JPS57128621A - Preparation of prolonged release type composite - Google Patents
Preparation of prolonged release type compositeInfo
- Publication number
- JPS57128621A JPS57128621A JP1260681A JP1260681A JPS57128621A JP S57128621 A JPS57128621 A JP S57128621A JP 1260681 A JP1260681 A JP 1260681A JP 1260681 A JP1260681 A JP 1260681A JP S57128621 A JPS57128621 A JP S57128621A
- Authority
- JP
- Japan
- Prior art keywords
- prolonged release
- active substance
- physiologically active
- type composite
- heat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To obtain a prolonged release type composite, having improved hardness and strength and extended prolonged release performance, by heat-treating a mixed system consisting of a polypeptide, a heat denaturing protein, a physiologically active substance and a mixture of water with an organic solvent.
CONSTITUTION: A mixed system consisting of a polypeptide, e.g. poly-alanine or poly-glycine, a heat denaturing protein, e.g. β-globulin or γ-globulin, a physiologically active substance, e.g. bleomycin hydrochloride or mitomycin C, and a mixture of water with an organic solvent of a suitable composition is molded into a suitable form and then heat-treated at room temperature W100°C and further irradiated with light or ionizing radiation, e.g. gamma rays, to give a prolonged release type composite containing the physiologically active substance. The irradiation with the light or ionizing radiation prolongs the dissolution of the physiologically active substance from the composite and improves the hardness and strength thereof.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1260681A JPS57128621A (en) | 1981-01-30 | 1981-01-30 | Preparation of prolonged release type composite |
US06/340,989 US4483807A (en) | 1981-01-27 | 1982-01-20 | Process for producing a slow release composite |
DE3249683A DE3249683C2 (en) | 1981-01-27 | 1982-01-25 | Method of making a composite with long-term release |
DE19823202255 DE3202255A1 (en) | 1981-01-27 | 1982-01-25 | METHOD FOR PRODUCING A COMPOSITE WITH LONG-TERM RELEASE |
DE3249684A DE3249684C2 (en) | 1981-01-27 | 1982-01-25 | Process for producing a long-term release composite |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1260681A JPS57128621A (en) | 1981-01-30 | 1981-01-30 | Preparation of prolonged release type composite |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57128621A true JPS57128621A (en) | 1982-08-10 |
Family
ID=11810007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1260681A Pending JPS57128621A (en) | 1981-01-27 | 1981-01-30 | Preparation of prolonged release type composite |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57128621A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60231609A (en) * | 1984-04-28 | 1985-11-18 | Terumo Corp | Liposome pharmaceutical |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5040718A (en) * | 1973-05-17 | 1975-04-14 | ||
JPS5553214A (en) * | 1978-10-09 | 1980-04-18 | Merck Patent Gmbh | Molded mixture based on reabsorbent collagen in body*its manufacture and its medical use |
-
1981
- 1981-01-30 JP JP1260681A patent/JPS57128621A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5040718A (en) * | 1973-05-17 | 1975-04-14 | ||
JPS5553214A (en) * | 1978-10-09 | 1980-04-18 | Merck Patent Gmbh | Molded mixture based on reabsorbent collagen in body*its manufacture and its medical use |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60231609A (en) * | 1984-04-28 | 1985-11-18 | Terumo Corp | Liposome pharmaceutical |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS57106626A (en) | Cytotoxic protein complex and its preparation | |
IT8019341A0 (en) | PROCEDURE FOR THE PREPARATION OF LATECES OF VINYL ACETATE/ETHYLENE COPOLYMERS AND LATECES OBTAINED THROUGH SAID PROCEDURE. | |
DK19887D0 (en) | PEPTIDES WITH VASOR RELAXING, NATURURETIC AND DIURETIC EFFECTS, PROCEDURES FOR THEIR PREPARATION, MENTALS CONTAINING THE COMPOUNDS AND THEIR USE | |
JPS536560A (en) | Manufacture of cathode for direct heating type cathode ray tube | |
DK158488C (en) | PROCEDURE FOR THE PREPARATION OF BLOOD CELL PROTEIN AND HOME BY DIVOLUTION OF HAEMOGLOBIN | |
JPS57128621A (en) | Preparation of prolonged release type composite | |
NO881215L (en) | PROCEDURE FOR THE PREPARATION OF ALGES WITH IMPROVED BIOLOGICAL EFFECTS. | |
JPS5610254A (en) | New rheumatism factor measuring reagent | |
BE892292A (en) | BIOLOGICALLY ACTIVE SUBSTANCE, PROCESS FOR PREPARING THE SAME, AND IMMUNOACTIVE COMPOSITION | |
DE3781700D1 (en) | Cathode ray tubes with ion trap. | |
IT1207583B (en) | PHARMACEUTICAL COMPOSITION INCLUDING AN ORGANIC ZINC COMPLEX AND PROCEDURE FOR PREPARING THE ACTIVE SUBSTANCE. | |
DE3583698D1 (en) | PERCUTANIC ABSORPTION ACCELERATOR AND PREPARATION CONTAINING THEM. | |
JPS5241238A (en) | Insect attractant composition | |
EP0278061A3 (en) | Active carbon granulates and process for their preparation | |
JPS5299217A (en) | Vermin attractants | |
JPS57106610A (en) | Preparation of prolonged release type composite | |
IT8767940A0 (en) | MICROBIOLOGICAL PROCEDURE FOR THE PREPARATION OF 9 ALPHA-HYDROXY4-ANDROSTENE-3,17 DIONE | |
NO904219L (en) | PROCEDURE FOR THE PREPARATION OF AN EPOXY MATERIAL WITH HIGH SOLID CONTENT. | |
PT65644B (en) | PROCESS FOR THE PREPARATION OF 1,3-SUBSTITUTED TRIAZIN-2,4-DIONES AND THEIR USE AS INSECTICIDES | |
IT8223388A0 (en) | POLYMERS AND PROCEDURE FOR THE STABILIZATION MIXTURE FOR THE PREPARATION OF THIS MIXTURE. | |
DK154143C (en) | PURE 6,6-DIIODPENICILLANIC ACID AND PROCEDURE FOR PREPARING THEREOF BY DIAZOTING 6BETA-AMINOPENICILLANIC ACID IN THE PRESENT OF IOD | |
JPS5281062A (en) | Treatment of exhaust gas from production of agricultural chemicals | |
JPS57126415A (en) | Preparation of prolonged release type composite | |
Misra | CORRELATION BETWEEN OUTDOOR AND ACCELERATED WEATHERING TESTS | |
JPS51114492A (en) | Preparation of amino resins |