CA1223831A
(en)
|
1982-06-23 |
1987-07-07 |
Dean Engelhardt |
Modified nucleotides, methods of preparing and utilizing and compositions containing the same
|
US4948882A
(en)
*
|
1983-02-22 |
1990-08-14 |
Syngene, Inc. |
Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
|
USRE43096E1
(en)
|
1984-01-16 |
2012-01-10 |
California Institute Of Technology |
Tagged extendable primers and extension products
|
US5821058A
(en)
*
|
1984-01-16 |
1998-10-13 |
California Institute Of Technology |
Automated DNA sequencing technique
|
JPH0692392B2
(ja)
*
|
1986-04-04 |
1994-11-16 |
信彦 勝沼 |
新規プソイドウリジン誘導体
|
US5384241A
(en)
*
|
1987-09-11 |
1995-01-24 |
Enzo Diagnostics, Inc. |
Specific binding assay compound with inhibitive self-quenching characteristics
|
US4965349A
(en)
*
|
1987-12-24 |
1990-10-23 |
Applied Biosystems, Inc. |
Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
|
DE68917479D1
(de)
*
|
1988-02-24 |
1994-09-15 |
Inst Rech Chim Biolog |
Derivate von deoxy-2'-uridin substituiert in der 5, 3' oder 5' stellung durch acylierte alpha-amino-gruppen, verfahren zur herstellung und arzneimittel daraus.
|
US5324831A
(en)
*
|
1988-04-06 |
1994-06-28 |
The United States Of America As Represented By The Secretary Of Health And Human Services |
Phosphoramidite reagent for chemical synthesis of modified DNA
|
DE3835772A1
(de)
*
|
1988-10-20 |
1990-04-26 |
Deutsches Krebsforsch |
Tumorhemmende saccharid-konjugate
|
IT1228293B
(it)
*
|
1989-02-06 |
1991-06-07 |
Angeli Inst Spa |
Benzoderivati di composti eterociclici contenenti azoto.
|
JPH05500799A
(ja)
*
|
1989-06-05 |
1993-02-18 |
ギリアド サイエンシス,インコーポレイテッド |
エキソヌクレアーゼ抵抗性オリゴヌクレオチドおよびその調製方法
|
US5256775A
(en)
*
|
1989-06-05 |
1993-10-26 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides
|
US5744101A
(en)
|
1989-06-07 |
1998-04-28 |
Affymax Technologies N.V. |
Photolabile nucleoside protecting groups
|
US6416952B1
(en)
|
1989-06-07 |
2002-07-09 |
Affymetrix, Inc. |
Photolithographic and other means for manufacturing arrays
|
US6955915B2
(en)
|
1989-06-07 |
2005-10-18 |
Affymetrix, Inc. |
Apparatus comprising polymers
|
US6406844B1
(en)
|
1989-06-07 |
2002-06-18 |
Affymetrix, Inc. |
Very large scale immobilized polymer synthesis
|
US6919211B1
(en)
|
1989-06-07 |
2005-07-19 |
Affymetrix, Inc. |
Polypeptide arrays
|
US6309822B1
(en)
|
1989-06-07 |
2001-10-30 |
Affymetrix, Inc. |
Method for comparing copy number of nucleic acid sequences
|
US5143854A
(en)
|
1989-06-07 |
1992-09-01 |
Affymax Technologies N.V. |
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
|
US5800992A
(en)
|
1989-06-07 |
1998-09-01 |
Fodor; Stephen P.A. |
Method of detecting nucleic acids
|
US6346413B1
(en)
|
1989-06-07 |
2002-02-12 |
Affymetrix, Inc. |
Polymer arrays
|
US5424186A
(en)
|
1989-06-07 |
1995-06-13 |
Affymax Technologies N.V. |
Very large scale immobilized polymer synthesis
|
US6551784B2
(en)
|
1989-06-07 |
2003-04-22 |
Affymetrix Inc |
Method of comparing nucleic acid sequences
|
US6040138A
(en)
|
1995-09-15 |
2000-03-21 |
Affymetrix, Inc. |
Expression monitoring by hybridization to high density oligonucleotide arrays
|
US5141813A
(en)
*
|
1989-08-28 |
1992-08-25 |
Clontech Laboratories, Inc. |
Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
|
DK0497875T3
(da)
*
|
1989-10-24 |
2000-07-03 |
Gilead Sciences Inc |
2'-modificerede oligonukleotider
|
US6005087A
(en)
*
|
1995-06-06 |
1999-12-21 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
US6506558B1
(en)
|
1990-03-07 |
2003-01-14 |
Affymetrix Inc. |
Very large scale immobilized polymer synthesis
|
ATE154246T1
(de)
*
|
1990-07-27 |
1997-06-15 |
Isis Pharmaceuticals Inc |
Nuklease resistente, pyrimidin modifizierte oligonukleotide, die die gen-expression detektieren und modulieren
|
DE69124522T2
(de)
*
|
1990-09-20 |
1997-09-25 |
Vysis, Inc., Downers Grove, Ill. |
Sonde zusammensetzungen für chromosom identifizierung und verfahren
|
EP1231282A3
(de)
|
1990-12-06 |
2005-05-18 |
Affymetrix, Inc. |
Verfahren und Zussamensetzungen für den Nachweis von Polymeren
|
YU187991A
(sh)
*
|
1990-12-11 |
1994-09-09 |
Hoechst Aktiengesellschaft |
3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba
|
US6309639B1
(en)
*
|
1991-02-05 |
2001-10-30 |
The Board Of Regents Of The University Of Oklahoma |
Method for inhibiting an inflammatory response using antibodies to P-selectin glycoprotein ligand
|
US6124267A
(en)
*
|
1991-02-05 |
2000-09-26 |
Southpac Trust Internationals, Inc. |
O-glycan inhibitors of selectin mediated inflammation derived from PSGL-1
|
US6136601A
(en)
*
|
1991-08-21 |
2000-10-24 |
Epoch Pharmaceuticals, Inc. |
Targeted mutagenesis in living cells using modified oligonucleotides
|
US6468740B1
(en)
|
1992-11-05 |
2002-10-22 |
Affymetrix, Inc. |
Cyclic and substituted immobilized molecular synthesis
|
US6943034B1
(en)
|
1991-11-22 |
2005-09-13 |
Affymetrix, Inc. |
Combinatorial strategies for polymer synthesis
|
US6864101B1
(en)
|
1991-11-22 |
2005-03-08 |
Affymetrix, Inc. |
Combinatorial strategies for polymer synthesis
|
EP0624059A4
(en)
*
|
1991-11-22 |
1994-12-21 |
Affymax Technologies N.V. |
Combinatorial strategies for polymer synthesis.
|
US5652099A
(en)
*
|
1992-02-12 |
1997-07-29 |
Conrad; Michael J. |
Probes comprising fluorescent nucleosides and uses thereof
|
DE69333073T2
(de)
*
|
1992-02-12 |
2004-04-15 |
Chromagen, Inc., San Diego |
Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
|
TW323284B
(de)
*
|
1992-03-23 |
1997-12-21 |
Novartis Ag |
|
US6235886B1
(en)
*
|
1993-09-03 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Methods of synthesis and use
|
US5695752A
(en)
*
|
1992-09-11 |
1997-12-09 |
The Regents Of The University Of California |
Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor
|
AU4848793A
(en)
|
1992-09-11 |
1994-04-12 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide and nucleotide amine analogs, methods of synthesis and use
|
US6194144B1
(en)
|
1993-01-07 |
2001-02-27 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry
|
CA2114355A1
(en)
*
|
1993-01-29 |
1994-07-30 |
Hidehiko Furukawa |
Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
|
US5412123A
(en)
*
|
1993-02-08 |
1995-05-02 |
Glycomed Incorporated |
Anthraquinone and anthracene derivatives as inhibitors of the cell-adhesion molecules of the immune system
|
US5955591A
(en)
*
|
1993-05-12 |
1999-09-21 |
Imbach; Jean-Louis |
Phosphotriester oligonucleotides, amidites and method of preparation
|
US5658880A
(en)
*
|
1993-06-16 |
1997-08-19 |
Glycomed Incorporated |
Sialic acid/fucose based medicaments
|
US5789385A
(en)
*
|
1993-06-16 |
1998-08-04 |
Glycomed Incorporated |
Sialyl Lewisx mimetics containing phenyl backbones
|
US5837689A
(en)
*
|
1993-06-16 |
1998-11-17 |
Glycomed Incorporated |
Sialyl lewis-x mimetics containing naphthyl backbones
|
US5508387A
(en)
*
|
1993-08-04 |
1996-04-16 |
Glycomed Incorporated |
Selectin binding glycopeptides
|
DE69415343T2
(de)
*
|
1993-10-27 |
1999-08-26 |
Ribozyme Pharmaceuticals |
2'-amido-und 2'-peptido-modifizierte oligonukleotide
|
US5824473A
(en)
*
|
1993-12-10 |
1998-10-20 |
California Institute Of Technology |
Nucleic acid mediated electron transfer
|
US6071699A
(en)
|
1996-06-07 |
2000-06-06 |
California Institute Of Technology |
Nucleic acid mediated electron transfer
|
US5952172A
(en)
|
1993-12-10 |
1999-09-14 |
California Institute Of Technology |
Nucleic acid mediated electron transfer
|
US5591578A
(en)
|
1993-12-10 |
1997-01-07 |
California Institute Of Technology |
Nucleic acid mediated electron transfer
|
US5575071A
(en)
*
|
1994-01-19 |
1996-11-19 |
Porter-Cable Corporation |
Toolless quickchange blade clamp for reciprocating saws
|
US7323298B1
(en)
|
1994-06-17 |
2008-01-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Microarray for determining the relative abundances of polynuceotide sequences
|
US5620850A
(en)
*
|
1994-09-26 |
1997-04-15 |
President And Fellows Of Harvard College |
Molecular recognition at surfaces derivatized with self-assembled monolayers
|
US8236493B2
(en)
*
|
1994-10-21 |
2012-08-07 |
Affymetrix, Inc. |
Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
|
FR2732344B1
(fr)
|
1995-04-03 |
1997-06-20 |
Genset Sa |
Oligonucleotides a liaison covalente transversale, procede de preparation et synthon utile dans le procede
|
WO1997014706A1
(en)
|
1995-10-19 |
1997-04-24 |
Nexstar Pharmaceuticals, Inc. |
Method for solution phase synthesis of oligonucleotides
|
US5705621A
(en)
*
|
1995-11-17 |
1998-01-06 |
Isis Pharmaceuticals, Inc. |
Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
|
EP0880598A4
(de)
|
1996-01-23 |
2005-02-23 |
Affymetrix Inc |
Verfahren zur analyse von nukleinsäure
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US6444423B1
(en)
|
1996-06-07 |
2002-09-03 |
Molecular Dynamics, Inc. |
Nucleosides comprising polydentate ligands
|
US6008334A
(en)
*
|
1996-07-24 |
1999-12-28 |
The Board Of Regents Of The University Of Oklahoma |
Base-protected nucleotide analogs with protected thiol groups
|
EP1537877A3
(de)
|
1996-10-11 |
2005-08-03 |
The Regents Of The University Of California |
Immunostimulierende Oligonucleotidekonjugate
|
US7381525B1
(en)
|
1997-03-07 |
2008-06-03 |
Clinical Micro Sensors, Inc. |
AC/DC voltage apparatus for detection of nucleic acids
|
US6096273A
(en)
|
1996-11-05 |
2000-08-01 |
Clinical Micro Sensors |
Electrodes linked via conductive oligomers to nucleic acids
|
US7045285B1
(en)
*
|
1996-11-05 |
2006-05-16 |
Clinical Micro Sensors, Inc. |
Electronic transfer moieties attached to peptide nucleic acids
|
US7393645B2
(en)
*
|
1996-11-05 |
2008-07-01 |
Clinical Micro Sensors, Inc. |
Compositions for the electronic detection of analytes utilizing monolayers
|
US7160678B1
(en)
|
1996-11-05 |
2007-01-09 |
Clinical Micro Sensors, Inc. |
Compositions for the electronic detection of analytes utilizing monolayers
|
US7014992B1
(en)
*
|
1996-11-05 |
2006-03-21 |
Clinical Micro Sensors, Inc. |
Conductive oligomers attached to electrodes and nucleoside analogs
|
US6346610B1
(en)
|
1997-06-03 |
2002-02-12 |
Ajinomoto Co., Ltd. |
Process for preparing antifungal V-28-3M
|
US20040006034A1
(en)
*
|
1998-06-05 |
2004-01-08 |
Eyal Raz |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
|
ATE252596T1
(de)
|
1997-06-06 |
2003-11-15 |
Dynavax Tech Corp |
Immunstimulierende oligonucleotide, zusammensetzungen davon, und verfahren zur verwendung davon
|
US6589940B1
(en)
|
1997-06-06 |
2003-07-08 |
Dynavax Technologies Corporation |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
|
US6013459A
(en)
*
|
1997-06-12 |
2000-01-11 |
Clinical Micro Sensors, Inc. |
Detection of analytes using reorganization energy
|
DE19741084A1
(de)
*
|
1997-09-18 |
1999-03-25 |
Knoell Hans Forschung Ev |
Hochaffine Nukleinsäuremoleküle mit funktionellen Gruppen zur spezifischen Erkennung von Zielmolekülen, ihre Herstellung und Verwendung
|
US7090804B2
(en)
|
1998-01-27 |
2006-08-15 |
Clinical Mirco Sensors, Inc. |
Amplification of nucleic acids with electronic detection
|
US6686150B1
(en)
|
1998-01-27 |
2004-02-03 |
Clinical Micro Sensors, Inc. |
Amplification of nucleic acids with electronic detection
|
US6562798B1
(en)
*
|
1998-06-05 |
2003-05-13 |
Dynavax Technologies Corp. |
Immunostimulatory oligonucleotides with modified bases and methods of use thereof
|
US6761816B1
(en)
|
1998-06-23 |
2004-07-13 |
Clinical Micro Systems, Inc. |
Printed circuit boards with monolayers and capture ligands
|
US6290839B1
(en)
|
1998-06-23 |
2001-09-18 |
Clinical Micro Sensors, Inc. |
Systems for electrophoretic transport and detection of analytes
|
US7087148B1
(en)
|
1998-06-23 |
2006-08-08 |
Clinical Micro Sensors, Inc. |
Binding acceleration techniques for the detection of analytes
|
US6716394B2
(en)
|
1998-08-11 |
2004-04-06 |
Caliper Technologies Corp. |
DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
|
US6447724B1
(en)
|
1998-08-11 |
2002-09-10 |
Caliper Technologies Corp. |
DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
|
AU5479599A
(en)
*
|
1998-08-11 |
2000-03-06 |
Caliper Technologies Corporation |
Methods and systems for sequencing dna by distinguishing the decay times of fluorescent probes
|
US6288221B1
(en)
|
1998-08-20 |
2001-09-11 |
Duke University |
Methods of synthesis of halogen base-modified oligonucleotides and subsequent labeling with a metal-catalyzed reaction
|
US6740518B1
(en)
|
1998-09-17 |
2004-05-25 |
Clinical Micro Sensors, Inc. |
Signal detection techniques for the detection of analytes
|
JP2003524602A
(ja)
*
|
1998-09-18 |
2003-08-19 |
ダイナバックス テクノロジーズ コーポレイション |
IgE関連疾患の治療方法と、その治療において使用する組成物
|
US6541617B1
(en)
*
|
1998-10-27 |
2003-04-01 |
Clinical Micro Sensors, Inc. |
Detection of target analytes using particles and electrodes
|
US6545264B1
(en)
|
1998-10-30 |
2003-04-08 |
Affymetrix, Inc. |
Systems and methods for high performance scanning
|
US6184347B1
(en)
|
1998-11-19 |
2001-02-06 |
Agilent Technologies Inc. |
Minimization of blooming in high-density arrays by using reactive wash reagents
|
US6264891B1
(en)
*
|
1998-12-22 |
2001-07-24 |
Eos Biotechnology, Inc. |
Apparatus and method for concurrent chemical synthesis
|
US6833267B1
(en)
*
|
1998-12-30 |
2004-12-21 |
Clinical Micro Sensors, Inc. |
Tissue collection devices containing biosensors
|
CA2370478A1
(en)
|
1999-03-24 |
2000-09-28 |
Serge L. Beaucage |
N-acylphosphoramidites and their use in oligonucleotide synthesis
|
US6942771B1
(en)
|
1999-04-21 |
2005-09-13 |
Clinical Micro Sensors, Inc. |
Microfluidic systems in the electrochemical detection of target analytes
|
US7312087B2
(en)
|
2000-01-11 |
2007-12-25 |
Clinical Micro Sensors, Inc. |
Devices and methods for biochip multiplexing
|
US20020177135A1
(en)
*
|
1999-07-27 |
2002-11-28 |
Doung Hau H. |
Devices and methods for biochip multiplexing
|
AU779220B2
(en)
|
1999-07-26 |
2005-01-13 |
Clinical Micro Sensors, Inc. |
Sequence determination of nucleic acids using electronic detection
|
US7479285B1
(en)
|
1999-08-19 |
2009-01-20 |
Dynavax Technologies Corporation |
Methods of modulating an immune response using immunostimulatory sequences and compositions for use therein
|
WO2001016151A1
(fr)
*
|
1999-08-27 |
2001-03-08 |
Japan Science And Technology Corporation |
Acide nucleique a photocouplage reversible et phosphoroamidite
|
US6395142B1
(en)
*
|
1999-10-14 |
2002-05-28 |
Chemcycles, Inc. |
Method and apparatus for purifying low grade acetonitrile and other constituents from hazardous waste
|
US7223398B1
(en)
|
1999-11-15 |
2007-05-29 |
Dynavax Technologies Corporation |
Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof
|
US20030129251A1
(en)
|
2000-03-10 |
2003-07-10 |
Gary Van Nest |
Biodegradable immunomodulatory formulations and methods for use thereof
|
US20010046967A1
(en)
*
|
2000-03-10 |
2001-11-29 |
Gary Van Nest |
Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide
|
US20020107212A1
(en)
*
|
2000-03-10 |
2002-08-08 |
Nest Gary Van |
Methods of reducing papillomavirus infection using immunomodulatory polynucleotide sequences
|
US20020098199A1
(en)
|
2000-03-10 |
2002-07-25 |
Gary Van Nest |
Methods of suppressing hepatitis virus infection using immunomodulatory polynucleotide sequences
|
US20020028784A1
(en)
*
|
2000-03-10 |
2002-03-07 |
Nest Gary Van |
Methods of preventing and treating viral infections using immunomodulatory polynucleotide sequences
|
US7129222B2
(en)
*
|
2000-03-10 |
2006-10-31 |
Dynavax Technologies Corporation |
Immunomodulatory formulations and methods for use thereof
|
US7157437B2
(en)
*
|
2000-03-10 |
2007-01-02 |
Dynavax Technologies Corporation |
Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences
|
US6753143B2
(en)
|
2000-05-01 |
2004-06-22 |
Clinical Micro Sensors, Inc. |
Target analyte detection using asymmetrical self-assembled monolayers
|
JP4382265B2
(ja)
*
|
2000-07-12 |
2009-12-09 |
日本電気株式会社 |
酸化シリコン膜の形成方法及びその形成装置
|
US6397150B1
(en)
|
2000-07-27 |
2002-05-28 |
Visible Genetics Inc. |
Method and apparatus for sequencing of DNA using an internal calibrant
|
ES2347525T3
(es)
*
|
2000-12-27 |
2010-11-02 |
Dynavax Technologies Corporation |
Polinucleotidos inmunomoduladores y metodos para usuarios.
|
US6541626B2
(en)
*
|
2001-04-17 |
2003-04-01 |
Isis Pharmaceuticals, Inc. |
Process for selective N-acylation of purine nucleosides
|
EP2423335B1
(de)
*
|
2001-06-21 |
2014-05-14 |
Dynavax Technologies Corporation |
Chimäre immunmodulierende Verbindungen und Verwendungsverfahren dafür
|
US7785610B2
(en)
*
|
2001-06-21 |
2010-08-31 |
Dynavax Technologies Corporation |
Chimeric immunomodulatory compounds and methods of using the same—III
|
WO2003014316A2
(en)
*
|
2001-08-07 |
2003-02-20 |
Dynavax Technologies Corporation |
Immunomodulatory compositions, formulations, and methods for use thereof
|
US7222059B2
(en)
*
|
2001-11-15 |
2007-05-22 |
Siemens Medical Solutions Diagnostics |
Electrophoretic trace simulator
|
AU2002353001A1
(en)
*
|
2001-12-03 |
2003-06-17 |
The Government Of The United States Of America, Represented By The Secretary Of The Department Of He |
Thermolabile hydroxyl protecting groups and methods of use
|
US20030166282A1
(en)
|
2002-02-01 |
2003-09-04 |
David Brown |
High potency siRNAS for reducing the expression of target genes
|
EP3415625A1
(de)
|
2002-02-01 |
2018-12-19 |
Life Technologies Corporation |
Doppelsträngige oligonukleotide
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
FR2840611B1
(fr)
*
|
2002-06-06 |
2005-09-09 |
Cis Bio Int |
Entite fluorescente comportant un fluorophore lie de maniere covalente a au moins un oligonucleotide et comportant au moins un groupe fonctionnel et ses utilisations
|
US20100075423A1
(en)
*
|
2002-06-12 |
2010-03-25 |
Life Technologies Corporation |
Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
|
US20040033602A1
(en)
*
|
2002-06-12 |
2004-02-19 |
Ambion, Inc. |
Methods and compositions relating to polypeptides with RNase III domains that mediate RNA interference
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
KR20050052467A
(ko)
|
2002-08-12 |
2005-06-02 |
다이나박스 테크놀로지 코퍼레이션 |
면역조절 조성물, 이의 제조방법 및 이의 이용방법
|
WO2004027030A2
(en)
*
|
2002-09-18 |
2004-04-01 |
Isis Pharmaceuticals, Inc. |
Efficient reduction of target rna’s by single- and double-stranded oligomeric compounds
|
US7534872B2
(en)
*
|
2002-09-27 |
2009-05-19 |
Syngen, Inc. |
Compositions and methods for the use of FMOC derivatives in DNA/RNA synthesis
|
AU2003291755A1
(en)
|
2002-11-05 |
2004-06-07 |
Isis Pharmaceuticals, Inc. |
Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
|
US8158768B2
(en)
|
2002-12-23 |
2012-04-17 |
Dynavax Technologies Corporation |
Immunostimulatory sequence oligonucleotides and methods of using the same
|
US7625872B2
(en)
*
|
2002-12-23 |
2009-12-01 |
Dynavax Technologies Corporation |
Branched immunomodulatory compounds and methods of using the same
|
KR101309501B1
(ko)
|
2002-12-23 |
2013-09-24 |
다이나박스 테크놀로지 코퍼레이션 |
면역자극성 서열 올리고뉴클레오타이드 및 이의 이용방법
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
WO2005107404A2
(en)
*
|
2004-05-03 |
2005-11-17 |
The Penn State Research Foundation |
Methods and systems for nanoparticle enhancement of signals
|
JP2008501693A
(ja)
*
|
2004-06-03 |
2008-01-24 |
アイシス ファーマシューティカルズ、インク. |
遺伝子調節で使用するための個別に調節された鎖を有する二本鎖組成物
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
WO2006014437A2
(en)
*
|
2004-07-07 |
2006-02-09 |
The Penn State Research Foundation |
Methods and systems for nanoparticle enhancement of signals
|
EP1788875A4
(de)
*
|
2004-08-20 |
2010-12-15 |
Dharmacon Inc |
Neue polynukleotidsynthese durch markierungschemie
|
NZ553581A
(en)
|
2004-09-01 |
2011-04-29 |
Dynavax Tech Corp |
Methods and compositions for inhibition of innate immune responses and autoimmunity using immunoregulatory polynucleotides with a TGC sequence
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
WO2006137941A2
(en)
|
2004-11-12 |
2006-12-28 |
Ambion, Inc. |
Methods and compositions involving mirna and mirna inhibitor molecules
|
WO2006065751A2
(en)
*
|
2004-12-13 |
2006-06-22 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
|
CA2591582A1
(en)
*
|
2004-12-17 |
2006-06-22 |
Dynavax Technologies Corporation |
Methods and compositions for induction or promotion of immune tolerance
|
US20060142228A1
(en)
*
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
US20090286696A1
(en)
*
|
2005-02-04 |
2009-11-19 |
University Of Wollongong |
Double-Stranded Olidonucleotides and Uses Therefor
|
CN104857512A
(zh)
*
|
2006-11-09 |
2015-08-26 |
戴纳瓦克斯技术公司 |
使用免疫刺激性寡核苷酸进行长期的疾病修饰
|
US20080261913A1
(en)
|
2006-12-28 |
2008-10-23 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of liver disorders
|
JP5749492B2
(ja)
|
2007-10-26 |
2015-07-15 |
ダイナバックス テクノロジーズ コーポレイション |
免疫応答と自己免疫を阻害する方法及び組成物
|
JP5115312B2
(ja)
*
|
2008-05-02 |
2013-01-09 |
ソニー株式会社 |
核酸分離用担体の製造方法、及び核酸分離用担体とマイクロ流路系、並びに核酸分離方法と核酸分離装置
|
US8815817B2
(en)
*
|
2008-05-15 |
2014-08-26 |
Dynavax Technologies Corporation |
Long term disease modification using immunostimulatory oligonucleotides
|
WO2011123586A1
(en)
|
2010-04-01 |
2011-10-06 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
BR112012032240A2
(pt)
|
2010-06-16 |
2019-09-24 |
Dynavax Technologies Corporation |
método de tratamento utilizando inibidores tlr7 e/ou tlr9
|
WO2012110824A1
(en)
|
2011-02-18 |
2012-08-23 |
Astrazeneca Ab |
Binding agents with specificity for a nucleic acid modification
|
EP2691409B1
(de)
|
2011-03-31 |
2018-02-21 |
Idenix Pharmaceuticals LLC. |
Verbindungen und zusammensetzungen zur behandlung von virusinfektionen
|
US9228184B2
(en)
|
2012-09-29 |
2016-01-05 |
Dynavax Technologies Corporation |
Human toll-like receptor inhibitors and methods of use thereof
|
US9725474B2
(en)
|
2012-10-31 |
2017-08-08 |
Takeda Pharmaceutical Company Limited |
Modified nucleic acid
|
JP2016531122A
(ja)
|
2013-08-08 |
2016-10-06 |
ザ スクリップス リサーチ インスティテュートThe Scripps Research Institute |
非天然ヌクレオチドの取り込みによるインビトロの核酸の部位特異的な酵素標識のための方法
|
TWI638047B
(zh)
|
2014-04-09 |
2018-10-11 |
史基普研究協會 |
藉由核酸三磷酸酯轉運子將非天然或經修飾的核苷三磷酸酯輸入至細胞中
|
US11761007B2
(en)
|
2015-12-18 |
2023-09-19 |
The Scripps Research Institute |
Production of unnatural nucleotides using a CRISPR/Cas9 system
|
DK3475295T3
(da)
|
2016-06-24 |
2022-10-24 |
Scripps Research Inst |
Hidtil ukendt nukleosidtriphosphat-transportør og anvendelser deraf
|
TWI821192B
(zh)
|
2017-07-11 |
2023-11-11 |
美商新索思股份有限公司 |
非天然核苷酸之導入及其方法
|
BR112020002271A2
(pt)
|
2017-08-03 |
2020-07-28 |
Synthorx, Inc. |
conjugados de citocina para o tratamento de doenças proliferativas e infecciosas
|
KR20200127207A
(ko)
|
2018-02-26 |
2020-11-10 |
신톡스, 인크. |
Il-15 접합체 및 이의 용도
|
CN114949240A
(zh)
|
2019-02-06 |
2022-08-30 |
新索思股份有限公司 |
Il-2缀合物及其使用方法
|
KR20220034109A
(ko)
|
2019-06-14 |
2022-03-17 |
더 스크립스 리서치 인스티튜트 |
반합성 유기체의 복제, 전사 및 번역을 위한 시약 및 방법
|
CA3150163A1
(en)
|
2019-08-15 |
2021-02-18 |
Synthorx, Inc. |
Immuno oncology combination therapies with il-2 conjugates
|
AU2020337869A1
(en)
|
2019-08-23 |
2022-03-03 |
Synthorx, Inc. |
IL-15 conjugates and uses thereof
|
TW202124385A
(zh)
|
2019-09-10 |
2021-07-01 |
美商欣爍克斯公司 |
治療自體免疫疾病之il-2接合物及使用方法
|
MX2022005251A
(es)
|
2019-11-04 |
2022-06-08 |
Synthorx Inc |
Conjugados de interleuquina 10 y sus usos.
|
CN116209465A
(zh)
|
2020-06-25 |
2023-06-02 |
新索思股份有限公司 |
用il-2缀合物与抗egfr抗体的免疫肿瘤学组合疗法
|
EP4225375A1
(de)
|
2020-10-09 |
2023-08-16 |
Synthorx, Inc. |
Immunonkologische therapien mit il-2-konjugaten
|
IL301611A
(en)
|
2020-10-09 |
2023-05-01 |
Synthorx Inc |
Combined immuno-oncology treatment with pairs of IL-2 and pembrolizumab
|
TW202302148A
(zh)
|
2021-02-12 |
2023-01-16 |
美商欣爍克斯公司 |
使用il-2接合物和抗pd-1抗體或其抗原結合片段的肺癌組合療法
|
WO2022174101A1
(en)
|
2021-02-12 |
2022-08-18 |
Synthorx, Inc. |
Skin cancer combination therapy with il-2 conjugates and cemiplimab
|
WO2022256534A1
(en)
|
2021-06-03 |
2022-12-08 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
|
WO2023122573A1
(en)
|
2021-12-20 |
2023-06-29 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
|
WO2023122750A1
(en)
|
2021-12-23 |
2023-06-29 |
Synthorx, Inc. |
Cancer combination therapy with il-2 conjugates and cetuximab
|
WO2024136899A1
(en)
|
2022-12-21 |
2024-06-27 |
Synthorx, Inc. |
Cancer therapy with il-2 conjugates and chimeric antigen receptor therapies
|