DE3202255C2 - - Google Patents

Info

Publication number
DE3202255C2
DE3202255C2 DE3202255A DE3202255A DE3202255C2 DE 3202255 C2 DE3202255 C2 DE 3202255C2 DE 3202255 A DE3202255 A DE 3202255A DE 3202255 A DE3202255 A DE 3202255A DE 3202255 C2 DE3202255 C2 DE 3202255C2
Authority
DE
Germany
Prior art keywords
poly
physiologically active
active substance
protein
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3202255A
Other languages
German (de)
English (en)
Other versions
DE3202255A1 (de
Inventor
Masaharu Asano
Masaru Yoshida
Isao Takasaki Gunma Jp Kaetsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Atomic Energy Agency
Original Assignee
Japan Atomic Energy Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1067481A external-priority patent/JPS57126415A/ja
Priority claimed from JP1260681A external-priority patent/JPS57128621A/ja
Priority claimed from JP7956781A external-priority patent/JPS57197210A/ja
Application filed by Japan Atomic Energy Research Institute filed Critical Japan Atomic Energy Research Institute
Publication of DE3202255A1 publication Critical patent/DE3202255A1/de
Application granted granted Critical
Publication of DE3202255C2 publication Critical patent/DE3202255C2/de
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00Compositions of proteins; Compositions of derivatives thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10Macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/2045Polyamides; Polyaminoacids, e.g. polylysine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2063Proteins, e.g. gelatin
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/24Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24628Nonplanar uniform thickness material
    • Y10T428/24653Differential nonplanarity at margin
DE19823202255 1981-01-27 1982-01-25 Verfahren zur herstellung eines verbundstoffs mit langzeit-freigabe Granted DE3202255A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1067481A JPS57126415A (en) 1981-01-27 1981-01-27 Preparation of prolonged release type composite
JP1260681A JPS57128621A (en) 1981-01-30 1981-01-30 Preparation of prolonged release type composite
JP7956781A JPS57197210A (en) 1981-05-26 1981-05-26 Method for preparation of slow-releasing composite

Publications (2)

Publication Number Publication Date
DE3202255A1 DE3202255A1 (de) 1982-10-21
DE3202255C2 true DE3202255C2 (US06346242-20020212-C00002.png) 1987-07-09

Family

ID=27279047

Family Applications (3)

Application Number Title Priority Date Filing Date
DE3249684A Expired DE3249684C2 (US06346242-20020212-C00002.png) 1981-01-27 1982-01-25
DE3249683A Expired DE3249683C2 (de) 1981-01-27 1982-01-25 Verfahren zur Herstellung eines Verbundstoffs mit Langzeit-Freigabe
DE19823202255 Granted DE3202255A1 (de) 1981-01-27 1982-01-25 Verfahren zur herstellung eines verbundstoffs mit langzeit-freigabe

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE3249684A Expired DE3249684C2 (US06346242-20020212-C00002.png) 1981-01-27 1982-01-25
DE3249683A Expired DE3249683C2 (de) 1981-01-27 1982-01-25 Verfahren zur Herstellung eines Verbundstoffs mit Langzeit-Freigabe

Country Status (2)

Country Link
US (1) US4483807A (US06346242-20020212-C00002.png)
DE (3) DE3249684C2 (US06346242-20020212-C00002.png)

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5540939A (en) 1992-12-21 1996-07-30 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5601846A (en) 1992-06-15 1997-02-11 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US5667806A (en) 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US5766633A (en) 1993-04-22 1998-06-16 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
DE19739031A1 (de) * 1997-09-05 1999-03-11 Suwelack Nachf Dr Otto Mittel zur peroralen Verabreichung, seine Herstellung und Verwendung
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5976569A (en) 1994-09-29 1999-11-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US6071510A (en) 1995-03-31 2000-06-06 Emisphere Technologies, Inc. Modified amino acids and compositions comprising the same for delivering active agents
US6084112A (en) 1995-09-11 2000-07-04 Emisphere Technologies, Inc. Method for preparing ω-aminoalkanoic acid derivatives from cycloalkanones
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US6375983B1 (en) 1996-06-14 2002-04-23 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
US6413550B1 (en) 1992-06-15 2002-07-02 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US8686154B2 (en) 1997-02-07 2014-04-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5000803A (en) * 1982-09-30 1991-03-19 General Technology Applications, Inc. Freeze blending of reactive liquids and solids
US4981535A (en) * 1982-09-30 1991-01-01 General Technology Applications, Inc. Process for making finely divided solids
DE3417022A1 (de) * 1984-05-09 1985-11-14 Karl Prof. Dr.med. 7302 Ostfildern Theurer Traeger- und begleitstoffe fuer biologische wirk- und regulationsfaktoren aus zellen und geweben und deren anwendung
DE3688188T2 (de) * 1985-12-27 1993-10-14 Sumitomo Pharma Verfahren zur Herstellung einer Formulierung mit verzögerter Freisetzung.
CA1257199A (en) * 1986-05-20 1989-07-11 Paul Y. Wang Preparation containing bioactive macromolecular substance for multi-months release in vivo
CH671155A5 (US06346242-20020212-C00002.png) * 1986-08-18 1989-08-15 Clinical Technologies Ass
USRE35862E (en) * 1986-08-18 1998-07-28 Emisphere Technologies, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
US5271945A (en) * 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
JPH02138951A (ja) * 1988-08-30 1990-05-28 Asama Kasei Kk 安定化ビタミン粉末及びその製造方法
DE3921912A1 (de) * 1989-07-04 1991-01-17 Roehm Gmbh Polyasparaginsaeurederivate als ueberzugsmittel fuer arzneiformen und lebensmittel
US5439688A (en) * 1989-07-28 1995-08-08 Debio Recherche Pharmaceutique S.A. Process for preparing a pharmaceutical composition
CH679207A5 (US06346242-20020212-C00002.png) * 1989-07-28 1992-01-15 Debiopharm Sa
US5225205A (en) * 1989-07-28 1993-07-06 Debiopharm S.A. Pharmaceutical composition in the form of microparticles
US6344213B1 (en) 1996-03-29 2002-02-05 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5541155A (en) * 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5451410A (en) * 1993-04-22 1995-09-19 Emisphere Technologies, Inc. Modified amino acids for encapsulating active agents
US5820881A (en) * 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US5824345A (en) * 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US6060513A (en) * 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) * 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5863944A (en) * 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) * 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
US7220596B2 (en) * 1998-04-15 2007-05-22 Utah State University Real time detection of antigens
EP1068532A4 (en) * 1998-04-15 2003-07-16 Univ Utah State DETECTION OF REAL-TIME ANTIGENS
US7018654B2 (en) * 1999-03-05 2006-03-28 New River Pharmaceuticals Inc. Pharmaceutical composition containing an active agent in an amino acid copolymer structure
AU771188B2 (en) * 1999-03-05 2004-03-18 Shire Llc Use of protein conformation for the protection and release of chemical compounds
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US20040014082A1 (en) * 2000-08-11 2004-01-22 Invitrogen Corporation Highly homogeneous molecular markers for electrophoresis
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
US20060014697A1 (en) 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
CN103265356B (zh) * 2013-05-02 2015-07-01 青岛冠中生态股份有限公司 一种促进植物根瘤菌结瘤的人工土壤和肥料

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576758A (en) * 1966-10-17 1971-04-27 Ncr Co Treatment of polypeptide-containing hydrophilic polymeric capsule wall material with uranium and vanadium compounds
GB1234802A (en) * 1968-04-19 1971-06-09 British American Tobacco Co Improvements relating to the packing of liquids
US3780195A (en) * 1969-10-22 1973-12-18 Balchem Corp Encapsulation process
DK135268A (US06346242-20020212-C00002.png) * 1973-02-09
JPS5325006B2 (US06346242-20020212-C00002.png) * 1973-08-17 1978-07-24
DE2556733C3 (de) * 1975-12-17 1986-10-02 Armour Pharma GmbH & Co KG, 3440 Eschwege Verfahren zum Isolieren von Albumin aus Blutplasma
US4073835A (en) * 1976-01-30 1978-02-14 Toyo Ink Manufacturing Co., Ltd. Method of resin encapsulating electrical parts with UV curing of fire retardant resin
US4230687A (en) * 1978-05-30 1980-10-28 Griffith Laboratories U.S.A., Inc. Encapsulation of active agents as microdispersions in homogeneous natural polymeric matrices
CH637014A5 (de) * 1978-09-29 1983-07-15 Sandoz Ag Verfahren zur herstellung von suppositorien.

Cited By (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5601846A (en) 1992-06-15 1997-02-11 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US6071538A (en) 1992-06-15 2000-06-06 Emisphere Technologies, Inc. Oral delivery composition comprising supramolecular complex
US6348207B1 (en) 1992-06-15 2002-02-19 Emisiphere Technologies, Inc. Orally deliverable supramolecular complex
US6245359B1 (en) 1992-06-15 2001-06-12 Emisphere Technologies, Inc. Active agent transport systems
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US6413550B1 (en) 1992-06-15 2002-07-02 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5540939A (en) 1992-12-21 1996-07-30 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5955503A (en) 1993-04-22 1999-09-21 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US6100298A (en) 1993-04-22 2000-08-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5766633A (en) 1993-04-22 1998-06-16 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US6180140B1 (en) 1994-04-22 2001-01-30 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5976569A (en) 1994-09-29 1999-11-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6428780B2 (en) 1995-03-31 2002-08-06 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6071510A (en) 1995-03-31 2000-06-06 Emisphere Technologies, Inc. Modified amino acids and compositions comprising the same for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US6346242B1 (en) 1995-03-31 2002-02-12 Emishpere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US6100285A (en) 1995-06-07 2000-08-08 Emisphere Technologies, Inc. Method of solubilizing itraconazole
US6461545B1 (en) 1995-06-07 2002-10-08 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US5667806A (en) 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US6084112A (en) 1995-09-11 2000-07-04 Emisphere Technologies, Inc. Method for preparing ω-aminoalkanoic acid derivatives from cycloalkanones
US6375983B1 (en) 1996-06-14 2002-04-23 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US8686154B2 (en) 1997-02-07 2014-04-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
DE19739031A1 (de) * 1997-09-05 1999-03-11 Suwelack Nachf Dr Otto Mittel zur peroralen Verabreichung, seine Herstellung und Verwendung

