DE60034370T2 - Verfahren und vorrichtung zur analyse von zellen in einer vollblutprobe - Google Patents
Verfahren und vorrichtung zur analyse von zellen in einer vollblutprobe Download PDFInfo
- Publication number
- DE60034370T2 DE60034370T2 DE60034370T DE60034370T DE60034370T2 DE 60034370 T2 DE60034370 T2 DE 60034370T2 DE 60034370 T DE60034370 T DE 60034370T DE 60034370 T DE60034370 T DE 60034370T DE 60034370 T2 DE60034370 T2 DE 60034370T2
- Authority
- DE
- Germany
- Prior art keywords
- cell
- sample
- blood cells
- cells
- flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title description 12
- 238000009534 blood test Methods 0.000 title description 3
- 210000004027 cell Anatomy 0.000 claims description 184
- 239000000523 sample Substances 0.000 claims description 105
- 210000003743 erythrocyte Anatomy 0.000 claims description 67
- 210000000265 leukocyte Anatomy 0.000 claims description 55
- 210000004369 blood Anatomy 0.000 claims description 39
- 239000008280 blood Substances 0.000 claims description 39
- 210000001772 blood platelet Anatomy 0.000 claims description 38
- 210000000601 blood cell Anatomy 0.000 claims description 27
- 238000000149 argon plasma sintering Methods 0.000 claims description 26
- 230000005855 radiation Effects 0.000 claims description 24
- 230000003287 optical effect Effects 0.000 claims description 20
- 239000003153 chemical reaction reagent Substances 0.000 claims description 14
- 239000012470 diluted sample Substances 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 12
- 230000002159 abnormal effect Effects 0.000 claims description 9
- 101000619676 Drosophila melanogaster Lipid storage droplets surface-binding protein 2 Proteins 0.000 claims description 6
- 101000613960 Homo sapiens Lysine-specific histone demethylase 1B Proteins 0.000 claims description 6
- 102100040596 Lysine-specific histone demethylase 1B Human genes 0.000 claims description 6
- 230000002934 lysing effect Effects 0.000 claims description 6
- 101001050886 Homo sapiens Lysine-specific histone demethylase 1A Proteins 0.000 claims description 5
- 102100024985 Lysine-specific histone demethylase 1A Human genes 0.000 claims description 5
- 239000003085 diluting agent Substances 0.000 claims description 5
- 238000001917 fluorescence detection Methods 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 3
- 101100398801 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) LDS2 gene Proteins 0.000 claims 2
- 230000001678 irradiating effect Effects 0.000 claims 1
- 230000001902 propagating effect Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 description 36
- 238000004458 analytical method Methods 0.000 description 22
- 239000012530 fluid Substances 0.000 description 19
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 13
- 238000002156 mixing Methods 0.000 description 13
- 210000001995 reticulocyte Anatomy 0.000 description 13
- 102000001554 Hemoglobins Human genes 0.000 description 12
- 108010054147 Hemoglobins Proteins 0.000 description 12
- 230000000875 corresponding effect Effects 0.000 description 11
- 210000004698 lymphocyte Anatomy 0.000 description 10
- 210000002751 lymph Anatomy 0.000 description 8
- 239000007850 fluorescent dye Substances 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 210000000440 neutrophil Anatomy 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 5
- 230000002596 correlated effect Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 238000000569 multi-angle light scattering Methods 0.000 description 5
- 238000010791 quenching Methods 0.000 description 5
- 230000000171 quenching effect Effects 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- 208000034628 Celiac artery compression syndrome Diseases 0.000 description 4
- 108010004729 Phycoerythrin Proteins 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 210000003651 basophil Anatomy 0.000 description 4
- BBWBEZAMXFGUGK-UHFFFAOYSA-N bis(dodecylsulfanyl)-methylarsane Chemical compound CCCCCCCCCCCCS[As](C)SCCCCCCCCCCCC BBWBEZAMXFGUGK-UHFFFAOYSA-N 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- 210000003979 eosinophil Anatomy 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 210000001616 monocyte Anatomy 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 210000005259 peripheral blood Anatomy 0.000 description 4
