DE3784555T2 - Isolierung von bioaktivem, monomerem wachstumshormon. - Google Patents

Isolierung von bioaktivem, monomerem wachstumshormon.

Info

Publication number
DE3784555T2
DE3784555T2 DE8787304818T DE3784555T DE3784555T2 DE 3784555 T2 DE3784555 T2 DE 3784555T2 DE 8787304818 T DE8787304818 T DE 8787304818T DE 3784555 T DE3784555 T DE 3784555T DE 3784555 T2 DE3784555 T2 DE 3784555T2
Authority
DE
Germany
Prior art keywords
growth hormone
monomeral
bioactive
isolation
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787304818T
Other languages
English (en)
Other versions
DE3784555D1 (de
Inventor
Ren-Der Yang
Larry D Taber
Hamilton, Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Veterinary Inc
Original Assignee
Pitman Moore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pitman Moore Inc filed Critical Pitman Moore Inc
Publication of DE3784555D1 publication Critical patent/DE3784555D1/de
Application granted granted Critical
Publication of DE3784555T2 publication Critical patent/DE3784555T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8787304818T 1986-06-02 1987-06-01 Isolierung von bioaktivem, monomerem wachstumshormon. Expired - Fee Related DE3784555T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/869,702 US4705848A (en) 1986-06-02 1986-06-02 Isolation of bioactive, monomeric growth hormone

Publications (2)

Publication Number Publication Date
DE3784555D1 DE3784555D1 (de) 1993-04-15
DE3784555T2 true DE3784555T2 (de) 1993-07-01

Family

ID=25354104

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787304818T Expired - Fee Related DE3784555T2 (de) 1986-06-02 1987-06-01 Isolierung von bioaktivem, monomerem wachstumshormon.

Country Status (12)

Country Link
US (1) US4705848A (de)
EP (1) EP0248618B1 (de)
JP (1) JPH0822877B2 (de)
KR (1) KR960003548B1 (de)
AT (1) ATE86627T1 (de)
CA (1) CA1273592C (de)
DE (1) DE3784555T2 (de)
DK (1) DK282287A (de)
ES (1) ES2053537T3 (de)
IE (1) IE61977B1 (de)
IL (1) IL82735A0 (de)
MX (1) MX174060B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453363A (en) * 1985-10-23 1995-09-26 Boehringer Mannheim Gmbh Process for the activation of t-PA or Ing after genetic expression in prokaryotes
GB8701848D0 (en) * 1987-01-28 1987-03-04 Celltech Ltd Polypeptides
US4975529A (en) * 1989-08-18 1990-12-04 Monsanto Company Method of folding somatotropins
DK580789D0 (da) * 1989-11-20 1989-11-20 Novo Nordisk As Fremgangsmaade til oprensning af polypeptider
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
AU707719B2 (en) * 1995-07-21 1999-07-15 Amgen, Inc. Process for protein refolding by means of buffer exchange using a continuous stationary phase capable of separating proteins from salt
KR970006498A (ko) * 1995-07-31 1997-02-21 유충식 활성형 인성장호르몬의 정제 방법
US5912327A (en) * 1996-09-30 1999-06-15 Human Genome Sciences, Inc. Method of purifying chemokines from inclusion bodies
US6632425B1 (en) 1997-03-20 2003-10-14 Human Genome Sciences, Inc. Chemokine compositions
JP4798832B2 (ja) * 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の除去方法
KR100827750B1 (ko) * 2000-10-24 2008-05-07 쥬리디컬 파운데이션 더 케모-세로-쎄라퓨틱 리서치 인스티튜트 인체 혈청알부민 다량체의 단량체화 방법
KR102472497B1 (ko) 2010-11-12 2022-11-29 넥타르 테라퓨틱스 Ｉｌ-2 부분 및 중합체의 접합체

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ204477A (en) * 1982-06-07 1986-09-10 Celltech Ltd Recombinant dna method for production of chymosin:initial solubilisation of insoluble precursor
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
IE56372B1 (en) * 1982-12-22 1991-07-03 Genentech Inc Microbially produced rennet methods for its production and plasmids used for its production
GR79124B (de) * 1982-12-22 1984-10-02 Genentech Inc
JPS59166086A (ja) * 1983-03-09 1984-09-19 Teruhiko Beppu 新規な発現型プラスミドとそれらを用いて仔牛プロキモシン遺伝子を大腸菌内で発現させる方法
ATE107356T1 (de) * 1983-03-25 1994-07-15 Celltech Ltd Verfahren zur herstellung eines proteins.
NO841276L (no) * 1983-03-31 1984-10-01 Codon Genetic Eng Lab Rekombinant dna-koding for et polypeptid som utviser melkesammenloepende aktivitet
US4788144A (en) * 1985-06-28 1988-11-29 International Minerals & Chemical Corp. Fermentation process for the high level production of swine growth
US4766224A (en) * 1985-08-19 1988-08-23 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
US4656255A (en) * 1985-09-09 1987-04-07 International Minerals & Chemical Corp. Protein recovery

Also Published As

Publication number Publication date
DK282287A (da) 1987-12-03
JPH0822877B2 (ja) 1996-03-06
ATE86627T1 (de) 1993-03-15
ES2053537T3 (es) 1994-08-01
KR960003548B1 (ko) 1996-03-15
IE61977B1 (en) 1994-12-14
IL82735A0 (en) 1987-12-20
CA1273592A (en) 1990-09-04
EP0248618A3 (en) 1990-02-07
DE3784555D1 (de) 1993-04-15
MX174060B (es) 1994-04-18
EP0248618B1 (de) 1993-03-10
DK282287D0 (da) 1987-06-02
IE871422L (en) 1987-12-02
JPS63258492A (ja) 1988-10-25
EP0248618A2 (de) 1987-12-09
KR880000578A (ko) 1988-03-26
US4705848A (en) 1987-11-10
CA1273592C (en) 1990-09-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee