DE60036781T2 - Vorrichtung zur durchführung von intra-operativer angiographie - Google Patents
Vorrichtung zur durchführung von intra-operativer angiographie Download PDFInfo
- Publication number
- DE60036781T2 DE60036781T2 DE60036781T DE60036781T DE60036781T2 DE 60036781 T2 DE60036781 T2 DE 60036781T2 DE 60036781 T DE60036781 T DE 60036781T DE 60036781 T DE60036781 T DE 60036781T DE 60036781 T2 DE60036781 T2 DE 60036781T2
- Authority
- DE
- Germany
- Prior art keywords
- camera
- laser
- radiation
- vessel
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002583 angiography Methods 0.000 title description 3
- 230000005855 radiation Effects 0.000 claims abstract description 36
- 239000007850 fluorescent dye Substances 0.000 claims description 21
- 210000004204 blood vessel Anatomy 0.000 claims description 12
- 238000001356 surgical procedure Methods 0.000 claims description 9
- 230000003287 optical effect Effects 0.000 claims description 7
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 238000010009 beating Methods 0.000 claims description 2
- 230000001360 synchronised effect Effects 0.000 claims description 2
- 230000002526 effect on cardiovascular system Effects 0.000 claims 2
- 238000005286 illumination Methods 0.000 claims 1
- 210000005166 vasculature Anatomy 0.000 abstract description 14
- 239000012216 imaging agent Substances 0.000 abstract description 13
- 239000003795 chemical substances by application Substances 0.000 abstract description 11
- 230000000007 visual effect Effects 0.000 abstract description 5
- 238000012632 fluorescent imaging Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 73
- 210000001519 tissue Anatomy 0.000 description 47
- 230000002792 vascular Effects 0.000 description 29
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 27
- 230000017531 blood circulation Effects 0.000 description 25
- 241001465754 Metazoa Species 0.000 description 24
- 229960004657 indocyanine green Drugs 0.000 description 24
- 210000001367 artery Anatomy 0.000 description 16
- 238000011282 treatment Methods 0.000 description 16
- 210000004351 coronary vessel Anatomy 0.000 description 13
- 206010016717 Fistula Diseases 0.000 description 12
- 230000003890 fistula Effects 0.000 description 12
- 230000002093 peripheral effect Effects 0.000 description 12
- 238000004458 analytical method Methods 0.000 description 11
- 210000001105 femoral artery Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 239000000975 dye Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 230000002966 stenotic effect Effects 0.000 description 9
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- 238000002560 therapeutic procedure Methods 0.000 description 8
- 210000003462 vein Anatomy 0.000 description 7
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 6
- 229960004373 acetylcholine Drugs 0.000 description 6
- 230000003872 anastomosis Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 208000031481 Pathologic Constriction Diseases 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 230000036262 stenosis Effects 0.000 description 5
- 208000037804 stenosis Diseases 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 208000001647 Renal Insufficiency Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 210000001715 carotid artery Anatomy 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000004313 glare Effects 0.000 description 3
- 238000010191 image analysis Methods 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 201000006370 kidney failure Diseases 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000004807 localization Effects 0.000 description 3
- 230000010412 perfusion Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000008733 trauma Effects 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 241001136792 Alle Species 0.000 description 2
- 206010002329 Aneurysm Diseases 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 2
- 230000002491 angiogenic effect Effects 0.000 description 2
- 210000000709 aorta Anatomy 0.000 description 2
- 208000011775 arteriosclerosis disease Diseases 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 210000000748 cardiovascular system Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 2
- 229940043264 dodecyl sulfate Drugs 0.000 description 2
- 238000013171 endarterectomy Methods 0.000 description 2
- 210000004904 fingernail bed Anatomy 0.000 description 2
- 238000001631 haemodialysis Methods 0.000 description 2
- 210000005003 heart tissue Anatomy 0.000 description 2
- 230000000322 hemodialysis Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000007917 intracranial administration Methods 0.000 description 2
- 229960002725 isoflurane Drugs 0.000 description 2
- 210000004731 jugular vein Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- XQMVBICWFFHDNN-UHFFFAOYSA-N 5-amino-4-chloro-2-phenylpyridazin-3-one;(2-ethoxy-3,3-dimethyl-2h-1-benzofuran-5-yl) methanesulfonate Chemical compound O=C1C(Cl)=C(N)C=NN1C1=CC=CC=C1.C1=C(OS(C)(=O)=O)C=C2C(C)(C)C(OCC)OC2=C1 XQMVBICWFFHDNN-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 101100136062 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) PE10 gene Proteins 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000009443 Vascular Malformations Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 238000002052 colonoscopy Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 229940009976 deoxycholate Drugs 0.000 description 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000003708 edge detection Methods 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000000087 laser glass Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 210000001349 mammary artery Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229940067631 phospholipid Drugs 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000008389 polyethoxylated castor oil Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000005084 renal tissue Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000250 revascularization Effects 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 208000011818 severe chest pain Diseases 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000002352 surface water Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001042 thoracic artery Anatomy 0.000 description 1
- 210000000779 thoracic wall Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/026—Measuring blood flow
- A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Physiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Closed-Circuit Television Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15565299P | 1999-09-24 | 1999-09-24 | |
| US155652P | 1999-09-24 | ||
| PCT/US2000/022088 WO2001022870A1 (en) | 1999-09-24 | 2000-08-11 | Method and apparatus for performing intra-operative angiography |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60036781D1 DE60036781D1 (de) | 2007-11-29 |
| DE60036781T2 true DE60036781T2 (de) | 2008-07-24 |
Family
ID=22556243
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60045880T Expired - Lifetime DE60045880D1 (de) | 1999-09-24 | 2000-08-11 | Vorrichtung zur Durchführung einer intraoperativen Angiographie |
| DE60036781T Expired - Lifetime DE60036781T2 (de) | 1999-09-24 | 2000-08-11 | Vorrichtung zur durchführung von intra-operativer angiographie |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60045880T Expired - Lifetime DE60045880D1 (de) | 1999-09-24 | 2000-08-11 | Vorrichtung zur Durchführung einer intraoperativen Angiographie |
Country Status (15)
| Country | Link |
|---|---|
| EP (6) | EP1143852B1 (enExample) |
| JP (3) | JP3881550B2 (enExample) |
| KR (1) | KR100737620B1 (enExample) |
| CN (3) | CN1399528A (enExample) |
| AT (2) | ATE375749T1 (enExample) |
| AU (1) | AU782257B2 (enExample) |
| BR (1) | BR0014289A (enExample) |
| CA (1) | CA2339214C (enExample) |
| DE (2) | DE60045880D1 (enExample) |
| DK (2) | DK2910185T3 (enExample) |
| ES (2) | ES2292463T3 (enExample) |
| HK (1) | HK1040897B (enExample) |
| MX (1) | MXPA02003064A (enExample) |
| PT (2) | PT1143852E (enExample) |
| WO (1) | WO2001022870A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009000376A1 (de) * | 2009-01-22 | 2010-08-05 | Carl Zeiss Surgical Gmbh | Verfahren zur quantitativen Darstellung des Blutflusses |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050182434A1 (en) | 2000-08-11 | 2005-08-18 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
| AU2003248559A1 (en) * | 2002-05-22 | 2003-12-12 | Beth Israel Deaconess Medical Center | Device for wavelength-selective imaging |
| US7580185B2 (en) * | 2002-08-28 | 2009-08-25 | Carl Zeiss Surgical Gmbh | Microscopy system, microscopy method and a method of treating an aneurysm |
| JP4013128B2 (ja) * | 2002-09-12 | 2007-11-28 | 株式会社日立メディコ | 血流動態解析装置、方法、及び画像診断装置 |
| WO2004049947A2 (en) * | 2002-11-29 | 2004-06-17 | Given Imaging Ltd. | Methods device and system for in vivo diagnosis |
| DE10257743B4 (de) * | 2002-12-10 | 2006-11-23 | Irmgard Zerrle | Vorrichtung zur Bestimmung der Perfusion in einem Gewebebereich und des Blutflusses durch einzelne Blutgefäße |
| US8190231B2 (en) | 2003-11-20 | 2012-05-29 | Hamamatsu Photonics K.K. | Lymph node detecting apparatus |
| DE102004015682B4 (de) * | 2004-03-26 | 2008-07-31 | Bundesrepublik Deutschland, vertr. d. d. Bundesministerium für Wirtschaft und Technologie, dieses vertr. d. d. Präsidenten der Physikalisch-Technischen Bundesanstalt | Verfahren und Gerät zur Detektion eines in den Körper eines Lebewesens injizierten Farbstoff-Bolus |
| JP2006014868A (ja) | 2004-06-30 | 2006-01-19 | Hamamatsu Photonics Kk | リンパ節検出装置 |
| US20060239921A1 (en) | 2005-04-26 | 2006-10-26 | Novadaq Technologies Inc. | Real time vascular imaging during solid organ transplant |
| WO2006116634A2 (en) * | 2005-04-26 | 2006-11-02 | Novadaq Technologies, Inc. | Method and apparatus for vasculature visualization with applications in neurosurgery and neurology |
| NZ620811A (en) * | 2005-05-09 | 2015-09-25 | Theranos Inc | Point-of-care fluidic systems and uses thereof |
| JP4709600B2 (ja) * | 2005-07-15 | 2011-06-22 | 株式会社東芝 | X線診断装置、撮影角度最適化支援装置及びプログラム |
| US20070122344A1 (en) | 2005-09-02 | 2007-05-31 | University Of Rochester Medical Center Office Of Technology Transfer | Intraoperative determination of nerve location |
| DE102006004583A1 (de) * | 2006-02-01 | 2007-08-09 | Siemens Ag | Optische Abtasteinrichtung |
| RU2309668C1 (ru) | 2006-02-20 | 2007-11-10 | Александр Сергеевич Парфенов | Способ неинвазивного определения функции эндотелия и устройство для его осуществления |
| JP4954573B2 (ja) * | 2006-02-28 | 2012-06-20 | オリンパス株式会社 | 内視鏡システム |
| US20080161744A1 (en) | 2006-09-07 | 2008-07-03 | University Of Rochester Medical Center | Pre-And Intra-Operative Localization of Penile Sentinel Nodes |
| KR100867977B1 (ko) * | 2006-10-11 | 2008-11-10 | 한국과학기술원 | 인도시아닌 그린 혈중 농도 역학을 이용한 조직 관류 분석장치 및 그를 이용한 조직 관류 분석방법 |
| WO2008049084A2 (en) | 2006-10-18 | 2008-04-24 | Minnow Medical, Inc. | Tuned rf energy and electrical tissue characterization for selective treatment of target tissues |
| KR100818669B1 (ko) * | 2007-03-09 | 2008-04-02 | 한국과학기술원 | 하지 관류정도 측정장치 |
| US8406860B2 (en) | 2008-01-25 | 2013-03-26 | Novadaq Technologies Inc. | Method for evaluating blush in myocardial tissue |
| EP2249703B1 (en) * | 2008-01-25 | 2015-11-25 | Novadaq Technologies Inc. | Method for evaluating blush in myocardial tissue |
| US10219742B2 (en) | 2008-04-14 | 2019-03-05 | Novadaq Technologies ULC | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
| WO2009127972A2 (en) * | 2008-04-14 | 2009-10-22 | Novadaq Technologies Inc. | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
| KR100971458B1 (ko) * | 2008-04-18 | 2010-07-22 | 한국과학기술원 | 약물동역학을 이용한 혈관의 기능적 영상화 장치 및 방법 |
| WO2009135178A2 (en) | 2008-05-02 | 2009-11-05 | Flower Robert W | Methods for production and use of substance-loaded erythrocytes (s-les) for observation and treatment of microvascular hemodynamics |
| KR100949460B1 (ko) * | 2008-06-19 | 2010-03-29 | 한국과학기술원 | 수학적 모델에 기반한 약물동역학적 혈관 특성 추출 장치및 방법 |
| US8144958B2 (en) | 2008-09-11 | 2012-03-27 | Carl Zeiss Meditec Ag | Medical systems and methods |
| US20100092389A1 (en) * | 2008-10-10 | 2010-04-15 | The General Hospital Corporation | Detection of atherosclerosis using indocyanine green |
| KR100973183B1 (ko) * | 2008-10-29 | 2010-07-30 | 한국과학기술원 | 관류 정도 분석 장치 및 방법 |
| CN201664343U (zh) * | 2008-11-11 | 2010-12-08 | 深圳市莫廷影像技术有限公司 | 具有血管造影功能的手术显微镜系统 |
| WO2010056945A2 (en) * | 2008-11-13 | 2010-05-20 | Shalon Ventures, Inc. | Methods and systems for tissue processing and imaging |
| US10492671B2 (en) | 2009-05-08 | 2019-12-03 | Novadaq Technologies ULC | Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest |
| US8057400B2 (en) | 2009-05-12 | 2011-11-15 | Angiologix, Inc. | System and method of measuring changes in arterial volume of a limb segment |
| JP2013509902A (ja) * | 2009-11-04 | 2013-03-21 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 距離センサを使用した衝突の回避と探知 |
| KR101138909B1 (ko) * | 2010-04-15 | 2012-05-10 | 전남대학교산학협력단 | 소동물용 검사 및 수술 장치 |
| US11207042B2 (en) * | 2011-09-06 | 2021-12-28 | Koninklijke Philips N.V. | Vascular treatment outcome visualization |
| WO2013049123A1 (en) * | 2011-09-26 | 2013-04-04 | The Johns Hopkins University | Anisotropic processing of laser speckle images |
| EP2810603A4 (en) * | 2012-01-30 | 2015-11-04 | Ccs Inc | LIGHTING DEVICE FOR DETECTION OF TUMORS AND LIGHTING DEVICE FOR EXAMINATION |
| WO2013190391A2 (en) | 2012-06-21 | 2013-12-27 | Novadaq Technologies Inc. | Quantification and analysis of angiography and perfusion |
| CN104427926B (zh) * | 2012-06-28 | 2017-09-08 | 皇家飞利浦有限公司 | 使用内窥镜图像上的光体积描记对通畅性的评估 |
| US10426361B2 (en) | 2013-06-14 | 2019-10-01 | Novadaq Technologies ULC | Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography |
| WO2015041312A1 (ja) | 2013-09-20 | 2015-03-26 | 国立大学法人旭川医科大学 | 血管内血流動態の画像処理方法及びシステム |
| AU2015204201B2 (en) * | 2014-01-06 | 2019-11-28 | Body Vision Medical Ltd. | Surgical devices and methods of use thereof |
| KR102249824B1 (ko) * | 2014-02-24 | 2021-05-10 | 삼성전자주식회사 | 신체 정보 감지장치 및 이의 신체 정보 감지방법 |
| JP6866287B2 (ja) | 2014-08-15 | 2021-04-28 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 注射デバイスおよび注射デバイスに取り付けるように構成された補助デバイス |
| CA2963987A1 (en) | 2014-09-29 | 2016-04-07 | Novadaq Technologies Inc. | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
| JP6487544B2 (ja) | 2014-10-09 | 2019-03-20 | ノバダック テクノロジーズ ユーエルシー | 蛍光媒介光電式容積脈波記録法を用いた組織中の絶対血流の定量化 |
| WO2016123705A1 (en) | 2015-02-02 | 2016-08-11 | Novadaq Technologies Inc. | Methods and systems for characterizing tissue of a subject |
| US9996921B2 (en) | 2015-05-17 | 2018-06-12 | LIGHTLAB IMAGING, lNC. | Detection of metal stent struts |
| US10109058B2 (en) | 2015-05-17 | 2018-10-23 | Lightlab Imaging, Inc. | Intravascular imaging system interfaces and stent detection methods |
| US10123761B2 (en) | 2015-07-01 | 2018-11-13 | William E. Butler | Device and method for spatiotemporal reconstruction of a moving vascular pulse wave in the brain and other organs |
| JP6867385B2 (ja) * | 2015-07-25 | 2021-04-28 | ライトラボ・イメージング・インコーポレーテッド | 血管内データ視覚化方法 |
| CN108472088B (zh) * | 2015-09-23 | 2022-06-21 | 史赛克欧洲运营有限公司 | 用于管理从医学成像导出的数据的方法和系统 |
| JP2018534965A (ja) | 2015-09-23 | 2018-11-29 | ノバダック テクノロジーズ ユーエルシー | 組織の治癒を評価するための方法およびシステム |
| EP3370609B1 (en) * | 2015-11-03 | 2021-03-31 | Fresenius Medical Care Holdings, Inc. | Method and apparatus of assessment of access flow in hemodialysis patients by video imaging processing |
| CA3053274A1 (en) | 2016-02-16 | 2017-08-24 | Novadaq Technologies ULC | Facilitating assessment of blood flow and tissue perfusion using fluorescence-mediated photoplethysmography |
| CN109843176A (zh) | 2016-07-29 | 2019-06-04 | 诺瓦达克技术有限公司 | 用于利用机器学习来表征受验者的组织的方法和系统 |
| US11140305B2 (en) | 2017-02-10 | 2021-10-05 | Stryker European Operations Limited | Open-field handheld fluorescence imaging systems and methods |
| EP3651118B1 (en) * | 2017-06-01 | 2021-09-08 | Leica Instruments (Singapore) Pte. Ltd. | Method, image processor and device for observing an object containing a bolus of a fluorophore |
| BR112020025425A2 (pt) * | 2018-06-14 | 2021-03-16 | Perfusion Tech Aps | Sistema e método para avaliação de perfusão automática, e, método implementado por computador |
| JP7369695B2 (ja) * | 2018-07-25 | 2023-10-26 | 株式会社ダイセル | 測定システム、測定方法 |
| CN109523484B (zh) * | 2018-11-16 | 2023-01-17 | 中国民航大学 | 一种基于分形特征的手指静脉血管网络修复方法 |
| CA3127005A1 (en) | 2019-02-06 | 2020-08-13 | William E. Butler | Improved methods for angiography |
| WO2020163629A1 (en) | 2019-02-06 | 2020-08-13 | Butler William E | Spatiotemporal reconstruction of a moving vascular pulse wave from a plurality of lower dimensional angiographic projections |
| US11291422B2 (en) | 2019-03-27 | 2022-04-05 | William E. Butler | Reconstructing cardiac frequency phenomena in angiographic data |
| CN113905665B (zh) | 2019-04-04 | 2025-04-11 | 威廉·E·巴特勒 | 固有对照物光学互相关小波血管造影 |
| KR20220123227A (ko) * | 2019-11-25 | 2022-09-06 | 액티브 서지컬, 인크. | 의료 이미징을 위한 시스템 및 방법 |
| CN111012325B (zh) * | 2019-12-05 | 2022-07-29 | 华中科技大学苏州脑空间信息研究院 | 一种精准光调控系统及光调控方法 |
| DE102020102681B3 (de) * | 2020-02-03 | 2021-08-05 | Carl Zeiss Meditec Ag | Computerimplementiertes Verfahren, Computerprogramm und Operationssystem zur Bestimmung des Blutvolumenflusses durch einen Abschnitt eines Blutgefäßes in einem Operationsbereich |
| CN117320620A (zh) * | 2021-03-18 | 2023-12-29 | 华盛顿大学 | 血液稀释探测器 |
| CN113288015A (zh) * | 2021-04-01 | 2021-08-24 | 南京航空航天大学 | 一种血流及内源信号多模态内窥成像系统 |
| US12220272B2 (en) | 2021-05-12 | 2025-02-11 | Angiowave Imaging, Inc. | Motion-compensated wavelet angiography |
| WO2022269051A1 (en) | 2021-06-24 | 2022-12-29 | Perfusion Tech Aps | System and method for identifying an abnormal perfusion pattern |
| CN113951846B (zh) * | 2021-12-17 | 2022-04-12 | 北京麦邦光电仪器有限公司 | 脉搏波信号处理方法、装置及可读存储介质 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4394199A (en) * | 1981-09-08 | 1983-07-19 | Agnus Chemical Company | Explosive emulsion composition |
| JPS5970903A (ja) * | 1982-10-15 | 1984-04-21 | Olympus Optical Co Ltd | 内視鏡自動計測装置 |
| JPS5969721A (ja) * | 1982-10-15 | 1984-04-20 | Olympus Optical Co Ltd | 内視鏡計測装置 |
| US4619249A (en) * | 1985-07-24 | 1986-10-28 | Kim Landry | Transcutaneous intravenous illuminator |
| JPS62266025A (ja) * | 1986-05-10 | 1987-11-18 | 株式会社 メデイカルサイエンス | 血管内視ビデオシステム |
| JP2987816B2 (ja) * | 1989-01-30 | 1999-12-06 | オリンパス光学工業株式会社 | 蛍光観察装置 |
| CN1049781A (zh) * | 1989-09-02 | 1991-03-13 | 住友电气工业株式会社 | 用于血管外科的激光手术器械 |
| US5438989A (en) * | 1990-08-10 | 1995-08-08 | Hochman; Darryl | Solid tumor, cortical function, and nerve tissue imaging methods and device |
| JPH04297236A (ja) * | 1991-03-26 | 1992-10-21 | Toshiba Corp | ディジタルフルオログラフィ装置 |
| CA2042075C (en) * | 1991-05-08 | 2001-01-23 | Branko Palcic | Endoscopic imaging system |
| JP3297725B2 (ja) * | 1991-12-09 | 2002-07-02 | 国立循環器病センター総長 | 造影血管高精度管径計測装置 |
| US5279298A (en) * | 1992-11-20 | 1994-01-18 | The Johns Hopkins University | Method and apparatus to identify and treat neovascular membranes in the eye |
| JP3228627B2 (ja) * | 1993-03-19 | 2001-11-12 | オリンパス光学工業株式会社 | 内視鏡用画像処理装置 |
| US5394199A (en) * | 1993-05-17 | 1995-02-28 | The Johns Hopkins University | Methods and apparatus for improved visualization of choroidal blood flow and aberrant vascular structures in the eye using fluorescent dye angiography |
| JPH0765154A (ja) * | 1993-08-31 | 1995-03-10 | Toshiba Corp | 血管像の定量解析装置及びその定量解析方法 |
| JPH0779955A (ja) * | 1993-09-14 | 1995-03-28 | Toshiba Corp | X線撮影装置 |
| JPH07222712A (ja) * | 1994-02-10 | 1995-08-22 | Olympus Optical Co Ltd | 蛍光内視鏡装置 |
| FR2717365B1 (fr) | 1994-03-21 | 1996-05-15 | Rech Biolog Et | Dispositif d'imagerie endoscopique ou fibroscopique en fluorescence dans l'infrarouge. |
| JP3641495B2 (ja) * | 1994-07-19 | 2005-04-20 | 株式会社日立メディコ | 医用画像診断装置 |
| US6032070A (en) * | 1995-06-07 | 2000-02-29 | University Of Arkansas | Method and apparatus for detecting electro-magnetic reflection from biological tissue |
| US6096510A (en) | 1995-10-04 | 2000-08-01 | Cytoscan Sciences, Llc | Methods and systems for assessing biological materials using optical detection techniques |
| JP3896176B2 (ja) | 1996-05-21 | 2007-03-22 | 浜松ホトニクス株式会社 | 近赤外線蛍光トレーサーおよび蛍光イメージング方法 |
| JPH09308609A (ja) * | 1996-05-24 | 1997-12-02 | Canon Inc | 眼科用画像処理装置 |
| US5851181A (en) * | 1996-08-30 | 1998-12-22 | Esc Medical Systems Ltd. | Apparatus for simultaneously viewing and spectrally analyzing a portion of skin |
| JP3962122B2 (ja) * | 1996-11-20 | 2007-08-22 | オリンパス株式会社 | 内視鏡装置 |
| DE69732696T2 (de) * | 1997-01-08 | 2006-04-13 | Biosense Webster, Inc., Diamond Bar | Überwachung der myokardialen revaskularisation |
| US6122042A (en) * | 1997-02-07 | 2000-09-19 | Wunderman; Irwin | Devices and methods for optically identifying characteristics of material objects |
| EP0975258A1 (en) * | 1997-04-17 | 2000-02-02 | Avimo Group Limited | Ocular microcirculation examination and treatment apparatus |
| US6353750B1 (en) * | 1997-06-27 | 2002-03-05 | Sysmex Corporation | Living body inspecting apparatus and noninvasive blood analyzer using the same |
| US6101200A (en) | 1997-12-24 | 2000-08-08 | Nortel Networks Corporation | Laser module allowing simultaneous wavelength and power control |
| US6165170A (en) | 1998-01-29 | 2000-12-26 | International Business Machines Corporation | Laser dermablator and dermablation |
| AU756615B2 (en) * | 1998-03-18 | 2003-01-16 | Medi-Physics, Inc. | MR methods for imaging pulmonary and cardiac vasculature and evaluating blood flow using dissolved polarized 129Xe |
-
2000
- 2000-08-11 DK DK15160177.0T patent/DK2910185T3/en active
- 2000-08-11 EP EP00955472A patent/EP1143852B1/en not_active Revoked
- 2000-08-11 BR BR0014289-1A patent/BR0014289A/pt not_active Application Discontinuation
- 2000-08-11 CA CA2339214A patent/CA2339214C/en not_active Expired - Lifetime
- 2000-08-11 CN CN00816229A patent/CN1399528A/zh active Pending
- 2000-08-11 CN CN2008100949834A patent/CN101406392B/zh not_active Expired - Lifetime
- 2000-08-11 ES ES00955472T patent/ES2292463T3/es not_active Expired - Lifetime
- 2000-08-11 DK DK00955472T patent/DK1143852T3/da active
- 2000-08-11 MX MXPA02003064A patent/MXPA02003064A/es active IP Right Grant
- 2000-08-11 ES ES15160177.0T patent/ES2666182T3/es not_active Expired - Lifetime
- 2000-08-11 PT PT00955472T patent/PT1143852E/pt unknown
- 2000-08-11 HK HK02102594.4A patent/HK1040897B/en not_active IP Right Cessation
- 2000-08-11 AT AT00955472T patent/ATE375749T1/de active
- 2000-08-11 DE DE60045880T patent/DE60045880D1/de not_active Expired - Lifetime
- 2000-08-11 CN CN2007101371422A patent/CN101264014B/zh not_active Expired - Lifetime
- 2000-08-11 PT PT151601770T patent/PT2910185T/pt unknown
- 2000-08-11 KR KR1020027003815A patent/KR100737620B1/ko not_active Expired - Fee Related
- 2000-08-11 WO PCT/US2000/022088 patent/WO2001022870A1/en not_active Ceased
- 2000-08-11 EP EP20100186218 patent/EP2281503B1/en not_active Expired - Lifetime
- 2000-08-11 AU AU67675/00A patent/AU782257B2/en not_active Expired
- 2000-08-11 DE DE60036781T patent/DE60036781T2/de not_active Expired - Lifetime
- 2000-08-11 EP EP07015008A patent/EP1849408A3/en not_active Withdrawn
- 2000-08-11 EP EP07015006A patent/EP1852061A1/en not_active Withdrawn
- 2000-08-11 EP EP07015007A patent/EP1852063B1/en not_active Expired - Lifetime
- 2000-08-11 AT AT07015007T patent/ATE506005T1/de not_active IP Right Cessation
- 2000-08-11 JP JP2001526090A patent/JP3881550B2/ja not_active Expired - Lifetime
- 2000-08-11 EP EP15160177.0A patent/EP2910185B2/en not_active Expired - Lifetime
-
2006
- 2006-01-25 JP JP2006016878A patent/JP2006192280A/ja active Pending
-
2011
- 2011-03-10 JP JP2011053502A patent/JP5081992B2/ja not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009000376A1 (de) * | 2009-01-22 | 2010-08-05 | Carl Zeiss Surgical Gmbh | Verfahren zur quantitativen Darstellung des Blutflusses |
| DE102009000376B4 (de) | 2009-01-22 | 2019-03-28 | Carl Zeiss Meditec Ag | Verfahren zur quantitativen Darstellung des Blutflusses |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60036781T2 (de) | Vorrichtung zur durchführung von intra-operativer angiographie | |
| US7881777B2 (en) | Method and apparatus for performing intra-operative angiography | |
| US6915154B1 (en) | Method and apparatus for performing intra-operative angiography | |
| DE69332244T2 (de) | Verwendung eines farbstoffs zur herstellung eines agens zur bilddarstellung von kompakten tumoren und kombination eines farbstoffs mit einem apparat zur bilddarstellung von kompakten tumoren, des kortex und der nervenbahnen | |
| Fujisawa et al. | Value of a dynamic MR scan in predicting vascular ingrowth from free vascularized scapular transplant used for treatment of avascular femoral head necrosis | |
| HK1214115B (en) | Method for assessing tissue perfusion | |
| HK1108612B (en) | Apparatus for performing intra-operative angiography | |
| HK1107924A (en) | Method and apparatus for performing intra-operative angiography | |
| HK1108613A (en) | Method and apparatus for performing intra-operative angiography | |
| Grossart et al. | By JA Ambrose |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8363 | Opposition against the patent |