MY107377A - Novel cyclosporin galenic forms. - Google Patents

Novel cyclosporin galenic forms.

Info

Publication number
MY107377A
MY107377A MYPI90000191A MYPI19900191A MY107377A MY 107377 A MY107377 A MY 107377A MY PI90000191 A MYPI90000191 A MY PI90000191A MY PI19900191 A MYPI19900191 A MY PI19900191A MY 107377 A MY107377 A MY 107377A
Authority
MY
Malaysia
Prior art keywords
alkylene
galenic forms
glycol
ethanol
novel cyclosporin
Prior art date
Application number
MYPI90000191A
Inventor
Ulrich Posanski Dr
Birgit Hauer Dr
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898902898A external-priority patent/GB8902898D0/en
Priority claimed from GB898902901A external-priority patent/GB8902901D0/en
Priority claimed from GB898903147A external-priority patent/GB8903147D0/en
Priority claimed from GB898903663A external-priority patent/GB8903663D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MY107377A publication Critical patent/MY107377A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

PHARMACEUTICAL COMPOSITIONS COMPRISING (a) A CYCLOSPORIN AS ACTIVE INGREDIENT (b) A FATTY ACID SACCHARIDE MONOESTER AND (c) A DILUENT OR CARRIER.COMPONENTS (c) ARE TYPICALLY ETHANOL, AN ALKYLENE GLYCOL (E.G. 1, 2-PROPYLENE GLYCOL), AN ALKYLENE POLYOL (E.G. GLYCEROL), POLYALKYLENE GLYCOL (E.G. PEG), AN ALKYLENE POLYOL ETHER OR ESTER (E.G.A GELUCIR PRODUCT), PARAFFINUM PER- OR SUB-LIQUIDUM OR AN ORGANOSILICON OXIDE POLYMER, ETHANOL BEING LESS PREFERRED.
MYPI90000191A 1989-02-09 1990-02-07 Novel cyclosporin galenic forms. MY107377A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898902898A GB8902898D0 (en) 1989-02-09 1989-02-09 Improvements in or relating to organic compounds
GB898902901A GB8902901D0 (en) 1989-02-09 1989-02-09 Improvements in or relating to organic compounds
GB898903147A GB8903147D0 (en) 1989-02-13 1989-02-13 Improvements in or relating to organic compounds
GB898903663A GB8903663D0 (en) 1989-02-17 1989-02-17 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
MY107377A true MY107377A (en) 1995-11-30

Family

ID=27450262

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI90000191A MY107377A (en) 1989-02-09 1990-02-07 Novel cyclosporin galenic forms.

Country Status (25)

Country Link
JP (3) JP3484190B2 (en)
KR (1) KR0170769B1 (en)
AT (1) AT404552B (en)
AU (1) AU630413B2 (en)
BE (1) BE1003009A5 (en)
CA (1) CA2009533C (en)
CH (1) CH679277A5 (en)
CY (1) CY1903A (en)
DE (1) DE4003844B4 (en)
DK (1) DK176209B1 (en)
ES (1) ES2021942A6 (en)
FI (1) FI97524C (en)
FR (1) FR2642650B1 (en)
GB (1) GB2230440B (en)
HK (1) HK37296A (en)
HU (1) HU213394B (en)
IT (1) IT1240758B (en)
LU (1) LU87675A1 (en)
MY (1) MY107377A (en)
NL (1) NL195028C (en)
NO (1) NO301576B1 (en)
NZ (1) NZ232401A (en)
PH (1) PH30917A (en)
PT (1) PT93079B (en)
SE (1) SE511398C2 (en)

Families Citing this family (33)

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Publication number Priority date Publication date Assignee Title
KR0148748B1 (en) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 A multiphase cyclosporin composition
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
MX9201782A (en) † 1991-04-19 1992-10-01 Sandoz Ag PARTICLES OF BIOLOGICALLY ACTIVE SUBSTANCES, SUBSTANTIALLY INSOLUBLE IN WATER, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM.
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
EP0642332B1 (en) 1992-05-13 1997-01-15 Sandoz Ltd. Ophthalmic compositions containing a cyclosporin
US5759566A (en) * 1992-07-28 1998-06-02 Poli Industria Chimica Spa Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
DK0589843T3 (en) 1992-09-25 2002-04-02 Novartis Ag Cyclosporin-containing pharmaceutical preparations
ATE218878T1 (en) * 1993-04-20 2002-06-15 Novartis Erfind Verwalt Gmbh NEW PHARMACEUTICAL PREPARATIONS FOR ORAL ADMINISTRATION CONTAINING CYCLOSPORINE
DE4412201A1 (en) * 1993-04-20 1994-11-10 Rentschler Arzneimittel New pharmaceutical preparations for oral administration containing cyclosporin
DE4340781C3 (en) * 1993-11-30 2000-01-27 Novartis Ag Liquid preparations containing cyclosporin and process for their preparation
KR0146671B1 (en) * 1994-02-25 1998-08-17 김충환 Cyclosporin-containing powder composition
PT789580E (en) 1994-11-03 2002-09-30 Novartis Ag CYCLOSPORINE FORMULATIONS FOR ORAL ADMINISTRATION WITH SIMPLE COMPOSITION AND HIGH BIODISPONIBILITY AND PROCESS FOR ITS PRODUCTION
US5679566A (en) * 1995-01-20 1997-10-21 University Of Massachusetts Medical Center Yeast NMD2 gene
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
DE19544507B4 (en) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin containing preparations
US5798333A (en) * 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
AU762247B2 (en) * 1997-01-30 2003-06-19 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A
IL130797A0 (en) 1997-01-30 2001-01-28 Novartis Ag Hard gelatine capsules containing pharmaceutical compositions substantially free of any oil
CZ301382B6 (en) * 1997-03-12 2010-02-10 Abbott Laboratories Chad377/Ap6D-2 Hydrophilic binary systems for administering cyclosporin
NZ328751A (en) * 1997-09-16 1999-01-28 Bernard Charles Sherman Solid medicament containing an anionic surfactant and cyclosporin
US6447806B1 (en) 1999-02-25 2002-09-10 Novartis Ag Pharmaceutical compositions comprised of stabilized peptide particles
US6979672B2 (en) 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
JP4521554B2 (en) * 2004-03-31 2010-08-11 マイラン製薬株式会社 Cyclosporine preparation
JP5406530B2 (en) * 2005-10-26 2014-02-05 バナー ファーマキャプス， インコーポレイテッド Dual controlled release matrix system based on hydrophilic vehicle
AU2007230716B2 (en) 2006-03-28 2012-05-03 Javelin Pharmaceuticals, Inc. Formulations of low dose diclofenac and beta-cyclodextrin
US7495024B2 (en) 2006-08-07 2009-02-24 Via Pharmaceuticals, Inc. Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
DE102008059201A1 (en) 2008-11-27 2010-06-02 GÖPFERICH, Achim, Prof. Dr. In situ precipitating drug solutions
KR102146704B1 (en) 2018-04-13 2020-08-21 가천대학교 산학협력단 Cyclosporin a containing microstructures for transdermal and intradermal drug delivery
WO2023063376A1 (en) * 2021-10-13 2023-04-20 中外製薬株式会社 Composition including peptide compound and surfactant

Family Cites Families (15)

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FI65914C (en) * 1978-03-07 1984-08-10 Sandoz Ag FRAMEWORK FOR PHARMACEUTICAL COMPOSITION OF CYCLOSPORINE A
JPS61280435A (en) * 1985-04-04 1986-12-11 Kanji Takada Lymph orienting preparation of cyclosporin
NL8600050A (en) * 1986-01-13 1987-08-03 Sanico Nv PHARMACEUTICAL PREPARATION WITH DELAYED DELIVERY OF THE ACTIVE SUBSTANCE AND METHOD FOR PREPARING IT.
GB8602372D0 (en) * 1986-01-31 1986-03-05 Sandoz Ltd Organic compounds
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JP2536876B2 (en) * 1987-07-31 1996-09-25 寛治 高田 Dissolvable powder formulation of cyclosporine
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US5756450A (en) * 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
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Also Published As

Publication number Publication date
NL195028C (en) 2003-12-02
JP2001302538A (en) 2001-10-31
NO900577L (en) 1990-08-10
HU900701D0 (en) 1990-04-28
FI97524B (en) 1996-09-30
NZ232401A (en) 1992-10-28
ATA27290A (en) 1998-05-15
CA2009533C (en) 2002-11-12
DE4003844A1 (en) 1990-08-16
CH679277A5 (en) 1992-01-31
JP2006001947A (en) 2006-01-05
KR0170769B1 (en) 1999-02-01
IT9047609A0 (en) 1990-02-08
HU213394B (en) 1997-06-30
CA2009533A1 (en) 1990-08-09
FR2642650B1 (en) 1994-12-09
IT1240758B (en) 1993-12-17
IT9047609A1 (en) 1991-08-08
JP3484190B2 (en) 2004-01-06
PT93079A (en) 1990-08-31
JPH02235817A (en) 1990-09-18
FI97524C (en) 1997-01-10
LU87675A1 (en) 1991-10-08
BE1003009A5 (en) 1991-10-22
ES2021942A6 (en) 1991-11-16
NO301576B1 (en) 1997-11-17
AU4925290A (en) 1990-08-16
NL9000299A (en) 1990-09-03
NL195028B (en) 2003-08-01
CY1903A (en) 1996-11-22
NO900577D0 (en) 1990-02-07
SE9000441D0 (en) 1990-02-07
DK32790A (en) 1990-08-10
JP4073641B2 (en) 2008-04-09
DK32790D0 (en) 1990-02-07
FR2642650A1 (en) 1990-08-10
DE4003844B4 (en) 2007-09-20
PH30917A (en) 1997-12-23
GB2230440A (en) 1990-10-24
DK176209B1 (en) 2007-02-05
GB2230440B (en) 1993-05-19
PT93079B (en) 1996-04-30
GB9002504D0 (en) 1990-04-04
SE9000441L (en) 1991-08-08
FI900604A0 (en) 1990-02-07
SE511398C2 (en) 1999-09-20
AU630413B2 (en) 1992-10-29
KR900012625A (en) 1990-09-01
HK37296A (en) 1996-03-15
AT404552B (en) 1998-12-28

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