DE3861275D1 - Verfahren zur industriellen synthese von perindopril und dessen wichtigsten synthesezwischenprodukten. - Google Patents

Verfahren zur industriellen synthese von perindopril und dessen wichtigsten synthesezwischenprodukten.

Info

Publication number
DE3861275D1
DE3861275D1 DE8888402339T DE3861275T DE3861275D1 DE 3861275 D1 DE3861275 D1 DE 3861275D1 DE 8888402339 T DE8888402339 T DE 8888402339T DE 3861275 T DE3861275 T DE 3861275T DE 3861275 D1 DE3861275 D1 DE 3861275D1
Authority
DE
Germany
Prior art keywords
synthesis
perindoprile
industrial
intermediate products
main
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888402339T
Other languages
German (de)
English (en)
Inventor
Michel Vincent
Jean Baliarda
Bernard Marchand
Georges Remond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9354991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3861275(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of DE3861275D1 publication Critical patent/DE3861275D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Bending Of Plates, Rods, And Pipes (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Casting Devices For Molds (AREA)
DE8888402339T 1987-09-17 1988-09-16 Verfahren zur industriellen synthese von perindopril und dessen wichtigsten synthesezwischenprodukten. Expired - Lifetime DE3861275D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8712896A FR2620709B1 (fr) 1987-09-17 1987-09-17 Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese

Publications (1)

Publication Number Publication Date
DE3861275D1 true DE3861275D1 (de) 1991-01-24

Family

ID=9354991

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888402339T Expired - Lifetime DE3861275D1 (de) 1987-09-17 1988-09-16 Verfahren zur industriellen synthese von perindopril und dessen wichtigsten synthesezwischenprodukten.

Country Status (15)

Country Link
US (1) US4914214A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0308341B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH01110696A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE59047T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1336348C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3861275D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK171470B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2019703B3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2620709B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3001539T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE61453B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ226224A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
OA (1) OA08915A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT88527B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA886932B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (64)