- 239000011886 peripheral blood Substances 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- 229910052786 argon Inorganic materials 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 230000009089 cytolysis Effects 0.000 description 3
- 238000007405 data analysis Methods 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- -1 dodecyl β-D-maltose Chemical compound 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 238000000684 flow cytometry Methods 0.000 description 3
- 238000005534 hematocrit Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 2
- 210000004366 CD4-positive T-lymphocyte Anatomy 0.000 description 2
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 2
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000002189 fluorescence spectrum Methods 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 210000003714 granulocyte Anatomy 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000003458 metachromatic effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 240000003517 Elaeocarpus dentatus Species 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 239000000980 acid dye Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000004141 dimensional analysis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001215 fluorescent labelling Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000009652 hydrodynamic focusing Methods 0.000 description 1
- 238000010185 immunofluorescence analysis Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005464 sample preparation method Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 229930028731 β-maltose Natural products 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N2015/139—Measuring the ratio of AC/DC impedances
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/808—Optical sensing apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
Landscapes
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US251019 | 1999-02-16 | ||
| US09/251,019 US6228652B1 (en) | 1999-02-16 | 1999-02-16 | Method and apparatus for analyzing cells in a whole blood sample |
| PCT/US2000/002715 WO2000049385A2 (en) | 1999-02-16 | 2000-02-03 | Method and apparatus for analyzing cells in a whole blood sample |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60034370D1 DE60034370D1 (de) | 2007-05-24 |
| DE60034370T2 true DE60034370T2 (de) | 2007-12-20 |
Family
ID=22950141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60034370T Expired - Lifetime DE60034370T2 (de) | 1999-02-16 | 2000-02-03 | Verfahren und vorrichtung zur analyse von zellen in einer vollblutprobe |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6228652B1 (enExample) |
| EP (1) | EP1250585B1 (enExample) |
| JP (1) | JP4468590B2 (enExample) |
| DE (1) | DE60034370T2 (enExample) |
| WO (1) | WO2000049385A2 (enExample) |
Families Citing this family (159)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060322A (en) * | 1998-10-20 | 2000-05-09 | Coulter International Corp. | Method for identification of reticulated cells |
| JP3817091B2 (ja) * | 1999-07-02 | 2006-08-30 | テルモ株式会社 | 細胞数測定装置 |
| AU8026100A (en) * | 1999-10-15 | 2001-04-30 | The Administrators Of The Tulane Eductional Fund | Device for and method of simultaneously measuring light scatter from multiple liquid samples |
| US6587792B1 (en) * | 2000-01-11 | 2003-07-01 | Richard A. Thomas | Nuclear packing efficiency |
| US6646742B1 (en) * | 2000-02-19 | 2003-11-11 | Mwi, Inc. | Optical device and method for multi-angle laser light scatter |
| US6624621B2 (en) * | 2000-04-03 | 2003-09-23 | Howard L. North, Jr. | Particle counter volume sensor |
| US6890489B2 (en) * | 2000-04-26 | 2005-05-10 | Rheodyne, L.P. | Mass rate attenuator |
| US7630063B2 (en) * | 2000-08-02 | 2009-12-08 | Honeywell International Inc. | Miniaturized cytometer for detecting multiple species in a sample |
| US6784981B1 (en) * | 2000-06-02 | 2004-08-31 | Idexx Laboratories, Inc. | Flow cytometry-based hematology system |
| JP4494606B2 (ja) * | 2000-08-11 | 2010-06-30 | 浜松ホトニクス株式会社 | 液体含有物質分析装置及び液体含有物質分析方法 |
