DE69615339T2 - Verfahren zum nachweis des endogenen thrombin-potentials und thrombin substrate zur verwendung in diesen verfahren - Google Patents

Verfahren zum nachweis des endogenen thrombin-potentials und thrombin substrate zur verwendung in diesen verfahren

Info

Publication number
DE69615339T2
DE69615339T2 DE69615339T DE69615339T DE69615339T2 DE 69615339 T2 DE69615339 T2 DE 69615339T2 DE 69615339 T DE69615339 T DE 69615339T DE 69615339 T DE69615339 T DE 69615339T DE 69615339 T2 DE69615339 T2 DE 69615339T2
Authority
DE
Germany
Prior art keywords
thrombin
endogenic
detecting
methods
potential
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69615339T
Other languages
English (en)
Other versions
DE69615339D1 (de
Inventor
Coenraad Hemker
Thomas Rijkers
Ignatius Tesser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69615339D1 publication Critical patent/DE69615339D1/de
Publication of DE69615339T2 publication Critical patent/DE69615339T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69615339T 1995-01-10 1996-01-10 Verfahren zum nachweis des endogenen thrombin-potentials und thrombin substrate zur verwendung in diesen verfahren Expired - Lifetime DE69615339T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95200043 1995-01-10
PCT/NL1996/000018 WO1996021740A1 (en) 1995-01-10 1996-01-10 Methods of determining endogenous thrombin potential (etp) and thrombin substrates for use in said methods

Publications (2)

Publication Number Publication Date
DE69615339D1 DE69615339D1 (de) 2001-10-25
DE69615339T2 true DE69615339T2 (de) 2002-07-04

Family

ID=8219949

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69615339T Expired - Lifetime DE69615339T2 (de) 1995-01-10 1996-01-10 Verfahren zum nachweis des endogenen thrombin-potentials und thrombin substrate zur verwendung in diesen verfahren

Country Status (6)

Country Link
US (1) US6207399B1 (de)
EP (1) EP0802986B1 (de)
AU (1) AU4634896A (de)
DE (1) DE69615339T2 (de)
ES (1) ES2162025T3 (de)
WO (1) WO1996021740A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5708591A (en) 1995-02-14 1998-01-13 Akzo Nobel N.V. Method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions
US6898532B1 (en) 1995-06-07 2005-05-24 Biomerieux, Inc. Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample
US6321164B1 (en) 1995-06-07 2001-11-20 Akzo Nobel N.V. Method and apparatus for predicting the presence of an abnormal level of one or more proteins in the clotting cascade
US6429017B1 (en) 1999-02-04 2002-08-06 Biomerieux Method for predicting the presence of haemostatic dysfunction in a patient sample
US6502040B2 (en) 1997-12-31 2002-12-31 Biomerieux, Inc. Method for presenting thrombosis and hemostasis assay data
JP4486260B2 (ja) 1999-02-04 2010-06-23 バイオメリュー・インコーポレイテッド 患者サンプルにおける止血機能不全の存在を予測するための方法および装置
AU3553900A (en) * 1999-03-04 2000-09-21 Synapse B.V. Determination of biologically active forms of proteolytic enzymes
US6740496B1 (en) 1999-03-04 2004-05-25 Synapse B.V. Determination of biologically active forms of proteolytic enzymes
US7179612B2 (en) 2000-06-09 2007-02-20 Biomerieux, Inc. Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality
EP1367135A1 (de) * 2002-05-29 2003-12-03 Pentapharm AG Verbessertes Verfahren zur Beurteilung der Thrombinbildung in Blutplasma
DE10360628A1 (de) * 2003-12-19 2005-07-21 Dade Behring Marburg Gmbh Kontrollplasma für Thrombinaktivitätstests
DE102004059055A1 (de) 2004-12-07 2006-06-08 Dade Behring Marburg Gmbh Verfahren zur automatischen Bestimmung des endogenen Thrombinpotenzials
DE102005003145B4 (de) * 2005-01-21 2006-10-19 Dade Behring Marburg Gmbh Stablies, chromogenes Flüssigreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests
DE102005008066A1 (de) 2005-02-22 2006-08-24 Haemosys Gmbh Verfahren zur Bestimmung der Gesamtgerinnungsaktivität einer Blut- oder Plasmaprobe
US20090215080A1 (en) * 2005-10-13 2009-08-27 Activesite Pharmaceuticals Methods for identification of inhibitors of enzyme activity
EP2818871A1 (de) * 2013-06-28 2014-12-31 Roche Diagniostics GmbH Mittel und Verfahren zur universellen Kalibrierung von anti-Faktor-Xa-Tests
US20200200774A1 (en) 2017-06-20 2020-06-25 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for identifying whether patients with acute decompensated heart failure (adhf) exhibit a hypercoagulable state
EP4239338A1 (de) 2022-03-03 2023-09-06 Siemens Healthcare Diagnostics Products GmbH Globaltest zur feststellung des status des blutgerinnungssystems

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247454A (en) 1975-07-11 1981-01-27 Ab Kabi Novel chromogenic thrombin substrates
SE407571B (sv) 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
DE3428543A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue p-phenylendiamin-peptide und diese enthaltende reagenzien zur bestimmung von proteasen des blutgerinnungssystems
FR2611205B1 (fr) * 1987-02-20 1990-03-02 Serbio Dipeptides, procede de preparation et utilisation dans le dosage de proteases
NL8902406A (nl) * 1989-09-27 1991-04-16 Hendrik Coenraad Hemker Prof D Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit.

Also Published As

Publication number Publication date
EP0802986A1 (de) 1997-10-29
EP0802986B1 (de) 2001-09-19
ES2162025T3 (es) 2001-12-16
DE69615339D1 (de) 2001-10-25
WO1996021740A1 (en) 1996-07-18
AU4634896A (en) 1996-07-31
US6207399B1 (en) 2001-03-27

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