DE3546218A1 - Azoniaspironortropanolester, verfahren zu deren herstellung und pharmazeutisches mittel - Google Patents

Azoniaspironortropanolester, verfahren zu deren herstellung und pharmazeutisches mittel

Info

Publication number
DE3546218A1
DE3546218A1 DE19853546218 DE3546218A DE3546218A1 DE 3546218 A1 DE3546218 A1 DE 3546218A1 DE 19853546218 DE19853546218 DE 19853546218 DE 3546218 A DE3546218 A DE 3546218A DE 3546218 A1 DE3546218 A1 DE 3546218A1
Authority
DE
Germany
Prior art keywords
general formula
radical
nortropan
chloride
stage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19853546218
Other languages
German (de)
English (en)
Other versions
DE3546218C2 (enExample
Inventor
Wolf Dr Rer Nat Grimminger
Karl-Peter Dr Med Odenthal
Klaus Dr Rer Nat Goerler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus Holding GmbH
Original Assignee
Dr Madaus GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Madaus GmbH and Co filed Critical Dr Madaus GmbH and Co
Priority to DE19853546218 priority Critical patent/DE3546218A1/de
Priority to AT0339286A priority patent/AT397962B/de
Priority to SE8605531A priority patent/SE8605531L/xx
Priority to CH5198/86A priority patent/CH677793A5/de
Priority to US06/945,488 priority patent/US4855422A/en
Priority to FI865295A priority patent/FI865295L/fi
Priority to DD86298351A priority patent/DD255162A5/de
Priority to DK625986A priority patent/DK171042B1/da
Priority to PL1986263216A priority patent/PL150843B1/pl
Priority to GB8630809A priority patent/GB2184726B/en
Priority to NL8603303A priority patent/NL193184C/nl
Priority to ES8603662A priority patent/ES2004177A6/es
Priority to PT84022A priority patent/PT84022B/pt
Priority to AU66985/86A priority patent/AU584266B2/en
Priority to IT22877/86A priority patent/IT1198263B/it
Priority to YU224986A priority patent/YU46038B/sh
Priority to SI8612249A priority patent/SI8612249A8/sl
Priority to FR8618210A priority patent/FR2598417B1/fr
Priority to SU864028726A priority patent/SU1711674A3/ru
Priority to JP61308972A priority patent/JPH07110862B2/ja
Priority to HU865367A priority patent/HU201930B/hu
Priority to KR1019860011482A priority patent/KR930000113B1/ko
Priority to CS988386A priority patent/CS274287B2/cs
Priority to ZA869694A priority patent/ZA869694B/xx
Priority to BE2/61142A priority patent/BE906054A/fr
Priority to CA000526376A priority patent/CA1304369C/en
Publication of DE3546218A1 publication Critical patent/DE3546218A1/de
Priority to HRP-2249/86A priority patent/HRP930787A2/xx
Application granted granted Critical
Publication of DE3546218C2 publication Critical patent/DE3546218C2/de
Priority to NL9800002A priority patent/NL9800002A/nl
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE19853546218 1985-12-27 1985-12-27 Azoniaspironortropanolester, verfahren zu deren herstellung und pharmazeutisches mittel Granted DE3546218A1 (de)

Priority Applications (28)

Application Number Priority Date Filing Date Title
DE19853546218 DE3546218A1 (de) 1985-12-27 1985-12-27 Azoniaspironortropanolester, verfahren zu deren herstellung und pharmazeutisches mittel
AT0339286A AT397962B (de) 1985-12-27 1986-12-19 Verfahren zur herstellung von azoniaspironortropanolestern
SE8605531A SE8605531L (sv) 1985-12-27 1986-12-22 Azoniaspironortropanolester
CH5198/86A CH677793A5 (enExample) 1985-12-27 1986-12-22
FI865295A FI865295L (fi) 1985-12-27 1986-12-23 Azoniaspironortropanolester, foerfarande foer dess framstaellning och farmaceutiskt medel.
DD86298351A DD255162A5 (de) 1985-12-27 1986-12-23 Azoniaspironortropanolester, verfahren zu deren herstellung und pharmazeutische mittel
DK625986A DK171042B1 (da) 1985-12-27 1986-12-23 Fremgangsmåde til fremstilling af azoniaspironortropanolestere
PL1986263216A PL150843B1 (en) 1985-12-27 1986-12-23 Method of obtaining azoniaspironortropanol esters
GB8630809A GB2184726B (en) 1985-12-27 1986-12-23 Azoniaspironortropanol esters, processes for the preparation thereof and pharmaceutical compositions containing them
US06/945,488 US4855422A (en) 1985-12-27 1986-12-23 Process for the preparation of azoniaspironortropanol esters
IT22877/86A IT1198263B (it) 1985-12-27 1986-12-24 Esteri dell'azoniaspironortropanolo,procedimento per la loro preparazione,mezzi farmaceutici che li contengono e impiego di esteri dell'azoniaspironortropanolo come spasmolitico,asmaterapeutico e broncolitico
ES8603662A ES2004177A6 (es) 1985-12-27 1986-12-24 Procedimiento para la obtencion de esteres de azoniaespironortropanol
PT84022A PT84022B (pt) 1985-12-27 1986-12-24 Processo para a preparacao de esteres de azonia-espiro-nortropanol com efeitos terapeuticos da asma e broncoliticos e de composicoes farmaceuticas que os contem
AU66985/86A AU584266B2 (en) 1985-12-27 1986-12-24 Azoniaspironortropanol esters, processes for the preparation thereof and pharmaceutical compositions containing them
NL8603303A NL193184C (nl) 1985-12-27 1986-12-24 Werkwijze voor het bereiden van azoniaspironortropanolesters en farmaceutisch preparaat dat een dergelijke ester bevat.
YU224986A YU46038B (sh) 1985-12-27 1986-12-25 Postopek za pripravo azoniaspironortropanolestrov
SI8612249A SI8612249A8 (sl) 1985-12-27 1986-12-25 Postopek za pripravo azoniaspironortropanolestrov
SU864028726A SU1711674A3 (ru) 1985-12-27 1986-12-26 Способ получени азонийспиронортропанолового сложного эфира
JP61308972A JPH07110862B2 (ja) 1985-12-27 1986-12-26 アゾニアスピロノルトロパノ−ルエステル、その製法及び該化合物を含有する鎮痙剤
FR8618210A FR2598417B1 (fr) 1985-12-27 1986-12-26 Esters d'azoniaspironortropanols, procede pour leur preparation et medicaments les contenant
HU865367A HU201930B (en) 1985-12-27 1986-12-27 Process for producing azoniaspiro(notropanol) esters and pharmaceutical compositions comprising same
KR1019860011482A KR930000113B1 (ko) 1985-12-27 1986-12-27 아조니아스피로노르트로판올 에스테르의 제조방법
CS988386A CS274287B2 (en) 1985-12-27 1986-12-27 Method of azoniaspironortropanol esters production
ZA869694A ZA869694B (en) 1985-12-27 1986-12-29 Azoniaspironortropanol esters and their pharmaceutical use
BE2/61142A BE906054A (fr) 1985-12-27 1986-12-29 Esters d'azoniaspironortropanols, procede pour leur preparation et medicaments les contenant.
CA000526376A CA1304369C (en) 1985-12-27 1986-12-29 Azoniaspironortropanol esters and processes for the preparation thereof
HRP-2249/86A HRP930787A2 (en) 1985-12-27 1993-04-05 Azonyaspyronotropanolesters, process for their preparation and pharmaceutical preparations containing the same
NL9800002A NL9800002A (nl) 1985-12-27 1998-01-23 Werkwijze voor het bereiden van een geneesmiddel voor het behandelen van astma en aandoeningen van de bronchiën.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853546218 DE3546218A1 (de) 1985-12-27 1985-12-27 Azoniaspironortropanolester, verfahren zu deren herstellung und pharmazeutisches mittel

Publications (2)

Publication Number Publication Date
DE3546218A1 true DE3546218A1 (de) 1987-07-02
DE3546218C2 DE3546218C2 (enExample) 1993-07-22

Family

ID=6289623

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19853546218 Granted DE3546218A1 (de) 1985-12-27 1985-12-27 Azoniaspironortropanolester, verfahren zu deren herstellung und pharmazeutisches mittel

Country Status (7)

Country Link
US (1) US4855422A (enExample)
JP (1) JPH07110862B2 (enExample)
CS (1) CS274287B2 (enExample)
DD (1) DD255162A5 (enExample)
DE (1) DE3546218A1 (enExample)
DK (1) DK171042B1 (enExample)
ZA (1) ZA869694B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1029862A1 (de) * 1999-02-20 2000-08-23 Dr. R. Pfleger Chemische Fabrik GmbH Verfahren zum Herstellen von endo-Nortropin unter Verwendung von 8-Benzyl-nortropan-3-on-perchlorat als Zwischenprodukt, sowie letzteres Salz selbst
WO2008101728A1 (de) 2007-02-23 2008-08-28 K.H.S. Pharma Holding Gmbh Verfahren zur herstellung von azoniaspironortropinestern und von nortropan-3-on verbindungen

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
KR20080012932A (ko) * 2005-05-02 2008-02-12 베링거 인겔하임 인터내셔날 게엠베하 티오트로퓸 브로마이드의 신규한 결정형
KR20080024532A (ko) * 2005-06-15 2008-03-18 베링거 인겔하임 인터내셔날 게엠베하 신규한 티오트로퓸 염의 제조방법, 신규한 티오트로퓸 염및 이의 약제학적 조성물
CN101759696B (zh) * 2008-12-23 2012-02-29 扬子江药业集团有限公司 去甲托品醇的合成工艺改进
RU2665554C2 (ru) 2013-03-15 2018-08-31 Байомарин Фармасьютикал Инк. Ингибиторы hdac

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480626A (en) * 1967-05-18 1969-11-25 Chem Fab Dr R Pfleger Certain azoniaspironortropine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1194422B (de) * 1963-03-05 1965-06-10 Robert Pfleger Chem Fab Dr Verfahren zur Herstellung von Azoniaspironortropanderivaten
DE2003680A1 (de) * 1970-01-28 1971-08-05 Boehringer Sohn Ingelheim Benzilsaeurederivate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480626A (en) * 1967-05-18 1969-11-25 Chem Fab Dr R Pfleger Certain azoniaspironortropine derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Arzneim.-Forsch. 16, 1966, 1581-1591 *
Arzneim.-Forsch. 17, 1967, 714-726 *
Comprehensive Organic Chemistry (Barton, Sir D.), Bd.II, (1979), S. 6, 7, 876, 879 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1029862A1 (de) * 1999-02-20 2000-08-23 Dr. R. Pfleger Chemische Fabrik GmbH Verfahren zum Herstellen von endo-Nortropin unter Verwendung von 8-Benzyl-nortropan-3-on-perchlorat als Zwischenprodukt, sowie letzteres Salz selbst
US6191272B1 (en) 1999-02-20 2001-02-20 Dr. Robert Pfleger Chemische Fabrik, Gmbh Process for the preparation of endo-nortropine using 8-benzyl-nortropan-3-one perchlorate as the intermediate, as well as the latter salt
WO2008101728A1 (de) 2007-02-23 2008-08-28 K.H.S. Pharma Holding Gmbh Verfahren zur herstellung von azoniaspironortropinestern und von nortropan-3-on verbindungen

Also Published As

Publication number Publication date
DD255162A5 (de) 1988-03-23
DK625986D0 (da) 1986-12-23
DE3546218C2 (enExample) 1993-07-22
JPH07110862B2 (ja) 1995-11-29
DK625986A (da) 1987-06-28
CS274287B2 (en) 1991-04-11
US4855422A (en) 1989-08-08
CS988386A2 (en) 1990-08-14
ZA869694B (en) 1987-08-26
DK171042B1 (da) 1996-04-29
JPS62215588A (ja) 1987-09-22

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: MADAUS AG, 5000 KOELN, DE

D2 Grant after examination
8364 No opposition during term of opposition