ATE63748T1 - Enzymwiderstandsfaehige immunomodulatorische peptide. - Google Patents

Enzymwiderstandsfaehige immunomodulatorische peptide.

Info

Publication number
ATE63748T1
ATE63748T1 AT84307968T AT84307968T ATE63748T1 AT E63748 T1 ATE63748 T1 AT E63748T1 AT 84307968 T AT84307968 T AT 84307968T AT 84307968 T AT84307968 T AT 84307968T AT E63748 T1 ATE63748 T1 AT E63748T1
Authority
AT
Austria
Prior art keywords
enzyme resistant
immunomodulatory peptides
peptides
methods
immunoregulatory disorders
Prior art date
Application number
AT84307968T
Other languages
English (en)
Inventor
Gideon Goldstein
George Heavner
Daniel Kroon
Tapan Audhya
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Application granted granted Critical
Publication of ATE63748T1 publication Critical patent/ATE63748T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/66—Thymopoietins
    • C07K14/662—Thymopoietins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/66—Thymopoietins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/18—Thymus derived hormone or factor; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Vibration Dampers (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT84307968T 1983-11-18 1984-11-16 Enzymwiderstandsfaehige immunomodulatorische peptide. ATE63748T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/553,281 US4505853A (en) 1983-11-18 1983-11-18 Enzyme-resistant immunomodulatory peptides
EP84307968A EP0146266B1 (de) 1983-11-18 1984-11-16 Enzymwiderstandsfähige immunomodulatorische Peptide

Publications (1)

Publication Number Publication Date
ATE63748T1 true ATE63748T1 (de) 1991-06-15

Family

ID=24208835

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84307968T ATE63748T1 (de) 1983-11-18 1984-11-16 Enzymwiderstandsfaehige immunomodulatorische peptide.

Country Status (14)

Country Link
US (1) US4505853A (de)
EP (1) EP0146266B1 (de)
JP (2) JPH0753752B2 (de)
KR (1) KR940001007B1 (de)
AT (1) ATE63748T1 (de)
AU (1) AU579595B2 (de)
CA (1) CA1269498A (de)
DE (1) DE3484616D1 (de)
DK (1) DK167928B1 (de)
FI (1) FI86860C (de)
IL (1) IL73533A (de)
NO (1) NO166943C (de)
NZ (1) NZ210194A (de)
ZA (1) ZA848973B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3401545A1 (de) * 1983-08-03 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue peptide mit immunstimulierender wirkung, verfahren zu deren herstellung und deren verwendung
US4629723A (en) * 1984-06-27 1986-12-16 Ortho Pharmaceutical Corporation Potent thymopentin analogs
AU602483B2 (en) * 1985-01-18 1990-10-18 Immunetech Pharmaceuticals Immunoregulatory peptides
DE3619633A1 (de) * 1986-06-11 1987-12-17 Hoechst Ag Peptide mit einfluss auf die diurese und natriurese, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
IT1216908B (it) * 1987-03-19 1990-03-14 Eniricerche Spa Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche.
US5200506A (en) * 1987-03-19 1993-04-06 Eniricerche S.P.A. Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
US5656601A (en) * 1987-06-19 1997-08-12 Berlin-Chemie Ag Acylated splenopentins, methods for their synthesis and their use
JPH01125328A (ja) * 1987-07-30 1989-05-17 Centro Natl De Biopreparados 髄膜炎菌ワクチン
US5728680A (en) * 1987-12-30 1998-03-17 Cytoven J.V. Methods for normalizing numbers of lymphocytes
US5807830A (en) * 1987-12-30 1998-09-15 Cytoven J.V. Method for treatment of purulent inflammatory diseases
GB8807427D0 (en) * 1988-03-28 1988-05-05 National Biological Standards Board Peptides
WO1989009229A1 (en) * 1988-03-31 1989-10-05 Immunobiology Research Institute, Inc. Treatment of hiv viremic patients with thymopentin
NZ229004A (en) 1988-05-19 1993-09-27 Immunobiology Res Inst Inc Tetrapeptides having t cell helper acitivity
HU201095B (en) * 1988-06-14 1990-09-28 Richter Gedeon Vegyeszet New peptides inhibiting the activity of the immune system and pharmaceutical compositions comprising same, as well as process for producing these peptides and compositions
IT1226552B (it) * 1988-07-29 1991-01-24 Ellem Ind Farmaceutica Peptidi immunostimolanti.
US5225400A (en) * 1988-07-29 1993-07-06 Ellem Industria Farmaceutica S.R.L. Immunostimulating peptides, a process for their preparation and pharmaceutical compositions containing them
KR900701298A (ko) * 1988-09-30 1990-12-01 원본미기재 T-세포 억제작용을 보유한 펩티드
DE3833936C1 (de) * 1988-10-05 1989-09-21 Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin, De
US5811399A (en) * 1988-12-14 1998-09-22 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants
US5218089A (en) * 1988-12-23 1993-06-08 Sclavo S.P.A. Retro-inverso analogues of thymopentin and the method for their synthesis
IT1227908B (it) * 1988-12-23 1991-05-14 Eniricerche S P A Milano Sclav Nuovi analoghi retro-inversi della timopentina, il metodo per la loro sintesi ed il loro impiego per la preparazione di composizioni farmaceutiche
US5036050A (en) * 1989-01-12 1991-07-30 Immunobiology Research Institute, Inc. Compositions containing thymopentin for topical treatment of skin disorders
US5770576A (en) * 1989-08-30 1998-06-23 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity
JP2745351B2 (ja) * 1991-02-14 1998-04-28 富士写真フイルム株式会社 ペプチド誘導体及びその用途
JPH06507402A (ja) * 1991-03-20 1994-08-25 ワーナー−ランバート・コンパニー 治療活性を有するα−置換ポリペプチド
DK53291D0 (da) * 1991-03-25 1991-03-25 Carlbiotech Ltd As Smaa peptider og peptidrelaterede stoffer samt farmaceutiske praeparater indeholdende saadanne forbindelser
US5215964A (en) * 1991-06-03 1993-06-01 Immunobiology Research Institute, Inc. Peptides useful in regulating the immune and nervous systems
US6066622A (en) * 1991-10-28 2000-05-23 Cytran, Inc. Immunomodulating peptides and methods of use
US6100380A (en) * 1991-10-28 2000-08-08 Cytran, Inc. Immunomodulating peptides and methods of use
US5965698A (en) * 1993-04-23 1999-10-12 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
AU6770794A (en) * 1993-04-23 1994-11-21 Herbert J. Evans Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5952465A (en) * 1993-04-23 1999-09-14 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5928896A (en) * 1993-04-23 1999-07-27 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US6258550B1 (en) 1993-04-23 2001-07-10 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5639729A (en) * 1993-08-26 1997-06-17 Immunobiology Research Institute, Inc. Tripeptides useful in immune and CNS therapy
US6084066A (en) * 1993-10-29 2000-07-04 Virginia Commonwealth University Polypetides that include conformation-constraining groups which flank a protein-protein interaction site
US6849712B1 (en) * 1998-01-22 2005-02-01 Regents Of The University Of Minnesota Peptides with β1 integrin subunit dependent cell adhesion modulating activity
CN1927879B (zh) * 2006-09-25 2010-11-24 吉林大学 胸腺五肽活性异构体及其在药物制备中的应用
CN101168560B (zh) * 2006-10-23 2012-09-05 江苏正大天晴药业股份有限公司 N-取代肽酰胺，其药物组合物与用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4077949A (en) 1973-12-28 1978-03-07 Sloan-Kettering Institute For Cancer Research Polypeptide hormones of the thymus
US4002740A (en) 1975-08-21 1977-01-11 Gideon Goldstein Tridecapeptide compositions and methods
US4190646A (en) * 1975-11-11 1980-02-26 Sloan-Kettering Institute For Cancer Research Polypeptide compositions and methods
CA1157466A (en) * 1979-04-12 1983-11-22 Gideon Goldstein Peptides having thymopoietin-like activity
ZA802170B (en) * 1979-04-12 1981-11-25 Ortho Pharma Corp Peptides having thymopoietin-like activity
US4261886A (en) * 1980-03-13 1981-04-14 Ortho Pharmaceutical Corporation Peptides having thymopoietin-like activity
DE2938420A1 (de) 1979-09-22 1981-04-09 Hoechst Ag, 6000 Frankfurt Neue peptide und verfahren zu ihrer herstellung
US4309340A (en) * 1980-03-31 1982-01-05 American Home Products Corporation Polypeptide compositions
US4298523A (en) * 1980-06-17 1981-11-03 Ortho Pharmaceutical Corporation Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R
US4369137A (en) * 1980-06-17 1983-01-18 Ortho Pharmaceutical Corporation N-Protected pentapeptides useful as intermediates in the preparation of thymopoietin pentapeptide
US4361673A (en) 1980-09-19 1982-11-30 American Home Products Corporation Polypeptide compositions
US4305852A (en) * 1980-10-20 1981-12-15 American Home Products Corporation Polypeptide compositions

Also Published As

Publication number Publication date
JPS60123498A (ja) 1985-07-02
JP2633481B2 (ja) 1997-07-23
EP0146266A3 (en) 1987-08-12
IL73533A0 (en) 1985-02-28
AU579595B2 (en) 1988-12-01
ZA848973B (en) 1986-06-25
EP0146266B1 (de) 1991-05-22
KR850004594A (ko) 1985-07-25
CA1269498A (en) 1990-05-22
NO844579L (no) 1985-05-20
US4505853A (en) 1985-03-19
JPH0753752B2 (ja) 1995-06-07
FI86860C (fi) 1992-10-26
JPH07165791A (ja) 1995-06-27
DK167928B1 (da) 1994-01-03
DE3484616D1 (de) 1991-06-27
KR940001007B1 (ko) 1994-02-08
AU3565284A (en) 1985-05-23
FI86860B (fi) 1992-07-15
NZ210194A (en) 1988-11-29
FI844510A0 (fi) 1984-11-16
IL73533A (en) 1988-06-30
NO166943B (no) 1991-06-10
NO166943C (no) 1991-09-18
EP0146266A2 (de) 1985-06-26
DK545584A (da) 1985-05-19
FI844510L (fi) 1985-05-19
DK545584D0 (da) 1984-11-16

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee