DE3732642A1 - Transdermale, aus schichten aufgebaute pharmazeutische praeparate (pflaster) mit langanhaltender wirkung und verfahren zur herstellung derselben - Google Patents
Transdermale, aus schichten aufgebaute pharmazeutische praeparate (pflaster) mit langanhaltender wirkung und verfahren zur herstellung derselbenInfo
- Publication number
- DE3732642A1 DE3732642A1 DE19873732642 DE3732642A DE3732642A1 DE 3732642 A1 DE3732642 A1 DE 3732642A1 DE 19873732642 DE19873732642 DE 19873732642 DE 3732642 A DE3732642 A DE 3732642A DE 3732642 A1 DE3732642 A1 DE 3732642A1
- Authority
- DE
- Germany
- Prior art keywords
- vinyl acetate
- layer
- ethylene
- acetate copolymer
- transdermal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims description 20
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 12
- 230000005923 long-lasting effect Effects 0.000 title claims description 9
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 239000010410 layer Substances 0.000 claims description 74
- 229920001577 copolymer Polymers 0.000 claims description 37
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 34
- 239000005977 Ethylene Substances 0.000 claims description 34
- 238000003860 storage Methods 0.000 claims description 27
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical group CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 18
- 239000013543 active substance Substances 0.000 claims description 15
- 229920000642 polymer Polymers 0.000 claims description 14
- 239000012790 adhesive layer Substances 0.000 claims description 13
- 230000005855 radiation Effects 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 description 46
- 239000004480 active ingredient Substances 0.000 description 29
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 14
- 239000000006 Nitroglycerin Substances 0.000 description 14
- 229960003711 glyceryl trinitrate Drugs 0.000 description 14
- 239000000853 adhesive Substances 0.000 description 12
- 238000012377 drug delivery Methods 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000008187 granular material Substances 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 230000001070 adhesive effect Effects 0.000 description 5
- 238000004132 cross linking Methods 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 239000011505 plaster Substances 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000011888 foil Substances 0.000 description 4
- 229920001519 homopolymer Polymers 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 238000001125 extrusion Methods 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- DMBSFYPSHNCYAR-RJMJUYIDSA-N 1,3-dinitrooxypropan-2-yl nitrate (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O DMBSFYPSHNCYAR-RJMJUYIDSA-N 0.000 description 1
- VBIIBAYHACOVJL-UHFFFAOYSA-N 5-[1-(butylamino)-1-hydroxyethyl]benzene-1,3-diol Chemical compound CCCCNC(C)(O)C1=CC(O)=CC(O)=C1 VBIIBAYHACOVJL-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000003522 acrylic cement Substances 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 229960002504 capsaicin Drugs 0.000 description 1
- 235000017663 capsaicin Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- JBSLOWBPDRZSMB-FPLPWBNLSA-N dibutyl (z)-but-2-enedioate Chemical compound CCCCOC(=O)\C=C/C(=O)OCCCC JBSLOWBPDRZSMB-FPLPWBNLSA-N 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- HDERJYVLTPVNRI-UHFFFAOYSA-N ethene;ethenyl acetate Chemical group C=C.CC(=O)OC=C HDERJYVLTPVNRI-UHFFFAOYSA-N 0.000 description 1
- 238000010096 film blowing Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000005026 oriented polypropylene Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 230000010399 physical interaction Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 229920005638 polyethylene monopolymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229960005105 terbutaline sulfate Drugs 0.000 description 1
- KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Laminated Bodies (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU864117A HU196317B (en) | 1986-09-26 | 1986-09-26 | Process for producing layered medicine form of prolonged effect containing agent resorpting through epidermis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3732642A1 true DE3732642A1 (de) | 1988-04-07 |
Family
ID=10966971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19873732642 Withdrawn DE3732642A1 (de) | 1986-09-26 | 1987-09-28 | Transdermale, aus schichten aufgebaute pharmazeutische praeparate (pflaster) mit langanhaltender wirkung und verfahren zur herstellung derselben |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4814174A (cs) |
| JP (1) | JPS63277620A (cs) |
| AT (1) | AT393958B (cs) |
| BE (1) | BE1001165A4 (cs) |
| CS (1) | CS268838B2 (cs) |
| DD (1) | DD281348A5 (cs) |
| DE (1) | DE3732642A1 (cs) |
| FR (1) | FR2604356B1 (cs) |
| GB (1) | GB2195247B (cs) |
| HU (1) | HU196317B (cs) |
| IT (1) | IT1222735B (cs) |
| NL (1) | NL8702292A (cs) |
| PL (1) | PL153450B1 (cs) |
| YU (1) | YU46471B (cs) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990004611A1 (fr) * | 1988-10-26 | 1990-05-03 | Anatoly Yakovlevich Sorokin | Copolymeres d'alcool vynilique avec de l'acetat vynilique, reticules par du dialdehyde glutarique, procede pour leur obtention et preparation pharmaceutique a base de ceux-ci |
| DE4002281A1 (de) * | 1990-01-26 | 1991-08-01 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit dem wirkstoff tulobuterol |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69009540T2 (de) * | 1989-03-15 | 1994-09-29 | Nitto Denko Corp | Arzneimittel enthaltendes Heftpflaster. |
| US6316022B1 (en) * | 1995-06-07 | 2001-11-13 | Noven Pharmaceuticals, Inc. | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures |
| US6395292B2 (en) | 1996-02-02 | 2002-05-28 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2054488A1 (de) * | 1970-11-05 | 1972-05-10 | Alza Corp., Palo Alto, Calif. (V.StA.) | Einrichtung für die Verabreichung von Arzneimitteln |
| DE3131610A1 (de) * | 1980-08-11 | 1982-06-16 | G.D. Searle & Co., 60076 Skokie, Ill. | "auflage mit einem gehalt an mikroverkapseltem nitroglyzerin, die zur perkutanten verabreichung von nitroglyzerin geeignet ist" |
| US4377010A (en) * | 1978-11-08 | 1983-03-22 | The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Biocompatible material comprising a base polymer bulk graft polymerized with an ethylenically unsaturated carboxylic acid |
| US4477325A (en) * | 1982-07-12 | 1984-10-16 | Hollister Incorporated | Skin barrier composition comprising an irradiated crosslinked ethylene-vinyl acetate copolymer and polyisobutylene |
| EP0141592A2 (en) * | 1983-10-22 | 1985-05-15 | Smith and Nephew Associated Companies p.l.c. | Polymer blend films |
| WO1985005364A1 (en) * | 1984-05-10 | 1985-12-05 | The Secretary Of State For Defence In Her Britanni | Hydrophilic water swellable graft copolymer |
| DE3523065A1 (de) * | 1984-06-29 | 1986-01-09 | Alza Corp., Palo Alto, Calif. | Therapeutisches abgabesystem |
| EP0178140A2 (en) * | 1984-10-09 | 1986-04-16 | Alza Corporation | Transdermal therapeutic systems for the administration of nalozone, naltrexone and nalbuphine |
| EP0200562A2 (en) * | 1985-05-03 | 1986-11-05 | Alza Corporation | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS577409A (en) * | 1980-06-14 | 1982-01-14 | Nitto Electric Ind Co Ltd | Plaster |
| JPS6059207B2 (ja) * | 1981-03-13 | 1985-12-24 | 日東電工株式会社 | 複合製剤の製法 |
| US4725272A (en) * | 1981-06-29 | 1988-02-16 | Alza Corporation | Novel bandage for administering beneficial drug |
| US4486193A (en) * | 1981-07-22 | 1984-12-04 | Alza Corporation | Method for treating ischemic conditions by administering drug by two routes |
| US4650484A (en) * | 1983-02-03 | 1987-03-17 | Alza Corporation | Method for treating ischemic conditions |
| US4573996A (en) * | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
| CH672432A5 (cs) * | 1987-03-27 | 1989-11-30 | Hansruedi Naepflin |
-
1986
- 1986-09-26 HU HU864117A patent/HU196317B/hu not_active IP Right Cessation
-
1987
- 1987-09-25 DD DD87307258A patent/DD281348A5/de not_active IP Right Cessation
- 1987-09-25 IT IT22032/87A patent/IT1222735B/it active
- 1987-09-25 CS CS876900A patent/CS268838B2/cs unknown
- 1987-09-25 FR FR878713260A patent/FR2604356B1/fr not_active Expired - Lifetime
- 1987-09-25 BE BE8701086A patent/BE1001165A4/fr not_active IP Right Cessation
- 1987-09-25 GB GB8722648A patent/GB2195247B/en not_active Expired - Lifetime
- 1987-09-25 NL NL8702292A patent/NL8702292A/nl not_active Application Discontinuation
- 1987-09-25 PL PL1987267911A patent/PL153450B1/pl unknown
- 1987-09-25 AT AT0243787A patent/AT393958B/de not_active IP Right Cessation
- 1987-09-26 JP JP62239994A patent/JPS63277620A/ja active Granted
- 1987-09-28 US US07/101,623 patent/US4814174A/en not_active Expired - Fee Related
- 1987-09-28 DE DE19873732642 patent/DE3732642A1/de not_active Withdrawn
-
1988
- 1988-07-12 YU YU134388A patent/YU46471B/sh unknown
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2054488A1 (de) * | 1970-11-05 | 1972-05-10 | Alza Corp., Palo Alto, Calif. (V.StA.) | Einrichtung für die Verabreichung von Arzneimitteln |
| US4377010A (en) * | 1978-11-08 | 1983-03-22 | The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Biocompatible material comprising a base polymer bulk graft polymerized with an ethylenically unsaturated carboxylic acid |
| DE3131610A1 (de) * | 1980-08-11 | 1982-06-16 | G.D. Searle & Co., 60076 Skokie, Ill. | "auflage mit einem gehalt an mikroverkapseltem nitroglyzerin, die zur perkutanten verabreichung von nitroglyzerin geeignet ist" |
| US4477325A (en) * | 1982-07-12 | 1984-10-16 | Hollister Incorporated | Skin barrier composition comprising an irradiated crosslinked ethylene-vinyl acetate copolymer and polyisobutylene |
| EP0141592A2 (en) * | 1983-10-22 | 1985-05-15 | Smith and Nephew Associated Companies p.l.c. | Polymer blend films |
| WO1985005364A1 (en) * | 1984-05-10 | 1985-12-05 | The Secretary Of State For Defence In Her Britanni | Hydrophilic water swellable graft copolymer |
| DE3523065A1 (de) * | 1984-06-29 | 1986-01-09 | Alza Corp., Palo Alto, Calif. | Therapeutisches abgabesystem |
| EP0178140A2 (en) * | 1984-10-09 | 1986-04-16 | Alza Corporation | Transdermal therapeutic systems for the administration of nalozone, naltrexone and nalbuphine |
| EP0200562A2 (en) * | 1985-05-03 | 1986-11-05 | Alza Corporation | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990004611A1 (fr) * | 1988-10-26 | 1990-05-03 | Anatoly Yakovlevich Sorokin | Copolymeres d'alcool vynilique avec de l'acetat vynilique, reticules par du dialdehyde glutarique, procede pour leur obtention et preparation pharmaceutique a base de ceux-ci |
| DE4002281A1 (de) * | 1990-01-26 | 1991-08-01 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit dem wirkstoff tulobuterol |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0364484B2 (cs) | 1991-10-07 |
| ATA243787A (de) | 1991-07-15 |
| GB2195247A (en) | 1988-04-07 |
| IT8722032A0 (it) | 1987-09-25 |
| PL267911A1 (en) | 1988-08-18 |
| IT1222735B (it) | 1990-09-12 |
| NL8702292A (nl) | 1988-04-18 |
| US4814174A (en) | 1989-03-21 |
| FR2604356A1 (fr) | 1988-04-01 |
| CS690087A2 (en) | 1989-08-14 |
| GB8722648D0 (en) | 1987-11-04 |
| HU196317B (en) | 1988-11-28 |
| FR2604356B1 (fr) | 1991-07-05 |
| JPS63277620A (ja) | 1988-11-15 |
| CS268838B2 (en) | 1990-04-11 |
| AT393958B (de) | 1992-01-10 |
| YU46471B (sh) | 1993-10-20 |
| GB2195247B (en) | 1990-08-29 |
| HUT44707A (en) | 1988-04-28 |
| YU134388A (en) | 1990-04-30 |
| PL153450B1 (en) | 1991-04-30 |
| BE1001165A4 (fr) | 1989-08-01 |
| DD281348A5 (de) | 1990-08-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OR8 | Request for search as to paragraph 43 lit. 1 sentence 1 patent law | ||
| 8105 | Search report available | ||
| 8110 | Request for examination paragraph 44 | ||
| 8125 | Change of the main classification |
Ipc: A61L 15/44 |
|
| 8130 | Withdrawal |