DE60031422T2 - Peptidanaloga als selektive Inhibitoren der Thrombinaktivierung des proteaseaktivierten Rezeptors 1 - Google Patents

Peptidanaloga als selektive Inhibitoren der Thrombinaktivierung des proteaseaktivierten Rezeptors 1 Download PDF

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Publication number
DE60031422T2
DE60031422T2 DE60031422T DE60031422T DE60031422T2 DE 60031422 T2 DE60031422 T2 DE 60031422T2 DE 60031422 T DE60031422 T DE 60031422T DE 60031422 T DE60031422 T DE 60031422T DE 60031422 T2 DE60031422 T2 DE 60031422T2
Authority
DE
Germany
Prior art keywords
thrombin
formula
seq
amino acid
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60031422T
Other languages
German (de)
English (en)
Other versions
DE60031422D1 (de
Inventor
H. Alvin Ann Arbor SCHMAIER
Ahmed A. K. Scio Township Dexter HASAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thromgen Inc Ann Arbor
University of Michigan System
Thromgen Inc
University of Michigan Ann Arbor
Original Assignee
Thromgen Inc Ann Arbor
University of Michigan System
Thromgen Inc
University of Michigan Ann Arbor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thromgen Inc Ann Arbor, University of Michigan System, Thromgen Inc, University of Michigan Ann Arbor filed Critical Thromgen Inc Ann Arbor
Application granted granted Critical
Publication of DE60031422D1 publication Critical patent/DE60031422D1/de
Publication of DE60031422T2 publication Critical patent/DE60031422T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE60031422T 1999-08-17 2000-08-17 Peptidanaloga als selektive Inhibitoren der Thrombinaktivierung des proteaseaktivierten Rezeptors 1 Expired - Fee Related DE60031422T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/375,808 US6544750B1 (en) 1999-08-17 1999-08-17 Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1
US375808 1999-08-17
PCT/US2000/040669 WO2001012656A1 (en) 1999-08-17 2000-08-17 Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1

Publications (2)

Publication Number Publication Date
DE60031422D1 DE60031422D1 (de) 2006-11-30
DE60031422T2 true DE60031422T2 (de) 2007-08-23

Family

ID=23482441

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60031422T Expired - Fee Related DE60031422T2 (de) 1999-08-17 2000-08-17 Peptidanaloga als selektive Inhibitoren der Thrombinaktivierung des proteaseaktivierten Rezeptors 1

Country Status (9)

Country Link
US (1) US6544750B1 (https=)
EP (1) EP1212352B1 (https=)
JP (1) JP2003507389A (https=)
AT (1) ATE342914T1 (https=)
AU (1) AU764707B2 (https=)
CA (1) CA2382056A1 (https=)
DE (1) DE60031422T2 (https=)
IL (1) IL148173A0 (https=)
WO (1) WO2001012656A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US6841354B2 (en) * 2000-12-21 2005-01-11 Philadelphia, Health & Education Corporation Screening assay for anti-thrombotic/anti-platelet activity
WO2004002418A2 (en) * 2002-06-26 2004-01-08 Entremed, Inc Compositions and methods comprising protein activated receptor antagonists
US7074765B2 (en) * 2003-05-01 2006-07-11 The Regents Of The University Of Michigan Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
JP2008510726A (ja) * 2004-08-20 2008-04-10 エントレメッド インコーポレイテッド プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法
PT1737889E (pt) 2004-10-19 2010-12-13 Lonza Ag Método para síntese de péptidos em fase sólida
EP2645932B1 (en) 2010-12-02 2016-03-02 Becton, Dickinson and Company Blood collection devices containing blood stabilization agent
EP2988130A1 (en) * 2014-08-20 2016-02-24 Eppendorf Ag Method for coating a solid support
US20180214476A1 (en) * 2017-02-01 2018-08-02 North Carolina State University Thrombin-responsive hydrogels and devices for auto-anticoagulant regulation
CN113429459B (zh) * 2021-06-16 2022-07-26 昆明医科大学第一附属医院 一种抗血小板多肽及其药物组合物与其应用
CN116370339A (zh) * 2023-05-24 2023-07-04 南京百沃锐医药研究院有限公司 一种环肽用作抗皮肤光老化活性因子及用于制备抗光老化化妆品的用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2021951A1 (en) * 1989-07-28 1991-01-29 Ruth F. Nutt Fibrinogen receptor antagonists
WO1992007269A1 (en) 1990-10-11 1992-04-30 Pro-Soma S.A.R.L. Diagnostic method
US5461032A (en) * 1991-03-01 1995-10-24 Fmc Corporation Insecticidally effective peptides
IE20030749A1 (en) 1991-05-03 2003-11-12 Indiana University Foundation Human notch and delta binding domains in torporythmic proteins, and methods based thereon
WO1993003748A1 (en) 1991-08-13 1993-03-04 Temple University - Of The Commonwealth System Of Higher Education Modulation of blood pressure and inhibition of platelet activation with kininogen fragment
US5225531A (en) * 1992-04-09 1993-07-06 Washington University Hexapeptide Lys Gly Ala Gly Asp Val
US5747447A (en) * 1992-04-30 1998-05-05 Cor Therapeutics Stable polypeptide composition
US5589458A (en) 1992-11-13 1996-12-31 Thomas Jefferson University Compounds that inhibit T cell proliferation and methods for using the same
US5631131A (en) 1993-03-19 1997-05-20 Universite De Montreal cDNA probes and antibodies for human methenyltetrahydrofolate synthetase
US5491086A (en) 1993-05-14 1996-02-13 Hoffmann-La Roche Inc. Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species
US5762939A (en) 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
CA2221865C (en) * 1995-06-09 2007-12-11 The Regents Of The University Of Michigan Bradykinin analogs as selective thrombin inhibitors
CA2288027A1 (en) 1997-04-23 1998-10-29 The Regents Of The University Of Michigan Bradykinin analogs as selective inhibitors of cell activation
AU2662999A (en) 1998-02-09 1999-08-23 Genzyme Corporation Nucleic acid delivery vehicles
US6111075A (en) 1998-04-01 2000-08-29 Zymogenetics, Inc. Protese-activated receptor PAR4 (ZCHEMR2)

Also Published As

Publication number Publication date
AU7882200A (en) 2001-03-13
CA2382056A1 (en) 2001-02-22
US6544750B1 (en) 2003-04-08
WO2001012656A1 (en) 2001-02-22
IL148173A0 (en) 2002-09-12
EP1212352B1 (en) 2006-10-18
DE60031422D1 (de) 2006-11-30
AU764707B2 (en) 2003-08-28
ATE342914T1 (de) 2006-11-15
EP1212352A4 (en) 2002-12-04
JP2003507389A (ja) 2003-02-25
EP1212352A1 (en) 2002-06-12

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8339 Ceased/non-payment of the annual fee