DE4003844B4 - Neue Cyclosporin enthaltende galenische Formulierungen - Google Patents

Neue Cyclosporin enthaltende galenische Formulierungen Download PDF

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Publication number
DE4003844B4
DE4003844B4 DE4003844A DE4003844A DE4003844B4 DE 4003844 B4 DE4003844 B4 DE 4003844B4 DE 4003844 A DE4003844 A DE 4003844A DE 4003844 A DE4003844 A DE 4003844A DE 4003844 B4 DE4003844 B4 DE 4003844B4
Authority
DE
Germany
Prior art keywords
component
components
cyclosporin
composition according
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE4003844A
Other languages
German (de)
English (en)
Other versions
DE4003844A1 (de
Inventor
Birgit Dr. Hauer
Ulrich Dr. Posanski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898902898A external-priority patent/GB8902898D0/en
Priority claimed from GB898902901A external-priority patent/GB8902901D0/en
Priority claimed from GB898903147A external-priority patent/GB8903147D0/en
Priority claimed from GB898903663A external-priority patent/GB8903663D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE4003844A1 publication Critical patent/DE4003844A1/de
Application granted granted Critical
Publication of DE4003844B4 publication Critical patent/DE4003844B4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
DE4003844A 1989-02-09 1990-02-08 Neue Cyclosporin enthaltende galenische Formulierungen Expired - Lifetime DE4003844B4 (de)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB898902898A GB8902898D0 (en) 1989-02-09 1989-02-09 Improvements in or relating to organic compounds
GB02898/89 1989-02-09
GB898902901A GB8902901D0 (en) 1989-02-09 1989-02-09 Improvements in or relating to organic compounds
GB02901/89 1989-02-09
GB898903147A GB8903147D0 (en) 1989-02-13 1989-02-13 Improvements in or relating to organic compounds
GB03147/89 1989-02-13
GB898903663A GB8903663D0 (en) 1989-02-17 1989-02-17 Improvements in or relating to organic compounds
GB03663/89 1989-02-17

Publications (2)

Publication Number Publication Date
DE4003844A1 DE4003844A1 (de) 1990-08-16
DE4003844B4 true DE4003844B4 (de) 2007-09-20

Family

ID=27450262

Family Applications (1)

Application Number Title Priority Date Filing Date
DE4003844A Expired - Lifetime DE4003844B4 (de) 1989-02-09 1990-02-08 Neue Cyclosporin enthaltende galenische Formulierungen

Country Status (25)

Country Link
JP (3) JP3484190B2 (fr)
KR (1) KR0170769B1 (fr)
AT (1) AT404552B (fr)
AU (1) AU630413B2 (fr)
BE (1) BE1003009A5 (fr)
CA (1) CA2009533C (fr)
CH (1) CH679277A5 (fr)
CY (1) CY1903A (fr)
DE (1) DE4003844B4 (fr)
DK (1) DK176209B1 (fr)
ES (1) ES2021942A6 (fr)
FI (1) FI97524C (fr)
FR (1) FR2642650B1 (fr)
GB (1) GB2230440B (fr)
HK (1) HK37296A (fr)
HU (1) HU213394B (fr)
IT (1) IT1240758B (fr)
LU (1) LU87675A1 (fr)
MY (1) MY107377A (fr)
NL (1) NL195028C (fr)
NO (1) NO301576B1 (fr)
NZ (1) NZ232401A (fr)
PH (1) PH30917A (fr)
PT (1) PT93079B (fr)
SE (1) SE511398C2 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
MX9201782A (es) † 1991-04-19 1992-10-01 Sandoz Ag Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
ES2098739T3 (es) 1992-05-13 1997-05-01 Sandoz Ltd Composiciones oftalmicas conteniendo una cyclosporin.
US5759566A (en) * 1992-07-28 1998-06-02 Poli Industria Chimica Spa Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
EP0589843B1 (fr) 1992-09-25 2001-11-28 Novartis AG Compositions pharmaceutiques comprenant de la cyclosporine
DE4412201A1 (de) * 1993-04-20 1994-11-10 Rentschler Arzneimittel Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin
SK283442B6 (sk) * 1993-04-20 2003-07-01 Novartis Ag Farmaceutický prípravok na orálne podanie
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
RU2158601C2 (ru) 1994-11-03 2000-11-10 Новартис Аг Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения
US5679566A (en) * 1995-01-20 1997-10-21 University Of Massachusetts Medical Center Yeast NMD2 gene
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
US5798333A (en) * 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
AU762247B2 (en) * 1997-01-30 2003-06-19 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A
NZ336900A (en) * 1997-01-30 2001-06-29 Novartis Ag Hard gelatine capsules containing pharmaceutical compositions comprising cyclosporin A and being substantially free of any oil
SI0969856T1 (en) * 1997-03-12 2005-06-30 Abbott Laboratories Hydrophilic binary systems for the administration of cyclosporine
NZ328751A (en) * 1997-09-16 1999-01-28 Bernard Charles Sherman Solid medicament containing an anionic surfactant and cyclosporin
US6447806B1 (en) 1999-02-25 2002-09-10 Novartis Ag Pharmaceutical compositions comprised of stabilized peptide particles
US6979672B2 (en) 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
JP4521554B2 (ja) * 2004-03-31 2010-08-11 マイラン製薬株式会社 シクロスポリン製剤
US8333989B2 (en) * 2005-10-26 2012-12-18 Banner Pharmacaps, Inc. Hydrophilic vehicle-based dual controlled release matrix system
WO2007112272A2 (fr) 2006-03-28 2007-10-04 Javelin Pharmaceuticals, Inc. Formulations de diclofénac et de cyclodextrine bêta à faible dosage
US7495024B2 (en) 2006-08-07 2009-02-24 Via Pharmaceuticals, Inc. Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
DE102008059201A1 (de) * 2008-11-27 2010-06-02 GÖPFERICH, Achim, Prof. Dr. In situ präzipitierende Arzneistofflösungen
KR102146704B1 (ko) 2018-04-13 2020-08-21 가천대학교 산학협력단 사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체
WO2023063376A1 (fr) * 2021-10-13 2023-04-20 中外製薬株式会社 Composition comprenant un composé peptidique et un tensioactif

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4388307A (en) * 1978-03-07 1983-06-14 Sandoz Ltd. Galenical compositions
EP0296122A2 (fr) * 1987-06-17 1988-12-21 Sandoz Ag Cycloporines et leur emploi comme médicaments
FR2620336A1 (fr) * 1987-09-15 1989-03-17 Sandoz Sa Utilisation de monoesters solubles dans l'eau d'acides gras comme solubilisants de medicaments
US5756450A (en) * 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61280435A (ja) * 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤
NL8600050A (nl) * 1986-01-13 1987-08-03 Sanico Nv Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van.
GB8602372D0 (en) * 1986-01-31 1986-03-05 Sandoz Ltd Organic compounds
CA1290249C (fr) * 1986-04-09 1991-10-08 Cetus Corporation TRAITEMENT A BASE D'INTERLEUKINE-2 ET (OU) D'INTERFERON .beta. ET FACTEUR DE NECROSE TUMORALE
CA1341374C (fr) * 1986-11-13 2002-07-09 Alan N. Houghton Compositions et procede de traitement du cancer utilisant un anticorps monoclonal dirige contre le ganglioside gd3, ensemble avec il-2
JP2536876B2 (ja) * 1987-07-31 1996-09-25 寛治 高田 シクロスポリンの溶解性粉末状製剤
DE3830494B4 (de) * 1987-09-15 2006-05-18 Novartis Ag Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe
JP2792862B2 (ja) * 1988-07-30 1998-09-03 寛治 高田 経口腸溶製剤
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
JPH1038029A (ja) * 1996-07-26 1998-02-13 Ebara Corp 制振機能付き円板状構造物
JPH10280435A (ja) * 1997-04-03 1998-10-20 Sekisui Chem Co Ltd 地下室の構築方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4388307A (en) * 1978-03-07 1983-06-14 Sandoz Ltd. Galenical compositions
EP0296122A2 (fr) * 1987-06-17 1988-12-21 Sandoz Ag Cycloporines et leur emploi comme médicaments
FR2620336A1 (fr) * 1987-09-15 1989-03-17 Sandoz Sa Utilisation de monoesters solubles dans l'eau d'acides gras comme solubilisants de medicaments
US5756450A (en) * 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms

Also Published As

Publication number Publication date
GB2230440A (en) 1990-10-24
FI900604A0 (fi) 1990-02-07
IT9047609A0 (it) 1990-02-08
NL9000299A (nl) 1990-09-03
DK176209B1 (da) 2007-02-05
KR0170769B1 (ko) 1999-02-01
NL195028C (nl) 2003-12-02
JP2001302538A (ja) 2001-10-31
JPH02235817A (ja) 1990-09-18
JP2006001947A (ja) 2006-01-05
NO900577L (no) 1990-08-10
AU630413B2 (en) 1992-10-29
HU900701D0 (en) 1990-04-28
GB9002504D0 (en) 1990-04-04
NO301576B1 (no) 1997-11-17
FR2642650B1 (fr) 1994-12-09
LU87675A1 (fr) 1991-10-08
SE511398C2 (sv) 1999-09-20
JP4073641B2 (ja) 2008-04-09
MY107377A (en) 1995-11-30
PH30917A (en) 1997-12-23
IT9047609A1 (it) 1991-08-08
ATA27290A (de) 1998-05-15
PT93079B (pt) 1996-04-30
AT404552B (de) 1998-12-28
FR2642650A1 (fr) 1990-08-10
CA2009533C (fr) 2002-11-12
IT1240758B (it) 1993-12-17
FI97524C (fi) 1997-01-10
CA2009533A1 (fr) 1990-08-09
FI97524B (fi) 1996-09-30
GB2230440B (en) 1993-05-19
SE9000441L (sv) 1991-08-08
DE4003844A1 (de) 1990-08-16
NO900577D0 (no) 1990-02-07
DK32790D0 (da) 1990-02-07
BE1003009A5 (fr) 1991-10-22
DK32790A (da) 1990-08-10
KR900012625A (ko) 1990-09-01
ES2021942A6 (es) 1991-11-16
CY1903A (en) 1996-11-22
JP3484190B2 (ja) 2004-01-06
PT93079A (pt) 1990-08-31
HK37296A (en) 1996-03-15
HU213394B (en) 1997-06-30
NL195028B (nl) 2003-08-01
NZ232401A (en) 1992-10-28
CH679277A5 (fr) 1992-01-31
SE9000441D0 (sv) 1990-02-07
AU4925290A (en) 1990-08-16

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: A61K 38/13

8127 New person/name/address of the applicant

Owner name: NOVARTIS AG, BASEL, CH

8128 New person/name/address of the agent

Representative=s name: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

R082 Change of representative

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE

Representative=s name: DR. SCHOEN & PARTNER, DE

Representative=s name: DR. SCHOEN, NEYMEYR & PARTNER MBB, DE