DE3862434D1 - Verfahren zur herstellung eines 4,4-diphenylbutansaeurederivats. - Google Patents

Verfahren zur herstellung eines 4,4-diphenylbutansaeurederivats.

Info

Publication number
DE3862434D1
DE3862434D1 DE8888305179T DE3862434T DE3862434D1 DE 3862434 D1 DE3862434 D1 DE 3862434D1 DE 8888305179 T DE8888305179 T DE 8888305179T DE 3862434 T DE3862434 T DE 3862434T DE 3862434 D1 DE3862434 D1 DE 3862434D1
Authority
DE
Germany
Prior art keywords
dichlorophenyl
dihydro
acid
furanone
converting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888305179T
Other languages
English (en)
Inventor
George Joseph Quallich
Michael Trevelyan Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE3862434D1 publication Critical patent/DE3862434D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/15—Saturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Catalysts (AREA)
DE8888305179T 1987-06-11 1988-06-07 Verfahren zur herstellung eines 4,4-diphenylbutansaeurederivats. Expired - Fee Related DE3862434D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/060,577 US4777288A (en) 1987-06-11 1987-06-11 Process for preparing a 4,4-diphenylbutanoic acid derivative

Publications (1)

Publication Number Publication Date
DE3862434D1 true DE3862434D1 (de) 1991-05-23

Family

ID=22030394

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888305179T Expired - Fee Related DE3862434D1 (de) 1987-06-11 1988-06-07 Verfahren zur herstellung eines 4,4-diphenylbutansaeurederivats.

Country Status (29)

Country Link
US (1) US4777288A (de)
EP (1) EP0295050B1 (de)
JP (1) JPH0627098B2 (de)
KR (1) KR910000780B1 (de)
CN (2) CN1025328C (de)
AT (1) ATE62657T1 (de)
AU (1) AU586953B2 (de)
CA (1) CA1285574C (de)
CS (1) CS272238B2 (de)
DD (2) DD279013A5 (de)
DE (1) DE3862434D1 (de)
DK (1) DK175280B1 (de)
EG (1) EG18404A (de)
ES (1) ES2022621B3 (de)
FI (1) FI90657C (de)
GR (1) GR3001908T3 (de)
HU (2) HU198670B (de)
IE (1) IE61072B1 (de)
IL (1) IL86629A0 (de)
MX (1) MX172786B (de)
MY (2) MY103570A (de)
NO (1) NO167731C (de)
NZ (1) NZ224984A (de)
PH (1) PH25099A (de)
PL (2) PL153028B1 (de)
PT (1) PT87691B (de)
RU (2) RU1799377C (de)
YU (2) YU47120B (de)
ZA (1) ZA884161B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2124454C (en) * 1991-12-13 1997-08-26 George J. Quallich Process for preparing ketone enantiomer
US5196607A (en) * 1992-02-14 1993-03-23 Pfizer Inc. Process for preparing ketone enantiomer
US5466880A (en) * 1992-09-15 1995-11-14 Pfizer Inc. Process for preparing ketone enantiomer
CA2176500C (en) * 1993-11-30 1999-09-28 George J. Quallich Process for preparing a chiral tetralone
US6410794B1 (en) 1994-12-16 2002-06-25 Uop Llc Process for preparation of pharmaceutically desired chiral tetralone from tetralones
KR100412327B1 (ko) 1997-07-01 2003-12-31 화이자 인코포레이티드 서트랄린 염 및 서트랄린의 서방성 투여형
WO1999046233A1 (fr) * 1998-03-09 1999-09-16 Sumika Fine Chemicals Co., Ltd. Derives de l'alcool benzylique
IL132500A0 (en) 1998-10-29 2001-03-19 Pfizer Prod Inc Stereoselective microbial reduction of a racemic tetralone
IN187170B (de) 2000-01-04 2002-02-23 Sun Pharmaceutical Ind Ltd
FR2817256B1 (fr) * 2000-11-27 2005-07-15 Univ Pasteur Derives de l'acides 4-hydroxybutanoique et de son homologue superieur comme ligands des recepteurs du gamma- hydroxybutyrate (ghb), compositions pharmaceutiques les contenant et utilisations pharmaceutiques
CN100413856C (zh) * 2006-09-06 2008-08-27 大连来克精化有限公司 一种威士忌内酯的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3412146A (en) * 1965-08-13 1968-11-19 Geigy Chem Corp Process for preparation of diphenyl alkanoic acids
DE2112715A1 (de) * 1971-03-17 1972-10-05 Thomae Gmbh Dr K Neue 4-(4-Biphenylyl)-4-hydroxybuttersaeuren,ihre Salze,Ester und Lactone
US4556676A (en) * 1979-11-01 1985-12-03 Pfizer Inc. Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
FR2504127B1 (fr) * 1981-04-17 1985-07-19 Roussel Uclaf Nouveaux derives d'acides phenyl aliphatique carboxyliques, procede pour leur preparation et leur application comme medicaments
FR2521857B1 (fr) * 1982-02-23 1985-10-31 Solvay Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee
US4543428A (en) * 1983-03-11 1985-09-24 Oregon Graduate Center For Study & Research Production of a hexahydronaphthalenone compound
DE3615157A1 (de) * 1986-05-05 1987-11-12 Schwabe Willmar Gmbh & Co 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe
US4855500A (en) * 1988-05-04 1989-08-08 Pfizer Inc. Process for preparing a ketimine

Also Published As

Publication number Publication date
FI90657C (fi) 1994-03-10
HU213617B (en) 1997-08-28
ZA884161B (en) 1990-02-28
HUT47070A (en) 1989-01-30
IE61072B1 (en) 1994-09-21
IE881762L (en) 1988-12-11
KR890000393A (ko) 1989-03-14
ATE62657T1 (de) 1991-05-15
MX172786B (es) 1994-01-13
FI882779A (fi) 1988-12-12
PL278118A1 (en) 1989-08-21
FI882779A0 (fi) 1988-06-10
DK319088D0 (da) 1988-06-10
NO882566L (no) 1988-12-12
RU1799377C (ru) 1993-02-28
CN1031837A (zh) 1989-03-22
PL156829B1 (pl) 1992-04-30
DD287483A5 (de) 1991-02-28
YU47120B (sh) 1994-12-28
PT87691A (pt) 1988-07-01
CA1285574C (en) 1991-07-02
MY103570A (en) 1993-08-28
EP0295050A1 (de) 1988-12-14
GR3001908T3 (en) 1992-11-23
YU49242B (sh) 2004-12-31
MX11861A (es) 1993-03-01
CN1025328C (zh) 1994-07-06
PL272949A1 (en) 1989-07-10
DD279013A5 (de) 1990-05-23
PT87691B (pt) 1992-09-30
DK319088A (da) 1988-12-12
YU112788A (en) 1989-10-31
KR910000780B1 (ko) 1991-02-08
NZ224984A (en) 1990-04-26
NO882566D0 (no) 1988-06-10
YU60893A (sh) 1997-05-28
CS397688A2 (en) 1990-03-14
JPS649953A (en) 1989-01-13
US4777288A (en) 1988-10-11
PL153028B1 (en) 1991-02-28
CS272238B2 (en) 1991-01-15
EG18404A (en) 1993-02-28
CN1042129C (zh) 1999-02-17
RU1839670C (ru) 1993-12-30
NO167731B (no) 1991-08-26
PH25099A (en) 1991-02-19
MY107026A (en) 1995-08-30
NO167731C (no) 1992-03-04
IL86629A0 (en) 1988-11-30
DK175280B1 (da) 2004-08-09
AU1761388A (en) 1988-12-15
HU198670B (en) 1989-11-28
FI90657B (fi) 1993-11-30
ES2022621B3 (es) 1991-12-01
AU586953B2 (en) 1989-07-27
CN1100086A (zh) 1995-03-15
JPH0627098B2 (ja) 1994-04-13
EP0295050B1 (de) 1991-04-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee