IL82735A0 - Isolation of bioactive,monomeric growth hormone - Google Patents
Isolation of bioactive,monomeric growth hormoneInfo
- Publication number
- IL82735A0 IL82735A0 IL82735A IL8273587A IL82735A0 IL 82735 A0 IL82735 A0 IL 82735A0 IL 82735 A IL82735 A IL 82735A IL 8273587 A IL8273587 A IL 8273587A IL 82735 A0 IL82735 A0 IL 82735A0
- Authority
- IL
- Israel
- Prior art keywords
- growth hormone
- bioactive
- isolation
- solution
- monomeric
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 6
- 108010051696 Growth Hormone Proteins 0.000 title abstract 6
- 239000000122 growth hormone Substances 0.000 title abstract 6
- 230000000975 bioactive effect Effects 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
- 150000002357 guanidines Chemical class 0.000 abstract 2
- 210000003000 inclusion body Anatomy 0.000 abstract 2
- 239000012266 salt solution Substances 0.000 abstract 2
- 239000007853 buffer solution Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 229960000789 guanidine hydrochloride Drugs 0.000 abstract 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/869,702 US4705848A (en) | 1986-06-02 | 1986-06-02 | Isolation of bioactive, monomeric growth hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL82735A0 true IL82735A0 (en) | 1987-12-20 |
Family
ID=25354104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL82735A IL82735A0 (en) | 1986-06-02 | 1987-06-01 | Isolation of bioactive,monomeric growth hormone |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4705848A (xx) |
| EP (1) | EP0248618B1 (xx) |
| JP (1) | JPH0822877B2 (xx) |
| KR (1) | KR960003548B1 (xx) |
| AT (1) | ATE86627T1 (xx) |
| CA (1) | CA1273592C (xx) |
| DE (1) | DE3784555T2 (xx) |
| DK (1) | DK282287A (xx) |
| ES (1) | ES2053537T3 (xx) |
| IE (1) | IE61977B1 (xx) |
| IL (1) | IL82735A0 (xx) |
| MX (1) | MX174060B (xx) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453363A (en) * | 1985-10-23 | 1995-09-26 | Boehringer Mannheim Gmbh | Process for the activation of t-PA or Ing after genetic expression in prokaryotes |
| GB8701848D0 (en) * | 1987-01-28 | 1987-03-04 | Celltech Ltd | Polypeptides |
| US4975529A (en) * | 1989-08-18 | 1990-12-04 | Monsanto Company | Method of folding somatotropins |
| DK580789D0 (da) * | 1989-11-20 | 1989-11-20 | Novo Nordisk As | Fremgangsmaade til oprensning af polypeptider |
| US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
| US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
| WO1997004003A2 (en) * | 1995-07-21 | 1997-02-06 | Amgen Inc. | Process for protein refolding by means of buffer exchange using a continuous stationary phase capable of separating proteins from salts |
| KR970006498A (ko) * | 1995-07-31 | 1997-02-21 | 유충식 | 활성형 인성장호르몬의 정제 방법 |
| US5912327A (en) * | 1996-09-30 | 1999-06-15 | Human Genome Sciences, Inc. | Method of purifying chemokines from inclusion bodies |
| US6632425B1 (en) | 1997-03-20 | 2003-10-14 | Human Genome Sciences, Inc. | Chemokine compositions |
| ES2261487T3 (es) * | 2000-10-24 | 2006-11-16 | Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute | Metodo de monomerizacion de polimeros de albumina de suero humano. |
| JP4798832B2 (ja) * | 2000-10-24 | 2011-10-19 | 一般財団法人化学及血清療法研究所 | ヒト血清アルブミン多量体の除去方法 |
| HUE054318T2 (hu) * | 2010-11-12 | 2021-08-30 | Nektar Therapeutics | IL-2 molekularész konjugátumai és polimer |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2129810B (en) * | 1982-06-07 | 1985-09-18 | Celltech Ltd | A process for the preparation of chymosin |
| GR79124B (xx) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
| US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4518526A (en) * | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| IE56372B1 (en) * | 1982-12-22 | 1991-07-03 | Genentech Inc | Microbially produced rennet methods for its production and plasmids used for its production |
| US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| JPS59166086A (ja) * | 1983-03-09 | 1984-09-19 | Teruhiko Beppu | 新規な発現型プラスミドとそれらを用いて仔牛プロキモシン遺伝子を大腸菌内で発現させる方法 |
| WO1984003711A1 (en) * | 1983-03-25 | 1984-09-27 | Celltech Ltd | A process for the production of a protein |
| FI841288A (fi) * | 1983-03-31 | 1984-10-01 | Codon Genetic Eng Lab | Rekombinant-dna-kod foer uttryckning av polypeptid. |
| US4788144A (en) * | 1985-06-28 | 1988-11-29 | International Minerals & Chemical Corp. | Fermentation process for the high level production of swine growth |
| US4766224A (en) * | 1985-08-19 | 1988-08-23 | International Minerals & Chemical Corp. | Purification and activation of proteins from insoluble inclusion bodies |
| US4656255A (en) * | 1985-09-09 | 1987-04-07 | International Minerals & Chemical Corp. | Protein recovery |
-
1986
- 1986-06-02 US US06/869,702 patent/US4705848A/en not_active Expired - Lifetime
-
1987
- 1987-05-29 IE IE142287A patent/IE61977B1/en not_active IP Right Cessation
- 1987-06-01 ES ES87304818T patent/ES2053537T3/es not_active Expired - Lifetime
- 1987-06-01 JP JP62134993A patent/JPH0822877B2/ja not_active Expired - Lifetime
- 1987-06-01 EP EP87304818A patent/EP0248618B1/en not_active Expired - Lifetime
- 1987-06-01 AT AT87304818T patent/ATE86627T1/de not_active IP Right Cessation
- 1987-06-01 KR KR1019870005507A patent/KR960003548B1/ko not_active IP Right Cessation
- 1987-06-01 DE DE8787304818T patent/DE3784555T2/de not_active Expired - Fee Related
- 1987-06-01 IL IL82735A patent/IL82735A0/xx not_active IP Right Cessation
- 1987-06-02 CA CA538594A patent/CA1273592C/en not_active Expired
- 1987-06-02 DK DK282287A patent/DK282287A/da not_active Application Discontinuation
- 1987-06-02 MX MX027073A patent/MX174060B/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE86627T1 (de) | 1993-03-15 |
| JPS63258492A (ja) | 1988-10-25 |
| JPH0822877B2 (ja) | 1996-03-06 |
| DK282287A (da) | 1987-12-03 |
| US4705848A (en) | 1987-11-10 |
| MX174060B (es) | 1994-04-18 |
| CA1273592A (en) | 1990-09-04 |
| KR880000578A (ko) | 1988-03-26 |
| IE61977B1 (en) | 1994-12-14 |
| EP0248618B1 (en) | 1993-03-10 |
| DK282287D0 (da) | 1987-06-02 |
| DE3784555T2 (de) | 1993-07-01 |
| IE871422L (en) | 1987-12-02 |
| DE3784555D1 (de) | 1993-04-15 |
| ES2053537T3 (es) | 1994-08-01 |
| CA1273592C (en) | 1990-09-04 |
| EP0248618A2 (en) | 1987-12-09 |
| KR960003548B1 (ko) | 1996-03-15 |
| EP0248618A3 (en) | 1990-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |