MX9708426A - Polipeptido hk2 de variante estable. - Google Patents

Polipeptido hk2 de variante estable.

Info

Publication number
MX9708426A
MX9708426A MX9708426A MX9708426A MX9708426A MX 9708426 A MX9708426 A MX 9708426A MX 9708426 A MX9708426 A MX 9708426A MX 9708426 A MX9708426 A MX 9708426A MX 9708426 A MX9708426 A MX 9708426A
Authority
MX
Mexico
Prior art keywords
polypeptide
variant
stable variant
nucleic acid
acid molecule
Prior art date
Application number
MX9708426A
Other languages
English (en)
Inventor
Mohammad S Saedi
Stephen D Mikolajczyk
Donald J Tindall
Patrick C Roche
David G Bostwick
Abhay Kumar
Kristine Kuus-Reichel
Original Assignee
Hybritech Inc
Mayo Foundation For Medical
Education And Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc, Mayo Foundation For Medical, Education And Res filed Critical Hybritech Inc
Publication of MX9708426A publication Critical patent/MX9708426A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se provee una molécula de ácido nucléico aislada que codifica una variante de polipéptido hK2. Además se provee una variante de polipéptido hK2 aislada, purificada util para preparar composiciones y vacunas inmunogénicas. También se proveen métodos para emplear la molécula de ácido nucleico el polipéptido de la invencion.
MX9708426A 1995-05-02 1997-10-31 Polipeptido hk2 de variante estable. MX9708426A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42776795A 1995-05-02 1995-05-02
US08/622,046 US6103237A (en) 1993-07-22 1996-03-26 Stable variant hK2 polypeptide

Publications (1)

Publication Number Publication Date
MX9708426A true MX9708426A (es) 1998-08-30

Family

ID=27027506

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708426A MX9708426A (es) 1995-05-02 1997-10-31 Polipeptido hk2 de variante estable.

Country Status (7)

Country Link
US (1) US6103237A (es)
EP (1) EP0826056A2 (es)
JP (2) JPH11505111A (es)
AU (1) AU719502B2 (es)
CA (1) CA2219876C (es)
MX (1) MX9708426A (es)
WO (1) WO1996034964A2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103237A (en) * 1993-07-22 2000-08-15 Hybritech Incorporated Stable variant hK2 polypeptide
US20040259113A1 (en) * 1993-07-22 2004-12-23 Mayo Foundation For Medical Education And Research, Hybritech Incorporated Method for detection of metastatic prostate cancer
EP0804593A1 (en) * 1994-05-10 1997-11-05 Mayo Foundation For Medical Education And Research Recombinant hk2 polypeptide
FR2723378B1 (fr) * 1994-08-02 1996-10-31 Roussel Uclaf Sequence d'adn codant pour une proteine humaine tx apparentee a l'enzyme de conversion de l'interleukine-1beta, proteine tx, procede de production, compositions pharmaceutiques et leurs applications
ATE305140T1 (de) * 1996-07-15 2005-10-15 Mayo Foundation Verfahren zur detektion der hk2 polypeptide
ATE409743T1 (de) * 1996-11-04 2008-10-15 Novozymes As Subtilase varianten und verbindungen
US6479263B1 (en) 1996-11-14 2002-11-12 Baylor College Of Medicine Method for detection of micrometastatic prostate cancer
AU739546B2 (en) * 1997-04-30 2001-10-18 Hybritech Incorporated Forms of prostate specific antigen and methods for their detection
US7288636B2 (en) 1997-04-30 2007-10-30 Hybritech Incorporated Forms of prostate specific antigens and methods for their detection
US7659073B2 (en) 1997-04-30 2010-02-09 Hybritech Incorporated Forms of prostate specific antigens and methods for their detection
WO1998059073A1 (en) * 1997-06-20 1998-12-30 Mayo Foundation For Medical Education And Research Method for detection of breast cancer
EP1027457A1 (en) * 1997-10-28 2000-08-16 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
CA2360073C (en) 1999-01-28 2011-01-18 Gen-Probe Incorporated Probes and primers for detecting prostate specific antigen (psa) in a biological sample
FI990382A0 (fi) * 1999-02-23 1999-02-23 Arctic Partners Oy Ab Uusi diagnostinen menetelmä
US7238492B2 (en) * 2000-11-02 2007-07-03 University Of Iowa Research Foundation Method for predicting tumor recurrence
US6656684B1 (en) 2000-11-02 2003-12-02 University Of Iowa Research Foundation Method for predicting tumor recurrence
AUPS187002A0 (en) * 2002-04-22 2002-05-30 Queensland University Of Technology Condition-specific molecules and uses therefor
EP1711828A2 (en) * 2004-01-28 2006-10-18 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with kallikrein 2 (klk2)

Family Cites Families (32)

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NL154598B (nl) * 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3901654A (en) * 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3862925A (en) * 1973-07-05 1975-01-28 American Home Prod Preparation of somatotropin release inhibiting factor and intermediates therefor
US3842067A (en) * 1973-07-27 1974-10-15 American Home Prod Synthesis of(des-asn5)-srif and intermediates
JPS5726506B2 (es) * 1974-03-08 1982-06-04
US3935074A (en) * 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) * 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US4105602A (en) * 1975-02-10 1978-08-08 Armour Pharmaceutical Company Synthesis of peptides with parathyroid hormone activity
US4092408A (en) * 1975-08-28 1978-05-30 New England Nuclear Corporation Method for solid phase immunological assay of antigen
US3984533A (en) * 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) * 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4371515A (en) * 1978-12-26 1983-02-01 E-Y Laboratories, Inc. Method for forming an isolated lectin-immunological conjugate
US4446122A (en) * 1979-12-28 1984-05-01 Research Corporation Purified human prostate antigen
US4353982A (en) * 1980-04-10 1982-10-12 Hoffmann-La Roche Inc. Immunochemical assay for creatine kinase-MB isoenzyme
US4792528A (en) * 1982-05-21 1988-12-20 The Trustees Of Columbia University In The City Of New York Methods for obtaining monoclonal antibodies useful in enhanced sensitivity immunoassays
US4487715A (en) * 1982-07-09 1984-12-11 The Regents Of The University Of California Method of conjugating oligopeptides
US4629783A (en) * 1985-04-29 1986-12-16 Genetic Systems Corporation Synthetic antigen for the detection of AIDS-related disease
US4757048A (en) * 1985-11-05 1988-07-12 Biotechnology Research Associates J.V. Synthetic analogs of atrial natriuretic peptides
DE3684578D1 (de) * 1985-12-17 1992-04-30 Eastern Virginia Medical Autho Monoklonale antikoerper mit bindungsspezifitaet fuer menschliche prostatatumorantigene und methoden fuer ihre verwendung.
FI890889A7 (fi) * 1987-06-30 1989-02-24 Amgen Inc Kallikreinin tuottaminen
CA2096497A1 (en) * 1992-05-26 1993-11-27 Patricia Anne Spears Mycobacteria probes
DK0667920T3 (da) * 1992-10-29 2003-04-14 Univ Jefferson Fremgangsmåder til påvisning af prostatacancermetastase
US6103237A (en) * 1993-07-22 2000-08-15 Hybritech Incorporated Stable variant hK2 polypeptide
US5516639A (en) * 1993-07-22 1996-05-14 Mayo Foundation For Medical Education And Research Antibodies specific for human prostate glandular kallkrein
CA2187775A1 (en) * 1994-04-15 1995-10-26 Aaron E. Katz Method for molecular staging of prostate cancer
EP0804593A1 (en) * 1994-05-10 1997-11-05 Mayo Foundation For Medical Education And Research Recombinant hk2 polypeptide
WO1996021042A2 (en) * 1995-01-04 1996-07-11 Trustees Of Boston University Primers for the pcr amplification of metastatic sequences
EP0812356B1 (en) * 1995-02-24 2006-02-08 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen and uses thereof
US5614372A (en) * 1995-02-24 1997-03-25 Lilja; Hans Early detection of prostate cancer (CAP) by employing prostate specific antigen (PSA) and human glandular kallikrein (hGK-1)
GB2302874B (en) * 1995-06-29 1999-11-10 Orion Yhtymae Oy Novel proteins

Also Published As

Publication number Publication date
JP2006314327A (ja) 2006-11-24
WO1996034964A3 (en) 1997-03-13
US6103237A (en) 2000-08-15
JPH11505111A (ja) 1999-05-18
EP0826056A2 (en) 1998-03-04
AU5788996A (en) 1996-11-21
CA2219876A1 (en) 1996-11-07
AU719502B2 (en) 2000-05-11
CA2219876C (en) 2010-04-20
JP4205738B2 (ja) 2009-01-07
WO1996034964A2 (en) 1996-11-07

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