ES2162025T3 - Procedimientos para la determinacion del potencial de trombina endogena (etp) y sustratos de la trombina para su uso en esos procedimientos. - Google Patents
Procedimientos para la determinacion del potencial de trombina endogena (etp) y sustratos de la trombina para su uso en esos procedimientos.Info
- Publication number
- ES2162025T3 ES2162025T3 ES96902007T ES96902007T ES2162025T3 ES 2162025 T3 ES2162025 T3 ES 2162025T3 ES 96902007 T ES96902007 T ES 96902007T ES 96902007 T ES96902007 T ES 96902007T ES 2162025 T3 ES2162025 T3 ES 2162025T3
- Authority
- ES
- Spain
- Prior art keywords
- sample
- etp
- substrates
- group
- procedures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
UN PROCEDIMIENTO PARA DETERMINAR EL ETP (POTENCIAL DE TROMBINA ENDOGENO) DE UNA MUESTRA, PREFERIBLEMENTE EN UN ENSAYO CONTINUO, INCLUYENDO DICHA MUESTRA UNA ACTIVIDAD ANTICOAGULANTE TOTAL IGUAL O EQUIVALENTE A AL MENOS 0,07 U ISH/ML, EN EL CUAL UN SUSTRATO DE TROMBINA, O UNA SAL DEL MISMO, QUE ES SOLUBLE EN LA MUESTRA, SE APLICA EN UNA MANERA CONOCIDA POR SI MISMA, PARA DETERMINAR EL ETP DE UNA MUESTRA, ESTANDO SELECCIONADO DICHO SUSTRATO DE TROMBINA ENTRE EL GRUPO FORMADO POR SUSTRATOS DE FORMULA P INO, SIENDO DICHO GRUPO NO AROMATICO Y POLAR, VAL ES UN RADICAL VALINA UNIDO MEDIANTE UN ENLACE PEPTIDICO A XAA, XAA ES UN RADICAL AMINOACIDO QUE INCLUYE UN GRUPO GUANIDINO O UN GRUPO UREIDO TERMINAL, SEPARADO POR AL MENOS 2 ATOMOS DE CARBONO DEL ESQUELETO PEPTIDICO, ESTANDO DICHO RADICAL AMINOACIDO UNIDO A S, S ES UN GRUPO SEÑAL TAL COMO UN CROMOFORO, QUE PUEDE SER ENZIMATICAMENTE HIDROLIZADO. TAMBIEN PUEDEN UTILIZARSE OTROS SUSTRATOS, TALES COMO LOS SUSTRATOS QUE INCLUYEN LA ESTRUCTURA ZAA PIPECOLIL YAA RESENTA {SUB,D} TIROSINA, PRO REPRESENTA PROLINA, YAA ES UN RADICAL DE AMINOACIDO DISTINTO DE ARGININA, Y S ES UN MARCADOR SEÑAL. TAMBIEN SON APLICABLES LOS SUSTRATOS BOC TERMINACION DE ETP COMO TALES PUEDEN MEJORARSE MEDIANTE LA ADICION DE HIDROXILAMINA A LA MUESTRA, PARA EVITAR LA DESFIBRINACION DE LA MUESTRA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95200043 | 1995-01-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2162025T3 true ES2162025T3 (es) | 2001-12-16 |
Family
ID=8219949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96902007T Expired - Lifetime ES2162025T3 (es) | 1995-01-10 | 1996-01-10 | Procedimientos para la determinacion del potencial de trombina endogena (etp) y sustratos de la trombina para su uso en esos procedimientos. |
Country Status (6)
Country | Link |
---|---|
US (1) | US6207399B1 (es) |
EP (1) | EP0802986B1 (es) |
AU (1) | AU4634896A (es) |
DE (1) | DE69615339T2 (es) |
ES (1) | ES2162025T3 (es) |
WO (1) | WO1996021740A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5708591A (en) * | 1995-02-14 | 1998-01-13 | Akzo Nobel N.V. | Method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions |
US6321164B1 (en) | 1995-06-07 | 2001-11-20 | Akzo Nobel N.V. | Method and apparatus for predicting the presence of an abnormal level of one or more proteins in the clotting cascade |
US6429017B1 (en) | 1999-02-04 | 2002-08-06 | Biomerieux | Method for predicting the presence of haemostatic dysfunction in a patient sample |
US6898532B1 (en) | 1995-06-07 | 2005-05-24 | Biomerieux, Inc. | Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample |
US6502040B2 (en) | 1997-12-31 | 2002-12-31 | Biomerieux, Inc. | Method for presenting thrombosis and hemostasis assay data |
AU774889B2 (en) | 1999-02-04 | 2004-07-08 | Biomerieux, Inc. | A method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample |
PT1159448E (pt) * | 1999-03-04 | 2004-08-31 | Synapse Bv | Determinacao de formas biologicamente activas de enzimas proteoliticas |
US6740496B1 (en) | 1999-03-04 | 2004-05-25 | Synapse B.V. | Determination of biologically active forms of proteolytic enzymes |
US7179612B2 (en) | 2000-06-09 | 2007-02-20 | Biomerieux, Inc. | Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality |
EP1367135A1 (en) * | 2002-05-29 | 2003-12-03 | Pentapharm AG | Improved method for the assessment of thrombin formation in blood or plasma |
DE10360628A1 (de) * | 2003-12-19 | 2005-07-21 | Dade Behring Marburg Gmbh | Kontrollplasma für Thrombinaktivitätstests |
DE102004059055A1 (de) | 2004-12-07 | 2006-06-08 | Dade Behring Marburg Gmbh | Verfahren zur automatischen Bestimmung des endogenen Thrombinpotenzials |
DE102005003145B4 (de) * | 2005-01-21 | 2006-10-19 | Dade Behring Marburg Gmbh | Stablies, chromogenes Flüssigreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests |
DE102005008066A1 (de) | 2005-02-22 | 2006-08-24 | Haemosys Gmbh | Verfahren zur Bestimmung der Gesamtgerinnungsaktivität einer Blut- oder Plasmaprobe |
CA2626669A1 (en) * | 2005-10-13 | 2007-04-19 | Activesite Pharmaceuticals | Methods for indentification of inhibitors of enzyme activity |
EP2818871A1 (en) * | 2013-06-28 | 2014-12-31 | Roche Diagniostics GmbH | Means and methods for universal calibration of anti-Factor Xa tests |
WO2018234308A1 (en) | 2017-06-20 | 2018-12-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS FOR IDENTIFYING IF PATIENTS WITH ACUTE CARDIAC DISEASE FAILURE (ICAD) HAVE A HYPERCOAGULABLE CONDITION |
EP4239338A1 (de) | 2022-03-03 | 2023-09-06 | Siemens Healthcare Diagnostics Products GmbH | Globaltest zur feststellung des status des blutgerinnungssystems |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE407571B (sv) | 1975-07-11 | 1979-04-02 | Kabi Ab | Nya kromogena enzymsubstrat for serinproteaser |
US4247454A (en) | 1975-07-11 | 1981-01-27 | Ab Kabi | Novel chromogenic thrombin substrates |
DE3428543A1 (de) | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue p-phenylendiamin-peptide und diese enthaltende reagenzien zur bestimmung von proteasen des blutgerinnungssystems |
FR2611205B1 (fr) * | 1987-02-20 | 1990-03-02 | Serbio | Dipeptides, procede de preparation et utilisation dans le dosage de proteases |
NL8902406A (nl) * | 1989-09-27 | 1991-04-16 | Hendrik Coenraad Hemker Prof D | Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit. |
-
1996
- 1996-01-10 WO PCT/NL1996/000018 patent/WO1996021740A1/en active IP Right Grant
- 1996-01-10 US US08/860,808 patent/US6207399B1/en not_active Expired - Lifetime
- 1996-01-10 DE DE69615339T patent/DE69615339T2/de not_active Expired - Lifetime
- 1996-01-10 AU AU46348/96A patent/AU4634896A/en not_active Abandoned
- 1996-01-10 EP EP96902007A patent/EP0802986B1/en not_active Expired - Lifetime
- 1996-01-10 ES ES96902007T patent/ES2162025T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6207399B1 (en) | 2001-03-27 |
EP0802986B1 (en) | 2001-09-19 |
EP0802986A1 (en) | 1997-10-29 |
WO1996021740A1 (en) | 1996-07-18 |
DE69615339T2 (de) | 2002-07-04 |
AU4634896A (en) | 1996-07-31 |
DE69615339D1 (de) | 2001-10-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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