DE511782T1 - Polymerzusammensetzung zum Bleichen von Zähnen und andere Anwendungen davon. - Google Patents
Polymerzusammensetzung zum Bleichen von Zähnen und andere Anwendungen davon.Info
- Publication number
- DE511782T1 DE511782T1 DE0511782T DE92303648T DE511782T1 DE 511782 T1 DE511782 T1 DE 511782T1 DE 0511782 T DE0511782 T DE 0511782T DE 92303648 T DE92303648 T DE 92303648T DE 511782 T1 DE511782 T1 DE 511782T1
- Authority
- DE
- Germany
- Prior art keywords
- cellulose
- pharmaceutically
- polymer
- polymer composition
- veterinarily acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000642 polymer Polymers 0.000 title claims abstract 18
- 239000000203 mixture Substances 0.000 title claims abstract 16
- 238000004061 bleaching Methods 0.000 title claims abstract 5
- 239000007788 liquid Substances 0.000 claims abstract 6
- 239000007800 oxidant agent Substances 0.000 claims abstract 5
- 208000002064 Dental Plaque Diseases 0.000 claims abstract 2
- 208000025157 Oral disease Diseases 0.000 claims abstract 2
- 208000007565 gingivitis Diseases 0.000 claims abstract 2
- 208000030194 mouth disease Diseases 0.000 claims abstract 2
- 208000028169 periodontal disease Diseases 0.000 claims abstract 2
- -1 carboxy- Chemical class 0.000 claims 7
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 3
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims 3
- 229920013820 alkyl cellulose Polymers 0.000 claims 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 3
- 229920002678 cellulose Polymers 0.000 claims 3
- 239000001913 cellulose Substances 0.000 claims 3
- 235000010980 cellulose Nutrition 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
- SHWNNYZBHZIQQV-UHFFFAOYSA-J EDTA monocalcium diisodium salt Chemical compound [Na+].[Na+].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O SHWNNYZBHZIQQV-UHFFFAOYSA-J 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 208000004509 Tooth Discoloration Diseases 0.000 claims 2
- 206010044032 Tooth discolouration Diseases 0.000 claims 2
- 229940078916 carbamide peroxide Drugs 0.000 claims 2
- 230000036367 tooth discoloration Effects 0.000 claims 2
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical class OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960001425 deferoxamine mesylate Drugs 0.000 claims 1
- 210000003074 dental pulp Anatomy 0.000 claims 1
- 210000004262 dental pulp cavity Anatomy 0.000 claims 1
- IDDIJAWJANBQLJ-UHFFFAOYSA-N desferrioxamine B mesylate Chemical compound [H+].CS([O-])(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN IDDIJAWJANBQLJ-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008213 purified water Substances 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims 1
- GXVVGSXXQJBWDD-UHFFFAOYSA-M trisodium;dioxido(oxidooxy)borane;hydrate Chemical compound O.[Na+].[Na+].[Na+].[O-]OB([O-])[O-] GXVVGSXXQJBWDD-UHFFFAOYSA-M 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
- 239000007844 bleaching agent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Detergent Compositions (AREA)
- Dental Preparations (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (11)
1. Langzeinwirkende, filmbildende Polymerzusammensetzung,
welche enthält:
(a) ein wasserlösliches celluloseartiges Polymer, das ein Hydroxy- oder Carboxy-, Mono- oder
Di-(C1-4)alkylcellulosepolymer wie Hydroxypropylcellulose,
Hydroxypropylethylcellulose, Hydroxypropylmethylcellulose, Hydroxyethylcellulose, Hydroxyethylmethylcellulose
und/oder Carboxymethylcellulose ist;
(b) ein pharmazeutisch oder tiermedizinisch verträgliches Oxidationsmittel; und
einen pharmazeutisch oder tiermedizinisch verträglichen Träger.
2. Zusammensetzung nach Anspruch 1, die ferner einen pharmazeutisch
verträglichen, stabilisierenden, vorzugsweise in einer alkoholisch-wäßrigen Lösung löslichen Zusatzstoff,
enthält.
3. Zusammensetzung nach Anspruch 1 oder 2, die zusätzlich ein Edetatsalz wie Kalziumdinatriumedetat oder Tetranatriumedetat
oder Deferoxaminmesylat und/oder Zitronensäure enthält.
4. Zusammensetzung nach einem der Ansprüche 1 bis 3, wobei das Oxidationsmittel eine Peroxidverbindung, wie Wasserstoffperoxid,
Natrxumperoxyboratmonohydrat oder insbesondere Carbamidperoxid, ist, und zum Beispiel in
einer Menge von 1% (G/G) bis 15% (G/G) vorliegt.
5. Zusammensetzung nach einem der Ansprüche 1 bis 4, bei welcher das Polymer Hydroxypropylcellulose ist, die
geeigneterweise in einer Menge von 5% (G/G) bis 15% (G/G), wie z.B. etwa 12,5% (G/G) vorliegt.
6. Flüssige Polymerzusammensetzung, vorzugsweise nach einem
der Ansprüche 1 bis 5, welche etwa 12,5% (G/G) Hydroxypropylcellulose,
etwa 3,0% (G/G) Carbamidperoxid,
etwa 0,15% (G/G) Kalziumdinatriumedetat, etwa 60% (G/G)
Ethylalkohol und gereinigtes Wasser, das die Differenz zu 100% (G/G) bildet, enthält.
7. Verfahren zum äußeren Bleichen von Zähnen oder zum Verhindern einer äußeren Zahnverfärbung, wobei das Verfahren
die lokale Anwendung einer flüssigen Polymerzusammensetzung nach einem der Ansprüche 1 bis 6 an einem
Zahn eines Menschen oder Tieres umfaßt.
8. Verfahren nach Anspruch 7 zum äußeren Bleichen von verfärbten Zähnen, wobei die flüssige Polymerzusammensetzung
ein- bis dreimal täglich auf einem Zahn aufgetragen wird, oder zum Verhindern einer Zahnverfärbung, wobei
das flüssige Polymer ein- oder zweimal wöchentlich auf einem Zahn aufgetragen wird.
9. Verfahren zum inneren Bleichen von verfärbten Zähnen, umfassend das Einführen einer flüssigen Polymerzusammensetzung
nach einem der Ansprüche 1 bis 6 in die Pulpahöhle eines Zahnes eines Menschen oder Tieres, wie
zum Beispiel durch örtliche Anwendung der Zusammensetzung im Wurzelkanal, und vorzugsweise derart, daß die in
die Zahnpulpa eingeführte Zusammensetzung darin verschlossen ist.
10. Langzeitwirkende, filmbildende Polymerzusammensetzung,
welche
(a) ein wasserlösliches celluloseartiges Polymer, das ein Hydroxy- oder Carboxy-, Mono- oder
Di-(C1-4)alkylcellulosepolymer wie Hydroxypropylcellulose,
Hydroxypropylethylcellulose, Hydroxypropylmethylcellulose, Hydroxyethylcellulose, Hydroxyethylmethylcellulose
und/oder Carboxymethylcellulose ist;
(b) ein pharmazeutisch oder tiermedizinisch verträgliches Oxidationsmittel; und
einen pharmazeutisch oder tiermedizinisch verträglichen Träger, enthäIt,
zur Verwendung in der Medizin.
11. Verwendung einer langzeitwirkenden, filmbildenden
Polymerzusammensetzung, welche
(a) ein wasserlösliches celluloseartiges Polymer, das ein Hydroxy- oder Carboxy-, Mono- oder Di-(C1-4)
alkylcellulosepolymer wie Hydroxypropylcellulose, Hydroxypropylethylcellulose, Hydroxypropylmethylcellulose,
Hydroxyethylcellulose, Hydroxyethylmethylcellulose und/oder Carboxymethylcellulose ist;
(b) ein pharmazeutisch oder tiermedizinisch verträgliches Oxidationsmittel; und
einen pharmazeutisch oder tiermedizinisch verträglichen Träger enthält,
in der Herstellung eines Mittels zur Behandlung einer oralen oder periodontalen Erkrankung, wie Gingivitis
oder Zahnbelag.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL9793091A IL97930A (en) | 1991-04-23 | 1991-04-23 | Preparations for whitening two controlled release products that contain a super-oxygen compound |
Publications (1)
Publication Number | Publication Date |
---|---|
DE511782T1 true DE511782T1 (de) | 1994-09-22 |
Family
ID=11062285
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69227941T Expired - Fee Related DE69227941T2 (de) | 1991-04-23 | 1992-04-23 | Polymerzusammensetzung zum Bleichen von Zähnen und andere Anwendungen davon |
DE0511782T Pending DE511782T1 (de) | 1991-04-23 | 1992-04-23 | Polymerzusammensetzung zum Bleichen von Zähnen und andere Anwendungen davon. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69227941T Expired - Fee Related DE69227941T2 (de) | 1991-04-23 | 1992-04-23 | Polymerzusammensetzung zum Bleichen von Zähnen und andere Anwendungen davon |
Country Status (16)
Country | Link |
---|---|
US (1) | US5425953A (de) |
EP (1) | EP0511782B1 (de) |
JP (1) | JPH06128130A (de) |
KR (1) | KR920019333A (de) |
AT (1) | ATE174787T1 (de) |
AU (1) | AU656954B2 (de) |
CA (1) | CA2066917A1 (de) |
DE (2) | DE69227941T2 (de) |
ES (1) | ES2053412T3 (de) |
GR (1) | GR940300050T1 (de) |
HU (1) | HUT65094A (de) |
IL (1) | IL97930A (de) |
PL (1) | PL171141B1 (de) |
RU (1) | RU2106136C1 (de) |
TW (1) | TW436290B (de) |
ZA (1) | ZA922940B (de) |
Families Citing this family (136)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5279816A (en) * | 1991-11-22 | 1994-01-18 | Colgate-Palmolive Co. | Oral composition having improved tooth whitening effect |
US5462728A (en) * | 1994-04-05 | 1995-10-31 | Blank; Izhak | Pharmaceutical compositions |
US5500207A (en) * | 1994-11-18 | 1996-03-19 | Goulet; Marie-Kateri | Method of whitening teeth and composition therefore |
JP2000506490A (ja) * | 1995-08-18 | 2000-05-30 | ノボ ノルディスク アクティーゼルスカブ | 歯の漂白 |
US20050152950A1 (en) * | 1995-11-13 | 2005-07-14 | Saffran Bruce N. | Method and apparatus for macromolecular delivery using a coated membrane |
CN1061843C (zh) * | 1996-01-19 | 2001-02-14 | 黄力子 | 牙齿增白涂膜 |
US5718886A (en) * | 1996-03-11 | 1998-02-17 | Laclede Professional Products, Inc. | Stabilized anhydrous tooth whitening gel |
US6125325A (en) | 1996-04-25 | 2000-09-26 | Sirf Technology, Inc. | GPS receiver with cross-track hold |
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US6391283B1 (en) * | 1997-01-10 | 2002-05-21 | Ultradent Products, Inc. | Methods and apparatus for activating dental compositions |
US5858332A (en) * | 1997-01-10 | 1999-01-12 | Ultradent Products, Inc. | Dental bleaching compositions with high concentrations of hydrogen peroxide |
