DE3276241D1 - Expression of polypeptides in yeast - Google Patents

Expression of polypeptides in yeast

Info

Publication number
DE3276241D1
DE3276241D1 DE8282300949T DE3276241T DE3276241D1 DE 3276241 D1 DE3276241 D1 DE 3276241D1 DE 8282300949 T DE8282300949 T DE 8282300949T DE 3276241 T DE3276241 T DE 3276241T DE 3276241 D1 DE3276241 D1 DE 3276241D1
Authority
DE
Germany
Prior art keywords
yeast
bacteria
derived
phenotypic selection
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282300949T
Other languages
English (en)
Inventor
Ronald A Hitzeman
Franklin E Hagie Iv
Benjamin D Hall
Gustav Ammerer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Genentech Inc
Original Assignee
University of Washington
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22895764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3276241(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Washington, Genentech Inc filed Critical University of Washington
Application granted granted Critical
Publication of DE3276241D1 publication Critical patent/DE3276241D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/94—Saccharomyces
    • Y10S435/942—Saccharomyces cerevisiae
DE8282300949T 1981-02-25 1982-02-24 Expression of polypeptides in yeast Expired DE3276241D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23791381A 1981-02-25 1981-02-25

Publications (1)

Publication Number Publication Date
DE3276241D1 true DE3276241D1 (en) 1987-06-11

Family

ID=22895764

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282300949T Expired DE3276241D1 (en) 1981-02-25 1982-02-24 Expression of polypeptides in yeast

Country Status (10)

Country Link
US (4) US5919651A (de)
EP (1) EP0060057B1 (de)
JP (2) JPH0757190B2 (de)
AT (1) ATE27000T1 (de)
AU (1) AU553885B2 (de)
CA (1) CA1205026A (de)
DE (1) DE3276241D1 (de)
MY (1) MY101599A (de)
NZ (1) NZ199722A (de)
ZA (1) ZA821079B (de)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
US4460685A (en) * 1980-05-29 1984-07-17 New York University Method of enhancing the production of human γ Interferon
EP0062971B1 (de) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetisch modifizierte Mikroorganismen
JPS58146281A (ja) * 1981-10-19 1983-08-31 Suntory Ltd 酵母細胞の形質転換法
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
IE55817B1 (en) * 1982-05-19 1991-01-30 Gist Brocades Nv Cloning system for kluyveromyces species
GB2125047B (en) * 1982-08-09 1986-02-19 Ciba Geigy Ag Yeast hybrid vectors and their use for the production of polypeptides
AU584580B2 (en) * 1982-09-08 1989-06-01 Smith Kline - Rit Hepatitis B virus vaccine
JPH0716432B2 (ja) * 1982-10-20 1995-03-01 サントリー株式会社 酵母の高発現ベクタープラスミドを用いたペプチドの生産方法
EP0116201B1 (de) * 1983-01-12 1992-04-22 Chiron Corporation Sekretorische Expression in Eukaryoten
NO172595C (no) * 1983-02-07 1993-08-11 Battelle Memorial Institute Fremgangsmaate og ekspresjonsplasmid for fremstilling av hemagglutinin under kontroll av drosophila hsp-promoter
US4876197A (en) * 1983-02-22 1989-10-24 Chiron Corporation Eukaryotic regulatable transcription
CA1341116C (en) * 1983-02-22 2000-10-17 Rae Lyn Burke Yeast expression systems with vectors having gapdh or pyk promoters and synthesis or foreign protein
US4661454A (en) * 1983-02-28 1987-04-28 Collaborative Research, Inc. GAL1 yeast promoter linked to non galactokinase gene
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS60501140A (ja) * 1983-04-22 1985-07-25 アムジエン 酵母による外因性ポリペプチドの分泌
US7198919B1 (en) 1983-04-25 2007-04-03 Genentech, Inc. Use of alpha factor sequences in yeast expression systems
ZA843275B (en) * 1983-05-05 1984-12-24 Hoffmann La Roche Novel vectors for interferon expression
EP0143821A1 (de) * 1983-05-19 1985-06-12 Transgene S.A. Verfahren zur herstellung von catechol 2,3-oxygenase durch hefe, plasmid für dessen herstellung und verwendung
JPS60501290A (ja) * 1983-05-19 1985-08-15 ユニリ−バ−　ナ−ムロ−ゼ　ベンノ−トシヤ−プ 酵母細胞に新しく導入した遺伝子の発現改良
US4870008A (en) * 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
FR2552776B1 (fr) * 1983-10-03 1986-05-09 Transgene Sa Vecteurs d'expression d'une proteine antigenique de la rage dans les cellules eucaryotes et leur application a la preparation d'un vaccin
FR2562090B2 (fr) * 1984-03-27 1988-04-08 Transgene Sa Proteine antigenique de la rage glycosylee
EP0140762A1 (de) * 1983-10-03 1985-05-08 Transgene S.A. Vektoren zur Expression eines antigenischen Tollwutproteins in eukaryotischen Zellen und ihre Verwendung zur Herstellung eines Vakzins
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
PH23920A (en) * 1983-12-20 1990-01-23 Cetus Corp Glucoamylase cdna
GB8334261D0 (en) * 1983-12-22 1984-02-01 Bass Plc Fermentation processes
EP0154576A1 (de) * 1984-02-06 1985-09-11 INTERFERON SCIENCES, INC a Delaware Corporation Hybrid-Nucleinsäuresequenzen mit tandemartig angeordneten Genen
US4626505A (en) * 1984-02-24 1986-12-02 E. I. Du Pont De Nemours And Company Selectable markers for yeast transformation
US4745057A (en) * 1984-05-18 1988-05-17 Eli Lilly And Company Method, vectors and transformants for high expression of heterologous polypeptides in yeast
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US5683688A (en) * 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
SE8403929L (sv) * 1984-07-31 1986-02-21 Sten Gatenbeck Rekombinant-dna-molekyl, transformerade mikroorganismer och forfarande for framstellning av penicillin v-amidas
US4752473A (en) * 1984-10-12 1988-06-21 The Regents Of The University Of California Expression of glycosylated human influenza hemagglutinin proteins
CA1341423C (en) 1984-10-31 2003-03-04 Paul A. Luciw Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome
US7273695B1 (en) 1984-10-31 2007-09-25 Novartis Vaccines And Diagnostics, Inc. HIV immunoassays using synthetic envelope polypeptides
US7285271B1 (en) 1984-10-31 2007-10-23 Novartis Vaccines And Diagnostics, Inc. Antigenic composition comprising an HIV gag or env polypeptide
US4812405A (en) * 1986-02-18 1989-03-14 Phillips Petroleum Company Double auxotrophic mutants of Pichia pastoris and methods for preparation
JPS6447380A (en) * 1987-08-19 1989-02-21 Agency Ind Science Techn Steroid-oxidizing yeast strain
US7442525B1 (en) 1987-12-24 2008-10-28 Novartis Vaccines And Diagnostics, Inc. Method for expressing HIV polypeptides
US5580734A (en) * 1990-07-13 1996-12-03 Transkaryotic Therapies, Inc. Method of producing a physical map contigous DNA sequences
JP4236698B2 (ja) 1990-11-26 2009-03-11 ジェネティックス インスティチュート，リミテッド ライアビリティ カンパニー 宿主細胞でのｐａｃｅの発現およびその使用法
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5629167A (en) 1994-04-19 1997-05-13 Biocine S.P.A. Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay
US5804410A (en) * 1994-07-29 1998-09-08 Teijin Limited Nucleic acid sequence encoding trypsin-like enzyme and process for producing the enzyme
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US6197545B1 (en) 1996-09-25 2001-03-06 Vanderbilt University Genetically engineered yeast with modified signal peptidase complex
MX9605082A (es) 1996-10-24 1998-04-30 Univ Autonoma De Nuevo Leon Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano.
CA2308606A1 (en) 1997-11-06 1999-05-20 Chiron S.P.A. Neisserial antigens
PT1047784E (pt) 1998-01-14 2009-12-21 Novartis Vaccines & Diagnostic Antigénios de neisseria meningitidis
EP1965213A3 (de) 1998-02-04 2009-07-15 Invitrogen Corporation Microarrays und ihre Verwendungen
GB9808932D0 (en) 1998-04-27 1998-06-24 Chiron Spa Polyepitope carrier protein
EP2261343A3 (de) 1998-05-01 2012-01-18 Novartis Vaccines and Diagnostics, Inc. Antigene und Zusammensetzungen gegen Neisseria meningitidis
US7081360B2 (en) * 1998-07-28 2006-07-25 Cadus Technologies, Inc. Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
PT1228217E (pt) 1999-04-30 2013-01-28 Novartis Vaccines & Diagnostic Antígenos de neisseria conservados
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
GB9916529D0 (en) 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
ES2564463T3 (es) 1999-10-29 2016-03-22 Glaxosmithkline Biologicals S.A. Péptidos antigénicos de Neisseriales
US6232074B1 (en) * 1999-12-10 2001-05-15 Complegen, Inc. Functional gene array in yeast
BRPI0107679B8 (pt) 2000-01-17 2021-05-25 Chiron Spa composição compreendendo vesículas de membrana externa do grupo sérico b de neisseria meningitidis e um componente inorgânico e uso da mesma
CA2400318C (en) * 2000-02-08 2005-06-14 Allergan, Inc. Botulinum toxin pharmaceutical compositions
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
US20060269575A1 (en) * 2000-02-08 2006-11-30 Allergan, Inc. Botulinum toxin pharmaceutical compositions formulated with recombinant albumin
US7780967B2 (en) * 2000-02-08 2010-08-24 Allergan, Inc. Reduced toxicity Clostridial toxin pharmaceutical compositions
US8632785B2 (en) * 2000-02-08 2014-01-21 Allergan, Inc. Clostridial toxin pharmaceutical composition containing a gelatin fragment
EP1274720A4 (de) 2000-04-12 2004-08-18 Human Genome Sciences Inc Albumin enthaltende fusionsproteine
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
CN1654956A (zh) 2000-05-04 2005-08-17 耶鲁大学 用于筛选蛋白活性的高密度蛋白阵列
US7863020B2 (en) * 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US7625756B2 (en) 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
ES2252261T3 (es) * 2000-06-28 2006-05-16 Glycofi, Inc. Metodos para producir glicoproteinas modificadas.
US6737262B1 (en) * 2000-07-11 2004-05-18 Robert I. Bolla Animal feed containing polypeptides
JP2002057727A (ja) * 2000-08-10 2002-02-22 Hitachi Ltd 半導体集積回路および光通信モジュール
IL154853A0 (en) 2000-10-27 2003-10-31 Chiron Spa Nucleic acids and proteins from streptococcus groups a & b
US7083787B2 (en) * 2000-11-15 2006-08-01 Globeimmune, Inc. Yeast-dendritic cell vaccines and uses thereof
US6861237B2 (en) 2000-11-30 2005-03-01 Novo Nordisk A/S Production of heterologous polypeptides in yeast
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) * 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
DE10123980B4 (de) * 2001-05-17 2008-01-10 Tesa Ag Abschlussbandage
NZ562929A (en) 2001-12-12 2009-07-31 Novartis Vaccines & Diagnostic Immunisation against chlamydia trachomatis
CA2841097A1 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin and g-csf fusion proteins
CA2484556A1 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
AU2003243316A1 (en) 2002-05-24 2003-12-12 Nps Allelix Corp. Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
US20040018581A1 (en) * 2002-07-24 2004-01-29 Pharmacia And Upjohn Company Method for discovering substances for inhibiting enzymes
EP2279746B1 (de) 2002-11-15 2013-10-02 Novartis Vaccines and Diagnostics S.r.l. Oberflächenproteine in neisseria meningitidis
KR101455222B1 (ko) * 2002-12-16 2014-10-31 글로브이뮨 면역 요법으로서의 효모계 백신
US7439042B2 (en) * 2002-12-16 2008-10-21 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis C infection
US8343502B2 (en) * 2002-12-16 2013-01-01 Globeimmune, Inc. Yeast-based vaccines as immunotherapy
DE60335602D1 (de) * 2002-12-18 2011-02-17 Roche Diagnostics Gmbh Rekombinante Desoxyribonuclease I aus Rinder-Pankreas mit hoher spezifischer Aktivität
EP1433842B1 (de) 2002-12-18 2011-01-05 Roche Diagnostics GmbH Rekombinante Desoxyribonuclease I aus Rinder-Pankreas mit hoher spezifischer Aktivität
ATE387494T1 (de) * 2002-12-20 2008-03-15 Hoffmann La Roche Hitzelabile desoxyribonuklease i-varianten
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
EP1460425A1 (de) * 2003-03-17 2004-09-22 Boehringer Mannheim Gmbh Entglykosilierte Enzymen für Konjugaten
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
AU2004203649B2 (en) 2003-08-12 2006-01-12 F. Hoffmann-La Roche Ag Thermostable Taq polymerase fragment
DK1704234T3 (da) 2003-11-21 2012-05-07 Nps Pharma Inc Fremstilling af glucagon-lignende peptid 2 og analoger
ATE455849T1 (de) * 2003-12-05 2010-02-15 Hoffmann La Roche Rekombinante carboxypeptidase b und ihre aufreinigung
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
CN101437964B (zh) * 2004-10-18 2012-06-13 全球免疫股份有限公司 基于酵母的对慢性丙型肝炎感染的治疗
EP2330200B1 (de) 2004-12-23 2017-04-05 Albumedix A/S Genexpressionstechnik
JP4690787B2 (ja) * 2005-06-14 2011-06-01 株式会社日立製作所 微生物検知チップ及び微生物検知システム並びに微生物検知方法
CN101300346B (zh) 2005-06-24 2013-04-24 帝人制药株式会社 新型生理物质nesfatin及其相关物质、以及它们的用途
US20100034840A1 (en) * 2005-07-11 2010-02-11 David Apelian Compositions and methods for eliciting an immune response to escape mutants of targeted therapies
EP1926749B1 (de) * 2005-09-14 2011-07-27 Sanofi-Aventis Deutschland GmbH Spaltung von insulinvorstufen durch eine trypsinvariante
EP1934605B1 (de) * 2005-09-22 2014-03-26 Prosci Incorporated In hefemutanten produzierte glykosylierte polypeptide und verwendungsverfahren dafür
US20070172503A1 (en) * 2005-12-13 2007-07-26 Mycologics,Inc. Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines
BRPI0709340A2 (pt) * 2006-03-27 2013-04-16 Globeimmune Inc mutaÇço ras e composiÇÕes e mÉtodos de uso da mesma
ATE522541T1 (de) 2006-06-09 2011-09-15 Novartis Ag Bakterielle adhäsine konformere
SG10201405420QA (en) 2007-02-02 2014-10-30 Globeimmune Inc Methods for producing yeast-based vaccines
US20110076752A1 (en) * 2007-02-09 2011-03-31 Medimmune, Llc Antibody library display by yeast cell plasma membrane
CA2681246A1 (en) * 2007-03-19 2008-09-25 Globeimmune, Inc. Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer
JP2010535484A (ja) 2007-08-08 2010-11-25 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ トランスフェリン変異体と複合体
WO2010033841A1 (en) 2008-09-19 2010-03-25 Globeimmune, Inc. Immunotherapy for chronic hepatitis c virus infection
JP2012516878A (ja) 2009-02-06 2012-07-26 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ 精製プロセス
DK2396347T3 (en) 2009-02-11 2017-07-24 Albumedix As ALBUMIN VARIANTS AND CONJUGATES
EP3320915A1 (de) 2009-04-17 2018-05-16 Globeimmune, Inc. Kombinationsimmuntherapiezusammensetzungen gegen krebs sowie verfahren
WO2011032119A1 (en) 2009-09-14 2011-03-17 The Regents Of The University Of Colorado Modulation of yeast-based immunotherapy products and responses
CN102946900A (zh) 2010-03-11 2013-02-27 免疫设计公司 用于大流行流感的疫苗
EP2380905A1 (de) 2010-04-19 2011-10-26 Thrombotargets Europe, S.L. Phospholipidangereicherte Vesikel mit Gewebefaktor mit blutstillenden Aktivitäten sowie Verwendungen davon
US9254320B2 (en) 2010-12-17 2016-02-09 Globeimmune, Inc. Compositions and methods for the treatment or prevention of human adenovirus-36 infection
MA34956B1 (fr) 2011-02-12 2014-03-01 Globeimmune Inc Therapeutique a base de levure pour infection chronique par l'hepatite b
CN103648513B (zh) 2011-03-17 2018-10-12 全球免疫股份有限公司 酵母-Brachyury(短尾畸形)免疫治疗组合物
BR112013032381B1 (pt) 2011-06-14 2021-01-12 Globeimmune, Inc. composições à base de levedura e métodos para o tratamento ou prevenção de infecção pelo vírus da hepatite delta
CA2844500C (en) 2011-08-17 2022-05-10 Globeimmune, Inc. Yeast-muc1 immunotherapeutic compositions and uses thereof
CN104685360B (zh) 2012-06-26 2018-02-13 比奥德希克斯股份有限公司 用于选择和去选择用产生免疫应答的疗法治疗的癌症患者的质谱方法
SG11201507328RA (en) 2013-03-19 2015-10-29 Globeimmune Inc Yeast-based immunotherapy for chordoma
TWI728239B (zh) 2013-03-26 2021-05-21 美商環球免疫公司 治療或預防人類免疫缺乏病毒感染之組合物及方法
TWI654200B (zh) 2013-08-30 2019-03-21 環球免疫公司 治療或預防結核病的組合物及方法
WO2015157639A1 (en) 2014-04-11 2015-10-15 Globeimmune, Inc. Yeast-based immunotherapy and type i interferon sensitivity
CN111187338A (zh) 2014-06-12 2020-05-22 Ra制药公司 补体活性的调节
HRP20211824T1 (hr) 2015-01-28 2022-03-04 Ra Pharmaceuticals, Inc. Modulatori aktivnosti komplementa
KR20180054587A (ko) 2015-08-03 2018-05-24 글로브이뮨 변형된 효모-브라큐리 면역치료학적 조성물
HUE061759T2 (hu) 2015-12-16 2023-08-28 Ra Pharmaceuticals Inc Komplement aktivitás modulátorai
WO2018106859A1 (en) 2016-12-07 2018-06-14 Ra Pharmaceuticals, Inc. Modulators of complement activity
EP3622059A4 (de) 2017-05-10 2021-03-10 BayMedica, Inc. Rekombinante produktionssysteme für prenylierte polyketide der cannabinoid-familie
JP7311620B2 (ja) 2019-03-08 2023-07-19 メビオン・メディカル・システムズ・インコーポレーテッド 粒子線治療システムのためのコリメータおよびエネルギーデグレーダ

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237224A (en) * 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
CA1114295A (en) * 1977-11-02 1981-12-15 John H. Growdon Process and composition for treating disorders by administering choline or a compound that dissociates to choline
BG38165A3 (en) * 1977-11-08 1985-10-15 Genentech Inc,Us Method for preparing recombinant cloning vector suitable for transformation of microbial receptor
US4563424A (en) * 1979-11-05 1986-01-07 Genentech, Inc. Method and means for somatostatin protein conjugate expression
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
IE47890B1 (en) * 1977-11-08 1984-07-11 Genentech Inc Polypeptide production by expression in a recombinant microbial cloning vehicle, and cloning vehicles
US4356270A (en) * 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
FR2441659A1 (fr) * 1978-11-14 1980-06-13 Anvar Nouveaux plasmides hybrides et microorganismes les contenant
FR2480779B2 (fr) * 1979-08-30 1986-07-18 Anvar Vecteur contenant une sequence nucleotidique de l'antigene de surface du virus de l'hepatite b et procede de fabrication d'une molecule immunogene mettant en oeuvre ce vecteur
IE53176B1 (en) * 1978-12-22 1988-08-17 Biogen Nv Recombinant dna molecules and their method of production
AU542264B2 (en) * 1979-06-01 1985-02-14 G.D. Searle & Co. Plasmid vectors
FR2458585A1 (fr) * 1979-06-07 1981-01-02 Pasteur Institut Procede de production de proteines par expression des genes correspondants dans des micro-organismes et vecteurs susceptibles d'etre mis en oeuvre dans de tels procedes
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4431739A (en) * 1979-11-05 1984-02-14 Genentech, Inc. Transformant bacterial culture capable of expressing heterologous protein
US4425437A (en) * 1979-11-05 1984-01-10 Genentech, Inc. Microbial polypeptide expression vehicle
GB2068969B (en) * 1980-02-05 1983-07-27 Upjohn Co Gene expression
WO1981002425A1 (en) * 1980-02-25 1981-09-03 R Axel The use of eucaryotic promoter sequences in the production of proteinaceous materials
EP0035454A3 (de) * 1980-02-28 1982-03-03 Genentech, Inc. Desacetyl-thymosin-alpha-1, Verfahren zu dessen Herstellung und dessen Verwendung
CH651308A5 (de) * 1980-07-01 1985-09-13 Hoffmann La Roche Interferone und deren herstellung.
GR81946B (de) * 1980-09-25 1984-12-12 Genentech Inc
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
US4666847A (en) * 1981-01-16 1987-05-19 Collaborative Research, Inc. Recombinant DNA means and method
US4769238A (en) * 1981-08-04 1988-09-06 The Regents Of The University Of California Synthesis of human virus antigens by yeast
US4462199A (en) * 1981-08-13 1984-07-31 Xerox Corporation Rotary inserter
AU560472B2 (en) * 1981-08-25 1987-04-09 Celltech Limited Yeast expression vectors
AU561343B2 (en) 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna

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AU8065782A (en) 1982-09-02
US5854018A (en) 1998-12-29
JPH0757190B2 (ja) 1995-06-21
US5618676A (en) 1997-04-08
EP0060057A1 (de) 1982-09-15
ZA821079B (en) 1983-04-27
ATE27000T1 (de) 1987-05-15
MY101599A (en) 1991-12-17
NZ199722A (en) 1985-12-13
US5856123A (en) 1999-01-05
US5919651A (en) 1999-07-06
AU553885B2 (en) 1986-07-31
JPS57159489A (en) 1982-10-01
CA1205026A (en) 1986-05-27
JPH09182585A (ja) 1997-07-15

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