PT78732A - Processo para a preparacao de 13 alpha-alquilgonanos e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de 13 alpha-alquilgonanos e de composicoes farmaceuticas que os contem

Info

Publication number
PT78732A
PT78732A PT78732A PT7873284A PT78732A PT 78732 A PT78732 A PT 78732A PT 78732 A PT78732 A PT 78732A PT 7873284 A PT7873284 A PT 7873284A PT 78732 A PT78732 A PT 78732A
Authority
PT
Portugal
Prior art keywords
alkygonanes
alpha
preparing
pharmaceutical compositions
compositions containing
Prior art date
Application number
PT78732A
Other languages
English (en)
Other versions
PT78732B (de
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3321826A external-priority patent/DE3321826A1/de
Priority claimed from DE19843413036 external-priority patent/DE3413036A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of PT78732A publication Critical patent/PT78732A/pt
Publication of PT78732B publication Critical patent/PT78732B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT78732A 1983-06-15 1984-06-14 13-alpha-alkylgonane deren herstellung und diese enthaltende pharmazeutische praeparate PT78732B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3321826A DE3321826A1 (de) 1983-06-15 1983-06-15 13(alpha)-alkylgonane, deren herstellung und diese enthaltende pharmazeutische praeparate
DE19843413036 DE3413036A1 (de) 1984-04-04 1984-04-04 13(alpha)-alkylgonane, deren herstellung und diese enthaltende pharmazeutische praeparate

Publications (2)

Publication Number Publication Date
PT78732A true PT78732A (pt) 1985-01-01
PT78732B PT78732B (de) 1986-06-03

Family

ID=25811539

Family Applications (1)

Application Number Title Priority Date Filing Date
PT78732A PT78732B (de) 1983-06-15 1984-06-14 13-alpha-alkylgonane deren herstellung und diese enthaltende pharmazeutische praeparate

Country Status (16)

Country Link
EP (1) EP0129499B1 (pt)
JP (1) JPH02167296A (pt)
AU (1) AU572849B2 (pt)
CA (1) CA1307784C (pt)
DD (1) DD218624A5 (pt)
DE (1) DE3468030D1 (pt)
DK (1) DK166729B1 (pt)
ES (1) ES533260A0 (pt)
FI (1) FI78709C (pt)
GR (1) GR82210B (pt)
HU (1) HU191131B (pt)
IE (1) IE57620B1 (pt)
IL (1) IL72085A (pt)
NO (1) NO160521C (pt)
NZ (1) NZ208441A (pt)
PT (1) PT78732B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3446661A1 (de) * 1984-12-18 1986-06-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 13(alpha)-alkyl-17(beta)-(3-acyloxypropyl)-gonane
DE3506785A1 (de) * 1985-02-22 1986-08-28 Schering AG, Berlin und Bergkamen, 1000 Berlin 11ss-n,n-dimethylaminophenyl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3630030A1 (de) * 1986-09-01 1988-03-03 Schering Ag 13(alpha)-alkylgonan-(delta)(pfeil hoch)9(pfeil hoch)(pfeil hoch)((pfeil hoch)(pfeil hoch)1(pfeil hoch)1(pfeil hoch))(pfeil hoch)-5,10-epoxide
US4774236A (en) * 1986-09-17 1988-09-27 Research Triangle Institute 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
EP0310542B1 (de) * 1987-10-01 1994-06-08 Schering Aktiengesellschaft Antigestagen- und antiöstrogenwirksame Verbindungen zur Behandlung hormonabhängiger Tumoren
BE1004905A4 (fr) * 1987-12-30 1993-02-23 Roussel Uclaf Nouveaux derives 17beta-oh 19-nor steroides substitues en 17alpha, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
DE3822770A1 (de) * 1988-07-01 1990-01-04 Schering Ag 13-alkyl-11ss-phenylgonane
DE3832303A1 (de) * 1988-09-20 1990-04-12 Schering Ag 11ss-phenyl-14ssh-steroide
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
ES2189784T3 (es) * 1989-07-07 2003-07-16 Endorech Inc Procedimiento para el tratamiento de enfermedades relacionadas con adrogenos.
DE69032648T2 (de) * 1989-07-07 1999-04-08 Endorecherche Inc., Ste-Foy, Quebec Androgenderivate zur Hemming der Aktivität der Sexualsteroide
ATE172469T1 (de) * 1989-08-04 1998-11-15 Schering Ag 11 beta-aryl-gona-4,9-dien-3-one
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
DE4008584A1 (de) * 1990-03-15 1991-09-26 Schering Ag Verfahren zur herstellung von zwischenprodukten fuer die antigestagensynthese (onapristonsynthese)
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
CA2069956C (en) * 1990-08-18 2001-05-08 Alfred Weber Process for the production of 17-oxosteroids
US5472854A (en) * 1990-08-18 1995-12-05 Schering Aktiengesellschaft Process for the production of 17-oxosteroids via the fermentative oxidation of 17β-hydroxysteroids by Mycobacterium
US7704983B1 (en) 1992-03-02 2010-04-27 Eastern Virginia Medical School Antiprogestin method for reducing side effects associated with low dosage HRT and oral contraception
MX9301121A (es) * 1992-03-02 1993-09-01 Schering Ag Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina.
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
WO1993023053A1 (en) * 1992-05-21 1993-11-25 Endorecherche Inc. INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY
DE4413185A1 (de) * 1994-04-12 1995-10-19 Schering Ag 11beta,19-überbrückte 13alpha-Alkylsteroide
DE4415590A1 (de) * 1994-04-28 1995-11-02 Schering Ag Verfahren zur stereoselektiven Einführung einer Alkinylseitenkette an 11ß-Aryl-substituierten 13alpha-Alkylgonan-17-onen
DE4434488A1 (de) * 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
CA2253673C (en) 1996-05-01 2009-09-08 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
US6900193B1 (en) * 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
US10786461B2 (en) 2014-11-17 2020-09-29 Context Biopharma Inc. Onapristone extended-release compositions and methods
BR112018005999A2 (pt) * 2015-09-25 2019-01-08 Context Biopharma Inc métodos para a produção de intermediários de onapristona
KR20180113988A (ko) * 2015-12-15 2018-10-17 컨텍스트 바이오파마 인코포레이티드 비정질 오나프리스톤 조성물 및 그 제조방법
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
CA1304916C (en) * 1984-10-18 1992-07-14 Wilhelm Bannwarth Apparatus for the parallel performance of a plurality of chemical reaction sequences

Also Published As

Publication number Publication date
DK288184A (da) 1984-12-16
IE57620B1 (en) 1993-02-10
DK166729B1 (da) 1993-07-05
HU191131B (en) 1987-01-28
FI78709C (fi) 1989-09-11
GR82210B (pt) 1984-12-13
IL72085A (en) 1987-09-16
JPH0369919B2 (pt) 1991-11-05
ES8502612A1 (es) 1985-02-01
CA1307784C (en) 1992-09-22
NO160521C (no) 1989-04-26
EP0129499A3 (en) 1985-10-09
AU572849B2 (en) 1988-05-19
EP0129499B1 (de) 1987-12-09
NZ208441A (en) 1988-01-08
FI842395A0 (fi) 1984-06-13
IL72085A0 (en) 1984-10-31
EP0129499A2 (de) 1984-12-27
NO842394L (no) 1984-12-17
JPH02167296A (ja) 1990-06-27
IE841484L (en) 1984-12-15
DD218624A5 (de) 1985-02-13
PT78732B (de) 1986-06-03
DK288184D0 (da) 1984-06-12
FI78709B (fi) 1989-05-31
FI842395A (fi) 1984-12-16
DE3468030D1 (en) 1988-01-21
HUT36139A (en) 1985-08-28
ES533260A0 (es) 1985-02-01
AU2936184A (en) 1984-12-20
NO160521B (no) 1989-01-16

Similar Documents

Publication Publication Date Title
PT78732A (pt) Processo para a preparacao de 13 alpha-alquilgonanos e de composicoes farmaceuticas que os contem
PT81746B (pt) Processo para a preparacao de peptido-aldeidos e de composicoes farmaceuticas que os contem
PT81969B (pt) Processo para preparacao de 11 beta-fenil-esteroides e de composicoes farmaceuticas que os contem
PT84569B (pt) Processo para a preparacao de tiazepinas e de composicoes farmaceuticas que os contem
PT89009A (pt) Processo para a preparacao de novos derivados de fluorocitidina e composicoes farmaceuticas que os contem
PT81362B (pt) Processo para a preparacao de 9-amino-1,2,3,4-tetra-hidroacridin-1-ol e compostos relacionados e de composicoes farmaceuticas que os contem
PT80724B (pt) Processo para a preparacao de novos derivados de gangliosidos e de composicoes farmaceuticas que os contem
PT80892B (pt) Processo para a preparacao de derivados da quoinona e de composicoes farmaceuticas que os contem
PT88914A (pt) Processo para a preparacao de polipeptidos e de composicoes farmaceuticas que os contem
PT81041B (pt) Processo para a preparacao de derivados de etilenodiamina-monoamida e de composicoes farmaceuticas que os contem
PT83355B (pt) Processo para a preparacao de derivados de benzimidazole e de composicoes farmaceuticas que os contem
PT80246B (pt) Processo para a preparacao de novos derivados de cefalosporina e de composicoes farmaceuticas que os contem
PT81659B (pt) Processo para a preparacao de aminoacil-labdanos e de composicoes farmaceuticas que os contem
PT82984B (pt) Processo para a preparacao de derivados de poli-4-aminopirrole-2-carboxamido e de composicoes farmaceuticas que os contem
PT84358B (pt) Processo para a preparacao de naftotiazepinonas e de composicoes farmaceuticas que as contem
PT89234A (pt) Processo para a preparacao de novos compostos de amonio e de composicoes farmaceuticas que os contem
PT81502B (pt) Processo para a preparacao de derivados de colecalciferol e de composicoes farmaceuticas que os contem
PT78986A (pt) Processo para a preparacao de derivados basicos de cumarina e de composicoes farmaceuticas que os contem
PT80794B (pt) Processo para a preparacao de novas isoindolinil-alquilpiperazinas e de composicoes farmaceuticas que as contem
PT83593B (pt) Processo para a preparacao de 7-acil-benzoxazinonas e seus derivados e de composicoes farmaceuticas que os contem
PT87115A (pt) Processo para a preparacao de derivados da dihidropiridazinona e de composicoes farmaceuticas que os contem
PT87090A (pt) Processo para a preparacao de derivados de imidazopiridinas e de composicoes farmaceuticas que os contem
PT82960B (pt) Processo para a preparacao de derivados de 6-amino-pirimidina 5-substituidos e de composicoes farmaceuticas que os contem
PT83279B (pt) Processo para a preparacao de antibioticos peptidicos e de composicoes farmaceuticas que os contem
PT91787A (pt) Processo para a preparacao de tienopiranos substituidos e de composicoes farmaceuticas que os contem

Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19981231