JPH10251131A (ja) * | 1997-03-11 | 1998-09-22 | Sunstar Inc | 口腔用組成物 |
US6008264A (en) | 1997-04-30 | 1999-12-28 | Laser Med, Inc. | Method for curing polymeric materials, such as those used in dentistry, and for tailoring the post-cure properties of polymeric materials through the use of light source power modulation |
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ATE368428T1 (de) * | 1997-06-06 | 2007-08-15 | Procter & Gamble | Vorrichtung zur verabreichung von zahnbleicher unter verwendung eines streifens mit geringer biegesteifigkeit |
US6582708B1 (en) | 2000-06-28 | 2003-06-24 | The Procter & Gamble Company | Tooth whitening substance |
US5894017A (en) * | 1997-06-06 | 1999-04-13 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
US20020018754A1 (en) * | 1999-03-15 | 2002-02-14 | Paul Albert Sagel | Shapes for tooth whitening strips |
US5989569A (en) * | 1997-06-06 | 1999-11-23 | The Procter & Gamble Company | Delivery system for a tooth whitener using a permanently deformable strip of material |
US5879691A (en) | 1997-06-06 | 1999-03-09 | The Procter & Gamble Company | Delivery system for a tooth whitener using a strip of material having low flexural stiffness |
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-
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- 1991-04-23 IL IL9793091A patent/IL97930A/en not_active IP Right Cessation
-
1992
- 1992-04-22 US US07/871,969 patent/US5425953A/en not_active Expired - Lifetime
- 1992-04-22 RU SU5011597A patent/RU2106136C1/ru active
- 1992-04-23 HU HU9201354A patent/HUT65094A/hu unknown
- 1992-04-23 ES ES92303648T patent/ES2053412T3/es not_active Expired - Lifetime
- 1992-04-23 EP EP92303648A patent/EP0511782B1/de not_active Expired - Lifetime
- 1992-04-23 JP JP4130032A patent/JPH06128130A/ja active Pending
- 1992-04-23 KR KR1019920007085A patent/KR920019333A/ko active IP Right Grant
- 1992-04-23 CA CA002066917A patent/CA2066917A1/en not_active Abandoned
- 1992-04-23 AT AT92303648T patent/ATE174787T1/de not_active IP Right Cessation
- 1992-04-23 DE DE69227941T patent/DE69227941T2/de not_active Expired - Fee Related
- 1992-04-23 DE DE0511782T patent/DE511782T1/de active Pending
- 1992-04-23 AU AU15116/92A patent/AU656954B2/en not_active Ceased
- 1992-04-23 ZA ZA922940A patent/ZA922940B/xx unknown
- 1992-04-23 PL PL92294308A patent/PL171141B1/pl unknown
- 1992-08-15 TW TW081106469A patent/TW436290B/zh active
-
1994
- 1994-08-31 GR GR940300050T patent/GR940300050T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
RU2106136C1 (ru) | 1998-03-10 |
ES2053412T1 (es) | 1994-08-01 |
PL294308A1 (de) | 1993-02-08 |
CA2066917A1 (en) | 1992-10-24 |
KR920019333A (ko) | 1992-11-19 |
PL171141B1 (pl) | 1997-03-28 |
US5425953A (en) | 1995-06-20 |
AU656954B2 (en) | 1995-02-23 |
DE69227941D1 (de) | 1999-02-04 |
DE69227941T2 (de) | 1999-08-26 |
EP0511782A1 (de) | 1992-11-04 |
ES2053412T3 (es) | 1999-05-01 |
IL97930A (en) | 1996-06-18 |
TW436290B (en) | 2001-05-28 |
ZA922940B (en) | 1993-04-28 |
JPH06128130A (ja) | 1994-05-10 |
ATE174787T1 (de) | 1999-01-15 |
HU9201354D0 (en) | 1992-07-28 |
IL97930A0 (en) | 1992-06-21 |
EP0511782B1 (de) | 1998-12-23 |
AU1511692A (en) | 1992-10-29 |
HUT65094A (en) | 1994-04-28 |
GR940300050T1 (de) | 1994-08-31 |
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