DE3884140D1 - Azazyklische Verbindungen, ihre Herstellung und ihre Verwendung. - Google Patents

Azazyklische Verbindungen, ihre Herstellung und ihre Verwendung.

Info

Publication number
DE3884140D1
DE3884140D1 DE88118593T DE3884140T DE3884140D1 DE 3884140 D1 DE3884140 D1 DE 3884140D1 DE 88118593 T DE88118593 T DE 88118593T DE 3884140 T DE3884140 T DE 3884140T DE 3884140 D1 DE3884140 D1 DE 3884140D1
Authority
DE
Germany
Prior art keywords
preparation
azacyclic compounds
azacyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88118593T
Other languages
English (en)
Other versions
DE3884140T2 (de
Inventor
Lone Nielsen
Frank Waetjen
Jens W Kindtler
Preben Houlberg Olesen
Per Sauerberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK595287A external-priority patent/DK595287D0/da
Priority claimed from DK687087A external-priority patent/DK687087D0/da
Priority claimed from DK110288A external-priority patent/DK110288D0/da
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of DE3884140D1 publication Critical patent/DE3884140D1/de
Application granted granted Critical
Publication of DE3884140T2 publication Critical patent/DE3884140T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
DE88118593T 1987-11-13 1988-11-08 Azazyklische Verbindungen, ihre Herstellung und ihre Verwendung. Expired - Fee Related DE3884140T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK595287A DK595287D0 (da) 1987-11-13 1987-11-13 Azabicykliske forbindelser, deres fremstilling og anvendelse
DK687087A DK687087D0 (da) 1987-12-28 1987-12-28 Azacycliske forbindelser, deres fremstilling og anvendelse
DK110288A DK110288D0 (da) 1988-03-02 1988-03-02 Azacykliske forbindelser, deres fremstilling og anvendelse

Publications (2)

Publication Number Publication Date
DE3884140D1 true DE3884140D1 (de) 1993-10-21
DE3884140T2 DE3884140T2 (de) 1994-01-13

Family

ID=27221113

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88118593T Expired - Fee Related DE3884140T2 (de) 1987-11-13 1988-11-08 Azazyklische Verbindungen, ihre Herstellung und ihre Verwendung.

Country Status (15)

Country Link
US (2) US5262427A (de)
EP (1) EP0316718B1 (de)
JP (1) JP2831362B2 (de)
KR (1) KR890008139A (de)
AU (1) AU619770B2 (de)
CA (1) CA1340943C (de)
DE (1) DE3884140T2 (de)
ES (1) ES2059469T3 (de)
FI (1) FI95799C (de)
IE (1) IE63906B1 (de)
IL (1) IL88156A (de)
NO (1) NO171787C (de)
NZ (1) NZ226936A (de)
PH (1) PH25289A (de)
PT (1) PT88993B (de)

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GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
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IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
EP0338723B1 (de) * 1988-04-15 1993-08-04 Beecham Group Plc Chemische Verbindungen
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GB8830226D0 (en) * 1988-12-23 1989-02-22 Beecham Group Plc Novel compounds
US4937239A (en) * 1989-02-13 1990-06-26 Warner-Lambert Company Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0392803B1 (de) * 1989-04-13 2004-06-16 Beecham Group p.l.c. Chemische Verbindungen
EP0413545B1 (de) * 1989-08-16 1997-05-14 Beecham Group Plc Azabicyclische Verbindungen
DE69026197T2 (de) * 1989-10-07 1997-01-09 Beecham Group Plc Azabizyklische Verbindungen, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
DK40890D0 (da) * 1990-02-16 1990-02-16 Ferrosan As Substituerede urinstofforbindelser, deres fremstilling og anvendelse
EP0459568A3 (en) * 1990-05-31 1992-09-30 Merck Sharp & Dohme Ltd. Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
USRE35822E (en) * 1990-08-21 1998-06-09 Novo Nordisk A/S Heterocyclic compounds
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
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JPH06503563A (ja) * 1990-11-29 1994-04-21 アラーガン、インコーポレイテッド 高眼圧の処置におけるピリジン誘導体の用途
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US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
CA2126976A1 (en) * 1991-12-31 1993-07-08 Hisashi Takasugi Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
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US5242935A (en) * 1992-03-06 1993-09-07 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
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US5330994A (en) * 1992-03-24 1994-07-19 Warner-Lambert Company Tetrahydropyridine isoxazoline derivatives
US5276043A (en) * 1992-04-10 1994-01-04 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
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EP0596058A1 (de) * 1992-04-10 1994-05-11 Zeneca Limited Biphenylylchinuclidine Derivate als squalen synthase Inhibitoren.
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GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
DE69325662T2 (de) * 1992-10-23 2000-02-10 Merck Sharp & Dohme Dopamin rezeptor subtyp liganden
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Also Published As

Publication number Publication date
IE883208L (en) 1989-05-13
CA1340943C (en) 2000-04-04
FI95799C (fi) 1996-03-25
IL88156A0 (en) 1989-06-30
NO885052L (no) 1989-05-16
IL88156A (en) 1997-02-18
IE63906B1 (en) 1995-06-14
AU2460888A (en) 1989-05-18
NO171787B (no) 1993-01-25
PT88993A (pt) 1989-11-30
US5356912A (en) 1994-10-18
EP0316718A3 (en) 1989-12-20
AU619770B2 (en) 1992-02-06
EP0316718B1 (de) 1993-09-15
NO885052D0 (no) 1988-11-11
FI885223A0 (fi) 1988-11-11
JP2831362B2 (ja) 1998-12-02
PT88993B (pt) 1993-05-31
JPH01153688A (ja) 1989-06-15
NO171787C (no) 1993-05-05
NZ226936A (en) 1991-02-26
US5262427A (en) 1993-11-16
ES2059469T3 (es) 1994-11-16
FI885223A (fi) 1989-05-14
PH25289A (en) 1991-04-30
EP0316718A2 (de) 1989-05-24
FI95799B (fi) 1995-12-15
KR890008139A (ko) 1989-07-10
DE3884140T2 (de) 1994-01-13

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