IL148173A0 - Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1 - Google Patents
Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1Info
- Publication number
- IL148173A0 IL148173A0 IL14817300A IL14817300A IL148173A0 IL 148173 A0 IL148173 A0 IL 148173A0 IL 14817300 A IL14817300 A IL 14817300A IL 14817300 A IL14817300 A IL 14817300A IL 148173 A0 IL148173 A0 IL 148173A0
- Authority
- IL
- Israel
- Prior art keywords
- peptide analogs
- activated receptor
- selective inhibitors
- protease activated
- thrombin activation
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 108010070519 PAR-1 Receptor Proteins 0.000 title 1
- 102100037136 Proteinase-activated receptor 1 Human genes 0.000 title 1
- 229940124639 Selective inhibitor Drugs 0.000 title 1
- 108090000190 Thrombin Proteins 0.000 title 1
- 230000004913 activation Effects 0.000 title 1
- 229960004072 thrombin Drugs 0.000 title 1
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 235000018417 cysteine Nutrition 0.000 abstract 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 2
- 101001098529 Homo sapiens Proteinase-activated receptor 1 Proteins 0.000 abstract 1
- 101000713169 Homo sapiens Solute carrier family 52, riboflavin transporter, member 2 Proteins 0.000 abstract 1
- 102100036862 Solute carrier family 52, riboflavin transporter, member 2 Human genes 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000020411 cell activation Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/375,808 US6544750B1 (en) | 1999-08-17 | 1999-08-17 | Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1 |
| PCT/US2000/040669 WO2001012656A1 (en) | 1999-08-17 | 2000-08-17 | Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL148173A0 true IL148173A0 (en) | 2002-09-12 |
Family
ID=23482441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14817300A IL148173A0 (en) | 1999-08-17 | 2000-08-17 | Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6544750B1 (https=) |
| EP (1) | EP1212352B1 (https=) |
| JP (1) | JP2003507389A (https=) |
| AT (1) | ATE342914T1 (https=) |
| AU (1) | AU764707B2 (https=) |
| CA (1) | CA2382056A1 (https=) |
| DE (1) | DE60031422T2 (https=) |
| IL (1) | IL148173A0 (https=) |
| WO (1) | WO2001012656A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| US6841354B2 (en) * | 2000-12-21 | 2005-01-11 | Philadelphia, Health & Education Corporation | Screening assay for anti-thrombotic/anti-platelet activity |
| CA2490129A1 (en) * | 2002-06-26 | 2004-01-08 | Entremed, Inc. | Compositions and methods comprising protein activated receptor antagonists |
| US7074765B2 (en) * | 2003-05-01 | 2006-07-11 | The Regents Of The University Of Michigan | Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4 |
| US20060063930A1 (en) * | 2004-08-20 | 2006-03-23 | Agoston Gregory E | Compositions and methods comprising proteinase activated receptor antagonists |
| DK1737889T3 (da) | 2004-10-19 | 2011-01-03 | Lonza Ag | Fremgangsmåde til fastfase-peptidsyntese |
| US10299714B2 (en) | 2010-12-02 | 2019-05-28 | Becton, Dickinson And Company | Blood collection devices containing blood stabilization agent including variegin or analog thereof and/or a polysulfated disaccharide |
| EP2988130A1 (en) * | 2014-08-20 | 2016-02-24 | Eppendorf Ag | Method for coating a solid support |
| US20180214476A1 (en) * | 2017-02-01 | 2018-08-02 | North Carolina State University | Thrombin-responsive hydrogels and devices for auto-anticoagulant regulation |
| CN113429459B (zh) * | 2021-06-16 | 2022-07-26 | 昆明医科大学第一附属医院 | 一种抗血小板多肽及其药物组合物与其应用 |
| CN116370339A (zh) * | 2023-05-24 | 2023-07-04 | 南京百沃锐医药研究院有限公司 | 一种环肽用作抗皮肤光老化活性因子及用于制备抗光老化化妆品的用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2021951A1 (en) * | 1989-07-28 | 1991-01-29 | Ruth F. Nutt | Fibrinogen receptor antagonists |
| JPH05503712A (ja) | 1990-10-11 | 1993-06-17 | プロ―ソマ・サルル | 診断方法 |
| US5461032A (en) * | 1991-03-01 | 1995-10-24 | Fmc Corporation | Insecticidally effective peptides |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| AU2548992A (en) | 1991-08-13 | 1993-03-16 | Temple University - Of The Commonwealth System Of Higher Education | Modulation of blood pressure and inhibition of platelet activation with kininogen fragment |
| US5225531A (en) * | 1992-04-09 | 1993-07-06 | Washington University | Hexapeptide Lys Gly Ala Gly Asp Val |
| US5747447A (en) * | 1992-04-30 | 1998-05-05 | Cor Therapeutics | Stable polypeptide composition |
| US5589458A (en) | 1992-11-13 | 1996-12-31 | Thomas Jefferson University | Compounds that inhibit T cell proliferation and methods for using the same |
| US5631131A (en) | 1993-03-19 | 1997-05-20 | Universite De Montreal | cDNA probes and antibodies for human methenyltetrahydrofolate synthetase |
| US5491086A (en) | 1993-05-14 | 1996-02-13 | Hoffmann-La Roche Inc. | Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species |
| US5762939A (en) | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| DE69627191T2 (de) * | 1995-06-09 | 2004-01-08 | The Regents Of The University Of Michigan, Ann Arbor | Bradikininanaloge als selektive thrombininhibitoren |
| JP2001518119A (ja) | 1997-04-23 | 2001-10-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 細胞活性化の選択的阻害剤としてのブラジキニン類似体 |
| WO1999040214A2 (en) | 1998-02-09 | 1999-08-12 | Genzyme Corporation | Nucleic acid delivery vehicles |
| US6111075A (en) | 1998-04-01 | 2000-08-29 | Zymogenetics, Inc. | Protese-activated receptor PAR4 (ZCHEMR2) |
-
1999
- 1999-08-17 US US09/375,808 patent/US6544750B1/en not_active Expired - Fee Related
-
2000
- 2000-08-17 DE DE60031422T patent/DE60031422T2/de not_active Expired - Fee Related
- 2000-08-17 WO PCT/US2000/040669 patent/WO2001012656A1/en not_active Ceased
- 2000-08-17 AT AT00968987T patent/ATE342914T1/de not_active IP Right Cessation
- 2000-08-17 IL IL14817300A patent/IL148173A0/xx unknown
- 2000-08-17 CA CA002382056A patent/CA2382056A1/en not_active Abandoned
- 2000-08-17 EP EP00968987A patent/EP1212352B1/en not_active Expired - Lifetime
- 2000-08-17 JP JP2001517554A patent/JP2003507389A/ja active Pending
- 2000-08-17 AU AU78822/00A patent/AU764707B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1212352B1 (en) | 2006-10-18 |
| ATE342914T1 (de) | 2006-11-15 |
| DE60031422D1 (de) | 2006-11-30 |
| JP2003507389A (ja) | 2003-02-25 |
| AU7882200A (en) | 2001-03-13 |
| AU764707B2 (en) | 2003-08-28 |
| CA2382056A1 (en) | 2001-02-22 |
| EP1212352A1 (en) | 2002-06-12 |
| DE60031422T2 (de) | 2007-08-23 |
| WO2001012656A1 (en) | 2001-02-22 |
| US6544750B1 (en) | 2003-04-08 |
| EP1212352A4 (en) | 2002-12-04 |
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