JPS57197210A - Method for preparation of slow-releasing composite - Google Patents

Method for preparation of slow-releasing composite

Info

Publication number
JPS57197210A
JPS57197210A JP7956781A JP7956781A JPS57197210A JP S57197210 A JPS57197210 A JP S57197210A JP 7956781 A JP7956781 A JP 7956781A JP 7956781 A JP7956781 A JP 7956781A JP S57197210 A JPS57197210 A JP S57197210A
Authority
JP
Japan
Prior art keywords
nca
slow
composite
polypeptide
releasing composite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7956781A
Other languages
Japanese (ja)
Inventor
Masaharu Asano
Masaru Yoshida
Isao Kaetsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Agency
Original Assignee
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIPPON GENSHIRYOKU KENKYUSHO, Japan Atomic Energy Research Institute filed Critical NIPPON GENSHIRYOKU KENKYUSHO
Priority to JP7956781A priority Critical patent/JPS57197210A/en
Priority to US06/340,989 priority patent/US4483807A/en
Priority to DE3249684A priority patent/DE3249684C2/de
Priority to DE3249683A priority patent/DE3249683C2/en
Priority to DE19823202255 priority patent/DE3202255A1/en
Publication of JPS57197210A publication Critical patent/JPS57197210A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare slow-releasing composite containing a polypeptide having higher molecular weight than the raw material, as a matrix, by mixing an N- carboxyamino acid with a physiologically active substance, treating the mixture in a specific temperature range under pressure, and irradiating with light or ionizing radiation.
CONSTITUTION: An N-carboxyamino acid anhydride (NCA) (e.g. glycine NCA, alanine NCA, etc.) is mixed thoroughly with a physiologically active substance (e.g. bleomycin hydrochloride, 5-fluorouracil, etc.), formed to a proper shape at -20W+40°C and 10W20,000atm, and irradiated with light or ionizing radiation at -100W+40°C to obtain the objective slow-releasing composite. The above treatment enables the synthesis of a polypeptide having higher molecular weight than the NCA used as the raw material. The shape of the composite is, e.g. rod, cylinder, needle, sphere, film, etc. according to the use.
COPYRIGHT: (C)1982,JPO&Japio
JP7956781A 1981-01-27 1981-05-26 Method for preparation of slow-releasing composite Pending JPS57197210A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP7956781A JPS57197210A (en) 1981-05-26 1981-05-26 Method for preparation of slow-releasing composite
US06/340,989 US4483807A (en) 1981-01-27 1982-01-20 Process for producing a slow release composite
DE3249684A DE3249684C2 (en) 1981-01-27 1982-01-25
DE3249683A DE3249683C2 (en) 1981-01-27 1982-01-25 Method of making a composite with long-term release
DE19823202255 DE3202255A1 (en) 1981-01-27 1982-01-25 METHOD FOR PRODUCING A COMPOSITE WITH LONG-TERM RELEASE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7956781A JPS57197210A (en) 1981-05-26 1981-05-26 Method for preparation of slow-releasing composite

Publications (1)

Publication Number Publication Date
JPS57197210A true JPS57197210A (en) 1982-12-03

Family

ID=13693576

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7956781A Pending JPS57197210A (en) 1981-01-27 1981-05-26 Method for preparation of slow-releasing composite

Country Status (1)

Country Link
JP (1) JPS57197210A (en)

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