DE60038124D1 - Direktes screeningverfahren - Google Patents

Direktes screeningverfahren

Info

Publication number
DE60038124D1
DE60038124D1 DE60038124T DE60038124T DE60038124D1 DE 60038124 D1 DE60038124 D1 DE 60038124D1 DE 60038124 T DE60038124 T DE 60038124T DE 60038124 T DE60038124 T DE 60038124T DE 60038124 D1 DE60038124 D1 DE 60038124D1
Authority
DE
Germany
Prior art keywords
polypeptides
target
support
molecules
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60038124T
Other languages
English (en)
Other versions
DE60038124T2 (de
Inventor
Lucy Jessica Holt
Wildt Rudolf Maria De
Ian Tomlinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Domantis Ltd
Original Assignee
Domantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Domantis Ltd filed Critical Domantis Ltd
Application granted granted Critical
Publication of DE60038124D1 publication Critical patent/DE60038124D1/de
Publication of DE60038124T2 publication Critical patent/DE60038124T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
DE60038124T 1999-12-03 2000-12-04 Direktes screeningverfahren Expired - Lifetime DE60038124T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9928787 1999-12-03
GBGB9928787.2A GB9928787D0 (en) 1999-12-03 1999-12-03 Direct screening method
PCT/GB2000/004638 WO2001040803A1 (en) 1999-12-03 2000-12-04 Direct screening method

Publications (2)

Publication Number Publication Date
DE60038124D1 true DE60038124D1 (de) 2008-04-03
DE60038124T2 DE60038124T2 (de) 2009-02-12

Family

ID=10865784

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60038124T Expired - Lifetime DE60038124T2 (de) 1999-12-03 2000-12-04 Direktes screeningverfahren

Country Status (13)

