JPS57106610A - Preparation of prolonged release type composite - Google Patents

Preparation of prolonged release type composite

Info

Publication number
JPS57106610A
JPS57106610A JP18153180A JP18153180A JPS57106610A JP S57106610 A JPS57106610 A JP S57106610A JP 18153180 A JP18153180 A JP 18153180A JP 18153180 A JP18153180 A JP 18153180A JP S57106610 A JPS57106610 A JP S57106610A
Authority
JP
Japan
Prior art keywords
water
mixed solution
release type
type composite
heat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP18153180A
Other languages
Japanese (ja)
Other versions
JPS6042205B2 (en
Inventor
Masaharu Asano
Masaru Yoshida
Isao Kaetsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Agency
Original Assignee
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIPPON GENSHIRYOKU KENKYUSHO, Japan Atomic Energy Research Institute filed Critical NIPPON GENSHIRYOKU KENKYUSHO
Priority to JP18153180A priority Critical patent/JPS6042205B2/en
Publication of JPS57106610A publication Critical patent/JPS57106610A/en
Publication of JPS6042205B2 publication Critical patent/JPS6042205B2/en
Expired legal-status Critical Current

Links

Abstract

PURPOSE: To obtain a hard prolonged release type composite having a long prolonged releasing time of a physiologically active substance, by molding a system consisting of a heat denaturing protein, a mixed solution of water with an organic solvent and a physiologically active substance into a suitable shape, and heat-treating the resultant molded material.
CONSTITUTION: A system consisting of 10pts.wt. heat denaturing protein, e.g. albumin, γ-globuin or hemoglobin, with 0.01W10pts.wt. mixed solution of water with an organic solvent and 0.01W50pts.wt. physiologically active substance is molded into a suitable shape, and the resultant molded article is then heat- treated at room temperature W100°C to give the aimed prolonged release type composite. The prolonged release type composite prepared by using the mixed solution of water with the organic solvent has remarkable improved prolonged releasing properties compared with that of the water alone, and improved properties such as a slight porous structure formed in the composite. The heat treatment and the light or ionizing radiation provide better effects. Preferably, the mixed solution is used in an amount of 0.5W1pt.wt. based on 1pt.wt. water.
COPYRIGHT: (C)1982,JPO&Japio
JP18153180A 1980-12-22 1980-12-22 Method for producing sustained release complex Expired JPS6042205B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18153180A JPS6042205B2 (en) 1980-12-22 1980-12-22 Method for producing sustained release complex

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18153180A JPS6042205B2 (en) 1980-12-22 1980-12-22 Method for producing sustained release complex

Publications (2)

Publication Number Publication Date
JPS57106610A true JPS57106610A (en) 1982-07-02
JPS6042205B2 JPS6042205B2 (en) 1985-09-20

Family

ID=16102391

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18153180A Expired JPS6042205B2 (en) 1980-12-22 1980-12-22 Method for producing sustained release complex

Country Status (1)

Country Link
JP (1) JPS6042205B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795645A (en) * 1986-03-03 1989-01-03 Yissum Research And Development Sustained release tablets of theophylline
US5055300A (en) * 1988-06-17 1991-10-08 Basic Bio Systems, Inc. Time release protein

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795645A (en) * 1986-03-03 1989-01-03 Yissum Research And Development Sustained release tablets of theophylline
US5055300A (en) * 1988-06-17 1991-10-08 Basic Bio Systems, Inc. Time release protein

Also Published As

Publication number Publication date
JPS6042205B2 (en) 1985-09-20

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