IL146255A0 - Attenuated microorganisms for the treatment of infection - Google Patents

Attenuated microorganisms for the treatment of infection

Info

Publication number
IL146255A0
IL146255A0 IL14625500A IL14625500A IL146255A0 IL 146255 A0 IL146255 A0 IL 146255A0 IL 14625500 A IL14625500 A IL 14625500A IL 14625500 A IL14625500 A IL 14625500A IL 146255 A0 IL146255 A0 IL 146255A0
Authority
IL
Israel
Prior art keywords
infection
treatment
attenuated microorganisms
attenuated
microorganisms
Prior art date
Application number
IL14625500A
Other languages
English (en)
Original Assignee
Microscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microscience Ltd filed Critical Microscience Ltd
Publication of IL146255A0 publication Critical patent/IL146255A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255—Salmonella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42—Salmonella
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL14625500A 1999-05-10 2000-05-09 Attenuated microorganisms for the treatment of infection IL146255A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9910812.8A GB9910812D0 (en) 1999-05-10 1999-05-10 Vaccine composition
PCT/GB2000/001749 WO2000068261A2 (en) 1999-05-10 2000-05-09 Attenuated microorganisms for the treatment of infection

Publications (1)

Publication Number Publication Date
IL146255A0 true IL146255A0 (en) 2002-07-25

Family

ID=10853168

Family Applications (3)

Application Number Title Priority Date Filing Date
IL14625500A IL146255A0 (en) 1999-05-10 2000-05-09 Attenuated microorganisms for the treatment of infection
IL146255A IL146255A (en) 1999-05-10 2001-10-31 A weakening microorganism that disrupts the expression of the ssaV gene and has a weakening mutation that disrupts the expression of the aroC gene
IL186993A IL186993A (en) 1999-05-10 2007-10-29 Powerfully reduced microorganisms for the treatment of inflammation

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL146255A IL146255A (en) 1999-05-10 2001-10-31 A weakening microorganism that disrupts the expression of the ssaV gene and has a weakening mutation that disrupts the expression of the aroC gene
IL186993A IL186993A (en) 1999-05-10 2007-10-29 Powerfully reduced microorganisms for the treatment of inflammation

Country Status (28)

Country Link
US (3) US6756042B1 (xx)
EP (2) EP1702927B1 (xx)
JP (1) JP4583607B2 (xx)
KR (2) KR100680391B1 (xx)
CN (1) CN1177863C (xx)
AP (1) AP1470A (xx)
AT (2) ATE457998T1 (xx)
AU (1) AU763898B2 (xx)
BR (1) BRPI0010418B8 (xx)
CA (1) CA2372553C (xx)
CY (1) CY1107656T1 (xx)
CZ (1) CZ301926B6 (xx)
DE (2) DE60043868D1 (xx)
DK (1) DK1183269T3 (xx)
EA (1) EA004921B1 (xx)
ES (1) ES2277591T3 (xx)
GB (1) GB9910812D0 (xx)
HU (1) HUP0201117A3 (xx)
IL (3) IL146255A0 (xx)
MA (1) MA25411A1 (xx)
MX (1) MXPA01011477A (xx)
NO (1) NO329520B1 (xx)
NZ (1) NZ539260A (xx)
OA (1) OA11940A (xx)
PT (1) PT1183269E (xx)
TR (1) TR200702949T2 (xx)
WO (1) WO2000068261A2 (xx)
ZA (1) ZA200108912B (xx)

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PT889120E (pt) * 1994-12-09 2002-09-30 Microscience Ltd Genes de virulencia no grupo vgc2 de salmonella
US6936425B1 (en) * 1998-09-04 2005-08-30 Microscience Limited Attenuated salmonella SP12 mutants as antigen carriers
GB9910812D0 (en) * 1999-05-10 1999-07-07 Microscience Ltd Vaccine composition
GB0105924D0 (en) * 2001-03-09 2001-04-25 Microscience Ltd Promoter
US7449178B2 (en) * 2002-04-05 2008-11-11 Merial Limited Attenuated gram negative bacteria
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
US20110027321A1 (en) * 2007-05-25 2011-02-03 Emergent Product Development Gaithersburg Inc. Chlamydia Vaccine Comprising HtrA Polypeptides
WO2009158240A1 (en) 2008-06-16 2009-12-30 Emergent Product Development Uk Limited Salmonella vectored vaccines against chlamydia and methods of use
EP2318515A4 (en) * 2008-08-06 2012-11-14 Emergent Product Dev Uk Ltd DIFFICULT CLOSTRIDIUM VACCINES, AND METHODS OF USE
US20120064114A1 (en) * 2008-10-21 2012-03-15 Emergent Product Development United Kingdom Use of e. coli surface antigen 3 sequences for the export of heterologous antigens
US8481052B2 (en) * 2011-05-17 2013-07-09 Cj Cheiljedang Corporation Avirulent Salmonella gallinarum variants and pharmaceutical composition using the same
US10517939B2 (en) 2013-10-11 2019-12-31 Servicio Galego De Saúde (Sergas) Live attenuated vaccines
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
EP3922255A1 (en) 2020-06-10 2021-12-15 Prokarium Limited Cancer therapy
EP4124342A1 (en) 2021-07-28 2023-02-01 Prokarium Limited Cancer therapy with live attenuated bacteria
AU2022404718A1 (en) 2021-12-09 2024-05-30 Prokarium Limited Combination cancer therapy
WO2024061748A1 (en) 2022-09-21 2024-03-28 Prokarium Limited Salmonella strain with chromosomally integrated landing pad
GB202215134D0 (en) 2022-10-13 2022-11-30 Prokarium Ltd Composition

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US4704362A (en) * 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
DD147855A5 (de) * 1978-12-22 1981-04-22 Biogen Nv Verfahren zur erzeugung mindestens eines hbv-antigenwirkung aufweisenden polypeptids
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US5210035A (en) * 1980-05-19 1993-05-11 Board Of Trustees Of Leland Stanford Jr. University Non-reventing live vaccines
US4837151A (en) * 1980-05-19 1989-06-06 The Board Of Trustees Of The Leland Stanford Junior University, Stanford University Live vaccines comprising two mutations and foreign antigen
US4550081A (en) * 1980-05-19 1985-10-29 The Board Of Trustees Of The Leland Stanford Jr. University Non-reverting salmonella
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US4582800A (en) * 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression
US4757006A (en) * 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4677063A (en) * 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
US5643579A (en) * 1984-11-01 1997-07-01 American Home Products Corporation Oral vaccines
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
US5397697A (en) * 1989-01-10 1995-03-14 Ciba-Geigy Corporation Identification of plant-responsive genes of bacteria
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JP2001515468A (ja) 1997-02-14 2001-09-18 メルク エンド カンパニー インコーポレーテッド ポリヌクレオチドワクチン製剤
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US6936425B1 (en) * 1998-09-04 2005-08-30 Microscience Limited Attenuated salmonella SP12 mutants as antigen carriers
CA2348699A1 (en) * 1998-11-09 2000-05-18 Microscience Limited Virulence genes and proteins, and their use
GB9910812D0 (en) * 1999-05-10 1999-07-07 Microscience Ltd Vaccine composition
WO2001032697A2 (en) 1999-11-05 2001-05-10 L'unite De Recherche En Biologie Moleculaire (Urbm) Des Facultes Universitaires Notre Dame De La Paix (Fundp) Virulence genes and proteins from brucella melitensis, and their use
JP3414342B2 (ja) * 1999-11-25 2003-06-09 日本電気株式会社 集積回路チップの実装構造および実装方法
HUP0203880A2 (hu) * 1999-12-23 2003-03-28 Vmax Limited Virulencia gének, proteinek és alkalmazásuk
GB0011108D0 (en) 2000-05-08 2000-06-28 Microscience Ltd Virulence gene and protein and their use
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US7449178B2 (en) * 2002-04-05 2008-11-11 Merial Limited Attenuated gram negative bacteria

Also Published As

Publication number Publication date
NO329520B1 (no) 2010-11-01
OA11940A (en) 2006-04-12
DE60031974T2 (de) 2007-03-15
CY1107656T1 (el) 2013-04-18
CZ301926B6 (cs) 2010-08-04
BR0010418A (pt) 2003-07-22
AU763898B2 (en) 2003-07-31
AU4593200A (en) 2000-11-21
KR100811319B1 (ko) 2008-03-07
BR0010418B1 (pt) 2013-04-16
GB9910812D0 (en) 1999-07-07
BRPI0010418B8 (pt) 2021-05-25
EA200101187A1 (ru) 2002-04-25
JP2003509008A (ja) 2003-03-11
ZA200108912B (en) 2002-12-24
AP2001002317A0 (en) 2001-12-31
ATE346090T1 (de) 2006-12-15
CZ20014030A3 (cs) 2002-06-12
EP1702927A1 (en) 2006-09-20
EP1183269B1 (en) 2006-11-22
DE60031974D1 (de) 2007-01-04
NO20015464D0 (no) 2001-11-08
EA004921B1 (ru) 2004-10-28
PL354355A1 (en) 2004-01-12
CA2372553C (en) 2011-09-27
NZ539260A (en) 2007-01-26
EP1702927B1 (en) 2010-02-17
MXPA01011477A (es) 2002-06-04
KR100680391B1 (ko) 2007-02-08
CN1360594A (zh) 2002-07-24
IL186993A (en) 2010-02-17
DE60043868D1 (de) 2010-04-01
WO2000068261A3 (en) 2001-02-08
AP1470A (en) 2005-09-26
PT1183269E (pt) 2007-02-28
US20080274139A1 (en) 2008-11-06
NO20015464L (no) 2001-11-08
US6756042B1 (en) 2004-06-29
US7887816B2 (en) 2011-02-15
HUP0201117A2 (en) 2002-08-28
MA25411A1 (fr) 2002-04-01
WO2000068261A2 (en) 2000-11-16
HUP0201117A3 (en) 2004-01-28
DK1183269T3 (da) 2007-04-02
CN1177863C (zh) 2004-12-01
CA2372553A1 (en) 2000-11-16
TR200702949T2 (tr) 2007-08-21
KR20020018193A (ko) 2002-03-07
ATE457998T1 (de) 2010-03-15
ES2277591T3 (es) 2007-07-16
IL146255A (en) 2008-11-26
EP1183269A1 (en) 2002-03-06
US20040191866A1 (en) 2004-09-30
JP4583607B2 (ja) 2010-11-17
KR20060101563A (ko) 2006-09-25
US7211264B2 (en) 2007-05-01

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