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FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
US5212319A (en) * 1990-02-26 1993-05-18 Eli Lilly And Company Intermediates to 4-amino-hexahydrobenz[cd]indoles and processes therefor
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
AU2007203451B2 (en) * 2000-07-06 2010-09-02 Les Laboratoires Servier Pharmaceutical composition containing a crystalline form of perindopril tert-butylamine salt
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
AR036187A1 (es) * 2001-07-24 2004-08-18 Adir Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
PT1333026E (pt) * 2002-01-30 2007-09-17 Servier Lab ''processo para a preparação de perindopril com elevado grau de pureza e intermediários úteis para a sua síntese''
CA2477391A1 (en) * 2002-03-01 2003-09-12 Denis Schrier Method of treating osteoarthritis
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JPWO2004065368A1 (ja) * 2003-01-21 2006-05-18 大原薬品工業株式会社 トランドラプリル合成中間体の製造方法
DE60321233D1 (de) * 2003-02-28 2008-07-03 Servier S A Lab Verfahren zur herstellung von perindopril
EP1403275B1 (fr) * 2003-02-28 2005-10-19 Les Laboratoires Servier Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
EP1338591B1 (fr) * 2003-02-28 2005-10-26 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
GB0305066D0 (en) * 2003-03-06 2003-04-09 Ibm System and method for publish/subscribe messaging
DE60303904T2 (de) * 2003-04-09 2006-12-28 Les Laboratoires Servier Verfahren zur Synthese von (2S)-Indolin-2-carbonsäure, und Verwendung in der Synthese von Perindopril
WO2004099138A2 (en) * 2003-05-12 2004-11-18 Cipla Limited Process for the preparation of perindopril
SI21507A (sl) * 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
CN101333181A (zh) * 2003-06-24 2008-12-31 瑟维尔实验室 培哚普利特丁胺的新晶形
DE60313391T2 (de) * 2003-06-30 2008-01-17 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch geeigneten Salze
ES2336554T3 (es) * 2003-10-21 2010-04-14 Les Laboratoires Servier Nuevo metodo para la preparacion de perindopril erbumina cristalina.
US20050171165A1 (en) * 2003-11-12 2005-08-04 Bhirud Shekhar B. Process for the preparation of perindopril
DE60311942T2 (de) * 2003-11-19 2007-12-06 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
DK1422236T3 (da) * 2003-11-19 2007-06-11 Servier Lab Syntesefremgangsmåde for perindopril og farmaceutisk acceptable salte heraf
EP1420030A3 (fr) * 2003-12-10 2004-05-26 Les Laboratoires Servier Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
SI21703A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
HUE031058T2 (en) * 2004-03-29 2017-06-28 Servier Lab A method of producing a solid pharmaceutical composition
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
WO2005108365A1 (en) * 2004-05-07 2005-11-17 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
US20050250706A1 (en) * 2004-05-07 2005-11-10 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
US20060178422A1 (en) * 2004-05-31 2006-08-10 Ashok Kumar Process for making (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl] amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
JP4547245B2 (ja) * 2004-12-16 2010-09-22 株式会社パーマケム・アジア ペリンドプリルエルブミンのｉ型結晶、及びその製造方法
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
ES2314583T4 (es) 2005-01-06 2009-05-18 Ipca Laboratories Limited Proceso para sintesis de los derivados del acido (2s,3as,7as)-1-(s)-alanil-octahidro-1h-indol-2-carboxilico y su utilizacion en la sintesis de perindropil.
MY138209A (en) * 2005-03-11 2009-05-29 Servier Lab New (y) crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it.
US7728151B2 (en) * 2005-03-14 2010-06-01 Lupin Limited Process for the purification of perindopril
US7291745B2 (en) * 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
WO2007003947A2 (en) * 2005-07-05 2007-01-11 Cipla Limited Process for the synthesis of the ace inhibitor trandolapril
ATE549315T1 (de) * 2005-07-25 2012-03-15 Lek Pharmaceuticals Verfahren zur herstellung von kristallinem perindopril
US20070032661A1 (en) * 2005-08-03 2007-02-08 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of perindopril
EP1792896A1 (en) * 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
EA200600630A1 (ru) * 2006-04-20 2007-02-27 ИСМАГИЛОВ, Искандар Халиуллович ζ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА
EP1864973A1 (en) * 2006-06-09 2007-12-12 Sochinaz SA Process for the preparation of perindopril and salts thereof
EP2137148A1 (en) * 2007-03-22 2009-12-30 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
CN101514180B (zh) * 2008-02-20 2012-08-01 上海医药工业研究院 培哚普利叔丁铵盐的ⅰ晶型及其制备方法
PT2318365E (pt) 2008-06-24 2015-11-25 Mylan Lab Ltd Formas polimórficas inovadoras de (l)-arginina de perindopril e processo para a preparação dos mesmos
GB0910692D0 (en) 2009-06-20 2009-08-05 Teva Pharma Compound
SI23149A (sl) 2009-09-21 2011-03-31 Silverstone Pharma Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas
FR2985512B1 (fr) * 2012-01-05 2014-06-20 Servier Lab Procede de preparation du sel de l-arginine du perindopril
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN106631977A (zh) * 2016-11-11 2017-05-10 上海雅本化学有限公司 一种s‑吲哚啉‑2‑羧酸合成的优化方法
CN108752259A (zh) * 2018-07-04 2018-11-06 南京方生和医药科技有限公司 培哚普利消旋体及其中间体的制备方法

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FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3360065D1 (en) * 1982-03-08 1985-03-28 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung

Also Published As

Publication number Publication date
CA1336348C (fr) 1995-07-18
FR2620709A1 (fr) 1989-03-24
PT88527A (pt) 1988-10-01
IE61453B1 (en) 1994-11-02
GR3001539T3 (en) 1992-11-23
AU2236288A (en) 1989-03-23
DK515188D0 (da) 1988-09-15
EP0308341B1 (fr) 1990-12-12
EP0308341A1 (fr) 1989-03-22
OA08915A (fr) 1989-10-31
US4914214A (en) 1990-04-03
JPH0543717B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-07-02
DK515188A (da) 1989-03-18
ATE59047T1 (de) 1990-12-15
AU608363B2 (en) 1991-03-28
ZA886932B (en) 1989-05-30
FR2620709B1 (fr) 1990-09-07
JPH01110696A (ja) 1989-04-27
IE882806L (en) 1989-03-17
PT88527B (pt) 1993-03-31
ES2019703B3 (es) 1991-07-01
NZ226224A (en) 1990-09-26
DK171470B1 (da) 1996-11-11

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Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR