FR2545825B1 - 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanols, leur preparation et leurs utilisations therapeutiques - Google Patents
1-pyrimidinyloxy-3-hetarylalkylamino-2-propanols, leur preparation et leurs utilisations therapeutiquesInfo
- Publication number
- FR2545825B1 FR2545825B1 FR8406989A FR8406989A FR2545825B1 FR 2545825 B1 FR2545825 B1 FR 2545825B1 FR 8406989 A FR8406989 A FR 8406989A FR 8406989 A FR8406989 A FR 8406989A FR 2545825 B1 FR2545825 B1 FR 2545825B1
- Authority
- FR
- France
- Prior art keywords
- hetarylalkylamino
- pyrimidinyloxy
- propanols
- preparation
- therapeutic uses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/493,124 US4517188A (en) | 1983-05-09 | 1983-05-09 | 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2545825A1 FR2545825A1 (fr) | 1984-11-16 |
| FR2545825B1 true FR2545825B1 (fr) | 1987-10-09 |
Family
ID=23958998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8406989A Expired FR2545825B1 (fr) | 1983-05-09 | 1984-05-04 | 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanols, leur preparation et leurs utilisations therapeutiques |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4517188A (enExample) |
| JP (1) | JPS59206364A (enExample) |
| KR (1) | KR900005015B1 (enExample) |
| AT (1) | AT392966B (enExample) |
| AU (1) | AU576761B2 (enExample) |
| BE (1) | BE899608A (enExample) |
| CA (1) | CA1279064C (enExample) |
| CH (1) | CH659247A5 (enExample) |
| CY (1) | CY1522A (enExample) |
| DE (1) | DE3416976A1 (enExample) |
| DK (1) | DK166583C (enExample) |
| ES (3) | ES8604529A1 (enExample) |
| FI (1) | FI80268C (enExample) |
| FR (1) | FR2545825B1 (enExample) |
| GB (1) | GB2139623B (enExample) |
| GR (1) | GR81557B (enExample) |
| HK (1) | HK17590A (enExample) |
| IE (1) | IE57410B1 (enExample) |
| IT (1) | IT1175492B (enExample) |
| LU (1) | LU85354A1 (enExample) |
| NL (1) | NL8401450A (enExample) |
| PT (1) | PT78570A (enExample) |
| SE (1) | SE466309B (enExample) |
| SG (1) | SG4890G (enExample) |
| ZA (1) | ZA843378B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4598149A (en) * | 1984-03-02 | 1986-07-01 | Merck & Co., Inc. | 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents |
| PH22520A (en) * | 1984-11-12 | 1988-10-17 | Yamanouchi Pharma Co Ltd | Heterocyclic compounds having 4-lover alkyl-3-hydroxy-2-lower alkyl phenoxy-lower alkylene-y-group, and process of producing them |
| US5177215A (en) * | 1984-11-12 | 1993-01-05 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic compounds and pharmaceutical use thereof |
| JPS6242974A (ja) * | 1985-08-20 | 1987-02-24 | Ube Ind Ltd | ピリミジニルオキシアルカン酸アミド誘導体および除草剤 |
| US5030640A (en) * | 1989-01-05 | 1991-07-09 | Merck & Co., Inc. | Novel β-adrenergic agonists and pharmaceutical compositions thereof |
| US6818660B2 (en) | 1996-04-09 | 2004-11-16 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| SG99290A1 (en) | 1996-04-09 | 2003-10-27 | Nps Pharma Inc | Calcilytic compounds |
| US7202261B2 (en) | 1996-12-03 | 2007-04-10 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| TW483881B (en) | 1996-12-03 | 2002-04-21 | Nps Pharma Inc | Calcilytic compounds |
| US7037916B2 (en) | 1999-07-15 | 2006-05-02 | Pharmacopeia Drug Discovery, Inc. | Pyrimidine derivatives as IL-8 receptor antagonists |
| US20040009980A1 (en) * | 2000-10-25 | 2004-01-15 | Pradip Bhatnagar | Calcilytic compounds |
| CA2450073C (en) | 2001-07-25 | 2017-08-29 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| AU2004273057C1 (en) * | 2003-09-08 | 2011-06-30 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Non-peptide agonists and antagonists of adrenomedullin and gastrin releasing peptide |
| EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
| JP2010503710A (ja) | 2006-09-18 | 2010-02-04 | ラプトール ファーマシューティカル インコーポレイテッド | 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置 |
| ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| KR20180114970A (ko) | 2009-05-06 | 2018-10-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL300886A (enExample) * | 1962-11-23 | |||
| US4042586A (en) * | 1972-05-05 | 1977-08-16 | Merck Sharp & Dohme (I.A.) Corporation | 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines |
| US4193995A (en) * | 1972-05-05 | 1980-03-18 | Merck Sharp & Dohme (I.A.) Corp. | 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds and compositions |
| AR206801A1 (es) * | 1973-02-20 | 1976-08-23 | Ciba Geigy Ag | Procedimiento para la elaboracion de derivados del 1-pirid loxi-2-hidroxi-3-amino-propano |
| US4195090A (en) * | 1973-02-20 | 1980-03-25 | Ciba-Geigy Corporation | 2-(3-Amino-2-hydroxy-propoxy)pyridine derivatives and pharmaceutical compositions therewith |
| CH584209A5 (en) * | 1973-02-20 | 1977-01-31 | Ciba Geigy Ag | 3-amino-2-hydroxypropoxy substd. diazines and pyridines - with beta-adrenergic blocking or stimulating activity |
| CH567484A5 (enExample) * | 1973-04-05 | 1975-10-15 | Sandoz Ag | |
| JPS5839832B2 (ja) * | 1974-02-20 | 1983-09-01 | チバ ガイギ− アクチエンゲゼルシヤフト | 新規ピラジン化合物の製法 |
| US4139623A (en) * | 1974-05-14 | 1979-02-13 | C-G Corp. | Cyclic-substituted derivatives of 1-amino-2-propanol |
| CH588308A5 (enExample) * | 1975-02-18 | 1977-05-31 | Escher Wyss Ag | |
| GB1585950A (en) * | 1976-08-02 | 1981-03-11 | Ici Ltd | Pyrimidine compoudns and their use as herbicides |
| IT1165040B (it) * | 1979-04-23 | 1987-04-22 | Isf Spa | Alcossialchilidenidrazinopiridazione e procedimento per la loro preparazione |
| JPS55151570A (en) * | 1979-05-15 | 1980-11-26 | Takeda Chem Ind Ltd | Pyrimidine derivatives, their preparation and antimicrobial for agriculture |
| US4312398A (en) * | 1979-09-28 | 1982-01-26 | The Boeing Company | Method of forming fiber and metal composite structures |
| US4400201A (en) * | 1980-12-15 | 1983-08-23 | Sandoz Ltd. | Novel pyrimidinyl ethers, their use as herbicides, herbicidal compositions comprising said pyrimidinyl ethers and processes for the preparation thereof |
| US4321398A (en) * | 1981-05-07 | 1982-03-23 | Mead Johnson & Company | Thienyl and benzothienyl-tertiary butylaminophenoxypropanols |
-
1983
- 1983-05-09 US US06/493,124 patent/US4517188A/en not_active Expired - Fee Related
-
1984
- 1984-05-04 ZA ZA843378A patent/ZA843378B/xx unknown
- 1984-05-04 KR KR1019840002428A patent/KR900005015B1/ko not_active Expired
- 1984-05-04 FR FR8406989A patent/FR2545825B1/fr not_active Expired
- 1984-05-07 NL NL8401450A patent/NL8401450A/nl not_active Application Discontinuation
- 1984-05-08 SE SE8402476A patent/SE466309B/sv not_active IP Right Cessation
- 1984-05-08 GB GB08411636A patent/GB2139623B/en not_active Expired
- 1984-05-08 BE BE0/212896A patent/BE899608A/fr not_active IP Right Cessation
- 1984-05-08 CA CA000453766A patent/CA1279064C/en not_active Expired - Fee Related
- 1984-05-08 IE IE1137/84A patent/IE57410B1/en not_active IP Right Cessation
- 1984-05-08 IT IT20841/84A patent/IT1175492B/it active
- 1984-05-08 CH CH2253/84A patent/CH659247A5/de not_active IP Right Cessation
- 1984-05-08 DK DK227884A patent/DK166583C/da active
- 1984-05-08 FI FI841841A patent/FI80268C/fi not_active IP Right Cessation
- 1984-05-08 DE DE19843416976 patent/DE3416976A1/de not_active Ceased
- 1984-05-08 ES ES532282A patent/ES8604529A1/es not_active Expired
- 1984-05-08 AU AU27792/84A patent/AU576761B2/en not_active Ceased
- 1984-05-08 GR GR74645A patent/GR81557B/el unknown
- 1984-05-09 PT PT78570A patent/PT78570A/pt not_active IP Right Cessation
- 1984-05-09 AT AT1522/84A patent/AT392966B/de not_active IP Right Cessation
- 1984-05-09 JP JP59091166A patent/JPS59206364A/ja active Pending
- 1984-05-09 LU LU85354A patent/LU85354A1/fr unknown
-
1985
- 1985-07-15 ES ES545198A patent/ES8704154A1/es not_active Expired
-
1986
- 1986-02-13 ES ES551966A patent/ES8702372A1/es not_active Expired
-
1990
- 1990-01-19 SG SG48/90A patent/SG4890G/en unknown
- 1990-03-08 HK HK175/90A patent/HK17590A/xx unknown
- 1990-11-16 CY CY1522A patent/CY1522A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |