DE3856240D1 - Herstellung der p1 proteine und impfstoffe gegen gonorrhöe - Google Patents

Herstellung der p1 proteine und impfstoffe gegen gonorrhöe

Info

Publication number
DE3856240D1
DE3856240D1 DE3856240T DE3856240T DE3856240D1 DE 3856240 D1 DE3856240 D1 DE 3856240D1 DE 3856240 T DE3856240 T DE 3856240T DE 3856240 T DE3856240 T DE 3856240T DE 3856240 D1 DE3856240 D1 DE 3856240D1
Authority
DE
Germany
Prior art keywords
full length
protein
proteins
production
vaccine against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3856240T
Other languages
English (en)
Other versions
DE3856240T2 (de
Inventor
Nicholas Carbonetti
P Sparling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
University of North Carolina System
Original Assignee
University of North Carolina at Chapel Hill
University of North Carolina System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, University of North Carolina System filed Critical University of North Carolina at Chapel Hill
Application granted granted Critical
Publication of DE3856240D1 publication Critical patent/DE3856240D1/de
Publication of DE3856240T2 publication Critical patent/DE3856240T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE3856240T 1987-11-24 1988-11-23 Herstellung der p1 proteine und impfstoffe gegen gonorrhöe Expired - Lifetime DE3856240T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12472787A 1987-11-24 1987-11-24
US24275888A 1988-09-09 1988-09-09
PCT/US1988/004225 WO1989004873A1 (en) 1987-11-24 1988-11-23 Production of gonorrheal pi proteins and vaccines

Publications (2)

Publication Number Publication Date
DE3856240D1 true DE3856240D1 (de) 1998-09-24
DE3856240T2 DE3856240T2 (de) 1999-05-06

Family

ID=26822891

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3856240T Expired - Lifetime DE3856240T2 (de) 1987-11-24 1988-11-23 Herstellung der p1 proteine und impfstoffe gegen gonorrhöe

Country Status (12)

Country Link
US (2) US5736361A (de)
EP (2) EP0395706B1 (de)
JP (2) JP2803058B2 (de)
KR (1) KR970011309B1 (de)
AT (1) ATE169958T1 (de)
AU (1) AU629807B2 (de)
CA (1) CA1340506C (de)
DE (1) DE3856240T2 (de)
DK (1) DK175831B1 (de)
FI (1) FI102189B (de)
NO (1) NO302622B1 (de)
WO (1) WO1989004873A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340506C (en) * 1987-11-24 1999-04-20 Nicholas H. Carbonetti Production of gonorrheal pi proteins and vaccines
US7118757B1 (en) * 1988-12-19 2006-10-10 Wyeth Holdings Corporation Meningococcal class 1 outer-membrane protein vaccine
WO1992016643A1 (en) * 1991-03-14 1992-10-01 Imclone Systems Incorporated Recombinant hybrid porin epitopes
JPH11501203A (ja) * 1993-07-30 1999-02-02 ザ ユニバーシティー オブ ノースカロライナ アット チャペル ヒル 大腸菌およびサルモネラ菌中における淋菌ｐｉタンパクおよびワクチンの製造
US7252828B2 (en) 1998-07-15 2007-08-07 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
EA006233B1 (ru) * 1999-05-13 2005-10-27 Уайт Холдингз Корпорейшн Комбинированные адъювантные композиции для усиления иммунного ответа у позвоночного животного
AU782337B2 (en) * 1999-09-30 2005-07-21 Isis Innovation Limited Vaccines against Neisseria infection
PT1947187E (pt) * 2000-02-28 2011-07-04 Novartis Vaccines & Diagnostic Expressões híbridas de proteínas de neisseria
BR0115271A (pt) * 2000-11-10 2005-12-13 Wyeth Corp Composição antigênica, método para incrementar a capacidade de uma composição antigênica em elicitar a resposta imunológica de um hospedeiro vertebrado, em elicitar linfócitos t citotóxicos em um hospedeiro vertebrado, em elicitar um efeito terapêutico ou profilático anti-câncer em um hospedeiro vertebrado, em moderar uma resposta alérgica em um hospedeiro vertebrado, e em prevenir ou tratar doença caracterizada por deposição amilóide em um hospedeiro vertebrado, e, formulação adjuvante
AU2003295520B8 (en) 2002-11-12 2011-05-19 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for Staphylococcal infections
AU2003290867A1 (en) 2002-11-12 2004-06-03 The Brigham And Women's Hospital, Inc. Methods and products for treating staphylococcal infections
ES2415358T3 (es) 2004-04-21 2013-07-25 The Brigham And Women's Hospital, Inc. Péptidos de fijación a la poli-N-acetil glucosamina (PNAG/DPNAG) y procedimientos para el uso de los mismos
US7037698B2 (en) 2004-05-19 2006-05-02 Amano Enzyme Inc. Pyrroloquinoline quinone-dependent glucose dehydrogenase
RU2532911C2 (ru) 2008-07-21 2014-11-20 Дзе Брихэм Энд Уимен'З Хоспитал, Инк. Способы и композиции, относящиеся к синтетическим бета-1,6-глюкозаминолигосахаридам

