The Leland Stanford Junior University, Stanford University Live vaccines comprising two mutations and foreign antigen
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US4582800A (en) * 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression
US4757006A (en) * 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4677063A (en) * 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
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US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
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FR2664614B1 (fr) 1990-07-11 1992-10-16 Pasteur Institut Sequences nucleiques issues du genome de salmonella typhi, et leurs utilisations notamment pour le diagnostic in vitro de la presence de bacteries du genre salmonella dans les produits alimentaires.
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US5700683A (en) * 1995-02-17 1997-12-23 Pathogenesis Corporation Virulence-attenuating genetic deletions deleted from mycobacterium BCG
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GB9621091D0 (en) * 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
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US6585975B1 (en) * 1998-04-30 2003-07-01 Acambis, Inc. Use of Salmonella vectors for vaccination against helicobacter infection
DK1108034T3 (da) * 1998-09-04 2008-11-10 Emergent Product Dev Uk Ltd Svækkede salmonella SPI2-mutanter som antigenbærere
EP1914312A3 (de) * 1998-11-09 2008-10-08 Microscience Limited Virulenzgene und -proteine sowie ihre Anwendung
GB9910812D0 (en) * 1999-05-10 1999-07-07 Microscience Ltd Vaccine composition
WO2001032697A2 (en) 1999-11-05 2001-05-10 L'unite De Recherche En Biologie Moleculaire (Urbm) Des Facultes Universitaires Notre Dame De La Paix (Fundp) Virulence genes and proteins from brucella melitensis, and their use
JP3414342B2 (ja) * 1999-11-25 2003-06-09 日本電気株式会社 集積回路チップの実装構造および実装方法
NZ519669A (en) * 1999-12-23 2004-03-26 Vmax Ltd Streptococcus pyogenes virulence genes and proteins and their use
GB0011108D0 (en) 2000-05-08 2000-06-28 Microscience Ltd Virulence gene and protein and their use
GB0127657D0 (en) 2001-11-19 2002-01-09 Microscience Ltd Virulence genes and proteins and their use
US7449178B2 (en) * 2002-04-05 2008-11-11 Merial Limited Attenuated gram negative bacteria

Also Published As

Publication number Publication date
IL146255A0 (en) 2002-07-25
NO20015464L (no) 2001-11-08
PT1183269E (pt) 2007-02-28
TR200702949T2 (tr) 2007-08-21
KR100680391B1 (ko) 2007-02-08
PL354355A1 (en) 2004-01-12
CA2372553C (en) 2011-09-27
CN1360594A (zh) 2002-07-24
EA200101187A1 (ru) 2002-04-25
ES2277591T3 (es) 2007-07-16
EP1702927B1 (de) 2010-02-17
MA25411A1 (fr) 2002-04-01
BR0010418A (pt) 2003-07-22
CN1177863C (zh) 2004-12-01
ATE457998T1 (de) 2010-03-15
NZ539260A (en) 2007-01-26
AP1470A (en) 2005-09-26
BRPI0010418B8 (pt) 2021-05-25
OA11940A (en) 2006-04-12
HUP0201117A3 (en) 2004-01-28
ATE346090T1 (de) 2006-12-15
CZ20014030A3 (cs) 2002-06-12
US7887816B2 (en) 2011-02-15
AU763898B2 (en) 2003-07-31
AP2001002317A0 (en) 2001-12-31
GB9910812D0 (en) 1999-07-07
WO2000068261A3 (en) 2001-02-08
DE60031974T2 (de) 2007-03-15
BR0010418B1 (pt) 2013-04-16
CZ301926B6 (cs) 2010-08-04
JP4583607B2 (ja) 2010-11-17
IL186993A (en) 2010-02-17
KR100811319B1 (ko) 2008-03-07
DE60031974D1 (de) 2007-01-04
EA004921B1 (ru) 2004-10-28
MXPA01011477A (es) 2002-06-04
KR20060101563A (ko) 2006-09-25
WO2000068261A2 (en) 2000-11-16
DK1183269T3 (da) 2007-04-02
AU4593200A (en) 2000-11-21
ZA200108912B (en) 2002-12-24
EP1183269B1 (de) 2006-11-22
NO329520B1 (no) 2010-11-01
JP2003509008A (ja) 2003-03-11
HUP0201117A2 (en) 2002-08-28
US20040191866A1 (en) 2004-09-30
KR20020018193A (ko) 2002-03-07
CA2372553A1 (en) 2000-11-16
NO20015464D0 (no) 2001-11-08
US20080274139A1 (en) 2008-11-06
EP1702927A1 (de) 2006-09-20
US7211264B2 (en) 2007-05-01
EP1183269A1 (de) 2002-03-06
CY1107656T1 (el) 2013-04-18
US6756042B1 (en) 2004-06-29
IL146255A (en) 2008-11-26

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