Also Published As

Publication number Publication date
DE3202255A1 (de) 1982-10-21
DE3249684C2 (US06346242-20020212-C00002.png) 1987-01-08
US4483807A (en) 1984-11-20
DE3249683C2 (de) 1986-03-20

Similar Documents

Publication Publication Date Title
DE3202255C2 (US06346242-20020212-C00002.png)
Barker Peptides: roles in neuronal excitability.
DE69839021T3 (de) Neuartige exendin agonisten
EP0254289B1 (de) Mittel zur Behandlung von Arthrosen
CN112533676A (zh) 用于抑制cgrp的神经毒素
DE3520228A1 (de) Wasserloesliche bioaktive trockenfeststoffzusammensetzung, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate
DE69532436T2 (de) Einzelkettenformen des clycoprotein-hormon-quartetts
DE2628914C2 (US06346242-20020212-C00002.png)
DE4132005A1 (de) Kombination enthaltend wachstumsfaktoren und polyelektrolyte
DE3104815C2 (de) Verfahren zur Herstellung eines Verbundstoffs mit Langzeit-Freigabe
DE69534061T2 (de) Ein peptid, ein verfahren zu seiner darstellung und ein auf ihm basierende pharmazeutische zubereitung
EP1485120A1 (de) Verwendung eines oder mehrerer von plasma und zellwandbestandteilen befreiten natürlichen oder modifizierten sauerstoffbinder zur externen behandlung offener, insbesondere chronischer wunden
DE4203040A1 (de) Neue parathormonfragmente, deren herstellung und diese enthaltende arzneimittel
DE4221836A1 (de) Das biochemisch aufgereinigte Mistel-Lektin (ML-1) als therapeutisch anwendbarer Immunmodulator
DE69733575T2 (de) Verfahren und mittel zur schmerzbehandlung
DE69936638T2 (de) IGF-enthaltende injizierbare Formulierungen, enthaltend Succinat als Puffermittel
Louis et al. Diabetogenic polypeptide from human pituitaries similar to that excreted by proteinuric diabetic patients
DE2558537C2 (de) Verfahren zum Isolieren von Substanzen mit insulinähnlicher Wirksamkeit aus Blut oder Blutbestandteilen von Kälbern oder Schweinen
DE2405002B2 (de) Lösliches natives Kollagen aus menschlicher Plancenta sowie dieses als therapeutischen Wirkstoff enthaltendes Mittel
DE69635851T2 (de) Nichtantigenische Stabilisator und physiologisches aktives Mittel
DE69935338T2 (de) Verwendung von mit Pepsin behandelter Gelatine als Stabilisator für einspritzbare Stoffe enthaltend Proteinenspuren
RU2036651C1 (ru) Биогенный стимулятор для лечения и профилактики заболеваний сельскохозяйственных животных
DE2817144A1 (de) Verfahren zur herstellung von nicht immunogenen biologisch aktiven enzymatischen praeparaten aus unloeslichen proteinen
RU2146146C1 (ru) Репаративно-регенеративный препарат, способ его изготовления и лечебного использования по л.в.дубининой
WO2001045743A2 (de) Verwendung eines enzyms zur verbesserung der geweberesorption von arzneimitteln

Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8172 Supplementary division/partition in:

Ref country code: DE

Ref document number: 3249684

Format of ref document f/p: P

Q171 Divided out to:

Ref country code: DE

Ref document number: 3249684

8172 Supplementary division/partition in:

Ref country code: DE

Ref document number: 3249683

Format of ref document f/p: P

Q171 Divided out to:

Ref country code: DE

Ref document number: 3249683

AH Division in

Ref country code: DE

Ref document number: 3249683

Format of ref document f/p: P

AH Division in

Ref country code: DE

Ref document number: 3249684

Format of ref document f/p: P

AH Division in

Ref country code: DE

Ref document number: 3249684

Format of ref document f/p: P

Ref country code: DE

Ref document number: 3249683

Format of ref document f/p: P

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee