PT88993A - Processo de preparacao de compostos azaciclicos e de composicoes farmaceuticas que os contem - Google Patents

Processo de preparacao de compostos azaciclicos e de composicoes farmaceuticas que os contem

Info

Publication number
PT88993A
PT88993A PT88993A PT8899388A PT88993A PT 88993 A PT88993 A PT 88993A PT 88993 A PT88993 A PT 88993A PT 8899388 A PT8899388 A PT 8899388A PT 88993 A PT88993 A PT 88993A
Authority
PT
Portugal
Prior art keywords
preparing
pharmaceutical compositions
compositions containing
azacyclic compounds
azacyclic
Prior art date
Application number
PT88993A
Other languages
English (en)
Other versions
PT88993B (pt
Inventor
Frank Waetjen
Per Sauerberg
Preben H Olesen
Lone Nielsen
Jens W Kindler
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK595287A external-priority patent/DK595287D0/da
Priority claimed from DK687087A external-priority patent/DK687087D0/da
Priority claimed from DK110288A external-priority patent/DK110288D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of PT88993A publication Critical patent/PT88993A/pt
Publication of PT88993B publication Critical patent/PT88993B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT88993A 1987-11-13 1988-11-11 Processo de preparacao de compostos azaciclicos e de composicoes farmaceuticas que os contem PT88993B (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK595287A DK595287D0 (da) 1987-11-13 1987-11-13 Azabicykliske forbindelser, deres fremstilling og anvendelse
DK687087A DK687087D0 (da) 1987-12-28 1987-12-28 Azacycliske forbindelser, deres fremstilling og anvendelse
DK110288A DK110288D0 (da) 1988-03-02 1988-03-02 Azacykliske forbindelser, deres fremstilling og anvendelse

Publications (2)

Publication Number Publication Date
PT88993A true PT88993A (pt) 1989-11-30
PT88993B PT88993B (pt) 1993-05-31

Family

ID=27221113

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88993A PT88993B (pt) 1987-11-13 1988-11-11 Processo de preparacao de compostos azaciclicos e de composicoes farmaceuticas que os contem

Country Status (15)

Country Link
US (2) US5262427A (pt)
EP (1) EP0316718B1 (pt)
JP (1) JP2831362B2 (pt)
KR (1) KR890008139A (pt)
AU (1) AU619770B2 (pt)
CA (1) CA1340943C (pt)
DE (1) DE3884140T2 (pt)
ES (1) ES2059469T3 (pt)
FI (1) FI95799C (pt)
IE (1) IE63906B1 (pt)
IL (1) IL88156A (pt)
NO (1) NO171787C (pt)
NZ (1) NZ226936A (pt)
PH (1) PH25289A (pt)
PT (1) PT88993B (pt)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3789039T2 (de) * 1986-06-27 1994-06-09 Beecham Group Plc Verbrückte bicyclische N-heterocyclische Verbindungen.
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
EP0322182A3 (en) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
US5110828A (en) * 1988-04-15 1992-05-05 Beecham Group P.L.C. Azabicyclo oxime derivatives
CA2000041A1 (en) * 1988-10-13 1990-04-13 Barry S. Orlek Compounds
DE3839385A1 (de) * 1988-11-22 1990-05-23 Boehringer Ingelheim Kg Neue quinuclidine, ihre herstellung als arzneimittel und verfahren zu ihrer herstellung
GB8830226D0 (en) * 1988-12-23 1989-02-22 Beecham Group Plc Novel compounds
US4937239A (en) * 1989-02-13 1990-06-26 Warner-Lambert Company Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0392803B1 (en) * 1989-04-13 2004-06-16 Beecham Group p.l.c. Novel compounds
DE69030695T2 (de) * 1989-08-16 1998-01-08 Beecham Group Plc Azabicyclische Verbindungen
EP0427390B1 (en) * 1989-10-07 1996-03-27 Beecham Group Plc Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them
DK40890D0 (da) * 1990-02-16 1990-02-16 Ferrosan As Substituerede urinstofforbindelser, deres fremstilling og anvendelse
EP0459568A3 (en) * 1990-05-31 1992-09-30 Merck Sharp & Dohme Ltd. Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
USRE35822E (en) * 1990-08-21 1998-06-09 Novo Nordisk A/S Heterocyclic compounds
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
IE912974A1 (en) * 1990-08-24 1992-02-26 Beecham Group Plc Novel compounds
GB9019095D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds
EP0552213A1 (en) * 1990-10-12 1993-07-28 Beecham Group Plc 1,2,5,6-tetrahydropyridine oxime derivatives
ES2113939T3 (es) * 1990-11-29 1998-05-16 Allergan Inc Uso de derivados de piridina en el tratamiento de la hipertension ocular.
IE922270A1 (en) * 1991-07-26 1993-01-27 Akzo Nv Pyrazole derivatives
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
AU3171493A (en) * 1991-12-31 1993-07-28 Fujisawa Pharmaceutical Co., Ltd. Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5242934A (en) * 1992-03-02 1993-09-07 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
US5212188A (en) * 1992-03-02 1993-05-18 R. J. Reynolds Tabacco Company Method for treatment of neurodegenerative diseases
US5242935A (en) * 1992-03-06 1993-09-07 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
US5227385A (en) * 1992-03-13 1993-07-13 Wake Forest University Method for treatment of neurodegenerative diseases
US5288872A (en) * 1992-03-13 1994-02-22 Wake Forest University Compounds for treatment of neurodegenerative diseases
US5330994A (en) * 1992-03-24 1994-07-19 Warner-Lambert Company Tetrahydropyridine isoxazoline derivatives
US5276043A (en) * 1992-04-10 1994-01-04 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
US5214060A (en) * 1992-04-10 1993-05-25 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
CA2093778A1 (en) * 1992-04-10 1993-10-11 George R. Brown Heterocyclic compounds
US5187169A (en) * 1992-04-10 1993-02-16 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
SE9201478D0 (sv) * 1992-05-11 1992-05-11 Kabi Pharmacia Ab Heteroaromatic quinuclidinenes, their use and preparation
US5232933A (en) * 1992-05-21 1993-08-03 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
US5232932A (en) * 1992-05-21 1993-08-03 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
US5248690A (en) * 1992-07-07 1993-09-28 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
US5242916A (en) * 1992-07-07 1993-09-07 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
AU678186B2 (en) * 1992-10-23 1997-05-22 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
AU672644B2 (en) * 1992-12-23 1996-10-10 Neurosearch A/S Aryl substituted heterocyclic compounds
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
US5668148A (en) * 1995-04-20 1997-09-16 Merck & Co., Inc. Alpha1a adrenergic receptor antagonists
US5583140A (en) * 1995-05-17 1996-12-10 Bencherif; Merouane Pharmaceutical compositions for the treatment of central nervous system disorders
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
ES2191455T3 (es) 1998-08-18 2003-09-01 Ucb Sa Agonistas y antagonistas muscarinicos.
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
AP2004003052A0 (en) * 2001-11-19 2004-06-30 Elan Pharm Inc 3,4-Disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines and piperazines.
KR100448002B1 (ko) * 2002-02-01 2004-09-13 한국과학기술연구원 신규한 퀴누클리딘 화합물 및 그 제조방법
WO2006065217A1 (en) * 2004-12-16 2006-06-22 Astrazeneca Ab Nicotinic acetycholine receptor ligands
US7678363B2 (en) * 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2010502722A (ja) * 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
JP2010525020A (ja) * 2007-04-24 2010-07-22 ソルベイ・フアーマシユーチカルズ・ベー・ブイ ムスカリン性受容体への親和性を有する複素環式化合物
US8084473B2 (en) 2007-04-24 2011-12-27 Solvay Pharmaceuticals B.V. Heterocyclic compounds with affinity to muscarinic receptors
EP2296471A4 (en) 2008-05-15 2012-03-14 Univ Toledo MUSCARIC ACID AGONISTS AS COGNITIVE ENHANCERS
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US9549928B2 (en) 2011-04-29 2017-01-24 The University Of Toledo Muscarinic agonists as enhancers of cognitive flexibility

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132134C (pt) * 1963-03-22
US4144343A (en) * 1978-01-04 1979-03-13 Merck & Co., Inc. Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines
US4518601A (en) * 1982-06-16 1985-05-21 Ciba Geigy Corporation 2-(3-Pyridyl)-1,3,4-oxadiazoles and use thereof in pest control
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
GB8610432D0 (en) * 1986-04-29 1986-06-04 Akzo Nv Amino-thiazole & oxazole derivatives
DE3789039T2 (de) * 1986-06-27 1994-06-09 Beecham Group Plc Verbrückte bicyclische N-heterocyclische Verbindungen.
IL83275A (en) * 1986-09-08 1994-02-27 Novo Nordisk As Compounds 1,2, 4-Oxadiazolyl Pipridine Transformed, their preparation and pharmaceutical preparations containing them
US4786648A (en) * 1986-12-08 1988-11-22 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
US4710508A (en) * 1986-12-08 1987-12-01 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
ES2053748T3 (es) * 1987-09-10 1994-08-01 Merck Sharp & Dohme Oxazoles y tiazoles para el tratamiento de la demencia senil.
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
IT1233446B (it) * 1987-12-30 1992-04-01 Roussel Maestretti Spa Derivati della 3 piperidinocarbaldeide ossima, loro procedimento di preparazione e loro applicazione come farmaci
IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
US4937239A (en) * 1989-02-13 1990-06-26 Warner-Lambert Company Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents

Also Published As

Publication number Publication date
AU619770B2 (en) 1992-02-06
ES2059469T3 (es) 1994-11-16
JP2831362B2 (ja) 1998-12-02
PT88993B (pt) 1993-05-31
EP0316718A3 (en) 1989-12-20
EP0316718A2 (en) 1989-05-24
IL88156A (en) 1997-02-18
NZ226936A (en) 1991-02-26
FI95799B (fi) 1995-12-15
NO885052L (no) 1989-05-16
FI95799C (fi) 1996-03-25
US5262427A (en) 1993-11-16
CA1340943C (en) 2000-04-04
FI885223A0 (fi) 1988-11-11
NO171787B (no) 1993-01-25
DE3884140T2 (de) 1994-01-13
IL88156A0 (en) 1989-06-30
IE883208L (en) 1989-05-13
NO171787C (no) 1993-05-05
AU2460888A (en) 1989-05-18
US5356912A (en) 1994-10-18
KR890008139A (ko) 1989-07-10
DE3884140D1 (de) 1993-10-21
FI885223A (fi) 1989-05-14
NO885052D0 (no) 1988-11-11
IE63906B1 (en) 1995-06-14
EP0316718B1 (en) 1993-09-15
PH25289A (en) 1991-04-30
JPH01153688A (ja) 1989-06-15

Similar Documents

Publication Publication Date Title
PT88993A (pt) Processo de preparacao de compostos azaciclicos e de composicoes farmaceuticas que os contem
PT81969B (pt) Processo para preparacao de 11 beta-fenil-esteroides e de composicoes farmaceuticas que os contem
PT81746B (pt) Processo para a preparacao de peptido-aldeidos e de composicoes farmaceuticas que os contem
PT89094A (pt) Processo para a preparacao de 1-aril-3-quinolina-e 1-aril-3-isoquinolina-carboxamidas e de composicoes farmaceuticas que as contem
PT89793A (pt) Processo de preparacao de derivados de quinolina substituidos e de composicoes farmaceuticas que os contem
PT89009A (pt) Processo para a preparacao de novos derivados de fluorocitidina e composicoes farmaceuticas que os contem
PT81362B (pt) Processo para a preparacao de 9-amino-1,2,3,4-tetra-hidroacridin-1-ol e compostos relacionados e de composicoes farmaceuticas que os contem
PT78732A (pt) Processo para a preparacao de 13 alpha-alquilgonanos e de composicoes farmaceuticas que os contem
PT89661A (pt) Processo para a preparacao de compostos pirrolicos substituidos e de composicoes farmaceuticas que os contem
PT88914A (pt) Processo para a preparacao de polipeptidos e de composicoes farmaceuticas que os contem
PT88203A (pt) Processo para a preparacao de quinolonas e de composicoes farmaceuticas que as contem
PT84226B (pt) Processo para a preparacao de adenosinas n6-substituidas e de composicoes farmaceuticas que as contem
PT87201A (pt) Processo para a preparacao de novos derivados de cefalosporina 3,7-substituida e de composicoes farmaceuticas que os contem
PT83998B (pt) Processo de preparacao de novos derivados azaciclicos e de composicoes farmaceuticas que os contem
PT97437A (pt) Processo de preparacao de derivados de hidrato de carbono e de composicoes farmaceuticas que os contem
PT84681B (pt) Processo para a preparacao de carboxamidas heterociclicas e de composicoes farmaceuticas que as contem
PT84828B (pt) Processo para a preparacao de compostos heterociclicos triciclicos fundidos e de composicoes farmaceuticas que os contem
PT84358B (pt) Processo para a preparacao de naftotiazepinonas e de composicoes farmaceuticas que as contem
PT81659B (pt) Processo para a preparacao de aminoacil-labdanos e de composicoes farmaceuticas que os contem
PT81531B (pt) Processo para a preparacao de silibinina isenta de isosilibina e de composicoes farmaceuticas contendo silibinina
PT80246B (pt) Processo para a preparacao de novos derivados de cefalosporina e de composicoes farmaceuticas que os contem
PT89234A (pt) Processo para a preparacao de novos compostos de amonio e de composicoes farmaceuticas que os contem
PT83495B (pt) Processo para a preparacao de difenilpiperidinas n-substituidas e de composicoes farmaceuticas que as contem
PT88238A (pt) Processo para a preparacao de composicoes moluscicidas contendo quelatos de aluminio-(iii)e/ou de ferro-(iii)
PT89792A (pt) Processo de preparacao de derivados da quinolina substituidos e de composicoes farmaceuticas que os contem

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19921127

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20020531