ES2021942A6 - Cyclosporin compositions - Google Patents

Cyclosporin compositions

Info

Publication number
ES2021942A6
ES2021942A6 ES9000397A ES9000397A ES2021942A6 ES 2021942 A6 ES2021942 A6 ES 2021942A6 ES 9000397 A ES9000397 A ES 9000397A ES 9000397 A ES9000397 A ES 9000397A ES 2021942 A6 ES2021942 A6 ES 2021942A6
Authority
ES
Spain
Prior art keywords
cyclosporin
alkylene
glycol
compositions
monolaurate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9000397A
Other languages
Spanish (es)
Inventor
Birgit Hauer
Ulrich Posanski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898902898A external-priority patent/GB8902898D0/en
Priority claimed from GB898902901A external-priority patent/GB8902901D0/en
Priority claimed from GB898903147A external-priority patent/GB8903147D0/en
Priority claimed from GB898903663A external-priority patent/GB8903663D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES2021942A6 publication Critical patent/ES2021942A6/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Pharmaceutical compositions comprising (a) a cyclosporin as active ingredient (b) a fatty acid saccharide monoester and (c) a diluent or carrier. Components (c) are typically ethanol, an alkylene glycol (e.g. 1,2-propylene glycol), an alkylene polyol (e.g. glycerol), a polyalkylene glycol (e.g. PEG, RTM), an alkylene polyol ether or ester paraffin, or an organosilicon oxide polymer. Component (b) may be raffinose monolaurate or sucrose monolaurate. The compositions increase the in vivo availability of the cyclosporin.
ES9000397A 1989-02-09 1990-02-09 Cyclosporin compositions Expired - Lifetime ES2021942A6 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898902898A GB8902898D0 (en) 1989-02-09 1989-02-09 Improvements in or relating to organic compounds
GB898902901A GB8902901D0 (en) 1989-02-09 1989-02-09 Improvements in or relating to organic compounds
GB898903147A GB8903147D0 (en) 1989-02-13 1989-02-13 Improvements in or relating to organic compounds
GB898903663A GB8903663D0 (en) 1989-02-17 1989-02-17 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
ES2021942A6 true ES2021942A6 (en) 1991-11-16

Family

ID=27450262

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9000397A Expired - Lifetime ES2021942A6 (en) 1989-02-09 1990-02-09 Cyclosporin compositions

Country Status (25)

Country Link
JP (3) JP3484190B2 (en)
KR (1) KR0170769B1 (en)
AT (1) AT404552B (en)
AU (1) AU630413B2 (en)
BE (1) BE1003009A5 (en)
CA (1) CA2009533C (en)
CH (1) CH679277A5 (en)
CY (1) CY1903A (en)
DE (1) DE4003844B4 (en)
DK (1) DK176209B1 (en)
ES (1) ES2021942A6 (en)
FI (1) FI97524C (en)
FR (1) FR2642650B1 (en)
GB (1) GB2230440B (en)
HK (1) HK37296A (en)
HU (1) HU213394B (en)
IT (1) IT1240758B (en)
LU (1) LU87675A1 (en)
MY (1) MY107377A (en)
NL (1) NL195028C (en)
NO (1) NO301576B1 (en)
NZ (1) NZ232401A (en)
PH (1) PH30917A (en)
PT (1) PT93079B (en)
SE (1) SE511398C2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
MX9201782A (en) † 1991-04-19 1992-10-01 Sandoz Ag PARTICLES OF BIOLOGICALLY ACTIVE SUBSTANCES, SUBSTANTIALLY INSOLUBLE IN WATER, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM.
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
DK0642332T3 (en) 1992-05-13 1997-06-16 Sandoz Ltd Ophthalmic preparations containing cyclosporin
US5759566A (en) * 1992-07-28 1998-06-02 Poli Industria Chimica Spa Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
DK0589843T3 (en) 1992-09-25 2002-04-02 Novartis Ag Cyclosporin-containing pharmaceutical preparations
PT697881E (en) * 1993-04-20 2002-10-31 Novartis Ag NEW PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORINE FOR ORAL ADMINISTRATION
DE4412201A1 (en) * 1993-04-20 1994-11-10 Rentschler Arzneimittel New pharmaceutical preparations for oral administration containing cyclosporin
DE4340781C3 (en) * 1993-11-30 2000-01-27 Novartis Ag Liquid preparations containing cyclosporin and process for their preparation
KR0146671B1 (en) * 1994-02-25 1998-08-17 김충환 Cyclosporin-containing powder composition
CA2231404C (en) 1994-11-03 2009-02-17 Arzneimittelwerk Dresden Gmbh Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them
US5679566A (en) * 1995-01-20 1997-10-21 University Of Massachusetts Medical Center Yeast NMD2 gene
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
DE19544507B4 (en) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin containing preparations
US5798333A (en) * 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
AU762247B2 (en) * 1997-01-30 2003-06-19 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A
GB2355195B (en) * 1997-01-30 2001-09-12 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A
JP4718653B2 (en) * 1997-03-12 2011-07-06 アボツト・ラボラトリーズ Hydrophilic two-component system for administration of cyclosporine
NZ328751A (en) * 1997-09-16 1999-01-28 Bernard Charles Sherman Solid medicament containing an anionic surfactant and cyclosporin
US6447806B1 (en) 1999-02-25 2002-09-10 Novartis Ag Pharmaceutical compositions comprised of stabilized peptide particles
US6979672B2 (en) 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
JP4521554B2 (en) * 2004-03-31 2010-08-11 マイラン製薬株式会社 Cyclosporine preparation
US8333989B2 (en) * 2005-10-26 2012-12-18 Banner Pharmacaps, Inc. Hydrophilic vehicle-based dual controlled release matrix system
MX2008012495A (en) 2006-03-28 2009-01-07 Javelin Pharmaceuticals Inc Formulations of low dose diclofenac and beta-cyclodextrin.
US7495024B2 (en) 2006-08-07 2009-02-24 Via Pharmaceuticals, Inc. Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
DE102008059201A1 (en) * 2008-11-27 2010-06-02 GÖPFERICH, Achim, Prof. Dr. In situ precipitating drug solutions
KR102146704B1 (en) 2018-04-13 2020-08-21 가천대학교 산학협력단 Cyclosporin a containing microstructures for transdermal and intradermal drug delivery
JPWO2023063376A1 (en) * 2021-10-13 2023-04-20

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI65914C (en) * 1978-03-07 1984-08-10 Sandoz Ag FRAMEWORK FOR PHARMACEUTICAL COMPOSITION OF CYCLOSPORINE A
JPS61280435A (en) * 1985-04-04 1986-12-11 Kanji Takada Lymph orienting preparation of cyclosporin
NL8600050A (en) * 1986-01-13 1987-08-03 Sanico Nv PHARMACEUTICAL PREPARATION WITH DELAYED DELIVERY OF THE ACTIVE SUBSTANCE AND METHOD FOR PREPARING IT.
GB8602372D0 (en) * 1986-01-31 1986-03-05 Sandoz Ltd Organic compounds
CA1290249C (en) * 1986-04-09 1991-10-08 Cetus Corporation COMBINATION THERAPY USING INTERLEUKIN-2 AND/OR INTERFERON-.beta. AND TUMOR NECROSIS FACTOR
EP0267615A3 (en) * 1986-11-13 1989-05-03 Sloan-Kettering Institute For Cancer Research Compositions and method for treatment of cancer using monoclonal antibody against gd3 ganglioside together with il-2
ES2059558T3 (en) * 1987-06-17 1994-11-16 Sandoz Ag CYCLOSPORINS AND THEIR USE AS PHARMACEUTICAL PRODUCTS.
JP2536876B2 (en) * 1987-07-31 1996-09-25 寛治 高田 Dissolvable powder formulation of cyclosporine
HU205010B (en) * 1987-09-15 1992-03-30 Sandoz Ag Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
US5756450A (en) * 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
DE3830494B4 (en) * 1987-09-15 2006-05-18 Novartis Ag Water-soluble monoesters as solubilizers for pharmacologically active substances and pharmaceutical excipients
JP2792862B2 (en) * 1988-07-30 1998-09-03 寛治 高田 Oral enteric formulation
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
JPH1038029A (en) * 1996-07-26 1998-02-13 Ebara Corp Dick shape structure with vibration damping function
JPH10280435A (en) * 1997-04-03 1998-10-20 Sekisui Chem Co Ltd Construction method of basement

Also Published As

Publication number Publication date
HU213394B (en) 1997-06-30
KR900012625A (en) 1990-09-01
IT9047609A1 (en) 1991-08-08
DE4003844A1 (en) 1990-08-16
KR0170769B1 (en) 1999-02-01
AU4925290A (en) 1990-08-16
GB9002504D0 (en) 1990-04-04
GB2230440A (en) 1990-10-24
HK37296A (en) 1996-03-15
DK32790A (en) 1990-08-10
BE1003009A5 (en) 1991-10-22
CA2009533A1 (en) 1990-08-09
SE9000441D0 (en) 1990-02-07
NL195028C (en) 2003-12-02
JP3484190B2 (en) 2004-01-06
PT93079A (en) 1990-08-31
SE511398C2 (en) 1999-09-20
NO900577L (en) 1990-08-10
CH679277A5 (en) 1992-01-31
AT404552B (en) 1998-12-28
NL9000299A (en) 1990-09-03
PT93079B (en) 1996-04-30
JPH02235817A (en) 1990-09-18
DK176209B1 (en) 2007-02-05
FR2642650A1 (en) 1990-08-10
FI97524C (en) 1997-01-10
JP4073641B2 (en) 2008-04-09
IT9047609A0 (en) 1990-02-08
IT1240758B (en) 1993-12-17
PH30917A (en) 1997-12-23
NL195028B (en) 2003-08-01
FR2642650B1 (en) 1994-12-09
JP2001302538A (en) 2001-10-31
GB2230440B (en) 1993-05-19
CY1903A (en) 1996-11-22
DK32790D0 (en) 1990-02-07
NO900577D0 (en) 1990-02-07
LU87675A1 (en) 1991-10-08
SE9000441L (en) 1991-08-08
NZ232401A (en) 1992-10-28
AU630413B2 (en) 1992-10-29
JP2006001947A (en) 2006-01-05
MY107377A (en) 1995-11-30
DE4003844B4 (en) 2007-09-20
FI900604A0 (en) 1990-02-07
FI97524B (en) 1996-09-30
HU900701D0 (en) 1990-04-28
NO301576B1 (en) 1997-11-17
CA2009533C (en) 2002-11-12
ATA27290A (en) 1998-05-15

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Effective date: 20141120