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237224A (en) * 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
US4203971A (en) * 1978-03-23 1980-05-20 Government Of The United States Neisseria gonorrhoeae vaccine
DE2814039C3 (de) * 1978-03-31 1981-02-19 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig Verfahren zur Herstellung von Hybrid-Bakterien
US4351761A (en) * 1978-05-15 1982-09-28 Research Corporation Purified antigen to test for Neisseria gonorrhoeae antibodies
US4220638A (en) * 1978-10-12 1980-09-02 Merck & Co., Inc. Antigenic complex from N. Gonorrhoeae
US4288557A (en) * 1978-10-12 1981-09-08 Merck & Co., Inc. Antigenic complex from N. gonorrhoeae
US4239749A (en) * 1979-09-27 1980-12-16 United States Of America Neisseria gonorrhoeae vaccine
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
WO1983003354A1 (en) * 1982-03-30 1983-10-13 Us Army Neisseria gonorrhoeae vaccine
EP0178863A1 (de) * 1984-10-15 1986-04-23 Schering Corporation Expressionssysteme die sich der Bakteriophage-T7-Promotoren bedienen und Gensequenzen
US4681761A (en) * 1985-10-24 1987-07-21 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Major iron-regulated protein of Neisseria gonorrhoeae and its use as vaccine
US4786592A (en) * 1986-06-18 1988-11-22 Scripps Clinic And Research Foundation Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin
CA1340506C (en) * 1987-11-24 1999-04-20 Nicholas H. Carbonetti Production of gonorrheal pi proteins and vaccines

Also Published As

Publication number Publication date
JP3388171B2 (ja) 2003-03-17
EP0395706B1 (de) 1998-08-19
KR890701750A (ko) 1989-12-21
AU629807B2 (en) 1992-10-15
JP2803058B2 (ja) 1998-09-24
ATE169958T1 (de) 1998-09-15
AU2795989A (en) 1989-06-14
FI902569A0 (fi) 1990-05-23
DE3856240T2 (de) 1999-05-06
US5736361A (en) 1998-04-07
US6068992A (en) 2000-05-30
NO302622B1 (no) 1998-03-30
EP0869133A1 (de) 1998-10-07
NO902251D0 (no) 1990-05-22
CA1340506C (en) 1999-04-20
JPH03502881A (ja) 1991-07-04
FI102189B1 (fi) 1998-10-30
DK128490A (da) 1990-07-06
EP0395706A4 (en) 1991-11-13
KR970011309B1 (ko) 1997-07-09
JPH10234388A (ja) 1998-09-08
WO1989004873A1 (en) 1989-06-01
DK175831B1 (da) 2005-03-14
DK128490D0 (da) 1990-05-23
NO902251L (no) 1990-07-18
FI102189B (fi) 1998-10-30
EP0395706A1 (de) 1990-11-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN