DE60016029D1 - Substituierte 1,3,4-oxadiazole und methode zur senkung des tnf-alpha-spiegels - Google Patents

Substituierte 1,3,4-oxadiazole und methode zur senkung des tnf-alpha-spiegels

Info

Publication number
DE60016029D1
DE60016029D1 DE60016029T DE60016029T DE60016029D1 DE 60016029 D1 DE60016029 D1 DE 60016029D1 DE 60016029 T DE60016029 T DE 60016029T DE 60016029 T DE60016029 T DE 60016029T DE 60016029 D1 DE60016029 D1 DE 60016029D1
Authority
DE
Germany
Prior art keywords
tnf
substituted
oxadiazoles
alpha
lowering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60016029T
Other languages
English (en)
Other versions
DE60016029T2 (de
Inventor
Hon-Wah Man
George Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Application granted granted Critical
Publication of DE60016029D1 publication Critical patent/DE60016029D1/de
Publication of DE60016029T2 publication Critical patent/DE60016029T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Paper (AREA)
DE60016029T 1999-12-21 2000-12-19 Substituierte 1,3,4-oxadiazole und methode zur senkung des tnf-alpha-spiegels Expired - Lifetime DE60016029T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/470,203 US6326388B1 (en) 1999-12-21 1999-12-21 Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level
US470203 1999-12-21
PCT/US2000/034457 WO2001046183A1 (en) 1999-12-21 2000-12-19 SUBSTITUTED 1,3,4-OXADIAZOLES AND A METHOD OF REDUCING TNF-α LEVELS

Publications (2)

Publication Number Publication Date
DE60016029D1 true DE60016029D1 (de) 2004-12-23
DE60016029T2 DE60016029T2 (de) 2005-10-20

Family

ID=23866662

Family Applications (3)

Application Number Title Priority Date Filing Date
DE60016029T Expired - Lifetime DE60016029T2 (de) 1999-12-21 2000-12-19 Substituierte 1,3,4-oxadiazole und methode zur senkung des tnf-alpha-spiegels
DE60042902T Expired - Lifetime DE60042902D1 (de) 1999-12-21 2000-12-19 Substituierte 1,3,4-Oxadiazole und ein Verfahren zur Reduktion des TNF-alpha Spiegels
DE60045320T Expired - Lifetime DE60045320D1 (de) 1999-12-21 2000-12-19 Substituierte 1,3,4-Oxadiazole zur Behandlung oder Prophylaxe von Krankheiten

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE60042902T Expired - Lifetime DE60042902D1 (de) 1999-12-21 2000-12-19 Substituierte 1,3,4-Oxadiazole und ein Verfahren zur Reduktion des TNF-alpha Spiegels
DE60045320T Expired - Lifetime DE60045320D1 (de) 1999-12-21 2000-12-19 Substituierte 1,3,4-Oxadiazole zur Behandlung oder Prophylaxe von Krankheiten

Country Status (18)

Country Link
US (1) US6326388B1 (de)
EP (3) EP1510518B1 (de)
JP (1) JP4806151B2 (de)
KR (2) KR100832499B1 (de)
CN (1) CN1413211A (de)
AT (3) ATE441644T1 (de)
AU (1) AU782168B2 (de)
CA (1) CA2394615C (de)
DE (3) DE60016029T2 (de)
ES (3) ES2356238T3 (de)
FI (1) FI121708B (de)
HK (3) HK1050522B (de)
MX (1) MXPA02006084A (de)
NO (1) NO323449B1 (de)
NZ (1) NZ529009A (de)
PT (1) PT1242413E (de)
TW (2) TW200733960A (de)
WO (1) WO2001046183A1 (de)

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DE60130799T2 (de) 2000-11-30 2008-07-17 Children's Medical Center Corp., Boston Synthese von 4-aminothalidomid enantiomeren
USRE48890E1 (en) 2002-05-17 2022-01-11 Celgene Corporation Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7393862B2 (en) 2002-05-17 2008-07-01 Celgene Corporation Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
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US7776907B2 (en) * 2002-10-31 2010-08-17 Celgene Corporation Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
CA2505003A1 (en) * 2002-11-06 2004-05-27 Celgene Corporation Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases
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US20070190070A1 (en) * 2004-09-03 2007-08-16 Zeldis Jerome B Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
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US7893045B2 (en) 2007-08-07 2011-02-22 Celgene Corporation Methods for treating lymphomas in certain patient populations and screening patients for said therapy
US8703152B2 (en) 2008-06-03 2014-04-22 University Of Rochester Methods of treating inflammatory intestinal disease and managing symptoms thereof
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US8563580B2 (en) 2008-09-23 2013-10-22 Georgetown University Flavivirus inhibitors and methods for their use
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JP5718323B2 (ja) * 2009-05-29 2015-05-13 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 放射標識されたｐｄｅ１０阻害剤
US9408831B2 (en) 2010-04-07 2016-08-09 Celgene Corporation Methods for treating respiratory viral infection
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Also Published As

Publication number Publication date
JP2003518115A (ja) 2003-06-03
EP1462449A1 (de) 2004-09-29
EP1462449B1 (de) 2009-09-02
EP1242413A1 (de) 2002-09-25
FI20021192A0 (fi) 2002-06-19
PT1242413E (pt) 2005-03-31
HK1050522B (zh) 2005-09-02
HK1069581A1 (en) 2005-05-27
KR20020072283A (ko) 2002-09-14
JP4806151B2 (ja) 2011-11-02
FI20021192A (fi) 2002-08-21
US6326388B1 (en) 2001-12-04
DE60045320D1 (de) 2011-01-13
EP1510518B1 (de) 2010-12-01
NO20022937L (no) 2002-08-15
AU2278501A (en) 2001-07-03
KR100832499B1 (ko) 2008-05-26
ATE441644T1 (de) 2009-09-15
NO323449B1 (no) 2007-05-14
EP1510518A2 (de) 2005-03-02
NZ529009A (en) 2006-02-24
EP1510518A3 (de) 2006-11-22
HK1050522A1 (en) 2003-06-27
DE60016029T2 (de) 2005-10-20
HK1075890A1 (en) 2005-12-30
EP1242413A4 (de) 2003-04-23
ES2333011T3 (es) 2010-02-16
TWI280961B (en) 2007-05-11
FI121708B (fi) 2011-03-15
ATE489996T1 (de) 2010-12-15
TW200733960A (en) 2007-09-16
EP1462449B9 (de) 2010-03-10
ATE282612T1 (de) 2004-12-15
CN1413211A (zh) 2003-04-23
EP1242413B1 (de) 2004-11-17
ES2356238T3 (es) 2011-04-06
CA2394615C (en) 2010-03-02
KR20070049688A (ko) 2007-05-11
ES2233488T3 (es) 2005-06-16
NO20022937D0 (no) 2002-06-18
MXPA02006084A (es) 2004-10-14
AU782168B2 (en) 2005-07-07
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WO2001046183A1 (en) 2001-06-28
CA2394615A1 (en) 2001-06-28

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