DE3778135D1 - Verfahren zur herstellung von (+)-biotin. - Google Patents

Verfahren zur herstellung von (+)-biotin.

Info

Publication number
DE3778135D1
DE3778135D1 DE8787118342T DE3778135T DE3778135D1 DE 3778135 D1 DE3778135 D1 DE 3778135D1 DE 8787118342 T DE8787118342 T DE 8787118342T DE 3778135 T DE3778135 T DE 3778135T DE 3778135 D1 DE3778135 D1 DE 3778135D1
Authority
DE
Germany
Prior art keywords
compound
formula
biotin
image
thiolacetone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787118342T
Other languages
German (de)
English (en)
Inventor
John Dr Mcgarrity
Leander Dr Ing Tenud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of DE3778135D1 publication Critical patent/DE3778135D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8787118342T 1986-12-18 1987-12-10 Verfahren zur herstellung von (+)-biotin. Expired - Fee Related DE3778135D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH5051/86A CH670644A5 (US20030204162A1-20031030-M00001.png) 1986-12-18 1986-12-18

Publications (1)

Publication Number Publication Date
DE3778135D1 true DE3778135D1 (de) 1992-05-14

Family

ID=4287129

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787118342T Expired - Fee Related DE3778135D1 (de) 1986-12-18 1987-12-10 Verfahren zur herstellung von (+)-biotin.

Country Status (19)

Country Link
US (2) US4876350A (US20030204162A1-20031030-M00001.png)
EP (1) EP0273270B1 (US20030204162A1-20031030-M00001.png)
JP (2) JP2560360B2 (US20030204162A1-20031030-M00001.png)
AT (1) ATE74606T1 (US20030204162A1-20031030-M00001.png)
CA (1) CA1322757C (US20030204162A1-20031030-M00001.png)
CH (1) CH670644A5 (US20030204162A1-20031030-M00001.png)
DD (1) DD264920A5 (US20030204162A1-20031030-M00001.png)
DE (1) DE3778135D1 (US20030204162A1-20031030-M00001.png)
DK (1) DK638287A (US20030204162A1-20031030-M00001.png)
ES (1) ES2032428T3 (US20030204162A1-20031030-M00001.png)
FI (1) FI90423C (US20030204162A1-20031030-M00001.png)
GE (1) GEP19960473B (US20030204162A1-20031030-M00001.png)
HU (1) HU199475B (US20030204162A1-20031030-M00001.png)
IE (1) IE60518B1 (US20030204162A1-20031030-M00001.png)
IL (1) IL84770A (US20030204162A1-20031030-M00001.png)
NO (1) NO166941C (US20030204162A1-20031030-M00001.png)
PT (1) PT86401B (US20030204162A1-20031030-M00001.png)
SU (1) SU1600631A3 (US20030204162A1-20031030-M00001.png)
YU (1) YU46432B (US20030204162A1-20031030-M00001.png)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8720394D0 (en) * 1987-08-28 1987-10-07 Ici Plc Nucleotide probes
FI95034C (fi) * 1989-03-15 1995-12-11 Lonza Ag Menetelmä 1,3-substituoidun tetrahydro-1H-tieno/3,4-d/-imidatsol-2(3H)-on-4-ylideenipentaanihappoesterin valmistamiseksi
DE4107121C1 (US20030204162A1-20031030-M00001.png) * 1991-03-06 1992-06-11 Merck Patent Gmbh, 6100 Darmstadt, De
FI935609A (fi) * 1992-12-18 1994-06-19 Lonza Ag Dihydrofuroimidatsolijohdannaisten asymmetrinen hydraus
AU6679494A (en) * 1993-04-20 1994-11-08 Lonza Ltd. Asymmetric hydrogenation of furoimidazole derivatives
CA2122511A1 (en) * 1993-05-14 1994-11-15 John Mcgarrity Asymmetric hydrogenation of furoimidazole derivatives
DE4411101C2 (de) * 1994-03-30 1996-02-01 Merck Patent Gmbh Verfahren zur Herstellung eines D-(+)-Biotin-Zwischenproduktes
WO1998015557A1 (de) * 1996-10-09 1998-04-16 Lonza Ag Verfahren zur herstellung von (+)-biotin
PL210697B1 (pl) * 2001-10-19 2012-02-29 Isotechnika Inc Kompozycja zawierająca mieszaninę izomerów analogu cyklosporyny i zastosowanie tej mieszaniny
PT1436321E (pt) * 2001-10-19 2006-10-31 Isotechnika Inc Sintese de analogos de ciclosporina
CN103936759B (zh) * 2014-03-11 2016-01-13 新发药业有限公司 （3aS,6aR）-1,3-二苄基-四氢-4H-噻吩并[3,4-d]咪唑-2,4-（1H）-二酮的简便制备方法
CN104530076B (zh) * 2014-12-17 2016-08-17 新发药业有限公司 （3aS,6aR）-1,3-二苄基四氢-4H-噻吩并[3,4-d]咪唑-2,4-（1H）-二酮的合成方法
CN107686488B (zh) * 2016-08-05 2020-04-28 浙江医药股份有限公司新昌制药厂 一种生物素中间体的合成方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE154225C (US20030204162A1-20031030-M00001.png) *
US2784191A (en) * 1957-03-05 Process for the production of lactams
US2489235A (en) * 1947-07-24 1949-11-22 Hoffmann La Roche Synthesis of biotin
US2535010A (en) * 1948-10-02 1950-12-19 Rohm & Haas Transetherification of beta-ethersubstituted esters
DE850007C (de) * 1950-12-22 1952-09-22 Basf Ag Verfahren zur Herstellung von N-Aryl-ª‡-pyrrolidonen
JPS463580Y1 (US20030204162A1-20031030-M00001.png) * 1967-06-13 1971-02-06
BE759512A (fr) * 1969-11-29 1971-05-27 Hoffmann La Roche Lactone
DD111577A5 (US20030204162A1-20031030-M00001.png) * 1972-06-22 1975-02-20
JPS5315074B2 (US20030204162A1-20031030-M00001.png) * 1973-06-14 1978-05-22
JPS5067627A (US20030204162A1-20031030-M00001.png) * 1973-10-17 1975-06-06
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
IT1075280B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
IT1075564B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
JPS603387B2 (ja) * 1980-07-10 1985-01-28 住友化学工業株式会社 新規光学活性イミダゾリジン−２−オン誘導体およびその製法
DD154225A1 (de) * 1980-11-10 1982-03-03 Horst Seiferth Verfahren zur herstellung beschichteter textiler flaechengebilde
JPS5812272B2 (ja) * 1981-04-28 1983-03-07 電気化学工業株式会社 ４−ヒドロキシ−２−ピロリドンの製造法
DE3268046D1 (en) * 1981-12-07 1986-01-30 Hoffmann La Roche Process for the preparation of an optically active lactone, and starting products for the process
JPS58124791A (ja) * 1982-01-19 1983-07-25 Sumitomo Chem Co Ltd ビオチンの製造法
DK43985A (da) * 1984-03-09 1985-09-10 Hoffmann La Roche Fremgangsmaade til fremstilling af heterocycliske forbindelser
DE3580390D1 (de) * 1984-05-18 1990-12-13 Hoffmann La Roche Verfahren zur herstellung eines lactons.
DE3575717D1 (de) * 1984-08-25 1990-03-08 Merck Patent Gmbh Verfahren zur herstellung von (3a5,6ar)-und/oder(3ar,6a5)-1,3-dibenzyl-hexahydro-1h-furo(3,4-d)imidazol-2,4-dion.
FI83510C (fi) * 1985-02-22 1991-07-25 Ciba Geigy Ag Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara bi-2h- pyrroli(di)ndioner.
CH671227A5 (US20030204162A1-20031030-M00001.png) * 1986-12-02 1989-08-15 Lonza Ag

Also Published As

Publication number Publication date
IE60518B1 (en) 1994-07-27
PT86401B (pt) 1990-11-20
SU1600631A3 (ru) 1990-10-15
JPH08319290A (ja) 1996-12-03
HUT47290A (en) 1989-02-28
NO875279L (no) 1988-06-20
YU229487A (en) 1988-10-31
JPS63165387A (ja) 1988-07-08
DK638287D0 (da) 1987-12-04
IL84770A0 (en) 1988-05-31
NO875279D0 (no) 1987-12-17
ATE74606T1 (de) 1992-04-15
US5117003A (en) 1992-05-26
NO166941B (no) 1991-06-10
DK638287A (da) 1988-06-19
EP0273270A1 (de) 1988-07-06
CA1322757C (en) 1993-10-05
EP0273270B1 (de) 1992-04-08
GEP19960473B (en) 1996-06-26
FI875371A0 (fi) 1987-12-07
JP2560360B2 (ja) 1996-12-04
YU46432B (sh) 1993-10-20
DD264920A5 (de) 1989-02-15
ES2032428T3 (es) 1993-02-16
HU199475B (en) 1990-02-28
NO166941C (no) 1991-09-18
PT86401A (de) 1988-01-01
US4876350A (en) 1989-10-24
CH670644A5 (US20030204162A1-20031030-M00001.png) 1989-06-30
FI90423B (fi) 1993-10-29
FI90423C (fi) 1994-02-10
IL84770A (en) 1993-05-13
IE873307L (en) 1988-06-18
FI875371A (fi) 1988-06-19

Similar Documents

Publication Publication Date Title
DE3778135D1 (de) Verfahren zur herstellung von (+)-biotin.
DE69225468T2 (de) Verfahren zur herstellung von halomethyl-estern von alifatischer carbonsäure
KR830007654A (ko) 1,2-디히드로-3H-피롤로[1,2-a]피톤-1-카르복실 에스테르의 5-아로일화 방법
DE68901334D1 (de) Verfahren zur herstellung von 1-phenyl-2-diethyl-aminocarbonyl-2-phthalimidomethyl-cyclopropan z.
DE3767993D1 (de) Verfahren zur herstellung von thienylaethylaminen, und mittels des verfahrens hergestellte dithienylaethylamine.
DE3772308D1 (de) Verfahren zur herstellung von retinoylchloriden.
ATE123027T1 (de) Verfahren zur herstellung von (3,5- dioxopiperazinyl)-alkanen oder -alkenen.
ATE156134T1 (de) Verfahren zur herstellung von alkylpolyglukosiden
ATE119154T1 (de) Verfahren zur herstellung von 2-chlor-5- chlormethyl-pyridin.
DE3768123D1 (de) Verfahren zur herstellung von homoallylalkoholen.
ATE118008T1 (de) Verfahren zur herstellung von aminomethanphosphonsäure und aminomethyl- phosphinsäuren.
ATE117977T1 (de) Verfahren zur herstellung von alpha-beta- ungesättigten ketonen.
ATE131483T1 (de) Verfahren zur herstellung von penemen
DE69020377D1 (de) Verfahren zur Herstellung von für die Umwelt unbedenklichem Dicofol und dessen Formulierungen.
ATE312107T1 (de) Verfahren zur herstellung von alkyllithium- verbindungen
HUT46701A (en) Process for producing alpha-amino-alkyl-phosphonic acids
ATE16696T1 (de) Verfahren zur herstellung von 3-alkyl-6-methylbeta-resorcylsaeureestern.
DE69407938T2 (de) Verfahren zur herstellung von alpha-hydroximinophenylacetonitril
DE3582156D1 (de) Verfahren zur herstellung von benzimidazol-thiolen.
DE69407742T2 (de) Verfahren zur herstellung von alpha-alkoxy-iminophenylacetonitril
ATE42089T1 (de) Verfahren zur herstellung von bromfluoressigs|ure.
KR970010772A (ko) 7-아미노-3-메톡시메틸-3-세펨-4-카르복실산의 신규 제조방법
ATE167474T1 (de) Verfahren zur herstellung von n-alkylpyrazolen
RO84817B (ro) Procedeu de preparare a sarurilor acide de aditie ale 3, 4-diaciloximetilamino-metilbenzilalcoolilor
DE69025894T2 (de) Verfahren zur herstellung von dikalium-askorbat-2-sulphat

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee