DE3513168A1 - Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren) - Google Patents

Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren)

Info

Publication number
DE3513168A1
DE3513168A1 DE19853513168 DE3513168A DE3513168A1 DE 3513168 A1 DE3513168 A1 DE 3513168A1 DE 19853513168 DE19853513168 DE 19853513168 DE 3513168 A DE3513168 A DE 3513168A DE 3513168 A1 DE3513168 A1 DE 3513168A1
Authority
DE
Germany
Prior art keywords
biosensor
subclaim
biological
electronic
biosensor according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19853513168
Other languages
German (de)
English (en)
Other versions
DE3513168C2 (enExample
Inventor
Thomas 8000 München Dandekar
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Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19853513168 priority Critical patent/DE3513168A1/de
Priority to US06/850,727 priority patent/US4777019A/en
Publication of DE3513168A1 publication Critical patent/DE3513168A1/de
Application granted granted Critical
Publication of DE3513168C2 publication Critical patent/DE3513168C2/de
Granted legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403Cells and electrode assemblies
    • G01N27/414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/002Biomolecular computers, i.e. using biomolecules, proteins, cells
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/806Electrical property or magnetic property

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mathematical Physics (AREA)
  • Nanotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Artificial Intelligence (AREA)
  • Computational Linguistics (AREA)
  • Data Mining & Analysis (AREA)
  • Evolutionary Computation (AREA)
  • Computing Systems (AREA)
  • Software Systems (AREA)
  • Microelectronics & Electronic Packaging (AREA)
DE19853513168 1985-04-12 1985-04-12 Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren) Granted DE3513168A1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19853513168 DE3513168A1 (de) 1985-04-12 1985-04-12 Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren)
US06/850,727 US4777019A (en) 1985-04-12 1986-04-11 Biosensor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853513168 DE3513168A1 (de) 1985-04-12 1985-04-12 Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren)

Publications (2)

Publication Number Publication Date
DE3513168A1 true DE3513168A1 (de) 1986-10-16
DE3513168C2 DE3513168C2 (enExample) 1990-08-16

Family

ID=6267855

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19853513168 Granted DE3513168A1 (de) 1985-04-12 1985-04-12 Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren)

Country Status (2)

Country Link
US (1) US4777019A (enExample)
DE (1) DE3513168A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4027728A1 (de) * 1990-08-31 1992-03-05 Bayer Ag Immobilisierung von organischen makromolekuelen oder biopolymeren in einer polymermembran
WO1993020230A1 (en) * 1992-03-27 1993-10-14 Environmental & Medical Products Ltd Electrochemical detection of dna hybridisation
WO1999010530A1 (en) * 1997-08-22 1999-03-04 Molecular Sensors Limited Estimation of nucleic acid
DE19741716A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Adressierbares modulares Erkennungssystem, seine Herstellung und Verwendung
DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
WO2012160091A2 (de) 2011-05-23 2012-11-29 Roche Diagnostics Gmbh Sensorvorrichtung zum nachweis eines analyten

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5137827A (en) * 1986-03-25 1992-08-11 Midwest Research Technologies, Inc. Diagnostic element for electrical detection of a binding reaction
US5121050A (en) * 1987-07-04 1992-06-09 Horiba, Ltd. Method of measuring physical properties by super-thin liquid membrane forming mode and interface reaction detection type boisensor by super-thin liquid membrane forming mode
US5472880A (en) * 1988-05-24 1995-12-05 The Queen's University Of Belfast Conductance measurements in organic solvents
IT1224606B (it) * 1988-10-10 1990-10-04 Eniricerche Spa Sensore chimico monolitico a membrana ione selettiva di tipo chemfet eprocedimento per la sua realizzazione
CA2002660A1 (en) * 1988-11-10 1990-05-10 Susan J. Mroczkowski Method for electrical detection of a binding reaction
US6416952B1 (en) 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US6955915B2 (en) 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
DE4018053A1 (de) * 1990-02-26 1991-09-05 Akad Wissenschaften Ddr Biologisches schichtsystem
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
DK0834575T3 (da) 1990-12-06 2002-04-02 Affymetrix Inc A Delaware Corp Identifikation af nucleinsyrer i prøver
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
US20060222647A1 (en) * 1993-05-27 2006-10-05 Beavo Joseph A Methods and compositions for modulating the activity of PDE5
SE510733C2 (sv) 1995-01-03 1999-06-21 Chemel Ab Kemisk sensor baserad på utbytbar igenkänningskomponent samt användning därav
US6017496A (en) * 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5751629A (en) * 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5874214A (en) * 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US5741462A (en) * 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
DE19601488C1 (de) * 1996-01-17 1997-05-28 Itt Ind Gmbh Deutsche Verfahren zum Herstellen einer Meßeinrichtung sowie danach hergestellte Meßeinrichtung
US6203981B1 (en) * 1996-04-17 2001-03-20 Motorola, Inc. Transistor-based molecular detection apparatus and method
US5827482A (en) * 1996-08-20 1998-10-27 Motorola Corporation Transistor-based apparatus and method for molecular detection and field enhancement
IL119514A0 (en) 1996-10-29 1997-01-10 Yeda Res & Dev Molecular controlled semiconductor resistor (MOCSER) as a light and chemical sensor
US6060327A (en) 1997-05-14 2000-05-09 Keensense, Inc. Molecular wire injection sensors
US7220550B2 (en) * 1997-05-14 2007-05-22 Keensense, Inc. Molecular wire injection sensors
US6699667B2 (en) 1997-05-14 2004-03-02 Keensense, Inc. Molecular wire injection sensors
US6123819A (en) 1997-11-12 2000-09-26 Protiveris, Inc. Nanoelectrode arrays
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
TW496775B (en) * 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
CN1185492C (zh) 1999-03-15 2005-01-19 清华大学 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用
AU1429401A (en) * 1999-07-02 2001-02-05 Conceptual Mindworks, Inc. Organic semiconductor recognition complex and system
US7001792B2 (en) 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US8232582B2 (en) * 2000-04-24 2012-07-31 Life Technologies Corporation Ultra-fast nucleic acid sequencing device and a method for making and using the same
US6413792B1 (en) * 2000-04-24 2002-07-02 Eagle Research Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
EP1317553B1 (en) * 2000-09-12 2007-09-19 University of Washington Pde8a and uses thereof
GB0105831D0 (en) * 2001-03-09 2001-04-25 Toumaz Technology Ltd Method for dna sequencing utilising enzyme linked field effect transistors
US8114591B2 (en) 2001-03-09 2012-02-14 Dna Electronics Ltd. Sensing apparatus and method
KR100438822B1 (ko) * 2001-05-29 2004-07-05 삼성전자주식회사 핵산 돌연변이 분석 장치 및 그를 이용한 핵산 분석 방법
JP3883512B2 (ja) * 2001-04-23 2007-02-21 三星電子株式会社 微細流路の側壁に形成されたmosfetよりなる物質検出用チップ、これを含む物質検出装置、及び物質検出装置を利用した物質検出方法
EP1389350A1 (en) * 2001-05-24 2004-02-18 University of Saskatchewan Technologies Inc. Nucleic acid circuit elements and methods
US6483125B1 (en) 2001-07-13 2002-11-19 North Carolina State University Single electron transistors in which the thickness of an insulating layer defines spacing between electrodes
US6653653B2 (en) 2001-07-13 2003-11-25 Quantum Logic Devices, Inc. Single-electron transistors and fabrication methods in which a projecting feature defines spacing between electrodes
DE10152002A1 (de) * 2001-10-22 2003-05-08 Infineon Technologies Ag Halbleitervorrichtung mit mehrschichtigem Aufbau sowie Verfahren zu dessen Herstellung
US20030093225A1 (en) * 2001-11-13 2003-05-15 Fathallah-Shaykh Hassan M. Method for reducing noise in analytical assays
DE10163557B4 (de) * 2001-12-21 2007-12-06 Forschungszentrum Jülich GmbH Transistorbasierter Sensor mit besonders ausgestalteter Gateelektrode zur hochempfindlichen Detektion von Analyten
US20070178477A1 (en) * 2002-01-16 2007-08-02 Nanomix, Inc. Nanotube sensor devices for DNA detection
US20060228723A1 (en) * 2002-01-16 2006-10-12 Keith Bradley System and method for electronic sensing of biomolecules
EP1348951A1 (en) * 2002-03-29 2003-10-01 Interuniversitair Micro-Elektronica Centrum Molecularly controlled dual gated field effect transistor for sensing applications
GB0211564D0 (en) 2002-05-21 2002-06-26 Tournaz Technology Ltd Reference circuit
US6798200B2 (en) * 2002-06-03 2004-09-28 Long-Sheng Fan Batch-fabricated gradient and RF coils for submicrometer resolution magnetic resonance imaging and manipulation
US7948041B2 (en) 2005-05-19 2011-05-24 Nanomix, Inc. Sensor having a thin-film inhibition layer
US6673717B1 (en) 2002-06-26 2004-01-06 Quantum Logic Devices, Inc. Methods for fabricating nanopores for single-electron devices
JP4092990B2 (ja) * 2002-09-06 2008-05-28 株式会社日立製作所 生体および化学試料検査装置
JP2004144630A (ja) * 2002-10-25 2004-05-20 Nikon Corp 有機分子検出素子および有機分子検出装置
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
US20050019955A1 (en) * 2003-07-23 2005-01-27 Dahl Jeremy E. Luminescent heterodiamondoids as biological labels
US8053245B1 (en) 2003-07-29 2011-11-08 Nanotel Biotechnologies, Inc. System and method for detecting biochemicals using hydrated substrates based on liquid crystal polymers
JP2005077210A (ja) * 2003-08-29 2005-03-24 National Institute For Materials Science 生体分子検出素子及びそれを用いた核酸解析方法
KR101059562B1 (ko) 2004-02-20 2011-08-26 삼성전자주식회사 민감도가 향상된 바이오 fet
KR20050087955A (ko) * 2004-02-27 2005-09-01 삼성전자주식회사 드바이 길이 조절에 의한 바이오 fet를 이용한 바이오분자의 검출 방법
US8536661B1 (en) 2004-06-25 2013-09-17 University Of Hawaii Biosensor chip sensor protection methods
US7713849B2 (en) * 2004-08-20 2010-05-11 Illuminex Corporation Metallic nanowire arrays and methods for making and using same
WO2006024023A2 (en) * 2004-08-24 2006-03-02 Nanomix, Inc. Nanotube sensor devices for dna detection
WO2006022370A1 (ja) * 2004-08-27 2006-03-02 National Institute For Materials Science 電界効果デバイスを用いたdna塩基配列解析方法及び塩基配列解析装置
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
US7488991B2 (en) * 2004-12-03 2009-02-10 Yeda Research And Development Co. Ltd. Molecular controlled semiconductor device
KR100682918B1 (ko) * 2005-01-20 2007-02-15 삼성전자주식회사 표면 개질을 갖는 fet형 바이오 센서
KR100624459B1 (ko) * 2005-02-03 2006-09-19 삼성전자주식회사 생체분자의 전기적 검출 방법
US20060220006A1 (en) * 2005-04-01 2006-10-05 Yong Chen Molecular-doped transistor and sensor
KR100738081B1 (ko) * 2005-11-22 2007-07-12 삼성전자주식회사 무기막을 구비하는 fet 기반 바이오 센서, 그의 제조방법 및 그를 이용한 생분자 검출 방법
KR100773548B1 (ko) 2006-03-31 2007-11-07 삼성전자주식회사 이온 물질의 크기 및 농도를 동시에 검출하는 방법 및 장치
KR100773549B1 (ko) * 2006-04-03 2007-11-07 삼성전자주식회사 동일 전계 효과 트랜지스터를 이용하여 생분자를 검출하는방법
KR100773550B1 (ko) * 2006-04-03 2007-11-07 삼성전자주식회사 생분자의 고정 없이 전계 효과 트랜지스터를 이용하여생분자를 검출하는 방법
KR101195612B1 (ko) * 2006-04-10 2012-10-29 삼성전자주식회사 금층을 포함하는 전계 효과 트랜지스터, 상기 전계 효과 트랜지스터를 포함하는 미세유동장치, 및 상기 전계 효과 트랜지스터 및 미세유동장치를 이용하여 티올기를 포함하는 분석물을 검출하는 방법
KR100723426B1 (ko) * 2006-04-26 2007-05-30 삼성전자주식회사 이온 물질 검출용 전계 효과 트랜지스터 및 그를 이용한이온 물질 검출 방법
KR100889564B1 (ko) * 2006-12-04 2009-03-23 한국전자통신연구원 바이오 센서 및 그 제조 방법
EP4134667B1 (en) 2006-12-14 2025-11-12 Life Technologies Corporation Apparatus for measuring analytes using fet arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
KR101176547B1 (ko) * 2006-12-20 2012-08-24 리전츠 오브 더 유니버스티 오브 미네소타 잡음이 감소된 이온 물질 검출 장치 및 방법
US8198658B2 (en) * 2007-06-13 2012-06-12 Samsung Electronics Co., Ltd. Device and method for detecting biomolecules using adsorptive medium and field effect transistor
KR101465961B1 (ko) * 2007-10-09 2014-12-01 삼성전자주식회사 유전자 검출 방법 및 장치
KR100882554B1 (ko) * 2007-11-08 2009-02-12 삼성전자주식회사 생분자 동정 방법
US8180421B2 (en) * 2007-12-12 2012-05-15 Kimberly-Clark Worldwide, Inc. Resonance energy transfer based detection of nosocomial infection
US8222041B2 (en) * 2008-05-09 2012-07-17 University Of Florida Research Foundation, Inc. Oxygen and carbon dioxide sensing
EP2307577B1 (en) 2008-06-25 2015-06-03 Life Technologies Corporation Methods for measuring analytes using large scale fet arrays
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US8731847B2 (en) 2010-06-30 2014-05-20 Life Technologies Corporation Array configuration and readout scheme
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US10656088B2 (en) 2016-08-12 2020-05-19 Silanna UV Technologies Pte Ltd Ultraviolet biosensor
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3831432A (en) * 1972-09-05 1974-08-27 Texas Instruments Inc Environment monitoring device and system
DE2610530A1 (de) * 1975-03-12 1976-09-23 Univ Utah Selektiv chemisch empfindliche vorrichtungen

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4238757A (en) * 1976-03-19 1980-12-09 General Electric Company Field effect transistor for detection of biological reactions
US4219335A (en) * 1978-09-18 1980-08-26 E. I. Du Pont De Nemours And Company Immunochemical testing using tagged reagents
US4242096A (en) * 1977-11-14 1980-12-30 Minnesota Mining And Manufacturing Company Immunoassay for antigens
US4236893A (en) * 1979-04-09 1980-12-02 Minnesota Mining And Manufacturing Company Method for the assay of classes of antigen-specific antibodies
GB2072418B (en) * 1980-03-19 1984-03-14 Olympus Optical Co Ion sensor and method of manufacturing the same
US4444892A (en) * 1980-10-20 1984-04-24 Malmros Mark K Analytical device having semiconductive organic polymeric element associated with analyte-binding substance
GB8314523D0 (en) * 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4592894A (en) * 1983-11-22 1986-06-03 The United States Of America As Represented By The United States Department Of Energy Field emission chemical sensor for receptor/binder, such as antigen/antibody
US4591550A (en) * 1984-03-01 1986-05-27 Molecular Devices Corporation Device having photoresponsive electrode for determining analytes including ligands and antibodies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3831432A (en) * 1972-09-05 1974-08-27 Texas Instruments Inc Environment monitoring device and system
DE2610530A1 (de) * 1975-03-12 1976-09-23 Univ Utah Selektiv chemisch empfindliche vorrichtungen
US4020830A (en) * 1975-03-12 1977-05-03 The University Of Utah Selective chemical sensitive FET transducers
US4020830B1 (enExample) * 1975-03-12 1984-09-04

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4027728A1 (de) * 1990-08-31 1992-03-05 Bayer Ag Immobilisierung von organischen makromolekuelen oder biopolymeren in einer polymermembran
WO1993020230A1 (en) * 1992-03-27 1993-10-14 Environmental & Medical Products Ltd Electrochemical detection of dna hybridisation
GB2280754A (en) * 1992-03-27 1995-02-08 Environmental Med Prod Electrochemical detection of DNA hybridisation
GB2280754B (en) * 1992-03-27 1995-11-01 Environmental Med Prod Electrochemical detection of DNA hybridisation
WO1999010530A1 (en) * 1997-08-22 1999-03-04 Molecular Sensors Limited Estimation of nucleic acid
DE19741716A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Adressierbares modulares Erkennungssystem, seine Herstellung und Verwendung
DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
US6608186B1 (en) 1997-09-22 2003-08-19 Nanogen Recognomics Gmbh Pyranosyl nucleic acid conjugates
US6613894B1 (en) 1997-09-22 2003-09-02 Nanogen Recognomics Gmbh Method for producing a pyranosyl nucleic acid conjugate
US7777024B2 (en) 1997-09-22 2010-08-17 Aventis Research & Technologies Gmbh & Co. Process for preparing a pentopyranosyl nucleic acid conjugate
WO2012160091A2 (de) 2011-05-23 2012-11-29 Roche Diagnostics Gmbh Sensorvorrichtung zum nachweis eines analyten

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