| US20020086431A1 (en) * | 2000-08-21 | 2002-07-04 | Markham Walter Bruce | Sample preparation and slide plating apparatus and method |
| US20020028434A1 (en) * | 2000-09-06 | 2002-03-07 | Guava Technologies, Inc. | Particle or cell analyzer and method |
| JP4759188B2 (ja) * | 2000-09-18 | 2011-08-31 | シスメックス株式会社 | 血球検出器及びそれを備えた血液分析装置 |
| ATE434760T1 (de) | 2000-09-18 | 2009-07-15 | Sysmex Corp | Blutzellen-detektor, blutanalysegerät und blutanalyseverfahren unter verwendung des detektors |
| WO2002059575A2 (en) * | 2001-01-23 | 2002-08-01 | The Trustees Of Princeton University, Princeton University | Method and apparatus for analysis of biological solutions |
| US6793642B2 (en) * | 2001-05-07 | 2004-09-21 | Biomed Solutions, Llc | Flow cytometer |
| US6743190B2 (en) * | 2001-05-07 | 2004-06-01 | Biomed Solutions L.L.C. | Flow cytometer shunt |
| US20030027347A1 (en) * | 2001-05-25 | 2003-02-06 | Phyllis Shapiro | Automated method for correcting blood analysis parameter results affected by interference from exogenous blood substitutes in whole blood, plasma, and serum |
| DE10128449B4 (de) * | 2001-06-12 | 2004-07-15 | Robert Bosch Gmbh | Vorrichtung und Verfahren zur Prüfung eines Materials |
| WO2003012429A1 (en) * | 2001-07-27 | 2003-02-13 | Coulter International Corp. | Method for measurement of nucleated red blood cells |
| US6410330B1 (en) * | 2001-07-27 | 2002-06-25 | Coulter International Corp. | Method for measurement of nucleated red blood cells |
| US6472215B1 (en) * | 2001-07-27 | 2002-10-29 | Coulter International Corp. | Method of analyzing nucleated red blood cells in a blood sample |
| US6803208B2 (en) * | 2001-07-30 | 2004-10-12 | The United States Of America As Represented By The Secretary Of The Navy | Automated epifluorescence microscopy for detection of bacterial contamination in platelets |
| US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
| US8980568B2 (en) * | 2001-10-11 | 2015-03-17 | Aviva Biosciences Corporation | Methods and compositions for detecting non-hematopoietic cells from a blood sample |
| US6723563B2 (en) | 2001-12-03 | 2004-04-20 | Streck Laboratories Inc. | Hematology reference control |
| US6653137B2 (en) | 2001-12-03 | 2003-11-25 | Streck Laboratories Inc. | Hematology reference control |
| EP1365240B1 (en) * | 2002-05-22 | 2006-09-13 | Sysmex Corporation | Immunoassay methods, immunoassay apparatuses, and reagents for immunoassays |
| US7569393B2 (en) | 2002-06-28 | 2009-08-04 | International Technidyne Corporation | Analytical test cartridge; and, methods |
| JP4299597B2 (ja) * | 2002-07-29 | 2009-07-22 | シスメックス株式会社 | 血液分析装置及び方法 |
| US6794877B2 (en) * | 2002-07-31 | 2004-09-21 | International Technidyne Corporation | Apparatus and method for analytical determinations |
| US6743634B2 (en) * | 2002-08-23 | 2004-06-01 | Coulter International Corp. | Method and apparatus for differentiating blood cells using back-scatter |
| US20040166540A1 (en) * | 2003-02-24 | 2004-08-26 | Sysmex Corporation | Methods of detecting CD34 positive and negative hematopoietic stem cells in human samples |
| US20040219612A1 (en) * | 2003-05-02 | 2004-11-04 | Beckman Coulter, Inc. | Methods for detecting intracellular defensins in various leukocyte subpopulations |
| US20040228766A1 (en) * | 2003-05-14 | 2004-11-18 | Witty Thomas R. | Point of care diagnostic platform |
| US20040228765A1 (en) * | 2003-05-14 | 2004-11-18 | Witty Thomas R. | Point of care diagnostic platform |
| JP2005024472A (ja) * | 2003-07-04 | 2005-01-27 | Sysmex Corp | 幼若血小板測定装置 |
| EP1682865B1 (en) * | 2003-10-12 | 2018-08-15 | Beckman Coulter, Inc. | Method of using a reference control composition for measurement of nucleated red blood cells |
| US7095492B2 (en) * | 2003-12-19 | 2006-08-22 | Beckman Coulter, Inc. | Method and apparatus for measuring cell-by-cell hemoglobin |
| US7259007B2 (en) * | 2003-12-24 | 2007-08-21 | Glycofi, Inc. | Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins |
| JP4435581B2 (ja) * | 2004-01-07 | 2010-03-17 | シスメックス株式会社 | 免疫測定装置および方法 |
| US7208319B2 (en) * | 2004-02-10 | 2007-04-24 | Beckman Coulter, Inc. | Method of measurement of nucleated red blood cells |
| EP1714146B1 (en) * | 2004-02-10 | 2022-08-03 | Beckman Coulter, Inc. | Method of measurement of nucleated red blood cells |
| JP4417143B2 (ja) * | 2004-03-11 | 2010-02-17 | シスメックス株式会社 | 試料分析装置、プログラムおよびそのプログラムを記録した記録媒体 |
| US7625712B2 (en) * | 2004-05-21 | 2009-12-01 | Beckman Coulter, Inc. | Method for a fully automated monoclonal antibody-based extended differential |
| US7674598B2 (en) * | 2004-05-21 | 2010-03-09 | Beckman Coulter, Inc. | Method for a fully automated monoclonal antibody-based extended differential |
| US7075647B2 (en) * | 2004-06-30 | 2006-07-11 | Beckman Coulter, Inc. | Back-scatter detection in flow cytometers |
| US7340957B2 (en) | 2004-07-29 | 2008-03-11 | Los Alamos National Security, Llc | Ultrasonic analyte concentration and application in flow cytometry |
| FR2873813B1 (fr) * | 2004-07-30 | 2006-11-17 | Abx Sa | Procede et dispositif de caracterisation des composants cellulaires d'un liquide biologique |
| EP1777669A1 (en) * | 2004-08-04 | 2007-04-25 | Matsushita Electric Industrial Co., Ltd. | Invasion detection device |
| US8685711B2 (en) * | 2004-09-28 | 2014-04-01 | Singulex, Inc. | Methods and compositions for highly sensitive detection of molecules |
| US7392908B2 (en) * | 2005-01-12 | 2008-07-01 | Beckman Coulter, Inc. | Methods and apparatus for sorting particles hydraulically |
| US7678578B2 (en) * | 2005-02-07 | 2010-03-16 | Beckman Coulter, Inc. | Cell permeabilization and stabilization reagent and method of use |
| US20070077177A1 (en) * | 2005-03-16 | 2007-04-05 | Klaus Witt | Stimulated detection of sample compounds |
| US7113266B1 (en) * | 2005-03-30 | 2006-09-26 | Beckman Coulter, Inc. | Flow cytometer for differentiating small particles in suspension |
| FR2883973B1 (fr) * | 2005-03-31 | 2007-11-16 | C2 Diagnostics Sa | Cuve pour dispositif optique d'analyse sanguine, appareil d'analyse equipe d'une telle cuve |
| US7842247B2 (en) | 2005-08-19 | 2010-11-30 | Canadian Blood Services | Sample holder for dynamic light scattering |
| US7609369B2 (en) * | 2005-09-24 | 2009-10-27 | Beckman Coulter, Inc. | Methods of detection of iron deficiency and hemochromatosis |
| US7344890B2 (en) * | 2005-11-09 | 2008-03-18 | Beckman Coulter, Inc. | Method for discriminating platelets from red blood cells |
| EP1966588B1 (en) * | 2005-12-29 | 2018-12-12 | Honeywell International Inc. | Assay implementation in a microfluidic format |
| US7361510B2 (en) * | 2006-01-20 | 2008-04-22 | Beckman Coulter, Inc. | Methods of detection of iron deficiency |
| WO2007131507A2 (en) * | 2006-05-13 | 2007-11-22 | Dako Denmark A/S | Methods for flow cytometry analyses of cells without lysing subpopulations |
| WO2008008515A2 (en) * | 2006-07-14 | 2008-01-17 | Aviva Biosciences Corporation | Methods and compositions for detecting rare cells from a biological sample |
| WO2008063758A2 (en) | 2006-10-05 | 2008-05-29 | Massachussetts Institute Of Technology | Multifunctional encoded particles for high-throughput analysis |
| CN1945326A (zh) * | 2006-10-13 | 2007-04-11 | 江西特康科技有限公司 | 基于视觉形态的五分类全血细胞分析方法 |
| US7835000B2 (en) * | 2006-11-03 | 2010-11-16 | Los Alamos National Security, Llc | System and method for measuring particles in a sample stream of a flow cytometer or the like |
| US8062609B2 (en) | 2006-11-10 | 2011-11-22 | Luminex Corporation | Flow cytometer and fluidic line assembly with multiple injection needles |
| US20080121591A1 (en) * | 2006-11-29 | 2008-05-29 | Canon U.S. Life Sciences, Inc. | Device for nucleic acid preparation |
| US7674622B2 (en) * | 2006-12-22 | 2010-03-09 | Abbott Laboratories, Inc. | Method for determination of nucleated red blood cells and leukocytes in a whole blood sample in an automated hematology analyzer |
| EP1953526B1 (en) * | 2007-02-01 | 2017-08-30 | Sysmex Corporation | Hematological analyzer, method for analyzing body fluid and computer program product |
| US7837040B2 (en) * | 2007-04-09 | 2010-11-23 | Los Alamos National Security, Llc | Acoustic concentration of particles in fluid flow |
| US8083068B2 (en) | 2007-04-09 | 2011-12-27 | Los Alamos National Security, Llc | Apparatus for separating particles utilizing engineered acoustic contrast capture particles |
| US7618821B2 (en) * | 2007-04-13 | 2009-11-17 | Streck, Inc. | Simulated blood components and methods |
| JP5162177B2 (ja) * | 2007-07-31 | 2013-03-13 | シスメックス株式会社 | 粒子分析装置及び粒子分析方法 |
| US8528406B2 (en) * | 2007-10-24 | 2013-09-10 | Los Alamos National Security, LLP | Method for non-contact particle manipulation and control of particle spacing along an axis |
| US8263407B2 (en) | 2007-10-24 | 2012-09-11 | Los Alamos National Security, Llc | Method for non-contact particle manipulation and control of particle spacing along an axis |
| JP2011502264A (ja) * | 2007-10-29 | 2011-01-20 | ベックマン コールター， インコーポレイテッド | 血小板集団の迅速な抗体ベースの分析のための方法 |
| US8266951B2 (en) | 2007-12-19 | 2012-09-18 | Los Alamos National Security, Llc | Particle analysis in an acoustic cytometer |
| US9602777B2 (en) | 2008-04-25 | 2017-03-21 | Roche Diagnostics Hematology, Inc. | Systems and methods for analyzing body fluids |
| WO2012030313A1 (en) | 2008-04-25 | 2012-03-08 | James Winkelman | Method of determining a complete blood count and a white blood cell differential count |
| US8094299B2 (en) | 2008-07-24 | 2012-01-10 | Beckman Coulter, Inc. | Transducer module |
| TW201017149A (en) | 2008-08-06 | 2010-05-01 | Invitrox Inc | Use of focused light scattering techniques in biological applications |
| US8000940B2 (en) | 2008-10-08 | 2011-08-16 | Beckman Coulter, Inc. | Shape parameter for hematology instruments |
| US20100086962A1 (en) | 2008-10-08 | 2010-04-08 | Streck, Inc. | Hematology controls and methods |
| HU227875B1 (en) * | 2008-10-13 | 2012-05-29 | Diatron Medicinai Instr Laboratoriumi Diagnosztikai Fejlesztoe Gyarto Zartkoerueen Muekoedoe Reszven | Optical circulation cytometer furthermore testing method |
| FR2939199B1 (fr) * | 2008-12-02 | 2011-02-11 | C2 Diagnostics | Procede et dispositif de cytometrie en flux sans fluide de gainage |
| US9464978B2 (en) * | 2009-03-04 | 2016-10-11 | Beckman Coulter, Inc. | Cross-instrument method and system for cell population discrimination |
| JP5670052B2 (ja) * | 2009-03-26 | 2015-02-18 | シスメックス株式会社 | 血液分析装置、血液分析方法及びコンピュータプログラム |
| WO2010124202A1 (en) * | 2009-04-24 | 2010-10-28 | Beckman Coulter, Inc. | Method of characterizing particles |
| WO2010138391A2 (en) * | 2009-05-26 | 2010-12-02 | Invitrox, Inc. | Instrument and method for optical particle sensing |
| US20100329927A1 (en) * | 2009-06-26 | 2010-12-30 | Perez Carlos A | Pipelining Assembly For A Blood Analyzing Instrument |
| US9097704B2 (en) * | 2010-05-05 | 2015-08-04 | Abbott Laboratories | Method for hematology analysis |
| WO2011156434A2 (en) | 2010-06-07 | 2011-12-15 | Firefly Bioworks, Inc. | Nucleic acid detection and quantification by post-hybridization labeling and universal encoding |
| JP5868982B2 (ja) | 2010-09-16 | 2016-02-24 | ザ ジェネラル ホスピタル コーポレイション | 診断のための赤血球動力学 |
| CA2816014A1 (en) | 2010-11-03 | 2012-05-10 | Reametrix Inc. | Method and device for fluorescent measurement of samples |
| US9111343B2 (en) | 2011-01-18 | 2015-08-18 | Roche Diagnostics Hematology, Inc. | Microscope slide coordinate system registration |
| FR2971337B1 (fr) * | 2011-02-04 | 2013-03-01 | Horiba Abx Sas | Dispositif et procede de mesures multiparametriques de microparticules dans un fluide |
| CN105699277A (zh) * | 2011-04-28 | 2016-06-22 | 希森美康株式会社 | 血液分析装置及血液分析方法 |
| ES2902648T3 (es) * | 2011-05-04 | 2022-03-29 | Abbott Lab | Método de análisis de glóbulos rojos nucleados y analizador hematológico automatizado |
| EP3650831A1 (en) * | 2011-05-04 | 2020-05-13 | Abbott Laboratories | Basophil analysis system and method |
| JP6104233B2 (ja) * | 2011-05-04 | 2017-03-29 | アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ | 白血球分析システムおよび方法 |
| EP2520926B1 (en) * | 2011-05-05 | 2022-06-15 | Sysmex Corporation | Blood analyzer, blood analysis method, and computer program product |
| WO2013013229A1 (en) | 2011-07-21 | 2013-01-24 | Invitrox, Inc. | Instrument and method for optical particle sensing |
| US9201005B2 (en) * | 2011-12-29 | 2015-12-01 | Abbott Laboratories | Flow cytometry systems and methods for blocking diffraction patterns |
| WO2013134633A1 (en) * | 2012-03-09 | 2013-09-12 | Firefly Bioworks, Inc. | Methods and apparatus for classification and quantification of multifunctional objects |
| KR101963477B1 (ko) | 2012-07-05 | 2019-03-28 | 베크만 컬터, 인코포레이티드 | 백혈구 수치를 측정하기 위한 방법 및 장치 |
| BR112015003000A2 (pt) * | 2012-08-13 | 2017-07-04 | Beckman Coulter Inc | classificação de leucemia usando dados de cpd |
| CN104797924A (zh) | 2012-11-30 | 2015-07-22 | 贝克曼考尔特公司 | 使用cpd数据进行结核病筛查 |
| EP2939001B1 (en) | 2012-12-31 | 2019-12-04 | Beckman Coulter, Inc. | Systems and methods for platelet count with clump adjustment |
| US9939453B2 (en) | 2012-12-31 | 2018-04-10 | Beckman Coulter, Inc. | Immature platelet enumeration systems and methods |
| HK1218784A1 (zh) * | 2013-03-11 | 2017-03-10 | 罗氏血液诊断公司 | 對血細胞進行成像 |
| CN104981691B (zh) * | 2013-03-12 | 2020-03-31 | 雅培实验室 | 用于分析红细胞和血小板的试剂、体系及方法 |
| CN105051521B (zh) | 2013-03-15 | 2020-03-24 | 贝克曼考尔特公司 | 用于设计流式细胞术中的面板的系统和方法 |
| WO2014144868A1 (en) | 2013-03-15 | 2014-09-18 | Beckman Coulter, Inc. | Compound optical flow cells and method of manufacture and use |
| EP2997363A4 (en) * | 2013-05-13 | 2016-11-30 | Chiranjit Deka | APPARATUS AND METHODS FOR CELL ANALYSIS |
| US10324020B2 (en) * | 2013-12-23 | 2019-06-18 | Palo Alto Research Center Incorporated | Fluidic optical cartridge |
| CN107003224B (zh) * | 2014-08-20 | 2021-01-12 | 生物辐射实验室股份有限公司 | 光流体分选器 |
| US9500588B2 (en) | 2014-09-30 | 2016-11-22 | Perkinelmer Health Sciences, Inc. | Flow cell modules and liquid sample analyzers and methods including same |
| US9581491B2 (en) | 2014-09-30 | 2017-02-28 | Perkinelmer Health Sciences, Inc. | Flow cell modules and liquid sample analyzers and methods including same |
| US9612221B2 (en) | 2014-10-14 | 2017-04-04 | Chem-Aqua, Inc. + Pyxis Lab, Inc. | Opto-electrochemical sensing system for monitoring and controlling industrial fluids |
| FR3034198B1 (fr) | 2015-03-26 | 2019-05-31 | C2 Diagnostics | Appareil hydrofocus a solution d'analyse unique |
| JP6729558B2 (ja) * | 2015-03-31 | 2020-07-22 | ソニー株式会社 | 電気的特性測定装置、電気的特性測定方法、血液状態解析システム、及び該方法をコンピューターに実現させるための電気的特性測定用プログラム |
| EP3371591A4 (en) | 2015-11-02 | 2018-11-14 | Chiranjit Deka | Light scatter based apparatus and methods for hematology analysis using only three detectors |
| US10955423B2 (en) | 2015-12-15 | 2021-03-23 | The General Hospital Corporation | Methods of estimating blood glucose and related systems |
| EP3408773B1 (en) | 2016-01-28 | 2023-09-20 | Beckman Coulter, Inc. | Infection detection and differentiation systems and methods |
| WO2017177192A1 (en) | 2016-04-07 | 2017-10-12 | The General Hospital Corporation | White blood cell population dynamics |
| EP3465142B1 (de) * | 2016-05-27 | 2023-08-23 | Martin Kuhn | Durchflusszytometeranordnung |
| CN110249223B (zh) * | 2017-02-17 | 2020-10-20 | 深圳迈瑞生物医疗电子股份有限公司 | 血液细胞分析方法及血液细胞分析仪 |
| JP2020509491A (ja) | 2017-02-28 | 2020-03-26 | ベックマン コールター， インコーポレイテッド | 学際的疾患管理システム |
| US10648909B2 (en) * | 2017-05-25 | 2020-05-12 | Abbott Laboratories | Methods and systems for assessing flow cell cleanliness |
| CN109211737B (zh) * | 2017-06-30 | 2024-07-16 | 深圳迈瑞生物医疗电子股份有限公司 | 样本检测装置、样本分析仪及样本检测方法 |
| WO2019041270A1 (zh) * | 2017-08-31 | 2019-03-07 | 深圳迈瑞生物医疗电子股份有限公司 | 样本检测装置、样本分析仪及样本检测方法 |
| US11852640B2 (en) | 2017-10-27 | 2023-12-26 | Beckman Coulter, Inc. | Hematology analyzers and methods of operation |
| EP3776051B1 (en) | 2018-03-30 | 2024-03-06 | Idexx Laboratories, Inc. | Laser optics assembly of flow cytometer |
| US11538566B2 (en) | 2018-05-23 | 2022-12-27 | Beckman Coulter, Inc. | Sample analysis with test determination based on identified condition |
| CN112041938A (zh) | 2018-04-20 | 2020-12-04 | 拜克门寇尔特公司 | 败血症感染确定系统和方法 |
| US11521706B2 (en) | 2018-04-20 | 2022-12-06 | Beckman Coulter, Inc. | Testing and representing suspicion of sepsis |
| CA3073594A1 (en) * | 2018-04-23 | 2019-10-31 | Anpac Bio-Medical Science Co., Ltd. | New apparatus and methods for disease detection |
| CN111602046B (zh) * | 2018-04-28 | 2024-01-09 | 深圳迈瑞生物医疗电子股份有限公司 | 一种血液分析仪及分析方法 |
| US11022538B2 (en) | 2018-05-15 | 2021-06-01 | Government Of The United States Of America, As Represented By The Secretary Of Commerce | Quantum flow cytometer |
| WO2019240876A1 (en) | 2018-06-15 | 2019-12-19 | Beckman Coulter, Inc. | Method of determining sepsis in the presence of blast flagging |
| WO2021011356A1 (en) | 2019-07-12 | 2021-01-21 | Beckman Coulter, Inc. | Systems and methods for evaluating immune response to infection |
| CN114127558A (zh) | 2019-07-12 | 2022-03-01 | 贝克曼库尔特有限公司 | 用于评估对感染的免疫反应的系统和方法 |
| WO2021011349A1 (en) | 2019-07-12 | 2021-01-21 | Beckman Coulter, Inc. | Method of detecting sepsis using vital signs, including systolic blood pressure, hematology parameters, and combinations thereof |
| WO2021216752A1 (en) | 2020-04-21 | 2021-10-28 | Beckman Coulter, Inc. | Detection of medical condition, severity, risk, and acuity using parameters |
| CA3182847A1 (en) | 2020-06-17 | 2021-12-23 | Garland Christian Misener | Flow cytometer and laser optics assembly thereof |
| EP3933376A1 (en) * | 2020-07-02 | 2022-01-05 | Deutsches Rheuma-Forschungszentrum Berlin | Method and system for characterizing particles using an angular detection in a flow cytometer |
| AU2021306347A1 (en) * | 2020-07-10 | 2023-02-09 | Beckman Coulter, Inc | Automated sample preparation platform for cellular analysis |
| JP2023543217A (ja) | 2020-09-25 | 2023-10-13 | ベックマン コールター， インコーポレイテッド | 新型コロナウイルス感染症に関連付けられたｍｉｓ－ｃを評価する方法 |
| CN112557281B (zh) * | 2020-11-23 | 2022-06-24 | 深圳市科曼医疗设备有限公司 | 血液细胞分析仪的plt粒子检测方法和装置 |
| WO2022119594A1 (en) | 2020-12-02 | 2022-06-09 | Beckman Coulter, Inc. | Detection of medical condition, severity, risk, and acuity using parameters |
| WO2023159188A1 (en) | 2022-02-18 | 2023-08-24 | Beckman Coulter, Inc. | Detection of sepsis using hematology parameters |
| CN116990212A (zh) * | 2022-04-25 | 2023-11-03 | 深圳迈瑞生物医疗电子股份有限公司 | 检测原始细胞的血细胞分析仪及检测方法 |
| US11506587B1 (en) * | 2022-06-29 | 2022-11-22 | HLM Diagnostics Inc. | Liquid droplet and solid particle sensing device |
| CN115524276A (zh) * | 2022-10-18 | 2022-12-27 | 四川成电医联科技咨询有限公司 | 一种多频阻抗学的血细胞分类计数芯片及计数方法 |
| CN120476301A (zh) | 2022-12-05 | 2025-08-12 | 贝克曼库尔特有限公司 | 血液学流动系统界面 |
| WO2025076332A1 (en) | 2023-10-05 | 2025-04-10 | Beckman Coulter, Inc. | Determining parameter values in a biological analyzer |
| WO2025145095A1 (en) | 2023-12-29 | 2025-07-03 | Beckman Coulter, Inc. | Customized sample handling in biological analysis |
| WO2025240490A1 (en) | 2024-05-13 | 2025-11-20 | Beckman Coulter, Inc. | Detection of bacteremia using hematology parameters |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4673288A (en) * | 1981-05-15 | 1987-06-16 | Ratcom, Inc. | Flow cytometry |
| US4445391A (en) | 1981-10-19 | 1984-05-01 | Coulter Electronics, Inc. | Liquid metering and transfer valve assembly |
| US4507977A (en) | 1981-10-19 | 1985-04-02 | Coulter Electronics, Inc. | Liquid metering and transfer valve assembly |
| US4510438A (en) * | 1982-02-16 | 1985-04-09 | Coulter Electronics, Inc. | Coincidence correction in particle analysis system |
| GB2125181B (en) * | 1982-08-11 | 1986-01-29 | Coulter Electronics | Flow cells for particle study |
| CH651930A5 (en) * | 1983-03-24 | 1985-10-15 | Coulter Corp | Apparatus for analysis and sorting of particles |
| US4702889A (en) | 1986-01-16 | 1987-10-27 | Coulter Electronics Inc. | Liquid sampling valve |
| KR970007077B1 (ko) | 1987-03-13 | 1997-05-02 | 코울터 일렉트로닉스 인커퍼레이티드 | 광산란 기술을 이용한 다중-부분식별 분석 방법 |
| FR2621123B1 (fr) * | 1987-09-30 | 1989-12-01 | Commissariat Energie Atomique | Procede de fabrication d'un dispositif d'analyse optique d'un flux de microparticules et application a la fabrication d'un cytofluorimetre |
| JPH0718785B2 (ja) | 1988-09-19 | 1995-03-06 | 株式会社日立製作所 | フローセル装置 |
| CA1324894C (en) * | 1989-03-31 | 1993-12-07 | Maritime Scientific Services Ltd. | Method and apparatus for the identification of particles |
| US5255568A (en) | 1990-12-13 | 1993-10-26 | Coulter Corporation | Liquid sample/reagent metering and delivery method |
| JP3048260B2 (ja) * | 1991-07-29 | 2000-06-05 | シスメックス株式会社 | 白血球分類計数用試料調製方法 |
| EP0698211B1 (en) * | 1993-05-14 | 2003-04-02 | Coulter International Corporation | Reticulocyte analyzing method and apparatus utilizing light scatter techniques |
| JP3328032B2 (ja) * | 1993-11-04 | 2002-09-24 | シスメックス株式会社 | 粒子分析装置 |
| IL113805A0 (en) * | 1994-05-23 | 1995-08-31 | Coulter Corp | Detection of reticulocytes |
| ATE403491T1 (de) * | 1994-08-01 | 2008-08-15 | Abbott Lab | Vorrichtung und verfahren zur vorbereitung einer flüssigkeit |
| US5631165A (en) | 1994-08-01 | 1997-05-20 | Abbott Laboratories | Method for performing automated hematology and cytometry analysis |
| US5656499A (en) | 1994-08-01 | 1997-08-12 | Abbott Laboratories | Method for performing automated hematology and cytometry analysis |
| US5798827A (en) * | 1996-11-26 | 1998-08-25 | Coulter International Corp. | Apparatus and method for determination of individual red blood cell shape |
| US6060322A (en) * | 1998-10-20 | 2000-05-09 | Coulter International Corp. | Method for identification of reticulated cells |
-
1999
- 1999-02-16 US US09/251,019 patent/US6228652B1/en not_active Expired - Lifetime
-
2000
- 2000-02-03 WO PCT/US2000/002715 patent/WO2000049385A2/en not_active Ceased
- 2000-02-03 DE DE60034370T patent/DE60034370T2/de not_active Expired - Lifetime
- 2000-02-03 EP EP00908455A patent/EP1250585B1/en not_active Expired - Lifetime
- 2000-02-03 JP JP2000600077A patent/JP4468590B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003510557A (ja) | 2003-03-18 |
| DE60034370D1 (de) | 2007-05-24 |
| US6228652B1 (en) | 2001-05-08 |
| WO2000049385A3 (en) | 2002-08-08 |
| JP4468590B2 (ja) | 2010-05-26 |
| EP1250585B1 (en) | 2007-04-11 |
| WO2000049385A2 (en) | 2000-08-24 |
| EP1250585A2 (en) | 2002-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60034370T2 (de) | Verfahren und vorrichtung zur analyse von zellen in einer vollblutprobe | |
| DE69532511T2 (de) | Verfahren zur schnellen und gleichzeitigen analyse nukleierter roter blutzellen | |
| US10859484B2 (en) | Method for determining volume and hemoglobin content of individual red blood cells | |
| DE69534429T2 (de) | Verfahren und vorrichtung zur durchführung automatischer analysen | |
| DE69011198T2 (de) | Verfahren zur Differenzierung von Leukozyten mit Hilfe eines Durchflusszellmessgerätes. | |
| EP0177718B1 (de) | Verfahren und Vorrichtung zur Sortierung von mikroskopischen Partikeln | |
| DE68918004T2 (de) | Verfahren zur Analyse von Zellbestandteilen in einer Flüssigkeit. | |
| DE69632998T2 (de) | Hochempfindliches, genaues und präzises automatisiertes Messverfahren und Vorrichtung zur Identifizierung und Quantifizierung von Blutplättchen und zur Bestimmung des Blutplättchenaktivitätszustands unter Verwendung von Ganzblutproben | |
| EP2312311B1 (en) | Determination of white blood cell differential and reticulocytes counts | |
| DE69806802T2 (de) | Verfahren zur unterscheidung von erythroblasten | |
| DE3852270T2 (de) | Vielteilige differentielle analysiervorrichtung mit verwendung der lichtstreuungstechniken. | |
| DE69211434T2 (de) | Verfahren zur Probevorbereitung zur Klassifizierung und Zählung der Leukozyten | |
| DE69328296T2 (de) | Verfahren und materialien zur bestimmung der teilchenzahl in einem durchflusszytometer | |
| DE69924968T2 (de) | Verfahren zum unterscheiden von kernhaltigen roten blutzellen | |
| DE69628651T2 (de) | Zusammensetzungen und verfahren für die schnelle analyse von retikulozyten | |
| DE69326731T2 (de) | Kontroll-Teilchen für die Zellzählung und Instrumentenlinearität | |
| DE3854577T2 (de) | Methode zum screening von zellen oder anderen geformten körpern zur spezifizierung von populationen, die ausgewählte charakteristische eigenschaften exprimieren. | |
| DE69028399T2 (de) | Verfahren zum sichten von zellen oder geformten körpern mit ausgewählten eigenschaften unter benutzung eines nachweisparameters | |
| DE69223138T2 (de) | Verfahren und vorrichtung zum reihensichten mikroskopischer zellen unter verwendung von techniken zur streuung polarisierten lichts | |
| DE68928085T2 (de) | Verfahren zur auslese bestimmter zellen oder zellgebilden anhand von populationen mit ausgewählten merkmalen | |
| Lehner et al. | Automation in hematology | |
| DE4309328C2 (de) | Verfahren zur Differenzierung, Konzentrationsbestimmung und Sortierung von Erythrozyten, Thrombozyten und Leukozyten | |
| Lewis | New developments in haematology | |
| Persaud | Development of a helium-neon laser based flow cytometer for evaluation of particulate matter |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BECKMAN COULTER, INC., BREA, CALIF., US |