Country Link
US (1) US20030039958A1 (de)
EP (2) EP2000804A3 (de)
JP (1) JP2003515745A (de)
AT (1) ATE386939T1 (de)
AU (1) AU1541701A (de)
CA (1) CA2392981A1 (de)
DE (1) DE60038124T2 (de)
DK (1) DK1242821T3 (de)
ES (1) ES2300279T3 (de)
GB (1) GB9928787D0 (de)
NO (1) NO20022312L (de)
PT (1) PT1242821E (de)
WO (1) WO2001040803A1 (de)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
AU2001292959A1 (en) 2000-09-22 2002-04-02 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods and kits and systems for practicing the same
WO2005016230A2 (en) * 2002-06-07 2005-02-24 President And Fellows Of Harvard College Evaluating protein signatures
JP4880188B2 (ja) 2001-01-23 2012-02-22 プレジデント アンド フェロウズ オブ ハーバード カレッジ 核酸プログラム型タンパク質アレイ
AUPR378001A0 (en) * 2001-03-16 2001-04-12 Proteome Systems Ltd Protein chip
US20050019942A1 (en) * 2001-03-16 2005-01-27 Proteome Systems Ltd. Array-based biomolecule analysis
WO2003000404A1 (en) * 2001-06-22 2003-01-03 Domantis Limited Matrix screening method
US20040161741A1 (en) 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US9777312B2 (en) 2001-06-30 2017-10-03 Enzo Life Sciences, Inc. Dual polarity analysis of nucleic acids
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US6797393B2 (en) 2001-11-30 2004-09-28 Eastman Kodak Company Method for making biochip substrate
US6815078B2 (en) 2002-03-06 2004-11-09 Eastman Kodak Company Substrate for protein microarray containing functionalized polymer
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
ES2442615T5 (es) * 2002-07-18 2023-03-16 Merus Nv Producción recombinante de mezclas de anticuerpos
DE602004031589D1 (de) 2003-01-07 2011-04-14 Dyax Corp Kunitz-domäne-bibliothek
GB0304832D0 (en) * 2003-03-04 2003-04-09 Secr Defence Assay method
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP1639009B1 (de) 2003-05-30 2013-02-27 Merus B.V. Fab-bibliothek zur herstellung von einer mischung von antikörpern
EP1668111A4 (de) 2003-08-08 2008-07-02 Genenews Inc Osteoarthritis-biomarker und verwendungen davon
US7153896B2 (en) 2003-11-14 2006-12-26 Eastman Kodak Company Element for protein microarrays
DK1737971T3 (da) 2004-01-20 2017-11-13 Merus Nv Blandinger af bindingsproteiner
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
CN101495498B (zh) 2005-02-07 2013-09-18 基因信息公司 轻度骨关节炎生物标志物及其用途
WO2006089002A2 (en) * 2005-02-15 2006-08-24 Yale University Method for high throughput screening for antibodies and proteins inducing apoptosis
WO2006111424A1 (en) * 2005-04-22 2006-10-26 Life & Brain Gmbh Methods for identifying modulators of cb1 and cb2 cannabinoid receptors and their use in wound healing
US8239136B2 (en) 2005-10-21 2012-08-07 Genenews Inc. Method, computer system and computer-readable medium for determining a probability of colorectal cancer in a test subject
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
KR101778174B1 (ko) 2006-07-05 2017-09-13 카탈리스트 바이오사이언시즈, 인코포레이티드 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제
WO2008008858A2 (en) * 2006-07-12 2008-01-17 Trellis Bioscience, Inc. Cellspot™ applications
AU2007273055B2 (en) 2006-07-14 2014-05-01 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
CL2007002567A1 (es) 2006-09-08 2008-02-01 Amgen Inc Proteinas aisladas de enlace a activina a humana.
SG174077A1 (en) 2007-04-13 2011-09-29 Catalyst Biosciences Inc Modified factor vii polypetides and uses thereof
CL2008001887A1 (es) 2007-06-29 2008-10-03 Amgen Inc Proteinas de union a antigeno que se unen al receptor activado por proteasas 2 (par-2); acido nucleico que las codifica; vector y celula huesped; metodo de produccion; y composicion que las comprende.
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
EP2229473A4 (de) 2007-12-07 2011-02-02 Steven A Goldstein Identifizierung von toxinliganden
ES2334084B1 (es) 2007-12-21 2011-01-24 Inst Cientifico Tecnol Navarra Marcadores geneticos para el pronostico de la esclerosis multiple.
US9873957B2 (en) 2008-03-13 2018-01-23 Dyax Corp. Libraries of genetic packages comprising novel HC CDR3 designs
WO2009132287A2 (en) 2008-04-24 2009-10-29 Dyax Corp. Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
TWI547287B (zh) 2008-04-25 2016-09-01 戴埃克斯有限公司 Ｆｃ受體結合蛋白
CA2744523A1 (en) 2008-09-22 2010-03-25 Calmune Corporation Methods and vectors for display of molecules and displayed molecules and collections
EP2169078A1 (de) 2008-09-26 2010-03-31 Fundacion Gaiker Verfahren und Kits zur Diagnose und Abstufung von Kolorektalkrebs
JP2012505900A (ja) 2008-10-14 2012-03-08 ダイアクス コーポレーション 全身性強皮症に伴う肺線維症の治療および予防のためのｉｇｆ−ｉｉ／ｉｇｆ−ｉｉｅ結合タンパク質の使用
EP2408816B1 (de) 2009-03-20 2019-09-04 Amgen Inc. Alpha-4-beta-7-heterodimerspezifischer antagonistischer antikörper
MX2012001283A (es) 2009-07-31 2012-06-12 Amgen Inc Polipeptidos que se enlazan al inhibidor de tejidos de metaloproteinasa tipo tres (timp-3) composiciones y metodos.
AU2010291902A1 (en) 2009-09-14 2012-04-05 Dyax Corp. Libraries of genetic packages comprising novel HC CDR3 designs
US20110189183A1 (en) 2009-09-18 2011-08-04 Robert Anthony Williamson Antibodies against candida, collections thereof and methods of use
US20150359850A1 (en) 2009-11-25 2015-12-17 Santa Maria Biotherapeutics, Inc. Administration of an anti-activin-a compound to a subject
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
RS57870B1 (sr) 2010-01-06 2018-12-31 Dyax Corp Proteini koji vezuju kalikrein plazme
EP2558497A2 (de) 2010-04-15 2013-02-20 Amgen Inc. Menschlicher fgf-rezeptor und beta-klotho-bindeproteine
EP3508854A1 (de) 2010-04-27 2019-07-10 The Regents of The University of California Krebsbiomarker und verfahren zur verwendung davon
WO2012017208A1 (en) 2010-08-04 2012-02-09 Cizzle Biotechnology Limited Methods and compounds for the diagnosis and treatment of
EP2606066A1 (de) 2010-08-16 2013-06-26 Amgen Inc. Myostatinbindende antikörper, zusammensetzungen und verfahren
EP2428583A1 (de) 2010-09-10 2012-03-14 Bioftalmik, S.L. Verfahren zur Prognose des Erfolgs einer Filtrationsoperation und zur Bestimmung des Heilungsprozesses
AU2011352207B2 (en) 2010-12-31 2016-03-03 Bioatla, Llc Comprehensive monoclonal antibody generation
EP2671082B1 (de) 2011-02-02 2020-01-15 Amgen Inc. Verfahren und zusammensetzungen zur hemmung von igf-1r
CN103649334A (zh) 2011-05-12 2014-03-19 特拉斯雷神诺癌症医药有限公司 Kiaa1456表达在结肠癌患者中预测生存
BR112013030352B1 (pt) 2011-06-02 2020-05-19 Dyax Corp anticorpo anti-fcrn isolado, composição farmacêutica que compreende o dito anticorpo, ácido nucleico isolado, vetor, célula e uso terapêutico do dito anticorpo
US9574002B2 (en) 2011-06-06 2017-02-21 Amgen Inc. Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
US20120316077A1 (en) * 2011-06-07 2012-12-13 Charles Greef System And Method For Detection And Analysis Of A Molecule In A Sample
KR102091294B1 (ko) 2011-10-26 2020-04-16 암젠 인크 Uv 광으로의 노출로 인한 단백질 변형 및 분해의 감소 또는 제거 방법
ES2781866T3 (es) 2011-11-28 2020-09-08 Inst Catalana Recerca Estudis Avancats Métodos y kits para el pronóstico de cáncer colorrectal
WO2013092960A1 (en) 2011-12-22 2013-06-27 Fundacion Gaiker Methods and kits for the diagnosis of colorectal cancer
NZ630551A (en) 2012-04-20 2017-11-24 Merus Nv Methods and means for the production of ig-like molecules
EP2847219A1 (de) 2012-05-07 2015-03-18 Amgen Inc. Anti-erythropoietin-antikörper
CN115093480A (zh) 2012-05-31 2022-09-23 索伦托药业有限公司 与pd-l1结合的抗原结合蛋白
EP2863946A4 (de) 2012-06-21 2016-04-13 Sorrento Therapeutics Inc Antigenbindende proteine zur bindung von par-2
US9315579B2 (en) 2012-06-22 2016-04-19 Sorrento Therapeutics, Inc. Antigen binding proteins that bind CCR2
WO2013190081A1 (en) 2012-06-22 2013-12-27 Proyecto De Biomedicina Cima, S.L. Methods and reagents for the prognosis of cancer
WO2014004549A2 (en) 2012-06-27 2014-01-03 Amgen Inc. Anti-mesothelin binding proteins
WO2014022102A1 (en) 2012-08-01 2014-02-06 Amgen Inc. Methods of using anti-apoptotic compounds to modulate one or more properties of a cell culture
EP2917365B1 (de) 2012-11-12 2020-03-11 Institució Catalana de Recerca i Estudis Avançats Verfahren und kits zur prognose von kolorektalem karzinom
WO2014109858A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
CA2904713A1 (en) 2013-03-11 2014-10-09 Amgen Inc. Protein formulations comprising darbepoetin
AU2014244444A1 (en) 2013-03-14 2015-09-24 Amgen Inc. CHRDL-1 antigen binding proteins and methods of treatment
US9816088B2 (en) 2013-03-15 2017-11-14 Abvitro Llc Single cell bar-coding for antibody discovery
US11130980B2 (en) 2013-10-31 2021-09-28 Amgen Inc. Use of monensin to regulate glycosylation of recombinant proteins
US10106829B2 (en) 2014-01-29 2018-10-23 Amgen Inc. Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
SG10201912081RA (en) 2014-01-29 2020-02-27 Amgen Inc Overexpression of n-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
EA201790437A1 (ru) 2014-08-22 2017-08-31 Сорренто Терапьютикс, Инк. Антигенсвязывающие белки, связывающиеся с cxcr3
WO2016040767A2 (en) 2014-09-12 2016-03-17 Amgen Inc. Chrdl-1 epitopes and antibodies
EP3194593B1 (de) 2014-09-15 2019-02-06 AbVitro LLC Nukleotidbibliotheksequenzierung mit hohem durchsatz
WO2016061551A1 (en) 2014-10-17 2016-04-21 Amgen Inc. Antibodies directed to angiopoietin-1 and angiopoietin-2 for ocular therapies
EP3227687A4 (de) 2014-12-05 2018-10-24 Prelude, Inc. Dcis-wiederauftreten und invasiver brustkrebs
CN105669863B (zh) 2014-12-05 2019-09-13 鸿运华宁（杭州）生物医药有限公司 一种能与人内皮素受体特异性结合的抗体及其应用
WO2016130986A1 (en) 2015-02-13 2016-08-18 Sorrento Therapeutics, Inc. Antibody therapeutics that bind ctla4
US10100126B2 (en) 2015-03-10 2018-10-16 Sorrento Therapeutics, Inc. Antibody therapeutics that bind PSMA
WO2016164656A1 (en) 2015-04-08 2016-10-13 Sorrento Therapeutics, Inc. Antibody therapeutics that bind cd38
CA2997444A1 (en) 2015-09-29 2017-04-06 Amgen Inc. Asgr inhibitors for reducing cholesterol levels
CN109715821B (zh) 2016-01-29 2022-09-06 索伦托药业有限公司 与pd-l1结合的抗原结合蛋白
KR102439719B1 (ko) 2016-05-11 2022-09-02 암젠 인크 글루타민 합성효소 유전자내 상보성 벡터를 사용한 높은 수준의 헤테로머 단백질을 발현하는 세포의 직접적인 선택
EP3246415A1 (de) 2016-05-18 2017-11-22 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Verfahren zur prognose von prostatakrebs
TWI826351B (zh) 2016-05-31 2023-12-21 大陸商鴻運華寧（杭州）生物醫藥有限公司 Ｒ抗體,其藥物組合物及其應用
ES2688737A1 (es) 2017-05-04 2018-11-06 Universidad Del País Vasco / Euskal Herriko Unibertsitatea Método para diagnosticar placa ateroesclerótica inestable
ES2926722T3 (es) 2017-05-26 2022-10-27 Abvitro Llc Secuenciación de alto rendimiento de biblioteca de polinucleótidos y análisis de transcriptoma
CN107563133B (zh) * 2017-08-30 2021-05-04 大连理工大学 采用定量结构-活性关系模型预测有机化学品的氯自由基反应速率常数的方法
WO2019051335A1 (en) 2017-09-07 2019-03-14 Juno Therapeutics, Inc. METHODS OF IDENTIFYING CELLULAR CHARACTERISTICS RELATED TO RESPONSES ASSOCIATED WITH CELL THERAPY
CN117126279A (zh) 2018-03-20 2023-11-28 鸿运华宁（杭州）生物医药有限公司 Gipr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
CN110357959B (zh) 2018-04-10 2023-02-28 鸿运华宁（杭州）生物医药有限公司 Gcgr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
CN110655577A (zh) 2018-06-13 2020-01-07 鸿运华宁（杭州）生物医药有限公司 APJ抗体及其与Elabela的融合蛋白质，以及其药物组合物和应用
AU2019339508A1 (en) 2018-09-14 2021-04-15 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
SG11202105413QA (en) 2018-11-26 2021-06-29 Asociacion Centro De Investig Cooperativa En Biociencias Cic Biogune Methods for diagnosing and/or treating acute or chronic liver, kidney or lung disease
EP3674421A1 (de) 2018-12-28 2020-07-01 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Verfahren zur prognose von prostatakrebs
KR20220003055A (ko) 2019-04-30 2022-01-07 기가젠, 인코포레이티드 재조합 폴리클로날 단백질 및 이의 사용 방법
CN112239507A (zh) 2019-07-17 2021-01-19 鸿运华宁（杭州）生物医药有限公司 ETA抗体与TGF-β Trap的融合蛋白质，以及其药物组合物和应用
CN112521501A (zh) 2019-09-18 2021-03-19 鸿运华宁（杭州）生物医药有限公司 Gipr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
AU2020396548A1 (en) 2019-12-05 2022-07-14 Sorrento Therapeutics, Inc. Compositions and methods comprising an anti-CD47 antibody in combination with a tumor targeting antibody
JP2023515573A (ja) 2020-02-26 2023-04-13 ソレント・セラピューティクス・インコーポレイテッド 普遍的な遮蔽性部分を有する活性化可能な抗原結合性タンパク質
WO2021195089A1 (en) 2020-03-23 2021-09-30 Sorrento Therapeutics, Inc. Fc-coronavirus antigen fusion proteins, and nucleic acids, vectors, compositions and methods of use thereof
US20230168245A1 (en) 2020-04-24 2023-06-01 Sorrento Therapeutics, Inc. Lateral Flow Device for Detection of Neutralizing Antibodies Against SARS-COV-2
EP4139345A1 (de) 2020-04-24 2023-03-01 Sorrento Therapeutics, Inc. Dimere gedächtnis-antigenrezeptoren
CA3177152A1 (en) 2020-06-12 2021-12-16 David Scott Johnson Recombinant polyclonal proteins targeting covid-19 and methods of use thereof
US20230235059A1 (en) 2020-06-26 2023-07-27 Sorrento Therapeutics, Inc. Anti-pd1 antibodies and uses thereof
WO2022003146A1 (en) 2020-07-03 2022-01-06 Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) Methods for predicting the risk of local invasion and/or metastasis induced by an antiangiogenic treatment
WO2022031834A1 (en) 2020-08-05 2022-02-10 Gigagen, Inc. Recombinant polyclonal proteins targeting zika and methods of use thereof
TW202233660A (zh) 2020-10-30 2022-09-01 美商安進公司 過表現胰島素樣生長因子受體突變體以調節ｉｇｆ補充
US20240019426A1 (en) 2020-11-04 2024-01-18 Sorrento Therapeutics, Inc. Lateral Flow Devices for High Sensitivity Detection of Coronavirus Infection, and Methods of Making and Using the Same
WO2022192594A2 (en) 2021-03-11 2022-09-15 Sorrento Therapeutics, Inc. Nucleic acid molecules and vaccines comprising same for the prevention and treatment of coronavirus infections and disease
CN115141276A (zh) 2021-03-31 2022-10-04 鸿运华宁（杭州）生物医药有限公司 一种能与人内皮素受体特异性结合的抗体及其在糖尿病肾病和慢性肾病治疗中的应用
CN117916264A (zh) 2021-06-09 2024-04-19 索伦托药业有限公司 通过经由淋巴微针递送装置施用抗pd-1或抗pd-l1治疗剂来治疗癌症的方法
TW202328442A (zh) 2021-09-10 2023-07-16 美商安進公司 平臺宿主對ｉｇｆ—培養基之適應

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US31006A (en) 1861-01-01 Feeding mechanism for spoke-machines
FR2422956A1 (fr) 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
DE69132531T2 (de) 1990-12-06 2001-09-13 Affymetrix Inc Verbindungen und ihre Verwendung in einer binären Synthesestrategie
US5326691A (en) 1991-11-21 1994-07-05 John Hozier Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries
DE4237113B4 (de) * 1992-11-03 2006-10-12 "Iba Gmbh" Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins
US5516637A (en) * 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
US5736388A (en) * 1994-12-30 1998-04-07 Chada; Sunil Bacteriophage-mediated gene transfer systems capable of transfecting eukaryotic cells
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
CA2319828A1 (en) * 1998-01-29 1999-08-05 Miller, Samuel High density arrays for proteome analysis and methods and compositions therefor
EP1054973A1 (de) * 1998-02-11 2000-11-29 Maxygen, Inc. Antigen bibliothek immunisierung

Also Published As

Publication number Publication date
ATE386939T1 (de) 2008-03-15
CA2392981A1 (en) 2001-06-07
EP1242821A1 (de) 2002-09-25
DE60038124T2 (de) 2009-02-12
GB9928787D0 (en) 2000-02-02
NO20022312L (no) 2002-06-03
AU1541701A (en) 2001-06-12
JP2003515745A (ja) 2003-05-07
WO2001040803A1 (en) 2001-06-07
NO20022312D0 (no) 2002-05-15
PT1242821E (pt) 2008-07-14
EP2000804A2 (de) 2008-12-10
US20030039958A1 (en) 2003-02-27
DK1242821T3 (da) 2008-06-09
EP1242821B8 (de) 2008-05-28
ES2300279T3 (es) 2008-06-16
EP1242821B1 (de) 2008-02-20
EP2000804A3 (de) 2009-06-03

Similar Documents

Publication Publication Date Title
DE60038124D1 (de) Direktes screeningverfahren
Paulick et al. Cleavable hydrophilic linker for one-bead-one-compound sequencing of oligomer libraries by tandem mass spectrometry
Zhu et al. Protein arrays and microarrays
WO2005108615A3 (en) Nucleic-acid programmable protein arrays
CN1390263B (zh) 大处理量试验系统
Song et al. A novel and rapid encoding method based on mass spectrometry for “one-bead-one-compound” small molecule combinatorial libraries
DE60335000D1 (de) In vitro peptid-expressionsbank
Szostak Introduction: combinatorial chemistry
DK0859841T3 (da) Protein/(poly)peptidbiblioteker
EA200000684A1 (ru) Высокопроизводительная тест-система
CA2310267A1 (en) Rapid screening assay methods and devices
CA2276462A1 (en) Multiplexed molecular analysis system apparatus and method
WO2001005808A3 (en) In vitro selection and optional identification of polypeptides using solid support carriers
US20200064354A1 (en) Systems and methods for high throughput analysis of conformation in biological entities
Fandozzi et al. 2019 White paper on recent issues in bioanalysis: chromatographic assays (part 1–innovation in small molecules and oligonucleotides & mass spectrometric method development strategies for large molecule bioanalysis)
ATE311443T1 (de) Methoden zur durchforstung (screenen) von proteinen
CY1114429T1 (el) Μεθοδος και διαταξη για την αναλυση αρκετων αναλυτων ταυτοχρονα με εναν εσωτερικο ελεγχο
HUP0102457A2 (hu) Új, biológiai ligandumok és célmolekulák azonosítására szolgáló eljárások
KR100470825B1 (ko) 치료제로서의 엔티티 조합의 동정 방법
Hwang et al. OBOC small-molecule combinatorial library encoded by halogenated mass-tags
DE602006011350D1 (de) In situ protein mikroarray zusammenbau
Srebalus Barnes et al. Assessment of purity and screening of peptide libraries by nested ion mobility-TOFMS: identification of RNase S-protein binders
WO2002066984A3 (en) Arrays for determining binding of biomolecules
Vastl et al. Encoded silicon-chip-based platform for combinatorial synthesis and screening
DK0774116T3 (da) Fremgangsmåde til screening af biblioteker af forbindelser

Legal Events

Date Code Title Description
8364 No opposition during term of opposition