DE3416976A1 - 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanol-verbindungen, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten - Google Patents

1-pyrimidinyloxy-3-hetarylalkylamino-2-propanol-verbindungen, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten

Info

Publication number
DE3416976A1
DE3416976A1 DE19843416976 DE3416976A DE3416976A1 DE 3416976 A1 DE3416976 A1 DE 3416976A1 DE 19843416976 DE19843416976 DE 19843416976 DE 3416976 A DE3416976 A DE 3416976A DE 3416976 A1 DE3416976 A1 DE 3416976A1
Authority
DE
Germany
Prior art keywords
amino
propanol
oxy
dimethyl
hydrazino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19843416976
Other languages
German (de)
English (en)
Inventor
John E. Evansville Ind. Lawson
William L. Libertyville Ill. Matier
Herbert R. Evansville Ind. Roth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DE3416976A1 publication Critical patent/DE3416976A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DE19843416976 1983-05-09 1984-05-08 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanol-verbindungen, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten Ceased DE3416976A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/493,124 US4517188A (en) 1983-05-09 1983-05-09 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols

Publications (1)

Publication Number Publication Date
DE3416976A1 true DE3416976A1 (de) 1984-11-15

Family

ID=23958998

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19843416976 Ceased DE3416976A1 (de) 1983-05-09 1984-05-08 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanol-verbindungen, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten

Country Status (25)

Country Link
US (1) US4517188A (enExample)
JP (1) JPS59206364A (enExample)
KR (1) KR900005015B1 (enExample)
AT (1) AT392966B (enExample)
AU (1) AU576761B2 (enExample)
BE (1) BE899608A (enExample)
CA (1) CA1279064C (enExample)
CH (1) CH659247A5 (enExample)
CY (1) CY1522A (enExample)
DE (1) DE3416976A1 (enExample)
DK (1) DK166583C (enExample)
ES (3) ES8604529A1 (enExample)
FI (1) FI80268C (enExample)
FR (1) FR2545825B1 (enExample)
GB (1) GB2139623B (enExample)
GR (1) GR81557B (enExample)
HK (1) HK17590A (enExample)
IE (1) IE57410B1 (enExample)
IT (1) IT1175492B (enExample)
LU (1) LU85354A1 (enExample)
NL (1) NL8401450A (enExample)
PT (1) PT78570A (enExample)
SE (1) SE466309B (enExample)
SG (1) SG4890G (enExample)
ZA (1) ZA843378B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0377488A1 (en) * 1989-01-05 1990-07-11 Merck & Co. Inc. Novel beta-adrenergic agonists
US6022894A (en) * 1996-04-09 2000-02-08 Nps Pharmaceuticals, Inc. Method of using calcilytic compounds
US6432656B1 (en) 1996-12-03 2002-08-13 Nps Pharmaceuticals, Inc. Calcilytic compounds
US6818660B2 (en) 1996-04-09 2004-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
US7202261B2 (en) 1996-12-03 2007-04-10 Nps Pharmaceuticals, Inc. Calcilytic compounds

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598149A (en) * 1984-03-02 1986-07-01 Merck & Co., Inc. 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents
PH22520A (en) * 1984-11-12 1988-10-17 Yamanouchi Pharma Co Ltd Heterocyclic compounds having 4-lover alkyl-3-hydroxy-2-lower alkyl phenoxy-lower alkylene-y-group, and process of producing them
US5177215A (en) * 1984-11-12 1993-01-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic compounds and pharmaceutical use thereof
JPS6242974A (ja) * 1985-08-20 1987-02-24 Ube Ind Ltd ピリミジニルオキシアルカン酸アミド誘導体および除草剤
US7037916B2 (en) 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
US20040009980A1 (en) * 2000-10-25 2004-01-15 Pradip Bhatnagar Calcilytic compounds
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
AU2004273057C1 (en) * 2003-09-08 2011-06-30 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Non-peptide agonists and antagonists of adrenomedullin and gastrin releasing peptide
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195090A (en) * 1973-02-20 1980-03-25 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)pyridine derivatives and pharmaceutical compositions therewith
US4324788A (en) * 1979-04-23 1982-04-13 I.S.F. S.P.A. Alkoxyalkylidenhydrazinopridazines and process for their preparation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL300886A (enExample) * 1962-11-23
US4042586A (en) * 1972-05-05 1977-08-16 Merck Sharp & Dohme (I.A.) Corporation 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines
US4193995A (en) * 1972-05-05 1980-03-18 Merck Sharp & Dohme (I.A.) Corp. 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds and compositions
AR206801A1 (es) * 1973-02-20 1976-08-23 Ciba Geigy Ag Procedimiento para la elaboracion de derivados del 1-pirid loxi-2-hidroxi-3-amino-propano
CH584209A5 (en) * 1973-02-20 1977-01-31 Ciba Geigy Ag 3-amino-2-hydroxypropoxy substd. diazines and pyridines - with beta-adrenergic blocking or stimulating activity
CH567484A5 (enExample) * 1973-04-05 1975-10-15 Sandoz Ag
JPS5839832B2 (ja) * 1974-02-20 1983-09-01 チバ ガイギ− アクチエンゲゼルシヤフト 新規ピラジン化合物の製法
US4139623A (en) * 1974-05-14 1979-02-13 C-G Corp. Cyclic-substituted derivatives of 1-amino-2-propanol
CH588308A5 (enExample) * 1975-02-18 1977-05-31 Escher Wyss Ag
GB1585950A (en) * 1976-08-02 1981-03-11 Ici Ltd Pyrimidine compoudns and their use as herbicides
JPS55151570A (en) * 1979-05-15 1980-11-26 Takeda Chem Ind Ltd Pyrimidine derivatives, their preparation and antimicrobial for agriculture
US4312398A (en) * 1979-09-28 1982-01-26 The Boeing Company Method of forming fiber and metal composite structures
US4400201A (en) * 1980-12-15 1983-08-23 Sandoz Ltd. Novel pyrimidinyl ethers, their use as herbicides, herbicidal compositions comprising said pyrimidinyl ethers and processes for the preparation thereof
US4321398A (en) * 1981-05-07 1982-03-23 Mead Johnson & Company Thienyl and benzothienyl-tertiary butylaminophenoxypropanols

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195090A (en) * 1973-02-20 1980-03-25 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)pyridine derivatives and pharmaceutical compositions therewith
US4324788A (en) * 1979-04-23 1982-04-13 I.S.F. S.P.A. Alkoxyalkylidenhydrazinopridazines and process for their preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Med. Chem. 21 (1978), S. 123-6 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0377488A1 (en) * 1989-01-05 1990-07-11 Merck & Co. Inc. Novel beta-adrenergic agonists
US6022894A (en) * 1996-04-09 2000-02-08 Nps Pharmaceuticals, Inc. Method of using calcilytic compounds
US6521667B1 (en) 1996-04-09 2003-02-18 Nps Pharmaceuticals, Inc. Calcilytic compounds
US6818660B2 (en) 1996-04-09 2004-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
US6432656B1 (en) 1996-12-03 2002-08-13 Nps Pharmaceuticals, Inc. Calcilytic compounds
US7202261B2 (en) 1996-12-03 2007-04-10 Nps Pharmaceuticals, Inc. Calcilytic compounds

Also Published As

Publication number Publication date
GB2139623B (en) 1987-01-21
DK166583C (da) 1993-10-25
AU2779284A (en) 1984-11-15
ES8604529A1 (es) 1986-02-01
DK166583B (da) 1993-06-14
AU576761B2 (en) 1988-09-08
SE8402476D0 (sv) 1984-05-08
DK227884A (da) 1984-11-10
IT1175492B (it) 1987-07-01
IE57410B1 (en) 1992-08-26
JPS59206364A (ja) 1984-11-22
ES532282A0 (es) 1986-02-01
HK17590A (en) 1990-03-16
NL8401450A (nl) 1984-12-03
LU85354A1 (fr) 1985-03-21
ZA843378B (en) 1984-12-24
GR81557B (enExample) 1984-12-11
FI841841A0 (fi) 1984-05-08
CY1522A (en) 1990-11-16
ES8704154A1 (es) 1987-03-16
FI80268B (fi) 1990-01-31
CA1279064C (en) 1991-01-15
ES551966A0 (es) 1986-12-16
FR2545825B1 (fr) 1987-10-09
ES8702372A1 (es) 1986-12-16
IE841137L (en) 1984-11-09
IT8420841A0 (it) 1984-05-08
SE466309B (sv) 1992-01-27
KR900005015B1 (ko) 1990-07-16
BE899608A (fr) 1984-11-08
FR2545825A1 (fr) 1984-11-16
FI841841L (fi) 1984-11-10
US4517188A (en) 1985-05-14
DK227884D0 (da) 1984-05-08
GB2139623A (en) 1984-11-14
PT78570A (en) 1984-06-01
ATA152284A (de) 1990-12-15
AT392966B (de) 1991-07-25
CH659247A5 (de) 1987-01-15
FI80268C (fi) 1990-05-10
SE8402476L (sv) 1984-11-10
IT8420841A1 (it) 1985-11-08
SG4890G (en) 1990-07-13
ES545198A0 (es) 1987-03-16
GB8411636D0 (en) 1984-06-13
KR840008798A (ko) 1984-12-19

Similar Documents

Publication Publication Date Title
EP2508521B2 (de) Dimaleat einer Aminocrotonylverbindung und Verfahren zu ihrer Herstellung
AT392966B (de) Verfahren zur herstellung von neuen pyrimidin verbindungen und deren saeureadditionssalzen
DE3876813T4 (de) 3(2H)Pyridazinon, Verfahren zu dessen Herstellung und dieses enthaltendes Mittel gegen SRS-A.
EP0400519A1 (de) 2-Hydroxy-n-propylamine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JPH0314563A (ja) 新規４―フルオロ安息香酸誘導体
DE3423898A1 (de) Piperazinyl-alkyl-1,2,4-triazol-3-on-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel
EP0117403B1 (de) 6-(Acylaminoaryl)-3(2H)-pyridazinonderivate, ihre Herstellung und Verwendung
EP0124476A1 (de) Carboxamide, Verfahren zur Herstellung und pharmazeutische Präparate, die diese enthalten
DE3446778A1 (de) Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE69530988T2 (de) Benzimidazolderivate mit dopaminerger wirkung
DE2727469A1 (de) Neue hexahydropyrimidine, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
DE2461802A1 (de) Pyrazinderivate
EP0409048A2 (de) Aminoalkylsubstituierte 2-Aminothiazole und diese enthaltende therapeutische Mittel
DE3014813A1 (de) 2-hydroxy-5-(1-hydroxy-2-piperazinylethyl)benzoesaeure-derivate
EP0056486B1 (de) Phenylpiperazinyl-propanole von Hetarylphenolen, ihre Herstellung und diese enthaltende therapeutische Mittel
DE3223877C2 (enExample)
DE69907636T2 (de) 2-aminochinolinderivate mit d4-agonistischer wirkung
CH638517A5 (en) Process for preparing substituted aminoquinazoline derivatives
DD202566A5 (de) Verfahren zur herstellung von 1-phenylindazol-3-on-verbindungen
WO1992022539A1 (de) Aminoalkylsubstituierte thiazolin-2-one, ihre herstellung und verwendung
DE3331612A1 (de) Substituierte 1-pyridyloxy-3-indolylalkylamino-2-propanole, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel
DE69310186T2 (de) 1,2-dihydro-2-oxo-3-aminochinoxalin derivate, ihre verwendung als heilmittel
DD210266A5 (de) Verfahren zur herstellung von 3-(ureidocyclohexylamino)-propan-1,2-diolderivaten
DE3421252A1 (de) 1-phenoxy-3- hydroxyindolylalkylamino-3-propanolverbindungen, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten
EP0599152A1 (de) Triazinone une Triazinophthalazinone mit antiasthmatischer/antiallergischer, positiv inotroper und blutdrucksenkender Wirkung

Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: BRISTOL-MYERS SQUIBB CO. (N.D.GES.D.STAATES DELAWA

8128 New person/name/address of the agent

Representative=s name: KINZEBACH, W., DIPL.-CHEM. DR.PHIL. RIEDL, P., DIP

8110 Request for examination paragraph 44
8131 Rejection