JPS57128621A - Preparation of prolonged release type composite - Google Patents

Preparation of prolonged release type composite

Info

Publication number
JPS57128621A
JPS57128621A JP1260681A JP1260681A JPS57128621A JP S57128621 A JPS57128621 A JP S57128621A JP 1260681 A JP1260681 A JP 1260681A JP 1260681 A JP1260681 A JP 1260681A JP S57128621 A JPS57128621 A JP S57128621A
Authority
JP
Japan
Prior art keywords
prolonged release
active substance
physiologically active
type composite
heat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1260681A
Other languages
Japanese (ja)
Inventor
Masaharu Asano
Masaru Yoshida
Isao Kaetsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Agency
Original Assignee
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIPPON GENSHIRYOKU KENKYUSHO, Japan Atomic Energy Research Institute filed Critical NIPPON GENSHIRYOKU KENKYUSHO
Priority to JP1260681A priority Critical patent/JPS57128621A/en
Priority to US06/340,989 priority patent/US4483807A/en
Priority to DE3249683A priority patent/DE3249683C2/en
Priority to DE19823202255 priority patent/DE3202255A1/en
Priority to DE3249684A priority patent/DE3249684C2/en
Publication of JPS57128621A publication Critical patent/JPS57128621A/en
Pending legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

PURPOSE: To obtain a prolonged release type composite, having improved hardness and strength and extended prolonged release performance, by heat-treating a mixed system consisting of a polypeptide, a heat denaturing protein, a physiologically active substance and a mixture of water with an organic solvent.
CONSTITUTION: A mixed system consisting of a polypeptide, e.g. poly-alanine or poly-glycine, a heat denaturing protein, e.g. β-globulin or γ-globulin, a physiologically active substance, e.g. bleomycin hydrochloride or mitomycin C, and a mixture of water with an organic solvent of a suitable composition is molded into a suitable form and then heat-treated at room temperature W100°C and further irradiated with light or ionizing radiation, e.g. gamma rays, to give a prolonged release type composite containing the physiologically active substance. The irradiation with the light or ionizing radiation prolongs the dissolution of the physiologically active substance from the composite and improves the hardness and strength thereof.
COPYRIGHT: (C)1982,JPO&Japio
JP1260681A 1981-01-27 1981-01-30 Preparation of prolonged release type composite Pending JPS57128621A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP1260681A JPS57128621A (en) 1981-01-30 1981-01-30 Preparation of prolonged release type composite
US06/340,989 US4483807A (en) 1981-01-27 1982-01-20 Process for producing a slow release composite
DE3249683A DE3249683C2 (en) 1981-01-27 1982-01-25 Method of making a composite with long-term release
DE19823202255 DE3202255A1 (en) 1981-01-27 1982-01-25 METHOD FOR PRODUCING A COMPOSITE WITH LONG-TERM RELEASE
DE3249684A DE3249684C2 (en) 1981-01-27 1982-01-25 Process for producing a long-term release composite

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1260681A JPS57128621A (en) 1981-01-30 1981-01-30 Preparation of prolonged release type composite

Publications (1)

Publication Number Publication Date
JPS57128621A true JPS57128621A (en) 1982-08-10

Family

ID=11810007

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1260681A Pending JPS57128621A (en) 1981-01-27 1981-01-30 Preparation of prolonged release type composite

Country Status (1)

Country Link
JP (1) JPS57128621A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60231609A (en) * 1984-04-28 1985-11-18 Terumo Corp Liposome pharmaceutical

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5040718A (en) * 1973-05-17 1975-04-14
JPS5553214A (en) * 1978-10-09 1980-04-18 Merck Patent Gmbh Molded mixture based on reabsorbent collagen in body*its manufacture and its medical use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5040718A (en) * 1973-05-17 1975-04-14
JPS5553214A (en) * 1978-10-09 1980-04-18 Merck Patent Gmbh Molded mixture based on reabsorbent collagen in body*its manufacture and its medical use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60231609A (en) * 1984-04-28 1985-11-18 Terumo Corp Liposome pharmaceutical

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